Congenital Segmental Intestinal Dilatation: A 25-Year Review with Long-Term Follow-up at the Medical University of Innsbruck, Austria
Conclusion This is the first report of patients with CSID and cardiovascular defects. The clinical and surgical intervention for CSID also requires a thorough cardiologic evaluation in these patients. CSID remains an enigmatic entity pointing to the need for joint forces in identifying common loci for genetic investigations. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - July 11, 2019 Category: Perinatology & Neonatology Authors: Sergi, Consolato Hager, Thomas Hager, Josef Tags: Case Report Source Type: research

Effect and Complications of Everolimus Use for Giant Cardiac Rhabdomyomas with Neonatal Tuberous Sclerosis
We report herein a neonatal case of giant cardiac rhabdomyomas with TS and insufficient pulmonary blood flow from the right ventricle. Lipoprostaglandin E1 was necessary to maintain patency of the ductus arteriosus. We used everolimus, a mammalian target of rapamycin inhibitor, to diminish the cardiac rhabdomyomas. After treatment, the rhabdomyomas shrank rapidly, but the serum concentration of everolimus increased sharply (maximum serum trough level: 76.1 ng/mL) and induced complications including pulmonary hemorrhage, liver dysfunction, and acne. After the everolimus level decreased, the complications resolved. Everolimu...
Source: American Journal of Perinatology Reports - July 11, 2019 Category: Perinatology & Neonatology Authors: Shibata, Yuka Maruyama, Hidehiko Hayashi, Taiyu Ono, Hiroshi Wada, Yuka Fujinaga, Hideshi Fujino, Shuhei Nagasawa, Junko Amari, Shoichiro Tsukamoto, Keiko Ito, Yushi Tags: Case Report Source Type: research

Association of Bacterial Vaginosis with Vitamin D in Pregnancy: Secondary Analysis from the Kellogg Pregnancy Study
AJP Rep 2019; 09: e226-e234 DOI: 10.1055/s-0039-1693163 Objective Bacterial vaginosis (BV) is associated with vitamin D deficiency and poor pregnancy outcomes. We studied a nested cohort from a randomized controlled trial to investigate the association between BV and vitamin D concentration in pregnancy. Study Design Subjects with randomly assigned 400 versus 4,400 IU of daily cholecalciferol (vitamin D3) had vaginal swabs collected for Gram staining and Nugent score calculation, as well as plasma 25-hydroxyvitamin D (25(OH)D) measurement at three pregnancy time points. Results Fifty-two (21.2%) of ...
Source: American Journal of Perinatology Reports - July 11, 2019 Category: Perinatology & Neonatology Authors: Powell, Anna Maya Shary, Judy R. Louden, Christopher Ramakrishnan, Vishwanathan Eckard, Allison Ross Wagner, Carol L. Tags: Original Article Source Type: research

Urinary Ascites and Transient Intestinal Obstruction in a Preterm Infant: An Interesting Case of Posterior Urethral Valve
We report a preterm neonate with PUV who presented as nonimmune fetal hydrops with intestinal obstruction in the antenatal period. The mother of our patient is a 33-year-old woman who started her prenatal care at our hospital at 30 weeks' gestation. Her sonogram done at 32 weeks in our hospital revealed fetal hydrops. It showed polyhydramnios, mild pyelectasis of right kidney, normal left kidney, and fetal ascites. Amniocentesis revealed bile stained amniotic fluid. Ultrasound during the procedure showed dilated fetal bowel loops with increased echoes. Following delivery at 32 weeks postnatal exam showed ascites with absen...
Source: American Journal of Perinatology Reports - July 10, 2019 Category: Perinatology & Neonatology Authors: Mani, S. Kupferman, F. Kumar, K. Hazra, S. Sokal, M. Jean-Baptiste, D. Kim, R. Tags: Case Report Source Type: research

