Safety and Efficacy of Pegcetacoplan in Adult Patients with Paroxysmal Nocturnal Hemoglobinuria over 48 Weeks: 307 Open-Label Extension Study
ConclusionPegcetacoplan sustained long-term improvements in hemoglobin concentrations, fatigue reduction, and transfusion burden. Long-term safety findings corroborate the favorable profile established for pegcetacoplan.Trial RegistrationClinicalTrials.gov identifier, NCT03531255. (Source: Advances in Therapy)
Source: Advances in Therapy - April 4, 2024 Category: Drugs & Pharmacology Source Type: research
Modelling the Public Health Impact of MenACWY and MenC Adolescent Vaccination Strategies in Germany
ConclusionThe results of this study demonstrate that implementing MenACWY vaccination for adolescents in Germany is likely to notably reduce IMD incidence and mortality across age groups. However, the introduction of MenC adolescent vaccination shows only limited impact. Considering the extensive healthcare resources typically required for IMD management, these findings suggest the potential for economic benefits associated with the adoption of MenACWY adolescent vaccination, warranting further cost-effectiveness analysis. (Source: Infectious Diseases and Therapy)
Source: Infectious Diseases and Therapy - April 4, 2024 Category: Infectious Diseases Source Type: research
Group B Streptococcus Brain Abscess in a Neonate with Bilateral Otorrhea
Conclusion Brain abscess can occur as a sequela of GBS meningitis in neonates, but they are rare. Otogenic infections require prompt evaluation and treatment as they can progress to serious central nervous infections in neonates. [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents | Abstract | open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - April 4, 2024 Category: Perinatology & Neonatology Authors: Spencer, Emily E. Nostrand, Sarah Van Arya, Shreyas Tags: Case Report Source Type: research
Neonatal Elizabethkingia anophelis meningitis originating from the water reservoir of an automated infant milk dispenser, the Netherlands, February 2024
We report a Dutch case ofE. anophelis meningitis in a neonate, clonally related to samples taken from an automated infant milk dispenser located at the family’s residence. We inform about the emergence ofE. anophelis and suggest molecular surveillance in hospitals and other health settings. This is the first case connecting an automated formula dispenser to an invasive infection in a neonate. (Source: Eurosurveillance)
Source: Eurosurveillance - April 4, 2024 Category: Infectious Diseases Authors: B Ruben Brandsema, Ger-Jan Fleurke, Sigrid Rosema, Eke MW Schins, Jelte Helfferich and Erik Bathoorn Source Type: research
Modelling the Public Health Impact of MenACWY and MenC Adolescent Vaccination Strategies in Germany
ConclusionThe results of this study demonstrate that implementing MenACWY vaccination for adolescents in Germany is likely to notably reduce IMD incidence and mortality across age groups. However, the introduction of MenC adolescent vaccination shows only limited impact. Considering the extensive healthcare resources typically required for IMD management, these findings suggest the potential for economic benefits associated with the adoption of MenACWY adolescent vaccination, warranting further cost-effectiveness analysis. (Source: Infectious Diseases and Therapy)
Source: Infectious Diseases and Therapy - April 4, 2024 Category: Infectious Diseases Source Type: research
Available evidence on the co-administration of the four-component meningococcal B vaccine (4CMenB) with three vaccines at the same visit among pediatric individuals
Volume 20, Issue 1, December 2024 . (Source: Human Vaccines and Immunotherapeutics)
Source: Human Vaccines and Immunotherapeutics - April 3, 2024 Category: Allergy & Immunology Authors: Paolo BonanniStefano CastagnaGiovanni GabuttiSandro GiuffridaFederico MarchettiRocco RussoRosa PratoFrancesco Vitalea Dipartimento di Scienze della Salute, University of Florence, Florence, Italyb Medical Department, GSK, Verona, Italyc Coordinatore Nazio Source Type: research
An umbrella review of the diagnostic value of next-generation sequencing in infectious diseases
ConclusionThis umbrella analysis indicates that NGS is a promising technique for diagnosing pneumocystis pneumonia and periprosthetic/prosthetic joint infection with excellent sensitivity and specificity. More high-quality original research and SRs are needed to verify the current findings. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - April 3, 2024 Category: Drugs & Pharmacology Source Type: research
Strongyloides stercoralis infection masquerading as malignant ascites in a case of angiosarcoma
We present a case of a 56-year-old male with a known case of angiosarcoma liver with massive ascites and low-grade fever. He was clinically diagnosed as having malignant ascites and was planned for chemotherapy. During therapeutic cum diagnostic ascitic tap, cell block sections revealed the presence of cross sections of nematode S. stercoralis gravid uterus with eggs. Later, stool for ova and cysts also revealed multiple larval forms of the nematode. S. stercoralis hyperinfection is often accompanied by sepsis or meningitis with enteric organisms. Patient was started on tab. ivermectin 12 mg once a day for two days (in the...
