Congenital Perineal Groove Defect in Monozygotic Twin Infants: A Literature Review
AJP Rep 2021; 11: e54-e57 DOI: 10.1055/s-0041-1727145Perineal groove is a rare benign congenital anomaly with lesion that resembles perforation of mid-perineum or perineal raphe area. Most reported cases of congenital perineal groove presented as an isolated defect in term or early-term singleton female infants. Thus far, there is no reported case of this anomaly in monozygotic twins. Embryo pathogenesis of this female predominance congenital defect remains controversial. Many clinicians are unfamiliar with this congenital anomaly. This congenital defect tends to get self-resolved at around 2 year of age. Nevertheless, the...
Source: American Journal of Perinatology Reports - March 31, 2021 Category: Perinatology & Neonatology Authors: Harsono, Mimily Yanishevski, David Pourcyrous, Massroor Tags: Case Report Source Type: research

Pneumothorax in Neonates Born to COVID-19 –Positive Mothers: Fact or Fortuity?
We describe two SARS-CoV-2–negative neonates born to COVID-19–positive mothers at 38 and 33 weeks, respectively, admitted to our neonatal intensive care unit for respiratory distress and subsequently developed pneumothoraces. As diverse clinical presentations in various age groups are being described, it becomes difficult to differentiate the increased incidence of complications related to an underlying illness, from COVID-19–related illness. It remains to be seen if neonates with in utero exposure to SARS-CoV-2 have an elevated inflammatory response with pneumonitis and exaggerated lung disease, similar ...
Source: American Journal of Perinatology Reports - March 23, 2021 Category: Perinatology & Neonatology Authors: Kamity, Ranjith Nayak, Amrita Dumpa, Vikramaditya Tags: Case Report Source Type: research

Association between Levels of Total Cell-Free DNA and Development of Preeclampsia —A Literature Review
Conclusion Total cfDNA may play a role as a biochemical marker of PE, compared with fetal cfDNA. Large prospective studies with homogeneous populations and standardized methodology are needed to further confirm its predictive value. [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - March 16, 2021 Category: Perinatology & Neonatology Authors: Wu, Yi Werlang, Ana Cheng, Weiwei Lanes, Andrea Wen, Shi Wu Walker, Mark Tags: Case Report Source Type: research

Spontaneous Broad Ligament Hematoma after Vaginal Delivery Requiring Hysterectomy
Conclusion Though uncommon, broad ligament hematomas should be considered in postpartum women presenting with anemia and vaginal bleeding, even without hemodynamic instability. Recent intrauterine infections may predispose to hematoma infection. [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - February 18, 2021 Category: Perinatology & Neonatology Authors: Varvoutis, Megan Nguyen, Nguyen Thao Thi Grotegut, Chad Tags: Case Report Source Type: research

Expectant Management of Severe COVID-19 Pneumonia in Late Preterm Pregnancy and Subsequent Cholecystitis: Lessons Learned
Conclusion This case illustrates that delaying delivery is an option even in later gestational ages for maternal stabilization. A multidisciplinary approach and teamwork is needed to manage pregnant women with COVID-19 infection for optimal outcomes for both mother and fetus. Key Points [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - February 12, 2021 Category: Perinatology & Neonatology Authors: Mokhtari, Neggin B. Drassinower, Daphnie Orr, Lindsey A. Cobb, Nathan K. Mims, Oscar L. Landy, Helain J. Tags: Case Report Source Type: research

Association between Receipt of Intrapartum Magnesium Sulfate and Postpartum Hemorrhage
AJP Rep 2021; 11: e21-e25 DOI: 10.1055/s-0040-1721671 Objective The aim of the study is to investigate the association between intrapartum administration of magnesium sulfate in women with hypertensive disorders of pregnancy and postpartum hemorrhage. Study Design This was a retrospective cohort study of women diagnosed with a hypertensive disorder of pregnancy who delivered singleton gestations>32 weeks at a single, large volume tertiary care center between January 2006 and February 2015. Women who received intrapartum magnesium sulfate for seizure prophylaxis were compared with women who did not receiv...
Source: American Journal of Perinatology Reports - February 1, 2021 Category: Perinatology & Neonatology Authors: Miller, Emily M.S. Sakowicz, Allie Leger, Elise Lange, Elizabeth Yee, Lynn M. Tags: Original Article Source Type: research