The Effect of BML-111 in Preeclampsia Rat Model Induced by the Low Dose of Cadmium Chloride
Conclusions BML-111 has a potential therapeutic effect in pregnant rats with CdCl2-induced PE, which appears to be mediated through inhibition of inflammatory processes in the placenta. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - July 4, 2019 Category: Perinatology & Neonatology Authors: Zhang, KeKe Hu, Min Zhang, Lin Zhang, Qiong Huang, Yinping Tags: Original Article Source Type: research

Cerclage Location and Gestational Age at Delivery
AJP Rep 2019; 09: e195-e199 DOI: 10.1055/s-0039-1688778 Objective Multiple authors have suggested cerclage position is a determinant of “success.” We assessed the interaction between cervical length (CL), cerclage height (cerH), proximal residual length (PRL), gestational age at delivery, and rate of delivery ≤ 34 weeks, in this study. Study Design Present study is a retrospective cohort study of all cerclages placed at Maimonides Medical Center from 2006 to 2016. Outcomes: gestational age at delivery and delivery before 34 weeks; predictors: PRL, cerH, CL; and indications for c...
Source: American Journal of Perinatology Reports - June 28, 2019 Category: Perinatology & Neonatology Authors: Estrada, Fatima Karakash, Scarlett SeeToe, Terry Weedon, Jeremy Minkoff, Howard Tags: Original Article Source Type: research

Operative Vaginal Delivery Is a Safe Option in Women Undergoing a Trial of Labor after Cesarean
AJP Rep 2019; 09: e190-e194 DOI: 10.1055/s-0039-1692482 Objective To compare outcomes of operative intervention in the second stage of labor during trial of labor after cesarean (TOLAC). Study Design A secondary analysis of the Maternal-Fetal Medicine Units Network cesarean section registry was conducted. Analysis was by first attempted mode of delivery. Results A total of 1,837 met inclusion criteria. Subjects in the operative vaginal groups (OVDs) were more likely to have a prior vaginal delivery (vacuum 34.2%; forceps 34.3%) than the repeat cesarean delivery (RCD) group (22.6%; p 
Source: American Journal of Perinatology Reports - June 18, 2019 Category: Perinatology & Neonatology Authors: Krizman, Erin Grzebielski, Patricia Antony, Kathleen M. Sampene, Emmanuel Shanahan, Matthew Iruretagoyena, J. Igor Bohrer, Justin Tags: Original Article Source Type: research

A Current Commentary on Breech Vaginal Deliveries: The Changing Landscape of Patient versus Physician Autonomy
AJP Rep 2019; 09: e185-e189 DOI: 10.1055/s-0039-1692178 Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - June 14, 2019 Category: Perinatology & Neonatology Authors: Hill, Meghan G. Tags: Commentary Source Type: research

Oxytocin and Oxytocinase in the Obese and Nonobese Parturients during Induction and Augmentation of Labor
AJP Rep 2019; 09: e177-e184 DOI: 10.1055/s-0039-1692196 Objective To investigate differences in oxytocin (OXT) biodistribution between nonobese and obese parturients during labor. Study Design Patients with body mass index (BMI) of either ≥ 18 ≤ 24.9 kg/m2 (“nonobese”) or ≥ 30 kg/m2 (“obese”) undergoing elective induction of labor were included (N = 25 each). Blood samples were collected at baseline (T0), and 20 minutes after maximal OXT augmentation or adequate uterine contractions (T1) for OXT and oxytocinase assays. ...
Source: American Journal of Perinatology Reports - May 29, 2019 Category: Perinatology & Neonatology Authors: De Tina, Annemaria Juang, Jeremy McElrath, Thomas F. Baty, Jack D. Palanisamy, Arvind Tags: Original Article Source Type: research

Targeted Neonatal Echocardiography-Guided Therapy in Vein of Galen Aneurysmal Malformation: A Report of Two Cases with a Review of Physiology and Approach to Management
AJP Rep 2019; 09: e172-e176 DOI: 10.1055/s-0039-1688765Vein of Galen malformation results in predictable changes in physiology which exist on a continuum. Severe pulmonary hypertension may present as hypoxemia; however, excessive reduction in pulmonary vascular resistance may precipitate progressive pulmonary overcirculation and impaired systemic blood flow. Right ventricular performance and the patency and direction of the ductus arteriosus may play a crucial role in postductal organ perfusion. Physiological stabilization may be complex and variable over time. The utilization of targeted neonatal echocardiography to guide...
Source: American Journal of Perinatology Reports - May 29, 2019 Category: Perinatology & Neonatology Authors: Giesinger, R. E. Elsayed, Y. N. Castaldo, M. P. McNamara, P. J. Tags: Case Report Source Type: research

