Rapid diagnosis of a case of post-surgical meningitis with BioFire ® Joint Infection Panel
Rev Esp Quimioter. 2024 Mar 27:cuadrado27mar2024. doi: 10.37201/req/009.2024. Online ahead of print.NO ABSTRACTPMID:38533781 | DOI:10.37201/req/009.2024 (Source: Revista Espanola de Quimioterapia)
Source: Revista Espanola de Quimioterapia - March 27, 2024 Category: Drugs & Pharmacology Authors: B Cuadrado Garc ía A Madue ño Alonso A Mart ín Bermúdez L Romero-Acevedo P P érez Orán M Lecuona Fern ández Source Type: research
Evaluation of metagenomic and pathogen-targeted next-generation sequencing for diagnosis of meningitis and encephalitis in adults: A multicenter prospective observational cohort study in China
Next-generation sequencing (NGS) might aid in identification of causal pathogens. However, the optimal approaches applied to cerebrospinal fluid (CSF) for detection are unclear, and studies evaluating application of different NGS workflows for diagnosis of intracranial infections are limited. (Source: Journal of Infection)
Source: Journal of Infection - March 26, 2024 Category: Infectious Diseases Authors: Weibi Chen, Gang Liu, Lili Cui, Fei Tian, Jiatang Zhang, Jiahua Zhao, Ying Lv, Jianxin Du, Xinyu Huan, Yingfeng Wu, Yan Zhang Source Type: research
Predictions of Bedaquiline Central Nervous System Exposure in Patients with Tuberculosis Meningitis Using Physiologically based Pharmacokinetic Modeling
ConclusionsThe whole-body PBPK model for bedaquiline and M2 predicted unbound concentrations in brain to be significantly lower than the unbound concentrations in the lung at clinically relevant doses. Our findings suggest that bedaquiline may result in relatively inferior efficacy against drug-resistant TBM when compared with efficacy against drug-resistant pulmonary TB. (Source: Clinical Pharmacokinetics)
Source: Clinical Pharmacokinetics - March 26, 2024 Category: Drugs & Pharmacology Source Type: research
Paediatric meningitis in the conjugate vaccine era and a novel clinical decision model to predict bacterial aetiology
The aims of this study were to assess aetiology and clinical characteristics in childhood meningitis, and develop clinical decision rules to distinguish bacterial meningitis from other similar clinical syndromes. (Source: Journal of Infection)
Source: Journal of Infection - March 26, 2024 Category: Infectious Diseases Authors: Martin NG, Defres S, Willis L, Beckley R, Hardwick H, Coxon A, Kadambari S, Yu L-M, Liu X, Galal U, Conlin K, Griffiths MJ, Kneen R, Nadel S, Heath PT, Kelly DF, Solomon T, Sadarangani M, Pollard AJ, on behalf of the UK-ChiMES and ENCEPH-UK study groups Source Type: research
Predictions of Bedaquiline Central Nervous System Exposure in Patients with Tuberculosis Meningitis Using Physiologically based Pharmacokinetic Modeling
ConclusionsThe whole-body PBPK model for bedaquiline and M2 predicted unbound concentrations in brain to be significantly lower than the unbound concentrations in the lung at clinically relevant doses. Our findings suggest that bedaquiline may result in relatively inferior efficacy against drug-resistant TBM when compared with efficacy against drug-resistant pulmonary TB. (Source: Clinical Pharmacokinetics)
Source: Clinical Pharmacokinetics - March 26, 2024 Category: Drugs & Pharmacology Source Type: research
Varicella-Zoster Meningitis and Myelitis After Herpes Zoster Dermatitis Treatment With Amenamevir: A Case Series and Literature Review
In this report, we present four cases of VZV meningitis and myelitis following amenamevir treatment for HZ dermatitis with positive VZV DNA in cerebrospinal fluid (CSF) revealed by polymerase chain reaction (PCR). Three of them were considered immunocompromised hosts given the fact that two of these patients were taking immunosuppressive drugs for rheumatoid arthritis, and one patient had a history of sigmoid colon cancer (four months after resection). After HZ onset, amenamevir, which has poor CSF transfer, was prescribed for all the patients, and all of them developed central nervous complications by VZV (meningitis in t...
Source: Herpes - March 25, 2024 Category: Infectious Diseases Authors: Satoru Tada Yuta Kaito Akihiro Watanabe Yukio Sugiyama Akira Nishigaichi Takashi Miwa Kotaro Watanabe Takanori Hazama Daisuke Takahashi Source Type: research
Concurrent Outbreaks of Hepatitis A, Invasive Meningococcal Disease, and Mpox, Florida, USA, 2021-2022
Emerg Infect Dis. 2024 Apr;30(4). doi: 10.3201/eid3004.231392.ABSTRACTIn 2022, concurrent outbreaks of hepatitis A, invasive meningococcal disease (IMD), and mpox were identified in Florida, USA, primarily among men who have sex with men. The hepatitis A outbreak (153 cases) was associated with hepatitis A virus genotype IA. The IMD outbreak (44 cases) was associated with Neisseria meningitidis serogroup C, sequence type 11, clonal complex 11. The mpox outbreak in Florida (2,845 cases) was part of a global epidemic. The hepatitis A and IMD outbreaks were concentrated in Central Florida and peaked during March--June, wherea...