Clinical Characteristics of Mother –Infant Dyad and Placental Pathology in COVID-19 Cases in Predominantly African American Population
Conclusion COVID-19 does not appear to increase morbidity and mortality among pregnant women and their neonates in a predominantly AA population. Our study did not find any evidence of vertical transmission of COVID-19 infection nor any specific findings on placental pathology. Key Points [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - February 1, 2021 Category: Perinatology & Neonatology Authors: Jani, Sanket Jacques, Suzanne M Qureshi, Faisal Natarajan, Girija Bajaj, Sujit Velumula, Pradeep Agu, Cindy Bajaj, Monika Tags: Original Article Source Type: research

Biallelic Variants in LAMB1 Causing Hydranencephaly: A Severe Phenotype of a Rare Malformative Encephalopathy
Discussion The pathobiogenesis of hydranencephaly is incompletely understood and is attributed to vascular, infectious, or genetic etiology. Herein we present LAMB1 as a monogenic cause of fetal hydranencephaly which was incompatible with life. Previously, LAMB1-associated phenotype consisted of cobblestone lissencephaly and hydrocephalus, developmental delay, and seizures. Our proband expands the phenotypic spectrum of this malformative encephalopathy. [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abs...
Source: American Journal of Perinatology Reports - February 1, 2021 Category: Perinatology & Neonatology Authors: Sen, Kuntal Kaur, Shagun Stockton, David W. Nyhuis, Mary Roberson, Jacquelyn Tags: Case Report Source Type: research

Risk of Early Birth among Women with a Urinary Tract Infection: A Retrospective Cohort Study
AJP Rep 2021; 11: e5-e14 DOI: 10.1055/s-0040-1721668 Objective The aim of the study is to evaluate the risk of preterm birth (PTB,
Source: American Journal of Perinatology Reports - January 13, 2021 Category: Perinatology & Neonatology Authors: Baer, Rebecca J. Nidey, Nichole Bandoli, Gretchen Chambers, Brittany D. Chambers, Christina D. Feuer, Sky Karasek, Deborah Oltman, Scott P. Rand, Larry Ryckman, Kelli K. Jelliffe-Pawlowski, Laura L. Tags: Case Report Source Type: research

Congenital Adhesion Band Presenting as Intestinal Perforation in an Extremely Low Birth Weight Infant
AJP Rep 2021; 11: e1-e4 DOI: 10.1055/s-0040-1722729A 231/7-week-old and 560-g-weighing premature male infant was evaluated on day of life 33 for increased frequency of bradycardias, bilious residual, and an increase in abdominal girth. Physical examination was notable for distended and mild tender abdomen. Investigations revealed pneumoperitoneum with dilated bowel loops and a normal acid–base balance. An urgent exploratory laparotomy demonstrated isolated jejunal perforation with an adhesive band extending from the omentum to the base of the mesentery. A segmental jejunal resection followed by an end-to-end anastomo...
Source: American Journal of Perinatology Reports - January 13, 2021 Category: Perinatology & Neonatology Authors: Guillen, Juan Ramey, Stacey Parimi, Prabhu Satya Tags: Case Report Source Type: research

Prevalence and Neighborhood Geomapping of COVID-19 in an Underserved Chicago Pregnant Population
Conclusion The disproportionate hit of COVID-19 pandemic on the Hispanic and Black communities reflects in SARS-CoV-2 positivity rates in the obstetrical population. Our report provides data that may be useful to policy makers when prioritizing resources to communities in need. [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - December 3, 2020 Category: Perinatology & Neonatology Authors: Buhimschi, Catalin S. Elam, Gloria L. Locher, Stephen R. Norris-Stojak, Doreen Aldasoqi, Hayfaa Stephenson, Mary D. Buhimschi, Irina A. Tags: Case Report Source Type: research

Implementation of Evidence-Based Cervical Ripening Protocol: Outcomes and Next Steps
Conclusion Implementing evidence-based low-dose misoprostol with the concurrent cervical Foley did not change the time to delivery, time to vaginal-delivery, or likelihood of vaginal delivery in our population. This may be due to differences in labor management practices and incomplete fidelity to the protocol. Real-world effectiveness of these interventions will vary and should be considered when choosing an induction method. [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  | &nb...
Source: American Journal of Perinatology Reports - December 3, 2020 Category: Perinatology & Neonatology Authors: Zakama, Arthurine Sobhani, Nasim C. Lamar, Robyn Rosenstein, Melissa G. Tags: Case Report Source Type: research

