Associations Between the Lipidome and Epigenetic Aging
The body contains hundreds of different types of lipid molecules, participating in cellular metabolism in ways that are just as complex and relevant to health as the activities of other biomolecules. In the context of aging, this broad range of lipids are perhaps understudied in comparison to levels and roles of proteins and patterns of gene expression. The situation is much the same, however: researchers can readily and cost-effectively amass a vast amount of data, but the analysis of this data lags far behind the accumulation of ever more and ever larger omics databases. It is ever unclear as to whether any particular as...
Source: Fight Aging! - August 18, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
A Universal Epigenetic Aging Clock for All Mammalian Species
Epigenetic modifications to the nuclear genome, such as the addition of methyl groups to CpG sites, known as DNA methylation, adjust the structure of double-stranded DNA. That structure determines which gene sequences are accessible to transcription machinery, the first step in producing proteins. Thus epigenetics drives gene expression, and gene expression drives the behavior of cells. It is a feedback loop between environment, cell behavior, and epigenetics. The pattern of epigenetic modifications changes constantly in response to circumstances, but some changes are characteristic of aging. When discovered, this led to t...
Source: Fight Aging! - August 17, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Top 6 Companies Using AI In Drug Discovery And Development
What if coming up with a new drug could be measured in days rather than years? What if new medication would cost thousands instead of billions of dollars? Just look at how an AI pharma start-up developed a potential new drug in 46 days! Artificial intelligence technologies promise to speed up the process of drug discovery and development and make it more cost-effective. As the market is flourishing, and it takes time and effort to separate the wheat from the chaff, we collected the most promising AI pharma companies out there.
Drug design is a key area AI is revolutionizing. In one of our latest database projects, we de...
Source: The Medical Futurist - August 17, 2023 Category: Information Technology Authors: berci.mesko Tags: Artificial Intelligence in Medicine Future of Pharma Genomics research clinical trials AI drug development medication drug discovery drug research cure Source Type: blogs
Celebrating 10 Years of Biomedical Beat
This August marks 10 years of the blog! Throughout the past decade, we’ve brought you blog posts that explore basic science topics, quiz your knowledge, showcase cool images, and more! Some of our most-read favorites include:
We’ve also interviewed over a hundred NIGMS-funded scientists about their research, mentorship, and careers. To celebrate 10 years, we went back to two of the first researchers featured on the blog to see what they’re up to now.
Exploring Enzymes With Dr. Emily Scott
Credit: University of Michigan.
Around the time we first fe...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - August 16, 2023 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Molecular Structures Cool Tools/Techniques Profiles Research Roundup RNA Source Type: blogs
Fight Aging! Newsletter, August 14th 2023
This study demonstrates just how vital the thymus is to maintaining adult health."
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Does Amyloid-β Aggregation Cause Broad Disruption of Proteostasis?
https://www.fightaging.org/archives/2023/08/does-amyloid-%ce%b2-aggregation-cause-broad-disruption-of-proteostasis/
Researchers here speculate on the ability of insoluble amyloid-β aggregates to be broadly disruptive of the solubility of many other proteins, and thus disruptive to cell and tissue function. Is this important in aging? The evidence here shows the existence of the mechanism in a lower species, but that doesn't ...
Source: Fight Aging! - August 13, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
In the Long Run, Even Baseline Humans Will Live for a Very, Very Long Time
It is at present somewhat out of style to point out that, yes, obviously, it will be possible in the future to ensure that humans live for a very, very long time. That will be true for even baseline humans lacking all of the various genetic modifications one might propose a future scientific community to be capable of, modifications to introduce the numerous distinct forms of resilience to the mechanisms of mammalian aging exhibited by naked mole-rats, whales, elephants, bats and so forth. Control over aging is a subset of control over molecules and their positions. To be as reductionist as possible, degenerative aging is ...
Source: Fight Aging! - August 9, 2023 Category: Research Authors: Reason Tags: Healthy Life Extension Community Source Type: blogs
cGAS-STING Signalling Drives Age-Related Chronic Inflammation
The reaction of the innate immune system to damage characteristic of aging biology drives a great deal of age-related chronic inflammation. For example, mislocalized mitochondrial DNA arises as a consequence of age-related mitochondrial dysfunction, and can trigger innate immune sensors that evolved to detect bacterial DNA. Here, researchers look more closely at one of the important signaling pathways involved in the maladaptive innate immune response to damage and dysfunction in aging cells.
Low-grade inflammation is a hallmark of old age and a central driver of ageing-associated impairment and disease. Multiple ...
Source: Fight Aging! - August 9, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Donate to Support a Study of Allotopic Expression for the COX2 Mitochondrial Gene
Mitochondria, hundreds to a cell, are evolved descendants of the ancient bacteria that became symbiotic with the first, primitive cells. Mitochondria still behave a great deal like bacteria, in that they fuse together, replicate, carry a small circular genome, the mitochondrial DNA and promiscuously swap component parts. While the primary role of mitochondria is the generation of adenosine triphosphate (ATP), a chemical energy store used to power cell processes, they are also well integrated cellular components in a broader sense, influential in a range of fundamental cellular activities.