Source: Emerging Infectious Diseases - March 25, 2024 Category: Infectious Diseases Authors: Timothy J Doyle Megan Gumke Danielle Stanek Joshua Moore Brian Buck Timothy Locksmith Kelly Tomson Sarah Schmedes George Churchwell Shan Justin Hubsmith Baskar Krishnamoorthy Karalee Poschman Brandi Danforth Daniel Chacreton outbreak investigation team1 Source Type: research
Concurrent Outbreaks of Hepatitis A, Invasive Meningococcal Disease, and Mpox, Florida, USA, 2021-2022
Emerg Infect Dis. 2024 Apr;30(4). doi: 10.3201/eid3004.231392.ABSTRACTIn 2022, concurrent outbreaks of hepatitis A, invasive meningococcal disease (IMD), and mpox were identified in Florida, USA, primarily among men who have sex with men. The hepatitis A outbreak (153 cases) was associated with hepatitis A virus genotype IA. The IMD outbreak (44 cases) was associated with Neisseria meningitidis serogroup C, sequence type 11, clonal complex 11. The mpox outbreak in Florida (2,845 cases) was part of a global epidemic. The hepatitis A and IMD outbreaks were concentrated in Central Florida and peaked during March--June, wherea...
Source: Emerging Infectious Diseases - March 25, 2024 Category: Infectious Diseases Authors: Timothy J Doyle Megan Gumke Danielle Stanek Joshua Moore Brian Buck Timothy Locksmith Kelly Tomson Sarah Schmedes George Churchwell Shan Justin Hubsmith Baskar Krishnamoorthy Karalee Poschman Brandi Danforth Daniel Chacreton outbreak investigation team1 Source Type: research
Concurrent Outbreaks of Hepatitis A, Invasive Meningococcal Disease, and Mpox, Florida, USA, 2021-2022
Emerg Infect Dis. 2024 Apr;30(4). doi: 10.3201/eid3004.231392.ABSTRACTIn 2022, concurrent outbreaks of hepatitis A, invasive meningococcal disease (IMD), and mpox were identified in Florida, USA, primarily among men who have sex with men. The hepatitis A outbreak (153 cases) was associated with hepatitis A virus genotype IA. The IMD outbreak (44 cases) was associated with Neisseria meningitidis serogroup C, sequence type 11, clonal complex 11. The mpox outbreak in Florida (2,845 cases) was part of a global epidemic. The hepatitis A and IMD outbreaks were concentrated in Central Florida and peaked during March--June, wherea...
Source: Emerging Infectious Diseases - March 25, 2024 Category: Infectious Diseases Authors: Timothy J Doyle Megan Gumke Danielle Stanek Joshua Moore Brian Buck Timothy Locksmith Kelly Tomson Sarah Schmedes George Churchwell Shan Justin Hubsmith Baskar Krishnamoorthy Karalee Poschman Brandi Danforth Daniel Chacreton outbreak investigation team1 Source Type: research
Concurrent Outbreaks of Hepatitis A, Invasive Meningococcal Disease, and Mpox, Florida, USA, 2021-2022
Emerg Infect Dis. 2024 Apr;30(4). doi: 10.3201/eid3004.231392.ABSTRACTIn 2022, concurrent outbreaks of hepatitis A, invasive meningococcal disease (IMD), and mpox were identified in Florida, USA, primarily among men who have sex with men. The hepatitis A outbreak (153 cases) was associated with hepatitis A virus genotype IA. The IMD outbreak (44 cases) was associated with Neisseria meningitidis serogroup C, sequence type 11, clonal complex 11. The mpox outbreak in Florida (2,845 cases) was part of a global epidemic. The hepatitis A and IMD outbreaks were concentrated in Central Florida and peaked during March--June, wherea...
