Development of Mucoadhesive Microspheres for Intranasal Delivery of Fluconazole as an Alternative Treatment of Cryptococcal Meningitis Infection in Patients with Acquired Immunodeficiency
This study aimed to develop a mucoadhesive microsphere delivery system for fluconazole for the intranasal route. Microspheres of mucoadhesive fluconazole formulation variables, such as different amounts of drug concentration and polymer concentration, were prepared by a simple emulsion-crosslinking method. The prepared microspheres' surface was characterised by SEM (Scanning electron microscopy) and evaluated for particle size, entrapment efficiency, production yield, infrared spectroscopic study, in-vitro mucoadhesion, and in-vitro drug release. The results showed that formula 1 is the optimal mucoadhesive microsphere pre...
Source: Annales Pharmaceutiques Francaises - April 11, 2024 Category: Drugs & Pharmacology Authors: Amriani Sapra H M Hendrawan Sayyid M Amin None Syahrani Filia Ananda Kelsi Syamsu Nur Andi Dian Permana Source Type: research
Development of Mucoadhesive Microspheres for Intranasal Delivery of Fluconazole as an Alternative Treatment of Cryptococcal Meningitis Infection in Patients with Acquired Immunodeficiency
This study aimed to develop a mucoadhesive microsphere delivery system for fluconazole for the intranasal route. Microspheres of mucoadhesive fluconazole formulation variables, such as different amounts of drug concentration and polymer concentration, were prepared by a simple emulsion-crosslinking method. The prepared microspheres' surface was characterised by SEM (Scanning electron microscopy) and evaluated for particle size, entrapment efficiency, production yield, infrared spectroscopic study, in-vitro mucoadhesion, and in-vitro drug release. The results showed that formula 1 is the optimal mucoadhesive microsphere pre...
Source: Annales Pharmaceutiques Francaises - April 11, 2024 Category: Drugs & Pharmacology Authors: Amriani Sapra H M Hendrawan Sayyid M Amin None Syahrani Filia Ananda Kelsi Syamsu Nur Andi Dian Permana Source Type: research
Anti-aquaporin-4 immunoglobulin G/anti-myelin oligodendrocyte glycoprotein immunoglobulin G double-positive paraneoplastic neurological syndrome in a patient with triple-negative breast cancer
We report a rare case of paraneoplastic neurological syndrome with dual seropositivity of anti-aquaporin-4 and myelin oligodendrocyte glycoprotein antibodies in a 40 year-old woman with metastatic triple-negative breast cancer. She received multiple lines of anti-neoplastic treatment, including immunotherapy with pembrolizumab, as well as cytotoxic chemotherapy. Paraneoplastic meningoencephalomyelitis developed 2 years after diagnosis of breast cancer and 1 year after discontinuation of immunotherapy with pembrolizumab. She first developed longitudinally extending transverse myelitis followed by left optic neuritis and men...
Source: Clinical Breast Cancer - April 10, 2024 Category: Cancer & Oncology Authors: Amna Siddiqui Dylan Ross Ronak H Jani Vikram C Prabhu Shelly Lo Derek A Wainwright Stasia Rouse Tamer Refaat Yirong Zhu Jigisha P Thakkar Source Type: research
Anti-aquaporin-4 immunoglobulin G/anti-myelin oligodendrocyte glycoprotein immunoglobulin G double-positive paraneoplastic neurological syndrome in a patient with triple-negative breast cancer
We report a rare case of paraneoplastic neurological syndrome with dual seropositivity of anti-aquaporin-4 and myelin oligodendrocyte glycoprotein antibodies in a 40 year-old woman with metastatic triple-negative breast cancer. She received multiple lines of anti-neoplastic treatment, including immunotherapy with pembrolizumab, as well as cytotoxic chemotherapy. Paraneoplastic meningoencephalomyelitis developed 2 years after diagnosis of breast cancer and 1 year after discontinuation of immunotherapy with pembrolizumab. She first developed longitudinally extending transverse myelitis followed by left optic neuritis and men...
