An Omics View of the Inflammation of Aging
Aging is characterized by chronic inflammation, disruptive of cell and tissue function, a sizable contribution to the onset and progression of all of the common age-related conditions. The causes of this inflammation are known at the high level, such as the increasing presence of senescent cells and damage-associated molecular patterns, such as DNA debris from dead and dying cells. At the detail level, the real of genomics, transcriptomics, proteomics, and the other omics, much remains to be cataloged. There is the hope that a full map of inflammation in aging would point out more and better regulatory or signal molecules ...
Source: Fight Aging! - July 26, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, July 25th 2022
This study further demonstrates that AMD is not a single condition or an isolated disease, but is often a signal of systemic malfunction which could benefit from targeted medical evaluation in addition to localized eye care."
Microglia in the Aging Brain, Both Protective and Harmful
https://www.fightaging.org/archives/2022/07/microglia-in-the-aging-brain-both-protective-and-harmful/
A growing body of evidence implicates the changing behavior of microglia in the aging of the brain and onset of neurodegeneration. Microglia are analogous to macrophages, innate immune cells unique to the central nervous sys...
Source: Fight Aging! - July 24, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Glymphatic System Dysfunction Contributes to the Pathology of Cerebral Small Vessel Disease
The vasculature becomes dysfunctional with age, and cerebral small vessel disease is a catch-all category that includes a variety of different malfunctions in the biology of smaller blood vessels that act to reduce blood flow to the brain or damage brain tissue. In recent years, attention has turned to the drainage of cerebrospinal fluid from the brain, with the idea that failure of drainage with age contributes to a buildup of molecular waste and consequent pathology in the brain. The glymphatic system is one of the major paths of drainage, and here researchers provide evidence for its dysfunction to be involved in the co...
Source: Fight Aging! - July 22, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
TORdx LUNG Test for Donor Lung Assessment: Interview with Eric Brouwer, Chief Scientific Officer at SQI Diagnostics
SQI Diagnostics, a medtech company based in Canada, is developing the TORdx LUNG Test. The technology is intended to assist clinicians in assessing donor lungs in their suitability for transplantation. At present, clinicians typically assess donor lungs using qualitative variables, such as donor health and lung size. One of the most important factors, lung inflammation, is difficult to assess, and clinicians will often play it safe and reject an organ if there is any doubt about it.
This means that lungs that might actually be suitable for transplantation are often rejected, further compounding the lack of donor organs....
Source: Medgadget - July 18, 2022 Category: Medical Devices Authors: Conn Hastings Tags: Cardiac Surgery Exclusive Medicine Thoracic Surgery lung transplant sqi diagnostics Source Type: blogs
Fight Aging! Newsletter, July 18th 2022
In conclusion, we show that PVS morphology in mice is variable and that the structure and function of pia suggests a previously unrecognized role in regulating CSF transport and amyloid clearance in aging and disease.
Reversing Ovarian Fibrosis in Mice
https://www.fightaging.org/archives/2022/07/reversing-ovarian-fibrosis-in-mice/
Researchers here provide evidence for ovarian fibrosis to be an important mechanism in limiting the age at which female mammals can remain fertile. Interestingly, existing antifibrotic drugs can produce some reversal of this fibrosis, enough to restore ovulation in mice. Fibro...
Source: Fight Aging! - July 17, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Studies that Use Epigenetic Clocks Must Obtain Other Health Data as Well
Epigenetic clocks produce a value that correlates well with chronological age, and is thought to reflect biological age, in that people with higher epigenetic ages appear to have a worse risk of age-related disease. What underlying processes produce the characteristic epigenetic changes measured by the clocks, however? Without knowing this, it is hard to take clock data seriously as an assessment of the potential for any given novel intervention to slow or reverse aging. Perhaps the clock places too much weight on one specific mechanism of aging, or is insensitive to another, which would distort the outcome for potential t...
Source: Fight Aging! - July 11, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, July 11th 2022
In this study we employ a transcriptome-wide and multi-tissue approach to analyze the influence of both LTDR and short-term DR (STDR) at old age on the aging phenotype. We were able to characterize a common transcriptional gene network driving inflammaging in most of the analyzed tissues. This network is characterized by chromatin opening and upregulation in the transcription of innate immune system receptors and by activation of interferon signaling through interferon regulatory factors, inflammatory cytokines, and Stat1-mediated transcription. We also found that both DR interventions ameliorate this inflammaging phenotyp...
Source: Fight Aging! - July 10, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
In Search of More Ways to Destroy Senescent Cells by Unleashing p53
Based on animal data, the growing burden of senescent cells with age appears to provide a significant contribution to age-related degeneration. Cells become senescent in response to tissue injury, significant cellular damage, signaling from other senescent cells, or reaching the Hayflick limit on replication. In youth, senescent cells are efficiently cleared, either destroying themselves via programmed cell death, or being destroyed by the immune system. In later life, clearance slows, and as a result there are ever more lingering senescent cells delivering signals that disrupt tissue structure and function and provoking c...