Source: Emerging Infectious Diseases - March 25, 2024 Category: Infectious Diseases Authors: Timothy J Doyle Megan Gumke Danielle Stanek Joshua Moore Brian Buck Timothy Locksmith Kelly Tomson Sarah Schmedes George Churchwell Shan Justin Hubsmith Baskar Krishnamoorthy Karalee Poschman Brandi Danforth Daniel Chacreton outbreak investigation team1 Source Type: research
Concurrent Outbreaks of Hepatitis A, Invasive Meningococcal Disease, and Mpox, Florida, USA, 2021-2022
Emerg Infect Dis. 2024 Apr;30(4):633-43. doi: 10.3201/eid3004.231392.ABSTRACTIn 2022, concurrent outbreaks of hepatitis A, invasive meningococcal disease (IMD), and mpox were identified in Florida, USA, primarily among men who have sex with men. The hepatitis A outbreak (153 cases) was associated with hepatitis A virus genotype IA. The IMD outbreak (44 cases) was associated with Neisseria meningitidis serogroup C, sequence type 11, clonal complex 11. The mpox outbreak in Florida (2,845 cases) was part of a global epidemic. The hepatitis A and IMD outbreaks were concentrated in Central Florida and peaked during March--June,...
Source: Emerging Infectious Diseases - March 25, 2024 Category: Infectious Diseases Authors: Timothy J Doyle Megan Gumke Danielle Stanek Joshua Moore Brian Buck Timothy Locksmith Kelly Tomson Sarah Schmedes George Churchwell Shan Justin Hubsmith Baskar Krishnamoorthy Karalee Poschman Brandi Danforth Daniel Chacreton outbreak investigation team1 Source Type: research
Concurrent Outbreaks of Hepatitis A, Invasive Meningococcal Disease, and Mpox, Florida, USA, 2021-2022
Emerg Infect Dis. 2024 Apr;30(4):633-43. doi: 10.3201/eid3004.231392.ABSTRACTIn 2022, concurrent outbreaks of hepatitis A, invasive meningococcal disease (IMD), and mpox were identified in Florida, USA, primarily among men who have sex with men. The hepatitis A outbreak (153 cases) was associated with hepatitis A virus genotype IA. The IMD outbreak (44 cases) was associated with Neisseria meningitidis serogroup C, sequence type 11, clonal complex 11. The mpox outbreak in Florida (2,845 cases) was part of a global epidemic. The hepatitis A and IMD outbreaks were concentrated in Central Florida and peaked during March--June,...
Source: Emerging Infectious Diseases - March 25, 2024 Category: Infectious Diseases Authors: Timothy J Doyle Megan Gumke Danielle Stanek Joshua Moore Brian Buck Timothy Locksmith Kelly Tomson Sarah Schmedes George Churchwell Shan Justin Hubsmith Baskar Krishnamoorthy Karalee Poschman Brandi Danforth Daniel Chacreton outbreak investigation team1 Source Type: research
Magnolol attenuates macrophage pyroptosis triggered by Streptococcus equi subsp. zooepidemicus
Int Immunopharmacol. 2024 Mar 23;131:111922. doi: 10.1016/j.intimp.2024.111922. Online ahead of print.ABSTRACTStreptococcus equi subsp. zooepidemicus (SEZ) is a zoonotic bacterial pathogen that causes life-threatening infections and various diseases such as meningitis, endocarditis and pneumonia. With the use of antibiotics being severely restricted in the international community, an alternative to antibiotics is urgently needed against bacterial. In the present study, the herbal extract magnolol protected mice against SEZ infection, reflected by increased survival rate and reduced bacterial burden. A pro-inflammatory form...
Source: International Immunopharmacology - March 24, 2024 Category: Allergy & Immunology Authors: Yuxuan Liu Meijun Lu Qian Sun Zheng Guo Yongjin Lin Shun Li Yunfei Huang Yajuan Li Qiang Fu Source Type: research
Etiology, Clinical Presentation, and Outcomes of Bacterial Meningitis in Adult Patients: A Retrospective Study in Lithuania (2018-2021)
CONCLUSIONS Clinical characteristics of community-acquired acute bacterial meningitis differ based on etiological factors. Patient age, CSF WBC count, and headache may be significant predictive factors for outcomes of bacterial meningitis.PMID:38520034 | DOI:10.12659/MSM.942904 (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 23, 2024 Category: Research Authors: Greta Rynkevi č Emilijus Žilinskas Dovil ė Streckytė Daiva Radzi šauskienė R ūta Mameniškienė Source Type: research
Viruses, Vol. 16, Pages 494: Advances in Antiretroviral Therapy for Patients with Human Immunodeficiency Virus-Associated Tuberculosis
hen
Tuberculosis is one of the most common opportunistic infections and a prominent cause of death in patients with human immunodeficiency virus (HIV) infection, in spite of near-universal access to antiretroviral therapy (ART) and tuberculosis preventive therapy. For patients with active tuberculosis but not yet receiving ART, starting ART after anti-tuberculosis treatment can complicate clinical management due to drug toxicities, drug–drug interactions and immune reconstitution inflammatory syndrome (IRIS) events. The timing of ART initiation has a crucial impact on treatment outcomes, especially for pa...
Source: Viruses - March 23, 2024 Category: Virology Authors: Xiaoqin Le Yinzhong Shen Tags: Review Source Type: research