Efficacy of Non-Beta-lactam Antibiotics for Prevention of Cesarean Delivery Surgical Site Infections
Conclusion β-Lactam perioperative prophylaxis is associated with lower odds of a cesarean delivery surgical site infection compared with non-β-lactam antibiotics. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - April 30, 2019 Category: Perinatology & Neonatology Authors: Harris, Benjamin S. Hopkins, Maeve K. Villers, Margaret S. Weber, Jeremy M. Pieper, Carl Grotegut, Chad A. Swamy, Geeta K. Hughes, Brenna L. Heine, R Phillips Tags: Original Article Source Type: research

Cervical Pessary versus Expectant Management for the Prevention of Delivery Prior to 36 Weeks in Women with Placenta Previa: A Randomized Controlled Trial
Conclusion Although the study was underpowered to determine the primary outcome, safety and feasibility of CP in pregnancies complicated with previa were demonstrated. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - April 30, 2019 Category: Perinatology & Neonatology Authors: Stafford, Irene A. Garite, Thomas J. Maurel, Kimberly Combs, C. Andrew Heyborne, Kent Porreco, Richard Nageotte, Michael Baker, Susan Gopalani, Sameer Dola, Chi How, Helen Das, Anita F. Tags: Original Article Source Type: research

Timing of Antenatal Corticosteroid Administration in Monoamniotic Twins
Conclusion Administration of ACS on admission is not effective. Fetal heart rate tracing surveillance might be a better methodology to predict delivery and guide ACS administration. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - April 30, 2019 Category: Perinatology & Neonatology Authors: Bibbo, Carolina Easter, Sarah R. Saadeh, Michael Little, Sarah E. Robinson, Julian N. Tags: Original Article Source Type: research

Babesiosis in Pregnancy: An Imitator of HELLP Syndrome
AJP Rep 2019; 09: e147-e152 DOI: 10.1055/s-0039-1687873HELLP syndrome (hemolysis, elevated liver enzymes, and low platelets) is a serious pregnancy complication that can cause significant maternal and neonatal morbidity and mortality. There are several conditions that may occur in pregnancy that may imitate the laboratory findings and clinical presentation of HELLP syndrome. Babesiosis is a parasitic imitator of HELLP syndrome that can be spread by the tick, transfusions, or congenitally. Recognition and treatment of this condition is important to optimize maternal and fetal outcomes. [...] Thieme Medical Publishers 333 Se...
Source: American Journal of Perinatology Reports - April 29, 2019 Category: Perinatology & Neonatology Authors: Khangura, Raminder Kaur Williams, Nayo Cooper, Shontreal Prabulos, Anne- Marie Tags: Review Article Source Type: research

Effect of a High-Fat Diet and Metformin on Placental mTOR Signaling in Mice
This study was aimed to measure the effects of a high-fat diet and metformin on placental mechanistic target of rapamycin (mTOR) signaling in mice. Study Design Pregnant friend virus B (FVB)-strain mice were allocated on embryonic day (e) 0.5 to one of four groups; group 1: control diet (CD, 10% fat) + control treatment (CT), group 2: CD + metformin treatment (MT), group 3: high-fat diet (HFD, 60% fat) + CT, and group 4: HFD + MT. Metformin (2.5 mg/mL) was provided in water; CT mice received water. Fetuses and placentas were collected. Western blot measured pl...
Source: American Journal of Perinatology Reports - April 9, 2019 Category: Perinatology & Neonatology Authors: Grace, Matthew R. Dotters-Katz, Sarah K. Zhou, Chunxiao Manuck, Tracy Boggess, Kim Bae-Jump, Victoria Tags: Original Article Source Type: research

