Do Methods Known to Slow Aging Actually Slow Aging?
We examined central genetic and environmental lifespan regulators (putative anti-aging interventions, PAAIs; the following PAAIs were examined: mTOR loss-of-function, loss-of-function in growth hormone signaling, dietary restriction) for a possible countering of the signs and symptoms of aging. Importantly, in our study design, we included young treated groups of animals, subjected to PAAIs prior to the onset of detectable age-dependent phenotypic change. In parallel to our studies in mice, we assessed genetic variants for their effects on age-sensitive phenotypes in humans.
We observed that, surprisingly, many PAAI...
Source: Fight Aging! - April 22, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
YouthBio Therapeutics is Another New Partial Reprogramming Company
Partial reprogramming of cells to restore youthful epigenetic patterns, and thus gene expression, is becoming quite the popular field of development. Based on results in mice, it is thought that the in vivo application of the Yamanaka factors could be made safe enough to be the basis for practical whole-body rejuvenation therapies. While epigenetic reprogramming can't do much for DNA damage and some of the persistent molecular waste found in old tissues, among other issues, it has been shown to restore lost mitochondrial function. It may ameliorate a range of other issues as well, and could prove to be beneficial enough to...
Source: Fight Aging! - April 22, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
The Goal Must be to Cure Aging
A cure for aging, as presently envisaged, would be a matter of bringing aging under medical control. Not stopping its progression, but rather periodically repairing the damage that accumulates in tissues as a result of the normal operation of metabolism. Present goals in the longevity industry are largely unambitious, aimed at a very modest improvement over the present situation via adjustment of metabolism, such as via mimicking some of the effects of calorie restriction. Thus more advocacy for the better end goal is necessary. More persuasion! There are approaches that can repair the molecular damage of aging, such as se...
Source: Fight Aging! - April 21, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
How Bacteria-Infecting Viruses Could Save Lives
Dr. Ry Young. Credit: Texas A&M University.
“My parents told me that I already wanted to be a scientist when I was 7 or 8 years old. I don’t remember ever considering anything else,” says Ry Young, Ph.D., a professor of biochemistry, biophysics, and biology at Texas A&M University, College Station.
Dr. Young has been a researcher for more than 45 years and is a leading expert on bacteriophages—viruses that infect bacteria. He and other scientists have shown that phages, as bacteriophages are often called, could help us fight bacteria that have developed resistance to antibiotics. Antibiotic-resistant ...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - April 20, 2022 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Injury and Illness Bacteria Infectious Diseases Profiles Scientific Process Viruses Source Type: blogs
Fight Aging! Newsletter, April 18th 2022
In conclusion, our results suggest that SAH extends lifespan by inducing MetR or mimicking its downstream effects. Since the lifespan-extending effects of SAH are conserved in yeast and nematodes, and MetR extends the lifespan of many species, exposure to SAH is expected to have multiple benefits across evolutionary boundaries. Our findings offer the enticing possibility that in humans the benefits of a MetR diet can be achieved by promoting Met reduction with SAH. The use of endogenous metabolites, such as SAH, is considered safer than drugs and other substances, suggesting that it may be one of the most feasible ways to ...
Source: Fight Aging! - April 17, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, April 11th 2022
In conclusion, plasma levels of IGHA2, APOA and HPT are associated with subclinical atherosclerosis independently of traditional risk factors and offers potential to predict this disease. The panel could improve primary prevention strategies in areas where imaging is not available.
A Lesser Diversity of Circulating Antibodies in the Aging Killifish Immune System
https://www.fightaging.org/archives/2022/04/a-lesser-diversity-of-circulating-antibodies-in-the-aging-killifish-immune-system/
Short-lived killifish are one of the more recently adopted animal models of aging. All such models are a trade-off bet...
Source: Fight Aging! - April 10, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Mapping ‘psychedelic trips’ in the brain to better direct their therapeutic effects
This article was originally published on The Conversation.
To learn more:
Why MDMA-assisted psychotherapy may become an FDA-approved treatment for PTSD within 2 years
Next: Psychedelic-assisted psychotherapy?
The post Mapping ‘psychedelic trips’ in the brain to better direct their therapeutic effects appeared first on SharpBrains. (Source: SharpBrains)
Source: SharpBrains - April 4, 2022 Category: Neuroscience Authors: The Conversation Tags: Brain/ Mental Health academic research anxiety artificial intelligence brain regions cognitive-flexibility depression psychedelics psychiatric conditions psychotropic drugs therapeutic treat psychiatric conditions Source Type: blogs
Fight Aging! Newsletter, April 4th 2022
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - April 3, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
From Organ Designers To Telesurgery VR Planners: Healthcare Jobs in 2040
In this study, the researchers employed the VR prototype for surgical planning using a standard VR setup in two real cases of patients with liver tumours who were scheduled for surgery at a University Hospital for Visceral Surgery. Surgeons used the VR prototype before the surgery to plan the procedure in addition to their regular planning process. They used semi-structured interviews before and after the surgery to explore the benefits and pitfalls of VR surgical planning.
