Fight Aging! Newsletter, September 18th 2023
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
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Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - September 17, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Wanted: Division of Genetics and Molecular, Cellular, and Developmental Biology Program Directors
We’re seeking two highly qualified scientists to serve as program directors in the Genetic Mechanisms and Developmental and Cellular Processes Branches of our Division of Genetics and Molecular, Cellular, and Developmental Biology (GMCDB).
GMCDB supports research grants focused on understanding the structure and function of cells and cellular components and the cellular and molecular mechanisms that underlie inheritance, gene expression, and development. All prospective candidates should have expertise in the mechanism and regulation of genetics including basic molecular processes, cellular biology, and/or development...
Source: NIGMS Feedback Loop Blog - National Institute of General Medical Sciences - September 15, 2023 Category: Biomedical Science Authors: Chrissa Chverchko Tags: Job Announcements Source Type: blogs
The Times They Are A-Changing … .Fast
By KIM BELLARD
If you have been following my Twitter – oops, I mean “X” – feed lately, you may have noticed that I’ve been emphasizing The Coming Wave, the new book from Mustafa Suleyman (with Michael Bhaskar). If you have not yet read it, or at least ordered it, I urge you to do so, because, frankly, our lives are not going to be the same, at all. And we’re woefully unprepared.
One thing I especially appreciated is that, although he made his reputation in artificial intelligence, Mr. Suleyman doesn’t only focus on AI. He also discusses synthetic biology, quantum computing, robotics, and new energ...
Source: The Health Care Blog - September 14, 2023 Category: Consumer Health News Authors: matthew holt Tags: Health Tech AI Kim Bellard quantum computing Smart Pills synthetic biology The Coming Wave Source Type: blogs
Wanted: Division of Pharmacology, Physiology, and Biological Chemistry Branch Chief
We’re seeking a highly qualified scientist to serve as a branch chief in our Division of Pharmacology, Physiology, and Biological Chemistry (PPBC). This is a newly created position for the Division as it reorganizes into three branches. Applicants should have significant interest and experience in the scientific areas managed by the Division, which will continue to encompass all the existing research portfolios and will generally be arranged into branches covering physiology and clinical sciences, biochemistry and molecular pharmacology, and chemistry and chemical biology. For a listing of the current scientifi...
Source: NIGMS Feedback Loop Blog - National Institute of General Medical Sciences - September 11, 2023 Category: Biomedical Science Authors: Chrissa Chverchko Tags: Job Announcements Source Type: blogs
Revisiting Bivalves for the Study of the Determinants of Species Lifespan
Mammals have a very wide range in life spans, and the study of mammals might be thought to be more relevant to efforts to extend human longevity than the study of other taxonomic classes. It is quite unclear at this time whether moving genes and mechanisms between mammalian species is likely to produce meaningful gains cost-effectively in the near future, but we certainly won't know if we don't try. Meanwhile, bivalves are another class with a large range in species life span. There is much to be said for undertaking the same sort of search for the determinants of species life span in bivalves as is presently ongoing in ma...
Source: Fight Aging! - September 11, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, September 11th 2023
This article reviews the current regulatory role of miR-7 in inflammation and related diseases, including viral infection, autoimmune hepatitis, inflammatory bowel disease, and encephalitis. It expounds on the molecular mechanism by which miR-7 regulates the occurrence of inflammatory diseases. Finally, the existing problems and future development directions of miR-7-based intervention on inflammation and related diseases are discussed to provide new references and help strengthen the understanding of the pathogenesis of inflammation and related diseases, as well as the development of new strategies for clinical interventi...
Source: Fight Aging! - September 10, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Next: Harnessing Neuroplasticity, Medication AND Psychotherapy to treat mental health conditions
This article was originally published on The Conversation.
To Learn More:
Does ADHD treatment enable long-term academic success? (Yes, especially when pharmacological and non-pharma treatments are combined)
Survey of 2500 families finds what ADHD treatments seem to work/ not work as applied in the real world
What are cognitive abilities and how to boost them?
The post Next: Harnessing Neuroplasticity, Medication AND Psychotherapy to treat mental health conditions appeared first on SharpBrains. (Source: SharpBrains)
Source: SharpBrains - September 6, 2023 Category: Neuroscience Authors: The Conversation Tags: Brain/ Mental Health antidepressants anxiety Cognitive Neuroscience Combination therapy depression neuroplasticity psychedelics psychiatry Psychology Psychotherapy Source Type: blogs
A High Level Popular Science View of the Longevity Industry
The article I'll point out today is an entirely unremarkable, high level tour of the most discussed, most notable portions of the longevity industry and related research efforts. Twenty years ago, we'd all have been delighted to see the media both noticing translational aging research at all, and then actually taking seriously the prospect of treating aging as a medical condition. We've come a long way to now see summary discussions of work on the treatment of aging as business as usual, not really worth mentioning. Still, articles like this miss near all of the really interesting projects, and that is the way of high leve...