Sonographic Estimated Fetal Weight and Cesarean Delivery among Nulliparous Women with Obesity
This study was aimed to examine the association between having an ultrasound estimate of fetal weight (US-EFW) and mode of delivery among obese women. Study Design A retrospective cohort study of nulliparous women with a body mass index of ≥ 35 kg/m2 who delivered term singleton gestations. We examined whether having had an US-EFW within 35 days of delivery, or an US-EFW ≥ 90th percentile for gestational age, was associated with intrapartum cesarean delivery. Results Of 2,826 women, 22.5% (n = 636) had an US-EFW within 35 days of delivery. Having an US-EFW was...
Source: American Journal of Perinatology Reports - April 9, 2019 Category: Perinatology & Neonatology Authors: Dude, Annie M. Davis, Berkley Delaney, Katie Yee, Lynn M. Tags: Original Article Source Type: research

Pentalogy of Cantrell in Full Term Neonate
AJP Rep 2019; 09: e144-e146 DOI: 10.1055/s-0039-1683936Pentalogy of Cantrell (PC) is an uncommon congenital disorder characterized by severe defects in the chest and abdomen, including abdominal visceral prolapsed via umbilical cord (omphalocele), defect in the lower part of the sternum, defect in the front of the diaphragm, defects in the anterior part of the pericardium, and the ectopiacordis. Here, we report a 2-hour-old girl, weighing 3,500 g, who was referred to Shahid Madani Hospital in Khorramabad due to the large omphalocele on her chest with pulsating mass above it. The baby was the first child of a 24-year...
Source: American Journal of Perinatology Reports - April 9, 2019 Category: Perinatology & Neonatology Authors: Taee, Nadereh Goodarzi, Mojgan Faraji Safdari, Mohammad Bajelan, Amir Tags: Case Report Source Type: research

Successful Management of Pulmonary Arterial Hypertension by Monitoring N-Terminal Pro-B-Type Natriuretic Peptide Serum Levels in a Preterm Infant with Chronic Lung Disease: A Case Report
AJP Rep 2019; 09: e133-e137 DOI: 10.1055/s-0039-1684026We measured the serial changes in N-terminal probrain natriuretic peptide (NT-proBNP) levels in a 6-month-old male infant with chronic lung disease (CLD) complicated by pulmonary arterial hypertension (PAH). The patient was born at the 24th week of gestation weighing 695 g. At 1 month after birth, an echocardiogram confirmed the diagnosis of CLD with PAH. He was treated with inhaled nitric oxide (iNO) and oral sildenafil and discharged from the hospital. At 190 days of age, the patient was readmitted to our department because of a viral upper respiratory infecti...
Source: American Journal of Perinatology Reports - April 9, 2019 Category: Perinatology & Neonatology Authors: Seki, Keigo Iwashima, Satoru Uchiyama, Hiroki Ohishi, Akira Ishikawa, Takamichi Tags: Case Report Source Type: research

Prenatal Diagnosis and Successful Palliation of Absent Aortic Valve with Hypoplastic Left Heart Syndrome: A Case Report and Review of Literature
Conclusion Prenatal diagnosis of absent aortic valve should be suspected in the presence of severe aortic insufficiency in the fetal ECHO. Early postnatal intervention is critical as those patients are likely to deteriorate quickly. The over-sewing of the aortic valve may be important to prevent coronary steal and myocardial hypoperfusion which could potentially be detrimental. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - April 9, 2019 Category: Perinatology & Neonatology Authors: Qasim, Amna Johnson, Chelsea B. Aly, Muhammad A. Aly, Ashraf M. Tags: Case Report Source Type: research

Erratum: Persistence of Neonatal Brachial Plexus Palsy among Nulliparous Versus Parous Women
AJP Rep 2019; 09: e1-e1 DOI: 10.1055/s-0039-1687855 Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - April 4, 2019 Category: Perinatology & Neonatology Authors: McLaren, Rodney A. Chang, Kate W.-C. Ankumah, Nana-Ama E. Yang, Lynda J.-S. Chauhan, Suneet P. Tags: Erratum Source Type: research

