The Genetic Basis for Aging: Much Data, Few Conclusions
As this paper notes, there is a great deal of data regarding genetics and aging, but as yet little in the way of useful conclusions when it comes to applying this knowledge to extend the healthy human life span. From a reductionist point of view, it is clear that genetic differences lie at the root of the large differences in trajectory of aging and life span that are observed between species. The evidence to date suggests that genetic variance within a species has little impact on life span, however. The observe range of life expectancy within a species is mostly a matter of environment and lifestyle. A great deal of fund...
Source: Fight Aging! - January 12, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
A High Level View of Efforts to Modulate Inflammaging and Immunosenescence of the Aged Immune System
Change and disruption in the immune system is an important component of degenerative aging. Broadly, the immune system becomes ever more inflammatory (inflammaging) while also becoming ever less effective (immunosenescence). The immune system is not only responsible for defending against invasive pathogens and destroying errant cells, but it is also tightly integrated into the normal processes of tissue maintenance and operation. When immune cells become inflammatory, they abandon the range of tasks needed to keep tissues functional. Short-term inflammation is necessary in response to injury and infection, but unresolved, ...
Source: Fight Aging! - January 11, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Pharma – 2023 Health IT Predictions
As we head into 2023, we wanted to kick off the new year with a series of 2023 Health IT predictions. We asked the Healthcare IT Today community to submit their predictions and we received a wide ranging set of responses that we grouped into a number of themes. Check out our communities predictions below and be sure to add your own thoughts and/or places you disagree with these predictions in the comments and on social media.
Check out our community’s pharma predictions.
Jesse Cugliotta, Global Industry GTM Lead, Healthcare & Life Sciences at Snowflake
Industry investments in data platforms to enable decentra...
Source: EMR and HIPAA - January 9, 2023 Category: Information Technology Authors: John Lynn Tags: Health IT Company Healthcare IT 2023 Health IT Predictions Abrpo BrainCheck Doceree Harshit Jain Ian Chen Jesse Cugliotta Kimberly Powell Lance Hill Lauren Ohlsson Mike Montalto NVIDIA Ofer Sharon OncoHost PathAI Pharma Source Type: blogs
Fight Aging! Newsletter, January 9th 2023
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - January 8, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The Stage is Set for More Rapid Progress Towards Human Longevity in the Next Decade
Today's popular science article is a tour of a few of the higher profile lines of research and development relevant to treating aging as a medical condition. The state of the field has changed greatly over the last decade, not least of these changes being a vast increase in the funding devoted to clinical translation of age-slowing and rejuvenation therapies. Cynically, I suspect that it is the funding that ensures that the popular science press takes a more respectful tone than they did ten years ago. It is much harder to advance (in writing!) a knee-jerk dismissal of a field of science when billions of dollars of funding...
Source: Fight Aging! - January 6, 2023 Category: Research Authors: Reason Tags: Healthy Life Extension Community Source Type: blogs
Shawn Drew Gaillard to Direct GMCDB
I’m pleased to announce the selection of Shawn Drew Gaillard, Ph.D., as the new director of our Division of Genetics and Molecular, Cellular, and Developmental Biology (GMCDB). Shawn has been the acting director of the Division since February 2022. She will begin in this new role on January 15.
Shawn joined GMCDB as chief of the Developmental and Cellular Processes Branch in 2019, overseeing grants focused on organismal response to environmental stressors. Prior to this role, she was the research training officer at the National Institute of Allergy and Infectious Diseases, and before that, she was a program director in ...
Source: NIGMS Feedback Loop Blog - National Institute of General Medical Sciences - January 4, 2023 Category: Biomedical Science Authors: Chrissa Chverchko Tags: Director’s Messages Job Announcements NIGMS Staff News Source Type: blogs
Longer Lived Mammals Exhibit a Downregulated Methionine Metabolism
Long term restriction of dietary methionine intake is known to extend life in short-lived mammals. Methionine sensing is one of the triggers for the calorie restriction response, improving cell maintenance and adjusting metabolism into a state more resilient to the ongoing generation of molecular damage that contributes to degenerative aging. Researchers here note that methionine levels are lower in the heart tissue of longer-lived mammals, suggesting that altered methionine metabolism, maintaining lower levels of methionine in and around cells, is one of the adaptations that allows long-lived mammals to be long-lived. Thi...
Source: Fight Aging! - January 2, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
What is Known of Anti-Cancer Mechanisms in Longer-Lived Species
Risk of cancer is a function of cell numbers and division rates, but also of the efficiency of cancer suppression mechanisms. In order for a species to evolve a longer life span, cancer suppression must improve. In order for a species to evolve a larger body mass, cancer suppression must improve. As this paper notes, comparatively little is definitively known of the anti-cancer strategies of various long-lived mammals. Elephants duplicate the tumor suppressor gene TP53, but that doesn't occur in other large and long-lived species, so it is likely that each species takes its own path. It is far too early to say whether what...
