Fight Aging! Newsletter, May 8th 2023
In conclusion, NAT mitigated age-associated cerebral injury in mice through gut-brain axis. The findings provide novel evidence for the effect of NAT on anti-aging, and highlight the potential application of NAT as an effective intervention against age-related diseases.
Retinal Cell Reprogramming Restores Vision in Non-Human Primate Study
https://www.fightaging.org/archives/2023/05/retinal-cell-reprogramming-restores-vision-in-non-human-primate-study/
Early applications of in vivo cellular reprogramming to medicine are cautiously focused on retinal regeneration. The eye is as close to an isolated system...
Source: Fight Aging! - May 7, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Wanted: NIGMS Program Directors
We’re recruiting accomplished scientists for positions in our Division of Biophysics, Biomedical Technology, and Computational Biosciences (BBCB) and Division of Genetics and Molecular, Cellular, and Developmental Biology (GMCDB). The successful applicants will be responsible for scientific and administrative management of a portfolio of research grants and/or research training grants and career development awards, and will stimulate, plan, advise, direct, and evaluate program activities related to their field of expertise.
The two BBCB program director positions support research and training portfolios in biophys...
Source: NIGMS Feedback Loop Blog - National Institute of General Medical Sciences - May 3, 2023 Category: Biomedical Science Authors: Chrissa Chverchko Tags: Job Announcements Source Type: blogs
Science Snippet: The Power of Proteins
Some might think that protein is only important for weightlifters. In truth, all life relies on the activity of protein molecules. A single human cell contains thousands of different proteins with diverse roles, including:
Actin proteins in a cell’s cytoskeleton. Credit: Xiaowei Zhuang, HHMI, Harvard University, and Nature Publishing Group.
Providing structure. Proteins such as actin make up the three-dimensional cytoskeleton that gives cells structure and determines their shapes.
Aiding chemical reactions. Many proteins are biological catalysts called enzymes that speed up the rate of chemical reactions by redu...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - May 3, 2023 Category: Research Authors: Chrissa Chverchko Tags: Cells Molecular Structures Cellular Processes Medicines Proteins Science Snippet Source Type: blogs
Reviewing Present Biomarkers of Aging
Today's open access paper, with more than 120 contributing authors, is a tour of the broad topic of biomarkers of aging, an attempt to say at least something about every aspect of cellular biochemistry and functional capacity that is either used or proposed to be used to measure biological age, from grip strength to epigenetic clocks. Biological age is in one sense an aspirational concept, a way to measure the progression of aging that will accurately reflect mortality and disease risk. In another sense, biological age is self-evidently real. Different people age at different rates, and exhibit very different risk levels f...
Source: Fight Aging! - May 1, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, April 24th 2023
In this study, researchers show that mice lacking a functional ATF4 gene show little to no loss of grip strength and treadmill performance into late life; it is quite an impressive effect size. Assessments of muscle biochemistry do show age-related declines, but to a lesser degree than the controls. How ATF4 knockout functions to produce this outcome is an interesting question. The researchers point out a range of possible downstream and upstream targets that have been implicated in the regulation of muscle growth, but it will clearly require further work to identify the important mechanisms involved.
Aging slowly...
Source: Fight Aging! - April 23, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Career Conversations: Q & A With Polymer Chemist Frank Leibfarth
Credit: Courtesy of Dr. Frank Leibfarth.
“I love that you can change the molecular-level structure of a material, then pull it, bend it, or twist it and see firsthand how the molecular changes you introduced influence its stretchiness or bendiness,” says Frank Leibfarth Ph.D., an associate professor of chemistry at the University of North Carolina (UNC) at Chapel Hill. In an interview, Dr. Leibfarth shares with us his scientific journey, his use of chemistry to tackle challenges in human health and sustainability, and his beliefs on what makes a career in science exciting.
Q: What led you to study chemistry?
...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - April 19, 2023 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Chemistry, Biochemistry and Pharmacology Tools and Techniques Cool Tools/Techniques Profiles Source Type: blogs
Reviewing the Aging of the Gut Microbiome
Researchers here take a high level tour of what is known of age-related changes in the gut microbiome and how they influence health. Accumulating evidence shows a loss of beneficial populations that generate useful metabolites such as butyrate, accompanied by an increase in harmful populations that can provoke chronic inflammation. This is a likely a meaningful contribution to the onset and development age-related conditions, making it a priority to develop ways to reset the balance of populations in the gut microbiome. The best of the available approaches, given the evidence to date, is fecal microbiota transplantation fr...