Medicolegal Review: Perinatal Effexor Lawsuits and Legal Strategies Adverse to Prescribing Obstetric Providers
Conclusion To reduce the risk of liability exposure, obstetricians must adequately document informed consent in the medical records when prescribing medications to their pregnant patients. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - March 19, 2019 Category: Perinatology & Neonatology Authors: Kirsch, Nathan Pacheco, Luis D. Hossain, Amjad Phelps, John Y. Tags: Review Article Source Type: research

A Case of Massive Hepatic Infarction in a Patient with HELLP Syndrome
Conclusion Hepatic infarction is an extraordinarily rare complication of pre-eclampsia. Early recognition and prompt multidisciplinary management are vital to prevent catastrophic bleeding, hepatic failure, and death. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - March 19, 2019 Category: Perinatology & Neonatology Authors: Morgan, Jessica Della Torre, Micaela Whelan, Anna R. Rodriguez, Sophia M. DiGiovanni, Laura M. Tags: Case Report Source Type: research

Nutrition and Exercise Strategies to Prevent Excessive Pregnancy Weight Gain: A Meta-analysis
Conclusion Preventing excessive GWG is crucial, especially for OV or obese women. In the current study, nutrition-based intervention is the health system strategy that showed significant impact on preventing excessive GWG compared with routine prenatal care. Among women who are OV or have obesity, nutrition-only interventions hold the most promise compared with routine prenatal care. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - March 19, 2019 Category: Perinatology & Neonatology Authors: Craemer, Katherine A. Sampene, Emmanuel Safdar, Nasia Antony, Kathleen M. Wautlet, Cynthia K. Tags: Original Article Source Type: research

Incremental Cost of Prematurity by Week of Gestational Age
Conclusion We provide estimates of potential cost savings that could be attributable to interventions that delay or prevent preterm delivery. Cost differences were most extreme at the lower range of gestation (≤ 30 weeks); however, infants born moderately preterm (31–36 weeks) also contribute substantially to the burden, as they represent a higher proportion of total births. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - March 19, 2019 Category: Perinatology & Neonatology Authors: Walsh, Eileen M. Li, Sherian X. Black, Libby K. Kuzniewicz, Michael Tags: Original Article Source Type: research

The Value of Different Radiological Modalities in Assessment of Spontaneous Pneumomediastinum: Case Review and Diagnostic Perspective
We report an unusual presentation of significant spontaneous pneumomediastinum in a term newborn delivered by elective cesarean section with no history of active resuscitation at birth.Timely diagnosis of SPM is important for both management and prognosis. We believe that lung ultrasound (LUS) is a promising screening tool for early detection of PM in neonates, and could help avoid unnecessary exposure to radiation in delicate neonates. More simultaneous studies comparing chest X-ray (CXR), LUS, and computed tomography (CT) scans may help to prove the utility value of point-of-care ultrasounds as a primary diagnostic tool ...
Source: American Journal of Perinatology Reports - March 7, 2019 Category: Perinatology & Neonatology Authors: Jariwala, Poonam Singh Kalaniti, Kaarthigeyan Wonko, Neil Daspal, Sibasis Mugarab Samedi, Veronica Tags: Case Report Source Type: research

The Effect of Non-penicillin Antibiotic Regimens on Neonatal Outcomes in Preterm Premature Rupture of Membranes
Conclusions In this cohort, receiving NPCR in the setting of PPROM did not impact the overall risk of adverse neonatal outcomes or latency, but did increase the risk of endometritis. Alterations in individual neonatal morbidities suggest follow-up studies are needed. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - March 7, 2019 Category: Perinatology & Neonatology Authors: Siegel, Anne M. Heine, Robert Phillips Dotters-Katz, Sarah K. Tags: Original Article Source Type: research