Chylothorax Associated with Congenital Complete Atrioventricular Block
Conclusion In any case of CCAVB associated with atypical pleural effusion, one must consider the possibility of congenital chylothorax. [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - December 3, 2020 Category: Perinatology & Neonatology Authors: Fujino, Shuhei Maruyama, Hidehiko Tsukamoto, Keiko Ono, Hiroshi Isayama, Tetsuya Ito, Yushi Tags: Case Report Source Type: research

Neonatal Survivability following Previable PPROM after Hospital Readmission for Intervention
Conclusion Neonatal survival rate following pPPROM was 28.3%. Later gestational age at membrane rupture and increased latency periods are associated with increased neonatal survivability. Antibiotic administration following pPPROM increased latency duration. [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - December 3, 2020 Category: Perinatology & Neonatology Authors: LeMoine, Felicia Moore, Robert C. Chapple, Andrew Moore, Ferney A. Sutton, Elizabeth Tags: Case Report Source Type: research

California Cardiovascular Screening Tool: Findings from Initial Implementation
AJP Rep 2020; 10: e362-e368 DOI: 10.1055/s-0040-1718382 Objective American College of Obstetricians and Gynecologists (ACOG) recently published the California (CA) cardiovascular disease (CVD) screening algorithm for pregnant and postpartum women. We aim to prospectively determine screen-positive and true-positive rates of CVD among women across two populations. Study Design This is a prospective cohort study of obstetrical patients from April 2018 to July 2019 at academic medical centers in CA and New York (NY). We attempted to screen all patients at least once during their pregnancy care (prenatal or post...
Source: American Journal of Perinatology Reports - November 16, 2020 Category: Perinatology & Neonatology Authors: Blumenthal, Elizabeth A. Crosland, B. Adam Senderoff, Dana Santurino, Kathryn Garg, Nisha Bernstein, Megan Wolfe, Diana Hameed, Afshan Tags: Original Article Source Type: research

Sirolimus for Kaposiform Hemangioendothelioma and Kasabach-Merritt Phenomenon in a Neonate
We present a case of a neonate born with kaposiform hemangioendothelioma (KHE), complicated by Kasabach-Merritt phenomenon (KMP) and other serious conditions, who was successfully treated with sirolimus. In addition to complications from thrombocytopenia and fluid overload, during the course of therapy, our patient experienced supratherapeutic drug levels at the commonly accepted starting dose of sirolimus. Patients with KHE and KMP should be closely monitored for potential complications of both the initial disease and unexpected side effects of treatments. [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Flo...
Source: American Journal of Perinatology Reports - November 16, 2020 Category: Perinatology & Neonatology Authors: Cabrera, Trevor B. Speer, Allison L. Greives, Matthew R. Goff, Donna A. Menon, Neethu M. Reynolds, Eric W. Tags: Case Report Source Type: research

Neonatal Extremity Compartment Syndrome: A Rare Diagnosis Requiring Prompt Recognition
We report a case of upper extremity compartment syndrome from initial presentation until 3 months after discharge and discuss the importance of prompt diagnosis and timely surgical evaluation. [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - November 16, 2020 Category: Perinatology & Neonatology Authors: Severyn, Nicholas T. Kua, Kok Lim Tags: Case Report Source Type: research

Fetal Tachycardia in the Delivery Room: Fetal Distress, Supraventricular Tachycardia, or Both?
Conclusion SVT should be actively considered in the differential diagnosis of fetal tachycardia. Unrecognized fetal SVT may result in avoidable caesarean for suspected fetal distress, with potential prematurity-related problems. The cardiotocograph can be helpful if showing contact loss associated with rapid heart rate auscultation. The antenatal detection of fetal SVT is important as it can allow anticipation and prevention of neonatal SVT, which is potentially life-threatening if not detected and treated promptly. [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in...
Source: American Journal of Perinatology Reports - November 16, 2020 Category: Perinatology & Neonatology Authors: Bhatia, Satvinder Singh Burgess, Wendy H. Skinner, Jonathan R. Tags: Case Report Source Type: research

