Fight Aging! Newsletter, October 30th 2023
In conclusion, reported adherence to a healthy lifestyle is associated with reduced risk of all-cause and cause-specific mortality. Adherence to all four lifestyle factors resulted in the strongest protection.
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Source: Fight Aging! - October 29, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
An Aging Clock from Aqueous Humor
Our biochemistry changes with age in ways that are broadly similar from person to person, occurring due to the same underlying mechanisms of aging. Any sufficiently large set of biological data can in principle be used to find an aging clock, some combination of weighted measures that assesses biological age or chronological age. As an illustration of that point, researchers here use the contents of aqueous humor from the eye to do just that. This approach is unlikely to be widely used, given that clocks based on blood samples or other more easily accessible data work just as well when it comes to determining biological ag...
Source: Fight Aging! - October 26, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Understanding RNA-Modifying Enzymes: Q & A With Jeffrey Mugridge
Credit: Courtesy of Jeffrey Mugridge.
“One of the best aspects of research is the excitement of discovery, being the first person in the world to know a small detail about the system you’re studying,” says Jeffrey Mugridge, Ph.D., an assistant professor of chemistry and biochemistry at the University of Delaware in Newark. We talked with Dr. Mugridge about how a pet store job sparked his early interest in science, why he decided to change his career trajectory after graduate school, and what he believes is key to being a successful researcher.
Q: How did you first become interested in science?
A: ...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - October 25, 2023 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Chemistry, Biochemistry and Pharmacology Profiles RNA Source Type: blogs
Modest Calorie Restriction Improves Muscle Quality in Humans
The practice of calorie restriction is known to improve health in many ways. Researchers continue to perform analyses on the samples taken from the human CALERIE study that was conducted some years ago, in which comparatively mild calorie restriction produced worthwhile results in the study participants. Here, researchers note improvements in markers of muscle quality, as one might expect given the animal studies of calorie restriction in which similar improvements were observed in skeletal muscle.
The lifespan extension induced by 40% caloric restriction (CR) in rodents is accompanied by postponement of disease, ...
Source: Fight Aging! - October 20, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
How to Determine If NIGMS Might Fund Your Research
This post is the first in a series outlining NIGMS research priorities, funding opportunities, and the grant application process for those not familiar with our Institute and its programs. We encourage you to share this series with others in your network, and to sign up to receive all future Feedback Loop posts delivered straight to your inbox.
We receive many questions from prospective applicants about getting NIGMS funding for their research: How do I know if my research fits within the scientific interests of NIGMS? What grant programs does the Institute offer? What are NIGMS’ research priorities? Whom do I tal...
Source: NIGMS Feedback Loop Blog - National Institute of General Medical Sciences - October 19, 2023 Category: Biomedical Science Authors: Chrissa Chverchko Tags: Funding Opportunities Research Administration Resources NIGMS Grant Basics Submitting an Application Source Type: blogs
How Do Medicines Work?
Credit: iStock.
What we put into our bodies can affect how they function and what they do. For example, a sugary snack will probably make you feel differently than a high-protein meal. Similarly, different medicines elicit different responses in your body, and pharmacologists try to fine-tune each medicine to balance the desired (on-target) with the undesired (off-target) effects—a branch of pharmacology called pharmacodynamics.
Most medicines work by binding to a molecular target, usually proteins like receptors or enzymes, and either blocking or supporting its activity, which results in their therapeutic effects.
...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - October 16, 2023 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Chemistry, Biochemistry and Pharmacology Common questions Medicines Miniseries Source Type: blogs
Fight Aging! Newsletter, October 16th 2023
In conclusion, a number of studies have shown that CD4+ Treg cells are crucial in the maintenance of peripheral tolerance and have an important role in the control of atherosclerosis-related inflammation. Therefore, Treg cells are a promising target of major research efforts focused on immune-modulating therapies against atherosclerosis. Developing anti-atherosclerotic Treg-based therapies faces challenges. However, rapid progress in genetic, epigenetic, and molecular aspects of cellular immunology gives hope for a fast-track solution.
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Delivering Senolytic Nanoparticles to Atheroscle...
Source: Fight Aging! - October 15, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, October 9th 2023
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - October 8, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, October 2nd 2023
In conclusion, we identified several candidate genes that may confer cancer resistance in cetaceans, providing a new avenue for further research into the mechanisms of lifespan extension.