Mitochondrial DNA is a lot ...
Source: Fight Aging! - August 7, 2023 Category: Research Authors: Reason Tags: Activism, Advocacy and Education Source Type: blogs
Fight Aging! Newsletter, August 7th 2023
In conclusion, here, we demonstrate a novel mechanism for ESC-EVs to protect cells from senescence. However, whether ESC-EVs rejuvenate aged mice via miR-15b-5p and miR-290a-5p remains unknown. Next, we plan to use miR-15b-5p and miR-290a-5p antagonists while treating aged mice with ESC-EVs to further investigate the mechanism by which ESC-EVs resist aging in vivo.
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Fatty Acid Metabolism as a Commonality in Different Approaches to Slowing Aging
https://www.fightaging.org/archives/2023/08/fatty-acid-metabolism-as-a-commonality-in-different-approaches-to-slowing-aging/
It seem...
Source: Fight Aging! - August 6, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fatty Acid Metabolism as a Commonality in Different Approaches to Slowing Aging
In this study, we report systemic changes in the molecular regulation of biological processes under multiple lifespan-extending interventions, by jointly leveraging systems-level analyses on two mouse liver proteomic datasets, which were generated in the NIA Longevity Consortium, and a previously published mouse liver transcriptomic dataset. Differential Rank Conservation (DIRAC) analyses of mouse liver proteomics and transcriptomics data show that mechanistically distinct lifespan-extending interventions (acarbose, 17α-estradiol, rapamycin, and calorie restriction) generally tighten the regulation of biological modules. ...
Source: Fight Aging! - August 2, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Altered Mitochondrial Calcium Metabolism is a Major Factor in Inflammaging
In this study, we report a surprising discovery that mitochondrial Ca2+ (mCa2+) uptake capacity in macrophages drops significantly with age. This amplifies cytosolic Ca2+ (cCa2+) signaling and promotes NF-κB activation, rendering the macrophages prone to chronic low-grade inflammatory output at baseline and hyper-inflammatory when stimulated. Although mitochondrial dysfunction has long been a suspected driver of aging, our study pinpoints the mitochondrial calcium uniporter (MCU) complex as a keystone molecular apparatus that links age-related changes in mitochondrial physiology to macrophage-mediated inflammation.
...
Source: Fight Aging! - August 1, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, July 31st 2023
In conclusion, an SBP level below 130 mmHg was found to be associated with longevity among older women. The longer SBP was controlled at a level between 110 and 130 mmHg, the higher the survival probability to age 90. Preventing age-related rises in SBP and increasing the time with controlled BP levels constitute important measures for achieving longevity.
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Source: Fight Aging! - July 30, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Closing the Gap: Why Healthcare Needs More Gender Diversity in Leadership
The following is a guest article by Dr. Erica Barnell, MD, PhD, Co-Founder and Chief Science Officer at Geneoscopy
Women comprise 70% of the healthcare workforce and 59% of medical, biomedical, and health sciences graduates, yet are the minority at leadership levels — holding only 25% of senior executive roles. As a result, the lack of women in significant decision-making positions is evident.
According to U.S. Census estimates, no single ethnic or racial group will represent a majority of the U.S. population by 2055. The potential for more positive patient care experiences, greater innovation, and improved organizatio...
Source: EMR and HIPAA - July 26, 2023 Category: Information Technology Authors: Guest Author Tags: C-Suite Leadership Clinical Health IT Company Healthcare IT Dr. Erica Barnell Dr. Erica Barnell MD PhD Gender Bias Gender Diversity in Healthcare Leadership Geneoscopy Women in Healthcare Women in Leadership Women in STEM Women's H Source Type: blogs
Mitochondrial Copy Number in Immune Cells Strongly Correlates with 15-Year Mortality
We examined a random population sample in 2003/2005 (n = 9,360, age 45-69, the HAPIEE project) and followed up for 15 years. Using a nested case-control design, we selected non-external deaths among those free from baseline cardiovascular diseases (CVD) and cancer (n = 371), and a sex- and age-stratified control (n = 785). The odds ratios (ORs) of death were 1.06 per one-decile decrease in mtDNA-CN independent of age, sex, metabolic factors, smoking, alcohol intake, and education.
The age-sex-adjusted ORs of death in the second and first tertiles of mtDNA-CN vs. the top tertile were 2.35 and 1.59; an increased risk ...
Source: Fight Aging! - July 25, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, July 24th 2023
In this study, we tested the hypothesis that periodontal disease (PD) as a source of infection alters inflammatory activation and Aβ phagocytosis by the microglial cells.
Experimental PD was induced using ligatures in C57BL/6 mice for 1, 10, 20, and 30 days to assess the progression of PD. Animals without ligatures were used as controls. Ligature placement caused progressive periodontal disease and bone resorption that was already significant on day 1 post-ligation and continued to increase until day 30. The severity of periodontal disease increased the frequency of activated microglia in the brains on day 30 by 36...
Source: Fight Aging! - July 23, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
