Three-year follow-up of rheumatoid meningitis with matrix metalloprotease-9 levels in the serum and cerebrospinal fluid as indicators of disease activity: A case report
Rheumatoid meningitis (RM) is an extra-articular complication of rheumatoid arthritis (RA). Although reports of RM sine arthritis exist, most patients with this presentation were diagnosed with RA within one year of RM onset. There are no established biomarkers reflecting the disease activity of RM. This case report highlights the elevation of matrix metalloprotease (MMP)-9 levels during the acute phase of RM and decline during remission. Additionally, this is the first case report of RA diagnosed three years after the onset of RM. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - March 16, 2024 Category: Allergy & Immunology Authors: Keishu Murakami, Katsuichi Miyamoto, Jinsoo Koh, Yoshinori Kajimoto, Hidefumi Ito Tags: Short Communication Source Type: research
Clinical course and peculiarities of Parechovirus and Enterovirus central nervous system infections in newborns: a single-center experience
Conclusion: EV and HpEV CNS infections are not easily distinguishable by clinical features. In both cases, brain MRI abnormalities are not uncommon, and a severe course of the disease is possible. Hyper-ferritinemia may represent an additional diagnostic clue for HpEV infection, and its monitoring is recommended to intercept HLH early and initiate immunomodulatory treatment. Larger studies are needed to confirm our findings.What is Known:• Parechovirus and Enteroviruses are the most common viral pathogens responsible for sepsis and meningoencephalitis in neonates and young infants.• The clinical course and distinguishi...
Source: European Journal of Pediatrics - March 16, 2024 Category: Pediatrics Source Type: research
A multicenter clinical epidemiology of pediatric pneumococcal meningitis in China: results from the Chinese Pediatric Bacterial Meningitis Surveillance (CPBMS) 2019 –2020
ConclusionPediatric PM is more common in children aged 3 months to < 3 years old. Intracranial complications mostly occur in children < 1 year of age with fever being the most common clinical manifestations and subdural effusion and (or) empyema and hydrocephalus being the most common complications, respectively. CSF non-culture methods can facilitate improving the detection rate of pathogenic bacteria. More than 10% of PM children had adverse outcomes. S. pneumoniae strains are susceptible to vancomycin, linezolid, ertapenem, levofloxacin, moxifloxacin, rifampicin, and chloramphenicol. (Source: Frontiers in cellular...
Source: Frontiers in cellular and infection microbiology - March 15, 2024 Category: Microbiology Source Type: research
Rare case of septic shock combined with meningitis caused by Pasteurella multocida without a history of cat and dog bites
Pasteurella multocida is a zoonotic pathogen that mainly causes local skin and soft tissue infections in the human body through cat and dog bites. It rarely causes bacteraemia (or sepsis) and meningitis. We repor... (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - March 15, 2024 Category: Infectious Diseases Authors: Yijun Zhu, Fang Zhu, Xiaoyun Shan and Jingchao Shi Tags: Case Report Source Type: research
