Guide for the treatment of acute altered mental status. Iberoamerican Academy of Pediatric Neurology
Rev Neurol. 2024 Apr 16;78(8):229-235. doi: 10.33588/rn.7808.2023302.ABSTRACTIn pediatric patients, an acute altered mental status refers to a sudden and significant change in a child's brain function and level of consciousness. It may manifest as confusion, disorientation, agitation, lethargy or even a loss of consciousness. This condition is a medical emergency, and requires immediate evaluation and attention. There are several causes of acute altered mental status in children, including infections of the central nervous system such as meningitis or encephalitis, traumatic brain injury, metabolic disorders, seizures and ...
Source: Revista de Neurologia - April 15, 2024 Category: Neurology Authors: D L ópez F Espinel E Andrade A S Aguirre Source Type: research
Guide for the treatment of acute altered mental status. Iberoamerican Academy of Pediatric Neurology
Rev Neurol. 2024 Apr 16;78(8):229-235. doi: 10.33588/rn.7808.2023302.ABSTRACTIn pediatric patients, an acute altered mental status refers to a sudden and significant change in a child's brain function and level of consciousness. It may manifest as confusion, disorientation, agitation, lethargy or even a loss of consciousness. This condition is a medical emergency, and requires immediate evaluation and attention. There are several causes of acute altered mental status in children, including infections of the central nervous system such as meningitis or encephalitis, traumatic brain injury, metabolic disorders, seizures and ...
Source: Revista de Neurologia - April 15, 2024 Category: Neurology Authors: D L ópez F Espinel E Andrade A S Aguirre Source Type: research
Serogroup B Invasive Meningococcal Disease in Older Adults Identified by Genomic Surveillance, England, 2022 –2023
E. Loud et al. (Source: Emerging Infectious Diseases Journal)
Source: Emerging Infectious Diseases Journal - April 15, 2024 Category: Infectious Diseases Source Type: research
Efficacy, Safety and Quality of Life of Pegcetacoplan in Japanese Patients With Paroxysmal Nocturnal Hemoglobinuria Treated Within the Phase 3 PEGASUS Trial
CONCLUSION: These data suggest that Japanese patients with PNH can be effectively and safely managed with pegcetacoplan.CLINICALTRIALS: gov identifier: NCT03500549.PMID:38615657 | DOI:10.1159/000537696 (Source: Acta Haematologica)
Source: Acta Haematologica - April 14, 2024 Category: Hematology Authors: Hisakazu Nishimori Hideyuki Nakazawa Shinobu Tamura Toshiki Uchida Kensuke Usuki Johan Szamosi R égis Peffault de Latour Alexander R öth Jens Panse Source Type: research
Efficacy, Safety and Quality of Life of Pegcetacoplan in Japanese Patients With Paroxysmal Nocturnal Hemoglobinuria Treated Within the Phase 3 PEGASUS Trial
CONCLUSION: These data suggest that Japanese patients with PNH can be effectively and safely managed with pegcetacoplan.CLINICALTRIALS: gov identifier: NCT03500549.PMID:38615657 | DOI:10.1159/000537696 (Source: Acta Haematologica)
Source: Acta Haematologica - April 14, 2024 Category: Hematology Authors: Hisakazu Nishimori Hideyuki Nakazawa Shinobu Tamura Toshiki Uchida Kensuke Usuki Johan Szamosi R égis Peffault de Latour Alexander R öth Jens Panse Source Type: research
The Association Between Children's Autism Spectrum Disorders and Central Nervous System Infections: Using a Nationwide Claims Database
This study aimed to examine this issue using an extensive national database. Utilizing JMDC medical claims database, we conducted a retrospective cohort study of children with at least three years of follow-up from birth, ensuring the mother's information was available. The focus was on the relationship between ASD incidence and exposures like viral meningitis/encephalitis, bacterial meningitis, and intrauterine infections. Cox proportional hazards was used to calculate hazard ratios (HRs) with covariates such as presence of maternal history of mental illness, preterm, low birth weight, respiratory and cardiac disorder, ep...