Adverse Pregnancy Outcomes by Degree of Maternal Serum Analyte Elevation: A Retrospective Cohort Study
AJP Rep 2020; 10: e369-e379 DOI: 10.1055/s-0040-1716741 Objective The aim of this study was to evaluate rates of preterm birth (PTB) and obstetric complication with maternal serum analytes > 2.5 multiples of the median (MoM) by degree of elevation. Study Design Retrospective cohort study of singleton live-births participating in the California Prenatal Screening Program (2005–2011) examining PTB and obstetric complication for α-fetoprotein (AFP), human chorionic gonadotropin (hCG), unconjugated estriol (uE3), and inhibin A (INH) by analyte subgroup (2.5 to 
Source: American Journal of Perinatology Reports - November 16, 2020 Category: Perinatology & Neonatology Authors: Yeaton-Massey, Amanda Baer, Rebecca J. Rand, Larry Jelliffe-Pawlowski, Laura L. Lyell, Deirdre J. Tags: Case Report Source Type: research

Beyond Expert Opinion: A Comparison of Antibiotic Regimens for Infectious Urinary Tract Pathology in Pregnancy
Conclusion Receipt of antibiotics other than nitrofurantoin or SMZ-TMP for LUTI in pregnancy was not associated with increased risk of progression to pyelonephritis, PTB, or LBW. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - October 12, 2020 Category: Perinatology & Neonatology Authors: Krischak, Madison K. Rosett, Heather A. Sachdeva, Sarika Weaver, Kristin E. Heine, Robert Phillips Denoble, Anna E. Dotters-Katz, Sarah K. Tags: Original Article Source Type: research

Inpatient Biophysical Profiles and the Effect on Clinical Decision Making
AJP Rep 2020; 10: e357-e361 DOI: 10.1055/s-0040-1717141 Objective Our primary objective was to determine whether biophysical profiles (BPP) performed on the antepartum unit result in changes in clinical decision making. Study Design A retrospective cohort chart review was performed among women who had a BPP during hospital admission. BPP status was categorized as normal (8/8 points) and abnormal (6/8 or less points). The primary outcome, clinical decision making, was the need for prolonged external fetal monitoring (defined as > 2 hours) or decision to proceed with delivery. Secondar...
Source: American Journal of Perinatology Reports - October 12, 2020 Category: Perinatology & Neonatology Authors: Racusin, Diana A. Chauhan, Suneet P. Sibai, Baha Chen, Han-Yang Adimorah, Nesochi Piro, Mica Heye, Kristen Sharp, Charlotte WHNP-BC, MSN Blackwell, Sean Refuerzo, Jerrie Tags: Case Report Source Type: research

High Blood Pressure in a Urea Cycle Disorder: Case Report
Conclusion High blood pressure has been rarely described as a lead symptom for the debut of a UCD. We must take this into consideration as an early recognition and treatment of these disorders are of the utmost importance. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - October 6, 2020 Category: Perinatology & Neonatology Authors: Sol é, Carolina Arriaga, Mar ía Ca ñedo, Elvira Tags: Case Report Source Type: research

Mesenchymal Stem Cells Attenuate Lipopolysaccharide-Induced Inflammatory Response in Human Uterine Smooth Muscle Cells
Conclusion MSCs appear to play a role in significantly attenuating LPS-mediated inflammation via alteration of down-stream MAPKs. MSCs may represent a novel, cell-based therapy in women with increased risk of inflammatory-mediated preterm birth. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - September 22, 2020 Category: Perinatology & Neonatology Authors: Mani, Arunmani Hotra, John W. Blackwell, Sean C. Goetzl, Laura Refuerzo, Jerrie S. Tags: Case Report Source Type: research

Correlation of Obesity with External Cephalic Version Success among Women with One Previous Cesarean Delivery
Conclusion There was no correlation of BMI with the rate of successful ECV among women with one prior cesarean delivery. Given the similar success rates of ECV and adverse outcomes, obese women with one prior cesarean delivery should be offered ECV. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - September 22, 2020 Category: Perinatology & Neonatology Authors: McLaren, Rodney Atallah, Fouad Fisher, Nelli Minkoff, Howard Tags: Case Report Source Type: research

Debunking the Myth: Do Maternal-Fetal Medicine Fellows Negatively Impact Resident Obstetrical Skills?
AJP Rep 2020; 10: e319-e323 DOI: 10.1055/s-0040-1715168 Objective Residency applicants often express concern that fellows negatively impact surgical opportunities, especially with less common procedures. We sought to describe the impact of maternal-fetal medicine (MFM) fellows on resident surgical opportunities. Study Design Anonymous 27-question e-survey sent to obstetrics and gynecology (OBGYN) residents in the United States and Puerto Rico in March 2018. Questions included experience as primary surgeon, for fourth year residents only, comfort performing procedures postresidency, and demographics. Residen...
Source: American Journal of Perinatology Reports - September 22, 2020 Category: Perinatology & Neonatology Authors: Dotters-Katz, Sarah K. Grace, Matthew Heine, R Phillips Propst, Katie Tags: Case Report Source Type: research