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A Relationship Between the Gut Microbiome and Bone Density
https://www.fightaging.org/archives/2023/09/a-relationship-between-the-gut-microbiome-and-bone-density/
Changes in the gut microbiome take place with advancing age, an increase in populations that provoke chronic inflammation, a reduction in the populations producing beneficial metabolites. Even only considering rising levels of in...
Source: Fight Aging! - October 1, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Diversity Supplement Program Paves the Way for Talented Researchers
“I hope that one day I’m able to increase our understanding of evolution, and I also hope to increase access to research. I want others to know that this space is open to people who look like me, who come from disadvantaged backgrounds, and who are underrepresented in the sciences,” says Nkrumah Grant, Ph.D., a postdoctoral research associate (postdoc) in microbiology and molecular genetics at Michigan State University (MSU) in East Lansing.
Dr. Grant’s work receives support from the NIGMS Diversity Supplement Program (DSP), which is designed to improve the recruitment and training of promising researchers from ...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - September 27, 2023 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Diseases Microbes Profiles Training Source Type: blogs
Fight Aging! Newsletter, September 25th 2023
In conclusion, this individual patient data meta-analysis of longitudinal cohort studies found that antihypertensive use was associated with decreased dementia risk compared with individuals with untreated hypertension through all ages in late life. Individuals with treated hypertension had no increased risk of dementia compared with healthy controls.
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Results from Human Clinical Trials Do Not Support Metformin as a Longevity Drug
https://www.fightaging.org/archives/2023/09/results-from-human-clinical-trials-do-not-support-metformin-as-a-longevity-drug/
The SENS Research Fou...
Source: Fight Aging! - September 24, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The Adaptation-Maladaptation Framework of Aging
While a great deal is known about the ways in which old tissues differ from young tissues, there remains considerable room to theorize on how exactly aging is caused and progresses. Which manifestations are causative, and which downstream consequences, which mechanisms are important, which are side-effects or diversions. Theories of aging abound, alongside frameworks intended to steer thinking about aging. We stand in the opening years of a new era of medicine, in which the first rejuvenation therapies exist or are under development, senolytics that can clear senescent cells, alongside reprogramming strategies and potentia...
Source: Fight Aging! - September 22, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Chatting Apton Acquisition with PacBio CEO Christian Henry
PacBio CEO Christian Henry chatted with me recently by teleconference on a variety of topics, but the focus was the recent PacBio acquisition of Apton Biosystems for $85M in equity. As a regular reminder, my employer’s CEO reports in a sense to Henry, as he’s on the Board of Directors. A particularly interesting revelation by Henry is that PacBio had its eye on Apton in late 2021, essentially as soon as they completed theOmniome acquisition announced in July 2021 that formed the foundation for their now-released Onso short read instrument. PacBio believed then that the desktop instrument design from Omniome...
Source: Omics! Omics! - September 19, 2023 Category: Bioinformatics Authors: Keith Robison Source Type: blogs
Wanted: Biophysics Program Directors
UPDATE: The positions are now open, and will close September 27. Visit the Job Vacancies page for more information.
We’re recruiting accomplished scientists for program officer positions in the Division of Biophysics, Biomedical Technology, and Computational Biosciences (BBCB). The selected candidates will be responsible for scientific and administrative management of a portfolio of research grants, and will stimulate, plan, advise, direct, and evaluate program activities related to their field of expertise.
One program officer position is in the Biophysics Branch, which supports grant portfolios that apply te...
Source: NIGMS Feedback Loop Blog - National Institute of General Medical Sciences - September 18, 2023 Category: Biomedical Science Authors: Chrissa Chverchko Tags: Job Announcements Source Type: blogs
Wanted: BBCB Program Directors
UPDATE: The positions are now open, and will close September 27. Visit the Job Vacancies page for more information.
We’re recruiting accomplished scientists for program officer positions in the Division of Biophysics, Biomedical Technology, and Computational Biosciences (BBCB). The selected candidates will be responsible for scientific and administrative management of a portfolio of research grants, and will stimulate, plan, advise, direct, and evaluate program activities related to their field of expertise.
One program officer position is in the Biophysics Branch, which supports grant portfolios that apply te...
Source: NIGMS Feedback Loop Blog - National Institute of General Medical Sciences - September 18, 2023 Category: Biomedical Science Authors: Chrissa Chverchko Tags: Job Announcements Source Type: blogs