Source: Clinical Genitourinary Cancer - April 10, 2024 Category: Cancer & Oncology Authors: Amna Siddiqui Dylan Ross Ronak H Jani Vikram C Prabhu Shelly Lo Derek A Wainwright Stasia Rouse Tamer Refaat Yirong Zhu Jigisha P Thakkar Source Type: research
Successful treatment of penicillin-resistant pneumococcal meningitis following ventriculoperitoneal shunt in congenital hydrocephalus: A case report on the efficacy of linezolid
Asian J Surg. 2024 Apr 9:S1015-9584(24)00639-0. doi: 10.1016/j.asjsur.2024.04.007. Online ahead of print.NO ABSTRACTPMID:38599973 | DOI:10.1016/j.asjsur.2024.04.007 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - April 10, 2024 Category: Surgery Authors: Jun Wei Junjie Ning Source Type: research
Anti-aquaporin-4 immunoglobulin G/anti-myelin oligodendrocyte glycoprotein immunoglobulin G double-positive paraneoplastic neurological syndrome in a patient with triple-negative breast cancer
We report a rare case of paraneoplastic neurological syndrome with dual seropositivity of anti-aquaporin-4 and myelin oligodendrocyte glycoprotein antibodies in a 40 year-old woman with metastatic triple-negative breast cancer. She received multiple lines of anti-neoplastic treatment, including immunotherapy with pembrolizumab, as well as cytotoxic chemotherapy. Paraneoplastic meningoencephalomyelitis developed 2 years after diagnosis of breast cancer and 1 year after discontinuation of immunotherapy with pembrolizumab. She first developed longitudinally extending transverse myelitis followed by left optic neuritis and men...
Source: Clinical Breast Cancer - April 10, 2024 Category: Cancer & Oncology Authors: Amna Siddiqui Dylan Ross Ronak H Jani Vikram C Prabhu Shelly Lo Derek A Wainwright Stasia Rouse Tamer Refaat Yirong Zhu Jigisha P Thakkar Source Type: research
Anti-aquaporin-4 immunoglobulin G/anti-myelin oligodendrocyte glycoprotein immunoglobulin G double-positive paraneoplastic neurological syndrome in a patient with triple-negative breast cancer
We report a rare case of paraneoplastic neurological syndrome with dual seropositivity of anti-aquaporin-4 and myelin oligodendrocyte glycoprotein antibodies in a 40 year-old woman with metastatic triple-negative breast cancer. She received multiple lines of anti-neoplastic treatment, including immunotherapy with pembrolizumab, as well as cytotoxic chemotherapy. Paraneoplastic meningoencephalomyelitis developed 2 years after diagnosis of breast cancer and 1 year after discontinuation of immunotherapy with pembrolizumab. She first developed longitudinally extending transverse myelitis followed by left optic neuritis and men...
Source: Clinical Genitourinary Cancer - April 10, 2024 Category: Cancer & Oncology Authors: Amna Siddiqui Dylan Ross Ronak H Jani Vikram C Prabhu Shelly Lo Derek A Wainwright Stasia Rouse Tamer Refaat Yirong Zhu Jigisha P Thakkar Source Type: research
Successful treatment of penicillin-resistant pneumococcal meningitis following ventriculoperitoneal shunt in congenital hydrocephalus: A case report on the efficacy of linezolid
Asian J Surg. 2024 Apr 9:S1015-9584(24)00639-0. doi: 10.1016/j.asjsur.2024.04.007. Online ahead of print.NO ABSTRACTPMID:38599973 | DOI:10.1016/j.asjsur.2024.04.007 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - April 10, 2024 Category: Surgery Authors: Jun Wei Junjie Ning Source Type: research
Occludin and collagen IV degradation mediated by the T9SS effector SspA contributes to blood-brain barrier damage in ducks during Riemerella anatipestifer infection
In this study, we showed that obvious clinical symptoms, an increase in blood‒brain barrier (BBB) permeability, and the accumulation of inflammatory cytokines occurred after intravenous infection with the Yb2 strain but not the mutant strain Yb2ΔsspA, indicating that Yb2 infection can lead to cerebrovascular dysfunction and that the type IX secretion system (T9SS) effector SspA plays a critical role in this pathological process. In addition, we showed that Yb2 infection led to rapid degradation of occludin (a tight junction protein) and collagen IV (a basement membrane protein), which contributed to endothelial barrier ...
Source: Cell Research - April 9, 2024 Category: Cytology Authors: Zongchao Chen Min Zhu Dan Liu Mengsi Wu Pengfei Niu Yang Yu Chan Ding Shengqing Yu Source Type: research
Childhood vaccination coverage and regional differences in Swiss birth cohorts 2012-2021: Are we on track?