RNA-Sequencing of Umbilical Cord Blood to Investigate Spontaneous Preterm Birth: A Pilot Study
AJP Rep 2019; 09: e60-e66 DOI: 10.1055/s-0039-1678717 Objective To analyze the transcriptomic gene expression of umbilical cord blood leukocytes using RNA-sequencing from preterm birth (PTB) and term birth (TB). Study Design Eight women with spontaneous PTB (sPTB) and eight women with unlabored TB were enrolled prospectively. The sPTB and TB cohorts were matched for maternal age, race, mode of delivery, and fetal sex. Cord blood RNA was extracted and a globin depletion protocol was applied, then sequenced on the Illumina HiSeq 4000. Raw read counts were analyzed with DESeq2 to test for gene expression diffe...
Source: American Journal of Perinatology Reports - March 7, 2019 Category: Perinatology & Neonatology Authors: Vora, Neeta L. Parker, Joel S. Mieckowski, Piotr A. Smeester, Lisa Fry, Rebecca C. Boggess, Kim A. Tags: Original Article Source Type: research

Assessing Adverse Childhood Experiences during Pregnancy: Evidence toward a Best Practice
AJP Rep 2019; 09: e54-e59 DOI: 10.1055/s-0039-1683407 Objective To quantify the prevalence of adverse childhood experiences (ACEs) among a diverse urban cohort of pregnant women. Study Design The ACE survey was self-administered to 600 women categorized evenly between the waiting room, private examination rooms, and CenteringPregnancy group spaces. The percentage of women willing to complete the survey per location was compared using chi-square tests, and the mean ACE score per arm was compared using Wilcoxon's rank–sum test. Results Of the 660 women approached for participation, 5% declined; ...
Source: American Journal of Perinatology Reports - March 7, 2019 Category: Perinatology & Neonatology Authors: Nguyen, Megan W. Heberlein, Emily Covington-Kolb, Sarah Gerstner, Anne M. Gaspard, Amber Eichelberger, Kacey Y. Tags: Original Article Source Type: research

Risk Factors for Very Preterm Births in French Guiana: The Burden of Induced Preterm Birth
Conclusions Social factors were associated with spontaneous early preterm delivery, suggesting that efforts to reduce psychosocial stressors could lead to potential improvements. Vaginal infections were also associated with induced preterm labor suggesting that early diagnosis and treatment could reduce induced early preterm delivery. Preeclampsia was a major contributor to induced early preterm delivery. Reliable routine predictors of preeclampsia are still not available which makes its prevention impossible in first pregnancies. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in T...
Source: American Journal of Perinatology Reports - March 4, 2019 Category: Perinatology & Neonatology Authors: Leneuve-Dorilas, Malika Favre, Anne Louis, Alphonse Bernard, St éphanie Carles, Gabriel Nacher, Mathieu Tags: Case Report Source Type: research

Finding Understudied Disorders Potentially Associated with Maternal Morbidity and Mortality
Conclusion Our results demonstrate that clinical text provides additional comorbidities associated with maternal complications that need further clinical research. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - March 4, 2019 Category: Perinatology & Neonatology Authors: Rodriguez, Laritza M. Fushman, Dina Demner Tags: Case Report Source Type: research

How does Fetal Autopsy after Pregnancy Loss or Termination for Anomalies and other Complications Change Recurrence Risk?
Conclusion For the vast majority of cases, there is agreement between prenatal and autopsy diagnosis after pregnancy loss or termination for fetal anomalies. Only a small percentage of autopsies change recurrence risk. This may be useful when counseling women about method of termination and when counseling couples about whether to have an autopsy. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - February 18, 2019 Category: Perinatology & Neonatology Authors: Cassidy, Arianna Herrick, Claire Norton, Mary E. Ursell, Philip C. Vargas, Juan Kerns, Jennifer L. Tags: Original Article Source Type: research

A Novel Treatment for Massive Hemorrhage after Maternal Trauma in Pregnancy
Conclusion When other measures fail and a hysterectomy is considered unsafe, the combination of internal and external uterine compression is an option. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - February 13, 2019 Category: Perinatology & Neonatology Authors: Gonzalez, Maritza G. Wei, Ruth M. Hatch, Kenneth D. Gries, Lynn M. Hill, Meghan G. Tags: Case Report Source Type: research