Establishing Better Evidence on Remote Monitoring for Postpartum Hypertension: A Silver Lining of the Coronavirus Pandemic
AJP Rep 2020; 10: e315-e318 DOI: 10.1055/s-0040-1715169The transformation of our health care system in response to coronavirus disease 2019 (COVID-19) provides a unique opportunity to examine the use of telehealth for postpartum care. The postpartum period can pose significant risks and challenges, particularly for women with hypertensive disorders of pregnancy. Remote blood pressure monitoring has proven feasible and acceptable among women and providers but has not been widely implemented or researched. Early studies have identified improved outcomes with use of telehealth, including increased compliance with care and dec...
Source: American Journal of Perinatology Reports - September 22, 2020 Category: Perinatology & Neonatology Authors: Sawyer, Michala R. Jaffe, Elana F. Naqvi, Mariam Sarma, Amy Barth, William H. Goldfarb, Ilona T. Tags: Case Report Source Type: research

Sleep Duration during Pregnancy using an Activity Tracking Device
AJP Rep 2020; 10: e309-e314 DOI: 10.1055/s-0040-1715172 Objective The aim of this study was to describe sleep duration across gestation in women who wore an activity-tracking device (ATD) during pregnancy, and to study the association between sleep duration and adverse maternal and neonatal outcomes Study Design Women ≥ 18 years old who owned a smartphone were approached to participate in 2016 to 2017. Participants received instructions to wear and sync an ATD daily. Steps, sedentary hours, and sleep duration were wirelessly transmitted via cellular technology. We measured sleep duration for the m...
Source: American Journal of Perinatology Reports - September 22, 2020 Category: Perinatology & Neonatology Authors: Kominiarek, Michelle A. Yeh, Chen Balmert, Lauren C. Facco, Francesca Grobman, William Simon, Melissa Tags: Case Report Source Type: research

Interdisciplinary Approach for the Medical Management of Gestational Gigantomastia
Conclusion We highlight a successful interdisciplinary medical management approach, which helped to avoid a morbid, intrapartum breast reduction. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - September 22, 2020 Category: Perinatology & Neonatology Authors: Cabrera, Camila Radolec, Mackenzy Prescott, Angela De La Cruz, Carolyn Beck, Stacy Tags: Case Report Source Type: research

Late Presentation of Uterine Rupture Following Vaginal Birth After Cesarean Delivery: A Case Report
Conclusion Delivery after trial of labor after cesarean delivery usually decreases acuity; however, these patients remain at risk for significant complications. Clinicians should continue to assess patients in the immediate postpartum period and proceed with surgical intervention if necessary. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - September 22, 2020 Category: Perinatology & Neonatology Authors: Choi, Lindsey A. Chung, Ariel A. Pierce, Brian Tags: Case Report Source Type: research

Fetal Macrocephaly: A Novel Sonographic Finding in Congenital Myotonic Dystrophy
Conclusion CDM should be included in the differential diagnosis of third-trimester macrocephaly, especially in the presence of additional sonographic clues and when maternal medical history and physical examination are suggestive of DM. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - September 22, 2020 Category: Perinatology & Neonatology Authors: Shinar, Shiri Balakumar, Parry Shah, Vibhuti Chong, Karen Uster, Tami Chitayat, David Tags: Case Report Source Type: research

Infective Endocarditis as a Complication of Intravenous Drug Use in Pregnancy: A Retrospective Case Series and Literature Review
Conclusion Management of intravenous drug use-associated infective endocarditis in pregnancy involves more than treating the acute condition. In pregnant women with opioid use disorder and infective endocarditis, addiction and chronic psychosocial conditions need to be addressed to optimize care. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - September 22, 2020 Category: Perinatology & Neonatology Authors: Adesomo, Adebayo Gonzalez-Brown, Veronica Rood, Kara M. Tags: Case Report Source Type: research

