Combining Age-Slowing Interventions in Flies Doubles Life Span

In this study, we investigated whether the combined application of several interventions with potential anti-aging action causes a cumulative effect on lifespan extension in flies. As for anti-aging drugs, we used rapamycin, the well-known mTOR signaling inhibitor, and two plant-derived compounds, particularly, alkaloid berberine and carotenoid fucoxanthin, whose geroprotective properties have been studied on different biological models. We studied the effects of dietary restriction and co-administration of berberine, fucoxanthin, and rapamycin in constant darkness and low-temperature conditions using the D. melanogaster model. In addition, to address whether the long-lived strain demonstrates an enhanced geroprotective effect of the interventions' combinations, we studied the long-lived Enhancer of zeste (E(z)) mutant flies. In the current study, using a combination of several geroprotective interventions, we managed to more than double the lifespan of flies, which is significantly more than using each intervention separately. This is the first report on the increase of maximum flies' lifespan to more than 200 days (120% increase). This result is most likely associated with the synergistic effect of interventions that led to a global metabolic network reorganization and ultimately to beneficially affected lifespan through the modulation of several molecular signaling pathways at once. Link: https://doi.org/10.1038/s42003-022-03524-4
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs