Mendelian randomization analysis of 34,497 German Holstein cows to infer causal associations between milk production and health traits
CONCLUSIONS: Our results confirm the known negative genetic connection between health traits and MY in dairy cattle. In addition, they provide new information about causality, which for example points to the negative energy balance mediating the connection between these traits. This knowledge helps to better understand whether the negative genetic correlation is based on pleiotropy, linkage between causal variants for both trait complexes, or indeed on a causal association.PMID:38589805 | PMC:PMC11000328 | DOI:10.1186/s12711-024-00896-5 (Source: Genet Sel Evol)
Source: Genet Sel Evol - April 8, 2024 Category: Genetics & Stem Cells Authors: Helen Schneider Valentin Haas Ana-Marija Krizanac Clemens Falker-Gieske Johannes Heise Jens Tetens Georg Thaller J örn Bennewitz Source Type: research
Genes, Vol. 15, Pages 466: The Genome of Bifidobacterium longum subsp. infantis YLGB-1496 Provides Insights into Its Carbohydrate Utilization and Genetic Stability
This study used genome sequencing and morphology during continuous subculture to determine the carbohydrate utilization characteristics and genetic stability of YLGB-1496. The complete genome sequence of YLGB-1496 consists of 2,758,242 base pairs, 2442 coding sequences, and a GC content of 59.87%. A comparison of carbohydrate transport and metabolism genes of Bifidobacterium longum subsp. infantis (B. infantis) showed that YLGB-1496 was rich in glycosyl hydrolase 13, 20, 25, and 109 gene families. During continuous subculture, the growth characteristics and fermentation activity of the strain were highly stable. The bacter...
Source: Genes - April 8, 2024 Category: Genetics & Stem Cells Authors: Xiaoxia Li Jianjun Yang Shaoqi Shi Hanglian Lan Wen Zhao Weilian Hung Jian He Ran Wang Tags: Article Source Type: research
Sensors, Vol. 24, Pages 2362: Exploring Deep Learning to Predict Coconut Milk Adulteration Using FT-NIR and Micro-NIR Spectroscopy
This study demonstrated the feasibility of using deep-learning algorithms and NIR spectral data as a rapid, accurate, robust, and non-destructive way to evaluate coconut milk adulterants. Last but not least, Micro-NIR is more promising than FT-NIR in predicting coconut milk adulteration from solid adulterants, and it is portable for in situ measurements in the future. (Source: Sensors)
Source: Sensors - April 8, 2024 Category: Biotechnology Authors: Agustami Sitorus Ravipat Lapcharoensuk Tags: Article Source Type: research
Dysphoric Milk Ejection Reflex: Characteristics, Risk Factors, and Its Association with Depression Scores and Breastfeeding Self-Efficacy
Breastfeeding Medicine, Ahead of Print. (Source: Breastfeeding Medicine)
Source: Breastfeeding Medicine - April 8, 2024 Category: Perinatology & Neonatology Authors: Lina Nguyen Stephanie Stokes Kendall Alsup Jennifer Allen Carolyn Zahler-Miller Source Type: research
Mendelian randomization analysis of 34,497 German Holstein cows to infer causal associations between milk production and health traits
Claw diseases and mastitis represent the most important health issues in dairy cattle with a frequently mentioned connection to milk production. Although many studies have aimed at investigating this connectio... (Source: Genetics Selection Evolution)
Source: Genetics Selection Evolution - April 8, 2024 Category: Genetics & Stem Cells Authors: Helen Schneider, Valentin Haas, Ana-Marija Krizanac, Clemens Falker-Gieske, Johannes Heise, Jens Tetens, Georg Thaller and J örn Bennewitz Tags: Research Article Source Type: research
Multilevel modeling analysis of bottle feeding and its determinants among children 0 –23 months in East Africa: evidence from recent DHS data (2015–2022)
Despite breastfeeding recommendations, the prevalence and length of breast milk feeding in developing nations is rapidly decreasing, with bottle feeding taking its place. This reduces the effectiveness of brea... (Source: International Breastfeeding Journal)
Source: International Breastfeeding Journal - April 8, 2024 Category: Nursing Authors: Bewuketu Terefe, Adane Habtie and Bogale Chekole Tags: Research Source Type: research
MiR-103-5p deficiency suppresses lipid accumulation via upregulating PLSCR4 and its host gene PANK3 in goat mammary epithelial cells
In this study, miR-103 was knocked out in goat mammary epithelial cells (GMECs) by CRISPR/Cas9, and the accumulation of lipid droplets, triglycerides, and cholesterol in the cells was suppressed subsequently. Overexpression or knockdown of miR-103-5p and miR-103-3p in GMECs revealed that it was miR-103-5p that promoted lipid accumulation but not miR-103-3p. In addition, Pantothenate Kinase 3 (PANK3), the host gene of miR-103, and Phospholipid Scramblase 4 (PLSCR4) were identified as the target genes of miR-103-5p by dual fluorescein and miRNA pulldown. Furthermore, we identified that cellular lipid levels were negatively r...