Source: Journal of Autism and Developmental Disorders - April 12, 2024 Category: Psychiatry Authors: Takanori Yanai Satomi Yoshida Koji Kawakami Source Type: research
The Association Between Children's Autism Spectrum Disorders and Central Nervous System Infections: Using a Nationwide Claims Database
This study aimed to examine this issue using an extensive national database. Utilizing JMDC medical claims database, we conducted a retrospective cohort study of children with at least three years of follow-up from birth, ensuring the mother's information was available. The focus was on the relationship between ASD incidence and exposures like viral meningitis/encephalitis, bacterial meningitis, and intrauterine infections. Cox proportional hazards was used to calculate hazard ratios (HRs) with covariates such as presence of maternal history of mental illness, preterm, low birth weight, respiratory and cardiac disorder, ep...
Source: Journal of Autism and Developmental Disorders - April 12, 2024 Category: Psychiatry Authors: Takanori Yanai Satomi Yoshida Koji Kawakami Source Type: research
Viruses, Vol. 16, Pages 599: Circulation of West Nile Virus and Usutu Virus in Europe: Overview and Challenges
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West Nile Virus (WNV) and Usutu Virus (USUV) are both neurotropic mosquito-borne viruses belonging to the Flaviviridae family. These closely related viruses mainly follow an enzootic cycle involving mosquitoes as vectors and birds as amplifying hosts, but humans and other mammals can also be infected through mosquito bites. WNV was first identified in Uganda in 1937 and has since spread globally, notably in Europe, causing periodic outbreaks associated with severe cases of neuroinvasive diseases such as meningitis and encephalitis. USUV was initially isolated in 1959 in Swaziland and has also spread to Europe, primar...
Source: Viruses - April 12, 2024 Category: Virology Authors: Yannick Simonin Tags: Perspective Source Type: research
A real ‑world pharmacovigilance study of FDA adverse event reporting system events for daratumumab
CONCLUSION: Our study found potential new and unexpected AEs signals for daratumumab, suggesting prospective clinical studies are needed to confirm these results and illustrate their relationship.PMID:38600747 | DOI:10.1080/14740338.2024.2328321 (Source: Expert Opinion on Drug Safety)
Source: Expert Opinion on Drug Safety - April 11, 2024 Category: Drugs & Pharmacology Authors: Xiaolin Yun Yingying Zhou Danna Wu Yuanbo Liu Qiongshi Wu Source Type: research
Development of Mucoadhesive Microspheres for Intranasal Delivery of Fluconazole as an Alternative Treatment of Cryptococcal Meningitis Infection in Patients with Acquired Immunodeficiency
This study aimed to develop a mucoadhesive microsphere delivery system for fluconazole for the intranasal route. Microspheres of mucoadhesive fluconazole formulation variables, such as different amounts of drug concentration and polymer concentration, were prepared by a simple emulsion-crosslinking method. The prepared microspheres' surface was characterised by SEM (Scanning electron microscopy) and evaluated for particle size, entrapment efficiency, production yield, infrared spectroscopic study, in-vitro mucoadhesion, and in-vitro drug release. The results showed that formula 1 is the optimal mucoadhesive microsphere pre...