Response of an Obstetric Unit during the Coronavirus Disease of 2019 (COVID-19) Pandemic: Experiences from a Tertiary Care Center
Conclusion The COVID-19 pandemic has posed many unique challenges. Balancing communication, risks of infection to providers, patient autonomy and rights, and resources for testing and personal protective equipment were among the valuable lessons learnt. We have shared our experiences and described our observations and challenges in Westchester County, New York. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - September 22, 2020 Category: Perinatology & Neonatology Authors: Kumaraswami, Sangeeta Pradhan, Tana S. Vrabie-Wolf, Sorana Lodhi, Sadaf Rajendran, Geetha P. Tedjarati, Sean S. Grimes, Cara L. Tags: Case Report Source Type: research

Bayes Theorem and Protopathic Bias: Methodological Concerns When Addressing the Impact of Fetal Heart Rate Patterns on the Cesarean Section Rate
AJP Rep 2020; 10: e342-e345 DOI: 10.1055/s-0040-1713786Over the last 30 years, the caesarean section rate has reached global epidemic proportions. This trend is driven by multiple factors, an important one of which is the use and inconsistent interpretation of the electronic fetal monitoring (EFM) system. Despite its introduction in the 1960s, the EFM has not definitively improved neonatal outcomes, yet it has since significantly contributed to a seven-fold increase in the caesarean section rate. As we attempt to reduce the caesarean rates in the developed world, we should consider focusing on areas that have garnered litt...
Source: American Journal of Perinatology Reports - September 22, 2020 Category: Perinatology & Neonatology Authors: Balayla, Jacques Lasry, Ariane Gil, Yaron Volodarsky-Perel, Alexander Tags: Original Article Source Type: research

Duration of the Third Stage of Labor and Estimated Blood Loss in Twin Vaginal Deliveries
Conclusion Twin pregnancy is a known risk factor for postpartum hemorrhage. As the duration of the third stage prolongs, the risk for hemorrhage also increases. We recommend delivery of the placenta in twin pregnancies by 15 minutes to reduce this risk. Key Points [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - September 22, 2020 Category: Perinatology & Neonatology Authors: Whittington, Julie R. Pagan, Megan Daugherty, Kristen Cummings, Kelly Ounpraseuth, Songthip T. Eads, Lauren Magann, Everett F. Tags: Original Article Source Type: research

Associations among Discharge Opioid Prescribing and Inpatient Postpartum Opioid Usage after Delivery
Conclusion The number of opioid tablets prescribed at discharge had no association with inpatient postpartum consumption after VD or CD. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - September 22, 2020 Category: Perinatology & Neonatology Authors: Veade, Ashley McKinnish, Tyler Carter, Ebony Lewkowitz, Adam Tags: Original Article Source Type: research

In Utero Vertical Transmission of Coronavirus Disease 2019 in a Severely Ill 29-week Preterm Infant
We present a case of likely intrauterine transmission of COVID-19 infection in a critically ill premature infant born to a COVID-19 infected mother and describing her clinical course thus far. The clinical presentation in the infant is consistent with COVID-19 infection described so far in literature along with positive PCR, and positive COVID-19 serology: immunoglobulin G, immunoglobulin M, and immunoglobulin A. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Sourc...
Source: American Journal of Perinatology Reports - September 15, 2020 Category: Perinatology & Neonatology Authors: Gupta, Arpit Malhotra, Yogangi Patil, Uday Muradas, Ana R. Lee, William T. Krammer, Florian Amanat, Fatima Clare, Camille A. Vinod, Suja Ghaly, Emad Tags: Case Report Source Type: research

Air Leak Syndrome in Two Very Preterm Infants Born to Mothers with Coronavirus Disease 2019: An Association or a Coincidence?
We present here two very preterm infants born to mothers with COVID-19, whose respiratory course was significant for initial mild respiratory distress syndrome who developed acute onset severe air leak syndrome at approximately 24 to 36 hours of age requiring thoracentesis. Their respiratory status improved gradually with resolution of air leak and respiratory failure by 2 weeks of age. Both infants tested negative for SARS-CoV-2 by reverse transcriptase–polymerase chain reaction of multiple respiratory specimens collected beyond 24 hours after birth. As the incidence of severe air leak syndrome is rela...
Source: American Journal of Perinatology Reports - September 1, 2020 Category: Perinatology & Neonatology Authors: Reddy, Ajay Engelhardt, Krystin Jain, Deepak Tags: Case Report Source Type: research