Source: Indian Journal of Pathology and Microbiology - April 2, 2024 Category: Pathology Authors: Gurpreet K Walia Ramanjit S Akal Abhishek Singh Jayanth Pothedar Source Type: research
The application value of metagenomic next-generation sequencing technology in the diagnosis and treatment of neonatal infectious meningitis - a single center retrospective case-control study
CONCLUSION: Compared with classic meningitis detection methods, mNGS has better PPV, NPV, agreement rate, and AUC. mNGS could help improve the cure rate.PMID:38563313 | DOI:10.1080/01616412.2024.2337523 (Source: Neurological Research)
Source: Neurological Research - April 2, 2024 Category: Neurology Authors: Yun-Su Zou Zhao-Lan Cao Yan Guo Bei-Bei Wang Jia-Li Wang Rui Cheng Yang Yang Xiao-Guang Zhou Source Type: research
Strongyloides stercoralis infection masquerading as malignant ascites in a case of angiosarcoma
We present a case of a 56-year-old male with a known case of angiosarcoma liver with massive ascites and low-grade fever. He was clinically diagnosed as having malignant ascites and was planned for chemotherapy. During therapeutic cum diagnostic ascitic tap, cell block sections revealed the presence of cross sections of nematode S. stercoralis gravid uterus with eggs. Later, stool for ova and cysts also revealed multiple larval forms of the nematode. S. stercoralis hyperinfection is often accompanied by sepsis or meningitis with enteric organisms. Patient was started on tab. ivermectin 12 mg once a day for two days (in the...
Source: Indian Journal of Pathology and Microbiology - April 2, 2024 Category: Pathology Authors: Gurpreet K Walia Ramanjit S Akal Abhishek Singh Jayanth Pothedar Source Type: research
The application value of metagenomic next-generation sequencing technology in the diagnosis and treatment of neonatal infectious meningitis - a single center retrospective case-control study
CONCLUSION: Compared with classic meningitis detection methods, mNGS has better PPV, NPV, agreement rate, and AUC. mNGS could help improve the cure rate.PMID:38563313 | DOI:10.1080/01616412.2024.2337523 (Source: Neurological Research)
Source: Neurological Research - April 2, 2024 Category: Neurology Authors: Yun-Su Zou Zhao-Lan Cao Yan Guo Bei-Bei Wang Jia-Li Wang Rui Cheng Yang Yang Xiao-Guang Zhou Source Type: research
Strongyloides stercoralis infection masquerading as malignant ascites in a case of angiosarcoma
We present a case of a 56-year-old male with a known case of angiosarcoma liver with massive ascites and low-grade fever. He was clinically diagnosed as having malignant ascites and was planned for chemotherapy. During therapeutic cum diagnostic ascitic tap, cell block sections revealed the presence of cross sections of nematode S. stercoralis gravid uterus with eggs. Later, stool for ova and cysts also revealed multiple larval forms of the nematode. S. stercoralis hyperinfection is often accompanied by sepsis or meningitis with enteric organisms. Patient was started on tab. ivermectin 12 mg once a day for two days (in the...
Source: Indian Journal of Pathology and Microbiology - April 2, 2024 Category: Pathology Authors: Gurpreet K Walia Ramanjit S Akal Abhishek Singh Jayanth Pothedar Source Type: research
Strongyloides stercoralis infection masquerading as malignant ascites in a case of angiosarcoma
We present a case of a 56-year-old male with a known case of angiosarcoma liver with massive ascites and low-grade fever. He was clinically diagnosed as having malignant ascites and was planned for chemotherapy. During therapeutic cum diagnostic ascitic tap, cell block sections revealed the presence of cross sections of nematode S. stercoralis gravid uterus with eggs. Later, stool for ova and cysts also revealed multiple larval forms of the nematode. S. stercoralis hyperinfection is often accompanied by sepsis or meningitis with enteric organisms. Patient was started on tab. ivermectin 12 mg once a day for two days (in the...
Source: Indian Journal of Pathology and Microbiology - April 2, 2024 Category: Pathology Authors: Gurpreet K Walia Ramanjit S Akal Abhishek Singh Jayanth Pothedar Source Type: research
Strongyloides stercoralis infection masquerading as malignant ascites in a case of angiosarcoma
We present a case of a 56-year-old male with a known case of angiosarcoma liver with massive ascites and low-grade fever. He was clinically diagnosed as having malignant ascites and was planned for chemotherapy. During therapeutic cum diagnostic ascitic tap, cell block sections revealed the presence of cross sections of nematode S. stercoralis gravid uterus with eggs. Later, stool for ova and cysts also revealed multiple larval forms of the nematode. S. stercoralis hyperinfection is often accompanied by sepsis or meningitis with enteric organisms. Patient was started on tab. ivermectin 12 mg once a day for two days (in the...
Source: Indian Journal of Pathology and Microbiology - April 2, 2024 Category: Pathology Authors: Gurpreet K Walia Ramanjit S Akal Abhishek Singh Jayanth Pothedar Source Type: research