Source: International Journal of Biological Macromolecules - April 7, 2024 Category: Biochemistry Authors: Lu Zhu Hongyun Jiao Wenchang Gao Ping Gong Chenbo Shi Fuhong Zhang Jianqing Zhao Xuefeng Lu Baolong Liu Jun Luo Source Type: research
MiR-103-5p deficiency suppresses lipid accumulation via upregulating PLSCR4 and its host gene PANK3 in goat mammary epithelial cells
In this study, miR-103 was knocked out in goat mammary epithelial cells (GMECs) by CRISPR/Cas9, and the accumulation of lipid droplets, triglycerides, and cholesterol in the cells was suppressed subsequently. Overexpression or knockdown of miR-103-5p and miR-103-3p in GMECs revealed that it was miR-103-5p that promoted lipid accumulation but not miR-103-3p. In addition, Pantothenate Kinase 3 (PANK3), the host gene of miR-103, and Phospholipid Scramblase 4 (PLSCR4) were identified as the target genes of miR-103-5p by dual fluorescein and miRNA pulldown. Furthermore, we identified that cellular lipid levels were negatively r...
Source: International Journal of Biological Macromolecules - April 7, 2024 Category: Biochemistry Authors: Lu Zhu Hongyun Jiao Wenchang Gao Ping Gong Chenbo Shi Fuhong Zhang Jianqing Zhao Xuefeng Lu Baolong Liu Jun Luo Source Type: research
Turning weeds into feed: Ensiling Calotropis gigantea (Giant milkweed) reduces its toxicity and enhances its palatability for dairy cows
This study aimed to valorize GM as a potential new feed resource through the chemical and microbial biotransformation of toxic compounds that will henceforth, make the plant palatable for cows. After GM's ensiling using fermentative bacteria, the plant was sampled for UHPLC-MS/MS to analyse the metabolomic changes. Illumina Miseq of the 16 S rRNA fragment genes and ITS1 were used to describe the microbial composition and structure colonizing GM silage and contributing to the biodegradation of toxic compounds. Microbial functions were predicted from metataxonomic data and KEGG pathways analysis. Eight Holstein dairy cows as...
Source: Ecotoxicology and Environmental Safety - April 6, 2024 Category: Environmental Health Authors: Aurele Gnetegha Ayemele Yuehu Wang Lu Ma Dengpan Bu Jianchu Xu Source Type: research
Turning weeds into feed: Ensiling Calotropis gigantea (Giant milkweed) reduces its toxicity and enhances its palatability for dairy cows
This study aimed to valorize GM as a potential new feed resource through the chemical and microbial biotransformation of toxic compounds that will henceforth, make the plant palatable for cows. After GM's ensiling using fermentative bacteria, the plant was sampled for UHPLC-MS/MS to analyse the metabolomic changes. Illumina Miseq of the 16 S rRNA fragment genes and ITS1 were used to describe the microbial composition and structure colonizing GM silage and contributing to the biodegradation of toxic compounds. Microbial functions were predicted from metataxonomic data and KEGG pathways analysis. Eight Holstein dairy cows as...