CONCLUSION: Full vaccination coverage in Swiss children is still below 90 % with many vaccinations administered delayed. Given regional differences, missed or delayed booster vaccinations, and differences in vaccine-specific acceptability, more effort may be needed to achieve national vaccination targets.PMID:38593195 | DOI:10.1016/j.vaccine.2023.10.043 (Source: Vaccine)
Source: Vaccine - April 9, 2024 Category: Allergy & Immunology Authors: Simeon J Z ürcher Andri Signorell Anja L échot-Huser Christoph Aebi Carola A Huber Source Type: research
Childhood vaccination coverage and regional differences in Swiss birth cohorts 2012-2021: Are we on track?
CONCLUSION: Full vaccination coverage in Swiss children is still below 90 % with many vaccinations administered delayed. Given regional differences, missed or delayed booster vaccinations, and differences in vaccine-specific acceptability, more effort may be needed to achieve national vaccination targets.PMID:38593195 | DOI:10.1016/j.vaccine.2023.10.043 (Source: Vaccine)
Source: Vaccine - April 9, 2024 Category: Allergy & Immunology Authors: Simeon J Z ürcher Andri Signorell Anja L échot-Huser Christoph Aebi Carola A Huber Source Type: research
Occludin and collagen IV degradation mediated by the T9SS effector SspA contributes to blood –brain barrier damage in ducks during Riemerella anatipestifer infection
In this study, we showed that obvious clinical symptoms, an increase in blood ‒brain barrier (BBB) permeability, and the accumulation of inflammatory cytokines occurred after intravenous infection with the Yb2 strain but not the mutant strain Yb2ΔsspA, indicating that Yb2 infection can lead to cerebrovascular dysfunction and that the type IX secretion system (T9SS) effecto r SspA plays a critical role in this pathological process. In addition, we showed that Yb2 infection led to rapid degradation of occludin (a tight junction protein) and collagen IV (a basement membrane protein), which contributed to endothelial barrie...
Source: Veterinary Research - April 9, 2024 Category: Veterinary Research Source Type: research
Temperature Control in Acute Brain Injury: An Update
Semin Neurol DOI: 10.1055/s-0044-1785647Temperature control in severe acute brain injury (SABI) is a key component of acute management. This manuscript delves into the complex role of temperature management in SABI, encompassing conditions like traumatic brain injury (TBI), acute ischemic stroke (AIS), intracerebral hemorrhage (ICH), aneurysmal subarachnoid hemorrhage (aSAH), and hypoxemic/ischemic brain injury following cardiac arrest. Fever is a common complication in SABI and is linked to worse neurological outcomes due to increased inflammatory responses and intracranial pressure (ICP). Temperature management, particul...
Source: Seminars in Neurology - April 9, 2024 Category: Neurology Authors: Lin, Victor Tian, Cindy Wahlster, Sarah Castillo-Pinto, Carlos Mainali, Shraddha Johnson, Nicholas J. Tags: Review Article Source Type: research
Systematic Review: Success Rate of Endoscopic Endonasal versus Combined Endonasal and Transorbital Neuroendoscopic Approach for Nontraumatic Cerebrospinal Fluid Leak Repairs in the Lateral Recess of Sphenoid Sinus
Conclusion Both the endoscopic endonasal and transorbital approach provide a good success rate. However, due to the small TONES sample, large, randomized control trials are needed. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Journal of Neurological Surgery Part B: Skull Base)
Source: Journal of Neurological Surgery Part B: Skull Base - April 8, 2024 Category: Neurosurgery Authors: Ahmed, Umnia Nasir Siddiqui, Mohammed Saqlain Iftikhar, Haissan Jolly, Karan Nieto, Hannah Muzaffar, Jameel Tags: Original Article Source Type: research
Spatio-temporal brain invasion pattern of Streptococcus pneumoniae and dynamic changes in the cellular environment in bacteremia-derived meningitis
Neurobiol Dis. 2024 Apr 5:106484. doi: 10.1016/j.nbd.2024.106484. Online ahead of print.ABSTRACTStreptococcus pneumoniae (the pneumococcus) is the major cause of bacterial meningitis globally, and pneumococcal meningitis is associated with increased risk of long-term neurological sequelae. These include several sensorimotor functions that are controlled by specific brain regions which, during bacterial meningitis, are damaged by a neuroinflammatory response and the deleterious action of bacterial toxins in the brain. However, little is known about the invasion pattern of the pneumococcus into the brain. Using a bacteremia-...
Source: Neurobiology of Disease - April 7, 2024 Category: Neurology Authors: Kristine Farmen Miguel Tofi ño-Vian Katrin Wellfelt Lars Olsson Federico Iovino Source Type: research