Source: Annales Pharmaceutiques Francaises - April 11, 2024 Category: Drugs & Pharmacology Authors: Amriani Sapra H M Hendrawan Sayyid M Amin None Syahrani Filia Ananda Kelsi Syamsu Nur Andi Dian Permana Source Type: research
A real ‑world pharmacovigilance study of FDA adverse event reporting system events for daratumumab
CONCLUSION: Our study found potential new and unexpected AEs signals for daratumumab, suggesting prospective clinical studies are needed to confirm these results and illustrate their relationship.PMID:38600747 | DOI:10.1080/14740338.2024.2328321 (Source: Expert Opinion on Drug Safety)
Source: Expert Opinion on Drug Safety - April 11, 2024 Category: Drugs & Pharmacology Authors: Xiaolin Yun Yingying Zhou Danna Wu Yuanbo Liu Qiongshi Wu Source Type: research
Development of Mucoadhesive Microspheres for Intranasal Delivery of Fluconazole as an Alternative Treatment of Cryptococcal Meningitis Infection in Patients with Acquired Immunodeficiency
This study aimed to develop a mucoadhesive microsphere delivery system for fluconazole for the intranasal route. Microspheres of mucoadhesive fluconazole formulation variables, such as different amounts of drug concentration and polymer concentration, were prepared by a simple emulsion-crosslinking method. The prepared microspheres' surface was characterised by SEM (Scanning electron microscopy) and evaluated for particle size, entrapment efficiency, production yield, infrared spectroscopic study, in-vitro mucoadhesion, and in-vitro drug release. The results showed that formula 1 is the optimal mucoadhesive microsphere pre...
Source: Annales Pharmaceutiques Francaises - April 11, 2024 Category: Drugs & Pharmacology Authors: Amriani Sapra H M Hendrawan Sayyid M Amin None Syahrani Filia Ananda Kelsi Syamsu Nur Andi Dian Permana Source Type: research
Development of Mucoadhesive Microspheres for Intranasal Delivery of Fluconazole as an Alternative Treatment of Cryptococcal Meningitis Infection in Patients with Acquired Immunodeficiency
This study aimed to develop a mucoadhesive microsphere delivery system for fluconazole for the intranasal route. Microspheres of mucoadhesive fluconazole formulation variables, such as different amounts of drug concentration and polymer concentration, were prepared by a simple emulsion-crosslinking method. The prepared microspheres' surface was characterised by SEM (Scanning electron microscopy) and evaluated for particle size, entrapment efficiency, production yield, infrared spectroscopic study, in-vitro mucoadhesion, and in-vitro drug release. The results showed that formula 1 is the optimal mucoadhesive microsphere pre...
Source: Annales Pharmaceutiques Francaises - April 11, 2024 Category: Drugs & Pharmacology Authors: Amriani Sapra H M Hendrawan Sayyid M Amin None Syahrani Filia Ananda Kelsi Syamsu Nur Andi Dian Permana Source Type: research
A real ‑world pharmacovigilance study of FDA adverse event reporting system events for daratumumab
CONCLUSION: Our study found potential new and unexpected AEs signals for daratumumab, suggesting prospective clinical studies are needed to confirm these results and illustrate their relationship.PMID:38600747 | DOI:10.1080/14740338.2024.2328321 (Source: Expert Opinion on Drug Safety)
Source: Expert Opinion on Drug Safety - April 11, 2024 Category: Drugs & Pharmacology Authors: Xiaolin Yun Yingying Zhou Danna Wu Yuanbo Liu Qiongshi Wu Source Type: research
Development of Mucoadhesive Microspheres for Intranasal Delivery of Fluconazole as an Alternative Treatment of Cryptococcal Meningitis Infection in Patients with Acquired Immunodeficiency
This study aimed to develop a mucoadhesive microsphere delivery system for fluconazole for the intranasal route. Microspheres of mucoadhesive fluconazole formulation variables, such as different amounts of drug concentration and polymer concentration, were prepared by a simple emulsion-crosslinking method. The prepared microspheres' surface was characterised by SEM (Scanning electron microscopy) and evaluated for particle size, entrapment efficiency, production yield, infrared spectroscopic study, in-vitro mucoadhesion, and in-vitro drug release. The results showed that formula 1 is the optimal mucoadhesive microsphere pre...
Source: Annales Pharmaceutiques Francaises - April 11, 2024 Category: Drugs & Pharmacology Authors: Amriani Sapra H M Hendrawan Sayyid M Amin None Syahrani Filia Ananda Kelsi Syamsu Nur Andi Dian Permana Source Type: research