Neonatal Cerebellar Hemorrhage and Facial Nerve Palsy: An Unusual Association
We report the uncommon case of a late preterm infant born by spontaneous delivery who showed right peripheral facial palsy at 24 hours of life. Cranial ultrasound showed lateral ventricles dilatation and a diffuse hyperechoic round lesion in the right cerebellar hemisphere. The computed tomography scan confirmed a hemorrhagic lesion in the right cerebellar hemisphere and in the vermis with midline shift and intraventricular bleeding. Ommaya reservoir was inserted and used for a few days. The facial palsy gradually recovered to a complete remission after 6 weeks. Follow-up examinations at 12 and 18 months evidenced i...
Source: American Journal of Perinatology Reports - September 1, 2020 Category: Perinatology & Neonatology Authors: Coviello, Caterina Remaschi, Giulia Becciani, Sabrina Montano, Simona Corsini, Iuri Mussa, Federico Basile, Massimo Dani, Carlo Tags: Case Report Source Type: research

Implementation of a Postpartum Hemorrhage Safety Bundle at an Urban Safety-Net Hospital
Conclusion Keys to implementation included multidisciplinary stakeholder commitment, stepwise and iterative approach, and parallel systems for monitoring and evaluation Implementation of a PPH safety bundle is feasible in a resource-constrained setting. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - September 1, 2020 Category: Perinatology & Neonatology Authors: Joseph, Naima T. Worrell, Nikkia H. Collins, Janice Schmidt, Melanie Sobers, Grace Hutchins, Kathlyn Chahine, E. Britton Faya, Christine Lewis, Luanne Green, Victoria L. Castellano, Penny Z. Lindsay, Michael K. Tags: Case Report Source Type: research

Nasal High Frequency Oscillatory Ventilation for Respiratory Failure due to Respiratory Syncytial Virus Bronchiolitis: Case Report
AJP Rep 2020; 10: e253-e254 DOI: 10.1055/s-0040-1715179The authors describe a case of acute respiratory failure due to severe bronchiolitis. During high-flow nasal cannula ventilation, the blood's high levels of hypercapnia had taken them to plan the sedation and the orotracheal intubation. However, before attempting intubation, a nasal high frequency oscillatory ventilation cycle was performed and it led to a marked improvement in the blood gas, avoiding in this way the invasive ventilation. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents &nbs...
Source: American Journal of Perinatology Reports - August 26, 2020 Category: Perinatology & Neonatology Authors: Liberatore, Pio Maffei, Gianfranco Tags: Case Report Source Type: research

Carbetocin versus Oxytocin for the Prevention of Postpartum Hemorrhage in Cesarean Deliveries: A Retrospective Study of Two Consecutive Periods
Conclusion Carbetocin is not superior to oxytocin in preventing PPH. However, it does provide the advantage of requiring a single injection. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - August 26, 2020 Category: Perinatology & Neonatology Authors: Delorme, Pierre Kayem, Gilles Legardeur, H élène Roux-Dessarps, Louise Anne Girard, Guillaume Meunier, Geraldine Keita, Hawa Mandelbrot, Laurent Tags: Case Report Source Type: research

Use of Placental Growth Factor for Trisomy 21 Screening in Pregnancy: A Systematic Review
Conclusion Addition of PLGF to prenatal screening using serum analytes mildly improves trisomy 21 DRs as a function of FPRs. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - August 26, 2020 Category: Perinatology & Neonatology Authors: Badeghiesh, Ahmad Volodarsky-Perel, Alexander Lasry, Ariane Hemmings, Robert Gil, Yaron Balayla, Jacques Tags: Case Report Source Type: research

Safety and Efficacy of Higher Order Multifetal Pregnancy Reduction: A Single-Center Retrospective Study
Conclusion Perinatal outcomes were significantly improved by reducing the number of fetuses in higher order multifetal pregnancies. This study involved a large, diverse sample population, and the results can be used as a reference while conducting prenatal counseling. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - August 26, 2020 Category: Perinatology & Neonatology Authors: Liu, Yan Wang, Xie Tong Li, Hong Yan Hou, Hai Yan Wang, Hong Wang, Yan Tun Tags: Case Report Source Type: research