Source: Fight Aging! - April 18, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, April 17th 2023
In conclusion, oral NR altered the gut microbiota in rats and mice, but not in humans. In addition, NR attenuated body fat mass gain in rats, and increased fat and energy absorption in the HFD context.
Glycine Supplementation as a Methionine Restriction Mimetic
https://www.fightaging.org/archives/2023/04/glycine-supplementation-as-a-methionine-restriction-mimetic/
Supplementation with the non-essential amino acid glycine has been shown to modestly slow aging in short-lived laboratory species. In today's open access review paper, researchers note glycine supplementation as essentially a calorie restricti...
Source: Fight Aging! - April 16, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Chemistry Under the Big Top
Credit: ACES.
“Our main goal is to get elementary students excited to learn about STEM, and for them to see how beautiful and relevant science can be to communities in eastern Montana,” says Amanda Obery, Ph.D., an assistant professor in elementary education at Central Washington University in Ellensburg, Washington. Dr. Obery co-leads the Authentic Community Engagement in Science (ACES) project with Matt Queen, Ph.D., an assistant professor in biological and physical sciences at Montana State University Billings (MSUB).
A Custom STEM Curriculum with a Local Emphasis
ACES connects teachers and biomedical pr...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - April 10, 2023 Category: Research Authors: Matt Mills Tags: Being a Scientist STEM Education Profiles SEPA Training Source Type: blogs
Fight Aging! Newsletter, April 10th 2023
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - April 9, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Flawed Software Framing of Programmed Aging
The hypothesis that aging is a genetic program that is to some degree selected has always been a vocal minority view in the research community. There are just as many quite diverse theories of programmed aging as there are more mainstream evolutionary theories of aging that orbit the concept of antagonistic pleiotropy, the idea that lesser selection pressure in late life, because early reproduction means greater evolutionary fitness, allows for the evolution of mechanisms that are beneficial in youth and harmful in late life. There is even a fusion of the two sides: the hyperfunction theory of programmed aging suggests tha...
Source: Fight Aging! - April 5, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, April 3rd 2023
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - April 2, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
In Other Words: Not All Bases Are in the Ballpark
You might first think about sports when you hear the word base, but not all bases are on the baseball diamond. In chemistry, a base is a molecule that reacts with an acid, often by accepting a proton from the acid or from water. Baking soda and dish soap are common bases.
Credit: NIGMS.
A Building Block for Life
Bases are found throughout biological systems and in many molecules critical to life. The pH scale measures how acidic or basic (“alkaline”) liquids, such as water or blood, are. Liquids with a pH less than 7 are acidic, while liquids with a pH greater than 7 are basic. Electrolytes, like sodium, ca...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - March 29, 2023 Category: Research Authors: Chrissa Chverchko Tags: Cells Chemistry, Biochemistry and Pharmacology Molecular Structures DNA In Other Words RNA Source Type: blogs
The Business of Diabetes: 2023 Update on Glucose-Responsive Insulin
My readers may recall back in 2007, I interviewed the CEO of a startup then known as SmartCells, Inc. named Todd Zion (seehttps://blog.sstrumello.com/2007/06/conversation-with-smartcells-ceo-todd.html for my original post). In 2010, the big pharma giant Merck& Company, Inc. acquired SmartCells, Inc. (see my post athttps://blog.sstrumello.com/2010/12/merck-acquires-smartcells-inc.html for my coverage of that). For its part, Merck remained rather tight-lipped about revealing much of anything about that, although it did become the first-ever glucose responsive insulin to complete a clinical trial, which was known Merck ' ...
Source: Scott's Web Log - March 28, 2023 Category: Endocrinology Tags: Eli Lilly and Company Smart Insulin 2023 Merck Novo Nordisk SmartCells Source Type: blogs
Fight Aging! Newsletter, March 27th 2023
This study has potentially significant implications in the field of OA as it provides a novel strategy for OA treatment.
A Vicious Cycle of Heart Failure and Dementia
https://www.fightaging.org/archives/2023/03/a-vicious-cycle-of-heart-failure-and-dementia/
The end of life is not pretty. The body is a failing machine of many complex essential parts, and the failures cascade and feed into one another as it breaks down. There is pain, loss of capacity, loss of the self as the brain runs down. There is a tendency to paper over the ugly reality in public discussion, to not talk about the facts of the matter...
Source: Fight Aging! - March 26, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