Aortic Arch Thrombosis Associated with Fetal Cytomegalovirus Viremia
AJP Rep 2019; 09: e23-e26 DOI: 10.1055/s-0038-1675631Cytomegalovirus(CMV) associated thrombosis has been reported sporadically in the medical literature; however, its antenatal scenario has not been documented. We herein present the antenatal, Doppler's ultrasound and magnetic resonance angiographic features of thrombosis in the aortic arch showing extension toward the medial lumen of the brachiocephalic trunk with critical occlusion of the left common carotid artery and left subclavian artery in a term fetus to raise obstetricians'/ neonatologists'/pediatric cardiologists' awareness for the association between CMV viremia...
Source: American Journal of Perinatology Reports - February 1, 2019 Category: Perinatology & Neonatology Authors: Yapar Eyi, Elif Gul Altu ğ, Nahide Tags: Case Report Source Type: research

Obstetrical Outcomes of Head and Neck (Nonthyroid) Cancers: A 27-Year Retrospective Series and Literature Review
Conclusions HNCs are rare with diagnosis and management challenges during pregnancy. In this series, the cases diagnosed and managed previously to pregnancy presented better perinatal outcomes than the cases presented during pregnancy. The maternal outcomes appeared similar for HNC diagnosed before or after pregnancy. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - January 29, 2019 Category: Perinatology & Neonatology Authors: Figueir ó-Filho, Ernesto Antonio Horgan, Richard P. Muhanna, Nidal Parrish, Jacqueline Irish, Jonathan C. Maxwell, Cynthia V. Tags: Case Reports Source Type: research

Significant Hematochezia and Intracranial Bleeding in Neonatal Hereditary Hemorrhagic Telangiectasia
We report a female neonate with hematochezia on the 1st day of life secondary to multiple gastrointestinal arteriovenous malformations (AVMs) along with intracranial hemorrhage. We describe her clinical course and management, as well as her novel family mutation in ENG. This is the first reported HHT case with significant gastrointestinal bleeding in the newborn. We review neonatal HHT and raise the consideration for more directed prenatal imaging and delivery options for fetuses at high risk of HHT. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents&n...
Source: American Journal of Perinatology Reports - January 29, 2019 Category: Perinatology & Neonatology Authors: Merves, Matthew Parsons, Kimberly Alazraki, Adina Meisel, Jonathan Sauer, Cary Li, Hong Tags: Case Report Source Type: research

Simulation to Improve Trainee Skill and Comfort with Forceps-Assisted Vaginal Deliveries
AJP Rep 2019; 09: e6-e9 DOI: 10.1055/s-0039-1677736 Objective Simulation training is a powerful learning tool for low frequency events. Forceps-assisted vaginal deliveries (FAVD) are an important tool in reducing cesarean deliveries. The aim of this study is to create a high-fidelity simulation-based curriculum for residency education and investigate pre- and posttest skill and confidence. Methods A prospective cohort study was conducted involving obstetrics and gynecology residents over 2 academic years. Residents participated in one to three FAVD simulation trainings. All sessions involved video, didactic...
Source: American Journal of Perinatology Reports - January 21, 2019 Category: Perinatology & Neonatology Authors: Rose, Kelsey Jensen, Kirsten Guo, Rong Afshar, Yalda Tags: Original Article Source Type: research

Persistence of Neonatal Brachial Plexus Palsy among Nulliparous Versus Parous Women
AJP Rep 2019; 09: 001-005 DOI: 10.1055/s-0038-1677051 Objective Our objective was to compare persistence of neonatal brachial plexus palsy (NBPP) at 1 and 2 years in children of nulliparous versus parous women. Study Design We conducted a retrospective cohort study of children diagnosed with NBPP followed at the University of Michigan, Interdisciplinary Brachial Plexus Program (UM-BPP). Self-reported demographics, delivery history, including birth weight (BW) 
Source: American Journal of Perinatology Reports - January 4, 2019 Category: Perinatology & Neonatology Authors: McLaren, Rodney A. Chang, Kate W.-C. Ankumah, Nana-Ama E. Yang, Lynda J.-S. Chauhan, Suneet P. Tags: Original Article Source Type: research