Driving Factors of Preterm Birth Risk in Adolescents
We examined rates of spontaneous and indicated preterm births (S-PTB and I-PTB, respectively) and clinical risk factors for PTB in adolescents. Study Design This is a population-based, retrospective cohort using 2012 U.S. natality data of nulliparous women who delivered a nonanomalous singleton birth between 20 and 42 weeks' gestation. Maternal age included
Source: American Journal of Perinatology Reports - August 26, 2020 Category: Perinatology & Neonatology Authors: Perez, Marta J. Chang, Jen J. Temming, Lorene A. Carter, Ebony B. L ópez, Julia D. Tuuli, Methodius G. Macones, George A. Stout, Molly J. Tags: Original Article Source Type: research

Coronavirus Disease 2019 in a Premature Infant: Vertical Transmission and Antibody Response or Lack Thereof
We present here a preterm neonate born to a critically ill mother with SARV-CoV-2 with early evidence of infection with a positive reverse transcription polymerase chain reaction on day 1. Lack of parental contact prior to testing and strict adherence to recommended airborne precautions perinatally suggest vertical transmission of infection. Critical maternal illness and medications may have contributed to the need for extensive resuscitation at birth and highlight the importance of close fetal monitoring. Infant lacked immunoglobulin G antibody response by 3 weeks, presumably secondary to mild clinical course and prematur...
Source: American Journal of Perinatology Reports - August 19, 2020 Category: Perinatology & Neonatology Authors: Rivera-Hernandez, Pedro Nair, Jayasree Islam, Shamim Davidson, Lauren Chang, Arthur Elberson, Valerie Tags: Case Report Source Type: research

Impact of Excess Weight Gain on Risk of Postpartum Infection in Class III Obesity
AJP Rep 2020; 10: e213-e216 DOI: 10.1055/s-0040-1715165 Objective To assess the impact of gestational weight gain>20 pounds (more than Institute of Medicine [IOM] recommendations) on postpartum infectious morbidity in women with class III obesity. Methods This is a retrospective cohort of term, nonanomalous singleton pregnancies with body mass index ≥40 at a single institution from 2013 to 2017. Pregnancies with multiple gestation, late entry to care, and missing weight gain data are excluded. Primary outcome is a composite of postpartum infection (endometritis, urinary tract, respiratory, and wound i...
Source: American Journal of Perinatology Reports - August 19, 2020 Category: Perinatology & Neonatology Authors: Mitchell, Courtney J. Adkins, LaMani Tucker, Ann Brown, Haywood Siegel, Anne Dotter-Katz, Sarah Tags: Case Report Source Type: research

The Association between Glucose Levels and Adverse Pregnancy Outcomes in Nondiabetic Twin Pregnancies
Conclusion In women with twin pregnancies without GDM, elevated maternal glucose levels are not associated with preeclampsia, cesarean delivery, or neonatal hypoglycemia. The altered physiology of twin gestations may modify the effect of maternal hyperglycemia on perinatal outcomes as compared with singleton pregnancies. Current approaches to screening for and treating GDM during pregnancy might not adequately account for these unique considerations among twins. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract&nb...
Source: American Journal of Perinatology Reports - August 19, 2020 Category: Perinatology & Neonatology Authors: Cheung, Kevin Fox, Nathan S. Tags: Original Article Source Type: research

Labetalol-Induced Hepatotoxicity during Pregnancy: A Case Report
Conclusion Labetalol-induced hepatitis should be considered in the differential for transaminitis during pregnancy to prevent iatrogenic preterm delivery. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - August 3, 2020 Category: Perinatology & Neonatology Authors: Whelan, Anna Izewski, Joanna Berkelhammer, Charles Walloch, Jami Kay, Helen H. Tags: Case Report Source Type: research

Methadone for Opioid Use Treatment during Pregnancy: Trends in Postpartum Dose Adjustments
Conclusion Patients using methadone for OUT during pregnancy achieved minimal dose decreases postpartum. Patients should be counseled that postpartum dose tapers may be challenging and about alternatives to methadone for OUT. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - August 3, 2020 Category: Perinatology & Neonatology Authors: Ward, Clara Christensen, Carl W. Tags: Original Article Source Type: research

Effectiveness of Progestogens as Maintenance Tocolysis and Urogenital Cultures: Secondary Analysis of the PROTECT Trial
Conclusion Among women with negative urine culture, the rate of preterm birth
Source: American Journal of Perinatology Reports - August 3, 2020 Category: Perinatology & Neonatology Authors: Pignatti, Lucrezia D'Amico, Roberto Vergani, Patrizia Di Tommaso, Mariarosaria Acaia, Barbara Benedetto, Chiara Facchinetti, Fabio Tags: Original Article Source Type: research