Source: Fight Aging! - January 2, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, January 2nd 2023
In conclusion, circulating monocytes in older adults exhibit increased expression of activation, adhesion, and migration markers, but decreased expression of co-inhibitory molecules.
MERTK Inhibition Increases Bone Density via Increased Osteoblast Activity
https://www.fightaging.org/archives/2022/12/mertk-inhibition-increases-bone-density-via-increased-osteoblast-activity/
Bone density results from the balance of constant activity on the part of osteoblasts and osteoclasts, the former building bone, the latter breaking it down. With advancing age, the balance of activity shifts to favor osteoclasts, pro...
Source: Fight Aging! - January 1, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Look Back at 2022: Progress Towards the Treatment of Aging as a Medical Condition
At the end of 2022, we can reflect on the fact that we are steadily entering a new era of medicine, one in which mechanisms of aging are targeted rather than ignored. It is a profound change, one that will change the shape of a human life and ultimately the human condition by eliminating the greatest sources of suffering and death in the world. Year after year, we see increased funding, ongoing progress towards therapies capable of slowing aging or reversing aspects of aging, and a growing taxonomy of such potential therapies and their target mechanisms.
The view of aging in the medical community and public at large...
Source: Fight Aging! - December 30, 2022 Category: Research Authors: Reason Tags: Of Interest Source Type: blogs
A Conservative View of Aging Research and Development of Treatments Targeting Mechanisms of Aging
A present, the conservative scientific viewpoint on aging is that significant progress has been made in understanding how to produce therapies that might target mechanisms of aging, but these are still very early days in both (a) understanding in detail how those mechanisms give rise to the observed outcomes in aging, and (b) the development of age-slowing and rejuvenating therapies. It is most likely the case that more could be accomplished than is presently being accomplished, given greater will and funding. But the creation of a new field of medicine is a slow process, proceeding incrementally, taking years to convince ...
Source: Fight Aging! - December 27, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, December 26th 2022
This article on senolytic therapies to selectively remove senescent cells in old tissues is in part a matter of Unity Biotechnology talking up their position. The company suffered from first mover disadvantage in bringing senolytic drugs into clinical development. The field has made progress very rapidly over the last decade, and startups founded even just a couple of years after Unity's launch benefited from greater knowledge and a selection of better technologies to work with. Still, one can be talking up one's position and also be right. The accumulation of senescent cells is profoundly harmful, a significant contributi...
Source: Fight Aging! - December 25, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Longer RNA Transcripts Exhibit Greater Alterations in Amount with Aging
We present three lines of evidence supporting the biological importance of the uncovered transcriptome imbalance. First, in vertebrates the length association primarily displays a lower relative abundance of long transcripts in aging. Second, eight antiaging interventions of the Interventions Testing Program of the National Institute on Aging can counter this length association. Third, we find that in humans and mice the genes with the longest transcripts enrich for genes reported to extend lifespan, whereas those with the shortest transcripts enrich for genes reported to shorten lifespan.
Perhaps the most pressing ...
Source: Fight Aging! - December 23, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, December 19th 2022
In conclusion, p16 deletion or p16 positive cell clearance could be a novel strategy preventing long term HFD-induced skin aging.
Association of LDL-Cholesterol with Mortality
https://www.fightaging.org/archives/2022/12/association-of-ldl-cholesterol-with-mortality/
Researchers here report on a study of LDL-cholesterol and mortality risk in older people. As they note, data on this topic is conflicted once one moves beyond the matter of cardiovascular disease. Over a lifetime, higher LDL-cholesterol makes it easier to reach the tipping point at which cholesterol deposited in blood vessel walls produces e...
Source: Fight Aging! - December 18, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Career Conversations: Q & A with Biomolecular Engineer Markita Landry
Dr. Markita Landry. Credit: Vilcek Foundation.
“I have a hard time envisioning a career more exciting than science. It’s really magical to see an experimental result and, for a moment, be the only person in the universe to know something about the world,” says Markita Landry, Ph.D., an associate professor of chemical and biomolecular engineering at the University of California, Berkeley. In an interview, Dr. Landry shares with us her scientific journey, research with nanoparticles, and interests outside of the lab.
Q: What sparked your interest in science?
A: I was indirectly exposed to science growing up bec...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - December 14, 2022 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Tools and Techniques Cool Tools/Techniques Profiles Source Type: blogs