Within 20-30 years, AR/VR operation planners will help surgeons in the preparation for very complex surgical interventions. While the medical pr...
Source: The Medical Futurist - March 31, 2022 Category: Information Technology Authors: Andrea Koncz Tags: TMF Forecast E-Patients Future of Medicine Medical Education Science Fiction digital health healthcare jobs future jobs Source Type: blogs
Dibs on a RNA Computer
BY KIM BELLARD
I’ve given DNA a lot of love over the years — DNA as a storage medium, as a computing platform, as the basis for robots, as the tool for synthetic biology/biohacking, even used for the DNA-of-Things (DoT). DNA is the basis for all life as we know it, in every category of life we’ve found anywhere on earth. That we are now using it to achieve technological goals seems like one of humankind’s greatest accomplishments.
But where’s the love for RNA, DNA’s putative ancestor and still-partner? A few recent developments in RNA caught my eye that I wanted to give their due.
...
Source: The Health Care Blog - March 29, 2022 Category: Consumer Health News Authors: Ryan Bose-Roy Tags: Health Tech Source Type: blogs
Fight Aging! Newsletter, March 28th 2022
In conclusion, we summarized here evidence for a novel therapeutic approach to exploit the incredible ability of mitochondria to engage multifaceted neuroprotective stress response triggered by partial complex I inhibition. This approach promises relief for multiple human conditions, and to promote healthy aging to delay the onset of neurogenerative diseases, AD in particular, where age is the greatest risk factor. There is a mounting body of evidence generated in model organisms and humans in support of the safety of chronic application of complex I inhibitors. However, a better understanding of the molecular mechanisms i...
Source: Fight Aging! - March 27, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
An Approach to Growing the Cryonics Industry: Build a Hospital First, then Add Cryonics Services
My attention was recently drawn to Cryopets, a newly formed cryonics provider that has a novel approach to nudging the cryonics industry closer to the mainstream. As regular readers know, cryonics is the low-temperature storage of patients immediately following death, aimed at preservation of the fine structure of brain tissue that stores the data of the mind. Given a high quality preservation, and then indefinite maintenance at low temperature, at some point the societies of the high-tech future will have the capability to revive those patients. There is nothing magical about it; it "just" requires mature molecular nanote...
Source: Fight Aging! - March 25, 2022 Category: Research Authors: Reason Tags: Longevity Industry Source Type: blogs
Fight Aging! Newsletter, March 21st 2022
This study was the first to examine how these networks interact with physical activity and fitness to impact how the brain functions.
"This paper is exciting because it gives us some evidence that when people whose brain networks aren't functioning optimally engage in physical activity, we see improvement in their executive function and their independence. Maybe just take the stairs on the way to work. Stand up and walk around a little bit more. That's where you get the most bang for your buck, not crazy, high-intensity exercise."
Variations in Biological Age Across Organs in Younger Individuals
https:/...
Source: Fight Aging! - March 20, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The (sort of, partial) Father mRNA Vaccines Who Now Spreads Vaccine Misinformation (Part 1)
By DAVID WARMFLASH, MD
Robert W. Malone, MD MS, is a physician-scientist who will live in infamy, thanks to the Joe Rogan Experience Podcast boosting his visibility this past December regarding his criticism of COVID-19 vaccines, particularly the mRNA vaccines (Moderna and Pfizer-BioNTech). Subsequently, Malone was banned from Twitter, which further boosted his celebrity status. Describing himself as the inventor of mRNA vaccine technology, he has been reaching a growing number of people with a narrative that makes COVID-19 vaccination sound scary. We cannot embed clips from the Rogan interview, which lasted about three...
Source: The Health Care Blog - March 17, 2022 Category: Consumer Health News Authors: matthew holt Tags: COVID-19 Health Policy antivaxxer COVID-19 vaccine David Warmflash Joe Rogan Robert Malone Source Type: blogs
Epigenetic Aging Halts During Hibernation in Marmots
Continuing the recent run of interesting observations arising from the ability to assess epigenetic age, researchers here show that a hibernating species shows no uptick in epigenetic age over the period of hibernation. The metabolism of hibernation has been a topic of minor interest for some years in the context of aging and mechanisms of aging. The metabolic state of hibernation seems favorable in many of the same ways that are observed in states like calorie restriction, but perhaps for distinct reasons.
Yellow-bellied marmots are able to virtually halt the aging process during the seven to eight months they sp...
Source: Fight Aging! - March 17, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