Source: Cancer Control - April 6, 2024 Category: Cancer & Oncology Authors: Aurele Gnetegha Ayemele Yuehu Wang Lu Ma Dengpan Bu Jianchu Xu Source Type: research
Turning weeds into feed: Ensiling Calotropis gigantea (Giant milkweed) reduces its toxicity and enhances its palatability for dairy cows
This study aimed to valorize GM as a potential new feed resource through the chemical and microbial biotransformation of toxic compounds that will henceforth, make the plant palatable for cows. After GM's ensiling using fermentative bacteria, the plant was sampled for UHPLC-MS/MS to analyse the metabolomic changes. Illumina Miseq of the 16 S rRNA fragment genes and ITS1 were used to describe the microbial composition and structure colonizing GM silage and contributing to the biodegradation of toxic compounds. Microbial functions were predicted from metataxonomic data and KEGG pathways analysis. Eight Holstein dairy cows as...
Source: Ecotoxicology and Environmental Safety - April 6, 2024 Category: Environmental Health Authors: Aurele Gnetegha Ayemele Yuehu Wang Lu Ma Dengpan Bu Jianchu Xu Source Type: research
Neonatal < em > Elizabethkingia anophelis < /em > meningitis originating from the water reservoir of an automated infant milk dispenser, the Netherlands, February 2024
We report a Dutch case of E. anophelis meningitis in a neonate, clonally related to samples taken from an automated infant milk dispenser located at the family's residence. We inform about the emergence of E. anophelis and suggest molecular surveillance in hospitals and other health settings. This is the first case connecting an automated formula dispenser to an invasive infection in a neonate.PMID:38577802 | DOI:10.2807/1560-7917.ES.2024.29.14.2400177 (Source: Euro Surveill)
Source: Euro Surveill - April 5, 2024 Category: Infectious Diseases Authors: B Ruben Brandsema Ger-Jan Fleurke Sigrid Rosema Eke Mw Schins Jelte Helfferich Erik Bathoorn Source Type: research
Administration of silymarin in NAFLD/NASH: A systematic review and meta-analysis
CONCLUSIONS: Silymarin can regulate energy metabolism, attenuate liver damage, and improve liver histology in NAFLD patients. However, the effects of silymarin will need to be confirmed by further research.PMID:38579127 | DOI:10.1016/j.aohep.2023.101174 (Source: Annals of Hepatology)
Source: Annals of Hepatology - April 5, 2024 Category: Gastroenterology Authors: Shudi Li Fei Duan Suling Li Baoping Lu Source Type: research
Neonatal < em > Elizabethkingia anophelis < /em > meningitis originating from the water reservoir of an automated infant milk dispenser, the Netherlands, February 2024
We report a Dutch case of E. anophelis meningitis in a neonate, clonally related to samples taken from an automated infant milk dispenser located at the family's residence. We inform about the emergence of E. anophelis and suggest molecular surveillance in hospitals and other health settings. This is the first case connecting an automated formula dispenser to an invasive infection in a neonate.PMID:38577802 | DOI:10.2807/1560-7917.ES.2024.29.14.2400177 (Source: Euro Surveill)
Source: Euro Surveill - April 5, 2024 Category: Infectious Diseases Authors: B Ruben Brandsema Ger-Jan Fleurke Sigrid Rosema Eke Mw Schins Jelte Helfferich Erik Bathoorn Source Type: research
Glucose-regulatory hormones and growth in very preterm infants fed fortified human milk
CONCLUSION: Fortification with BC increased the plasma concentrations of several glucose-regulatory hormones. Concentrations of IGF-1 were positively, and leptin negatively, associated with growth. Glucose-regulatory hormone levels were affected by birth weight, milk intake and postnatal age, but not closely associated with growth in VPIs.IMPACT: Little is known about the variation in glucose-regulatory hormones in the early life of very preterm infants (VPIs). This study shows that the levels of glucose-regulatory hormones in plasma of VPIs are highly variable and modified by birth weight (appropriate or small for gestati...
Source: Pediatric Research - April 5, 2024 Category: Pediatrics Authors: Kristine Holgersen Martin Bo Rasmussen Itay Zamir Lise Aunsholt Gitte Zachariassen Per Torp Sangild Source Type: research