Source: Fight Aging! - September 5, 2023 Category: Research Authors: Reason Tags: Healthy Life Extension Community Source Type: blogs
Fight Aging! Newsletter, September 4th 2023
In conclusion, although the contribution of CRF to GrimAgeAccel and FitAgeAccel is relatively low compared to lifestyle-related factors such as smoking, the results suggest that the maintenance of CRF is associated with delayed biological ageing in older men.
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Release of Acetylcholine is Necessary for the Aging Brain to Compensate for a Lack of Neurogenesis
https://www.fightaging.org/archives/2023/09/release-of-acetylcholine-is-necessary-for-the-aging-brain-to-compensate-for-a-lack-of-neurogenesis/
Neurogenesis is the process by which new neurons are created by neural stem c...
Source: Fight Aging! - September 3, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Wanted: Division of Pharmacology, Physiology, and Biological Chemistry Branch Chief
We’re seeking a highly qualified scientist to serve as a branch chief in our Division of Pharmacology, Physiology, and Biological Chemistry (PPBC). This is a newly created position for the Division as it reorganizes into three branches. Applicants should have significant interest and experience in the scientific areas managed by the Division, which will continue to encompass all the existing research portfolios and will generally be arranged into branches covering physiology and clinical sciences, biochemistry and molecular pharmacology, and chemistry and chemical biology. For a listing of the current scientifi...
Source: NIGMS Feedback Loop Blog - National Institute of General Medical Sciences - August 30, 2023 Category: Biomedical Science Authors: Chrissa Chverchko Tags: Job Announcements Source Type: blogs
Intermittent Fasting Reduces Pathology in a Mouse Model of Alzheimer's Disease
The sizable body of work produced on calorie restriction and fasting over the last twenty years is supportive of the hypothesis that time spent hungry is an important factor determining the scale of benefits to health and longevity. The cellular response to a transient lack of nutrients involves improved cell maintenance, such as upregulation of autophagy to clear out damaged and worn molecular machinery. Looking at a level of organization above the cell, a transient state of hunger likely produces many other benefits to the way in which complex tissues and relationships between tissues function in the body. It dampens inf...
Source: Fight Aging! - August 30, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
A Perspective on the Coming Regulatory Shift to Approval of Drugs to Treat Aging
At some point, regulatory bodies that oversee the development of new medicine will accept that therapies can target causative mechanisms of aging in order to slow or reverse the progression of aging, and that there are viable ways to assess new treatments that treat aging. There is growing pressure from the academic community and longevity-focused biotech industry for the ability to run clinical trials to treat aging, rather than to treat one specific age-related disease.
While inevitable, this change will take some years to come to pass, and likely require greater consensus in the research community on reasonable a...
Source: Fight Aging! - August 29, 2023 Category: Research Authors: Reason Tags: Healthy Life Extension Community Source Type: blogs
Fight Aging! Newsletter, August 28th 2023
In conclusion, we identified 20 genes with significant evolutionary signals unique to long-lived species, which provided new insight into the lifespan extension of mammals and might bring new strategies to extend human lifespan.
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Trials of Xenotransplantation of Pig Organs into Humans Continue
https://www.fightaging.org/archives/2023/08/trials-of-xenotransplantation-of-pig-organs-into-humans-continue/
Researchers have genetically engineered pigs to overcome the known barriers to transplantation of pig organs into humans, and have reached the stage of conducting transplants i...
Source: Fight Aging! - August 27, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, August 21st 2023
This study aimed to investigate the association between frailty index and circulating CAP2 concentration in 467 community-dwelling older adults (median age: 79; range: 65-92 years). The selected robust regression model showed that circulating CAP2 concentration was not associated with chronological age, as well as sex and education. However, circulating CAP2 concentration was significantly and inversely associated with the frailty index: a 0.1-unit increase in frailty index leads to ~0.5-point mean decrease in CAP2 concentration. Furthermore, mean CAP2 concentration was significantly lower in frail participants (i.e., fr...
Source: Fight Aging! - August 21, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Young Plasma from Pigs Reduces Epigenetic Age in Old Rats
One interesting question in the development of new epigenetic clocks to measure biological age, particularly now that a large consortium of researchers has published a universal mammalian clock, is how one demonstrates that a new clock is in some way useful enough or interesting enough to spend time on. There are, after all, many published clocks at this point, and we might expect that the research community will attempt to standardize on the new universal clock. Why use another novel clock? One answer might be that the clock is optimized to give a large signal under a particular set of circumstances. Hence we arrive at st...
Source: Fight Aging! - August 21, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