Source: Fight Aging! - July 7, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, July 4th 2022
This study showed that centenarians had very specific changes in CD4+ T cell populations, which were manifested by an elevated Th17/Treg ratio in vivo, as well as a changed secretory phenotype. Although the T cells of centenarians cannot resist the aging-related expression of proinflammatory genes, their secretory phenotype was altered, explaining the relatively low level of inflammation in centenarians. These results suggested the presence of a mechanism to ameliorate inflammaging in centenarians. This may be achieved by reversing the imbalance of Th17/Treg cells and reducing pro-inflammatory cytokines.
Longevit...
Source: Fight Aging! - July 3, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
AI Adoption in Healthcare Requires Better Approaches to Patient Data
The following is a guest article by Vanessa Braunstein, Healthcare Product Marketing Lead at NVIDIA.
Building great AI models in healthcare and life sciences requires lots of data that is diverse, well-labeled, and spans across different patient types.
However, as AI gains traction, there are still a number of bottlenecks that slow down the process of developing robust AI models such as patient privacy, access to data, and lack of clinical expertise to annotate data for training.
In order to overcome these barriers, data scientists and developers have developed new solutions such as federated learning paradigms, AI models ...
Source: EMR and HIPAA - June 28, 2022 Category: Information Technology Authors: Guest Author Tags: AI/Machine Learning Analytics/Big Data C-Suite Leadership Health IT Company Healthcare IT Hospital - Health System Federated Learning GDPR Health Data Ethics Health Data Privacy Healthcare AI Healthcare AI Ethics Healthcare Neural Source Type: blogs
Fight Aging! Newsletter, June 27th 2022
In conclusion, this study confirms that innate immune training can be induced in aging healthy individuals as well as critically ill sepsis patients. We found that innate immune training can be induced regardless of age and there was no substantive difference in the immune trained phenotype as a function of age. We employed β-glucan as our immune training stimulus. The ability of glucan to induce the trained phenotype suggests that it may be possible to pharmacologically induce the immune trained phenotype in aging human immunocytes.
Sitting Time Correlates with Mortality Risk
https://www.fightaging.org/archi...
Source: Fight Aging! - June 26, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Polymer Brushes Capture and Release Proteins on Demand
Researchers at the Chalmers University of Technology in Sweden have developed a “polymer brush” system that can capture and release proteins on using electrical stimulation. Protein therapeutics are increasingly in demand, but creating them efficiently is still a challenge. Isolating therapeutic proteins from the liquid surrounding the cells used to produce them in biotechnological processes is difficult and inefficient, but the researchers behind this latest technology hope that the new technique will form an efficient and gentle way to achieve this. In addition, another exciting application may lie in controlled rele...
Source: Medgadget - June 22, 2022 Category: Medical Devices Authors: Conn Hastings Tags: Materials Medicine chalmersuniv Source Type: blogs
Career Conversations: Q & A with Medicinal Inorganic Chemist Eszter Boros
Dr. Eszter Boros. Credit: Courtesy of Dr. Eszter Boros.
“As a researcher, you get to learn something new every day, and that knowledge feeds more questions. It’s this eternal learning process, and I find that really enticing about being in science,” says Eszter Boros, Ph.D., an assistant professor of chemistry at Stony Brook University in Stony Brook, New York. Our interview with Dr. Boros highlights her journey of becoming a scientist and her research on biomedical applications of metals.
Q: What drew you to science?
A: I was born and raised in Switzerland, and I went to a linguistics-focused high school the...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - June 22, 2022 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Chemistry, Biochemistry and Pharmacology Profiles Source Type: blogs
Combining Age-Slowing Interventions in Flies Doubles Life Span
In this study, we investigated whether the combined application of several interventions with potential anti-aging action causes a cumulative effect on lifespan extension in flies. As for anti-aging drugs, we used rapamycin, the well-known mTOR signaling inhibitor, and two plant-derived compounds, particularly, alkaloid berberine and carotenoid fucoxanthin, whose geroprotective properties have been studied on different biological models.
We studied the effects of dietary restriction and co-administration of berberine, fucoxanthin, and rapamycin in constant darkness and low-temperature conditions using the D. melanog...
Source: Fight Aging! - June 22, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, June 20th 2022
This study showed a negative relationship between the gaps and the number of senescence cells. Moreover, we found a similar reduction in 30-month-old naturally and 7-month-old D-gal-induced aging rats. Given these consistent data from different eukaryotic organisms, it suggests that the Youth-DNA-GAP is a marker of phenotype-related aging degree
Towards Scaffold-Based Regeneration of Dental Pulp
https://www.fightaging.org/archives/2022/06/towards-scaffold-based-regeneration-of-dental-pulp/
Researchers are working towards the ability to regenerate the dental pulp inside teeth. Full regeneration of teeth ...
Source: Fight Aging! - June 19, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