Talcum Powder Toxicosis in Pregnancy
Conclusion This case highlights the importance of screening for mental health disorders, which may be exacerbated during the peripartum period. Patients' coping mechanisms for mental health disorders may have unintended consequences. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - December 28, 2018 Category: Perinatology & Neonatology Authors: Pennycuff, Jon F. Davenport, Abigail Ellis, Jane Patberg, Elizabeth Cwiak, Carrie Tags: Case Report Source Type: research

Challenges and Limitations of Clinical Trials on Labor Induction: A Review of the Literature
AJP Rep 2018; 08: e365-e378 DOI: 10.1055/s-0038-1676577Induction of labor is a common obstetric procedure performed in nearly a quarter of all deliveries in the United States. Pharmacological (prostaglandins, oxytocin) and/or mechanical methods (balloon catheters) are commonly used for labor induction; however, there is ongoing debate as to which method is the safest and most effective. This narrative review discusses key limitations of published trials on labor induction, including the lack of well-designed randomized controlled trials directly comparing specific methods of induction, heterogeneous trial populations, and ...
Source: American Journal of Perinatology Reports - December 26, 2018 Category: Perinatology & Neonatology Authors: Viteri, Oscar A. Sibai, Baha M. Tags: Review Article Source Type: research

Diagnostic Errors in the Neonatal Intensive Care Unit: A Case Series
AJP Rep 2018; 08: e379-e383 DOI: 10.1055/s-0038-1676619Diagnostic errors remain understudied in neonatal intensive care units (NICUs). The few available studies are primarily autopsy-based, and do not evaluate diagnostic errors that did not result in the patient's death. This case series presents 10 examples of nonlethal diagnostic errors in the NICU—classified according to the component of the diagnostic process which led to the error. These cases demonstrate the presence of diagnostic error in the NICU and highlight the need for further research on this important topic. [...] Thieme Medical Publishers 333 Seventh A...
Source: American Journal of Perinatology Reports - December 26, 2018 Category: Perinatology & Neonatology Authors: Shafer, Grant J. Suresh, Gautham Tags: Case Report Source Type: research

Pregnancies Complicated by Familial Hypertriglyceridemia: A Case Report
Conclusion Treatment with gemfibrozil in pregnancies complicated by hypertriglyceridemia may prevent complications without adverse maternal or fetal effects and could be considered in treating pregnant patients with severe hypertriglyceridemia. These cases also demonstrate the importance of medication compliance in the prevention of poor outcomes. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - December 26, 2018 Category: Perinatology & Neonatology Authors: Cao, Suzanne Dao, NhuChi Roloff, Kristina Valenzuela, Guillermo J. Tags: Case Report Source Type: research

Bronchopulmonary Sequestration with Fetal Hydrops in a Monochorionic Twin Successfully Treated with Multiple Courses of Betamethasone
Conclusion Antenatal steroids might be considered for noninvasive therapy in high-risk fetal patients with BPS especially when fetal intervention is unsuitable or not available. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - December 3, 2018 Category: Perinatology & Neonatology Authors: Pock, Radovan Stra ňák, Zbyněk Vojt ěch, Jiří Ha šlík, Lubomír Feyereisl, Jaroslav Krofta, Ladislav Tags: Case Report Source Type: research

Isolated Fetal Cardiac Abnormalities: Are They Really Isolated?
Conclusion Patients with a suspected isolated fetal cardiac anomaly on ultrasound should be aware of the possibility of other major structural abnormalities, especially in cases of conotruncal cardiac anomalies. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - November 30, 2018 Category: Perinatology & Neonatology Authors: Razavi, Armin S. Chasen, Stephen T. Tags: Case Report Source Type: research

Maternal and Neonatal Outcomes after Attempted External Cephalic Version among Women with One Previous Cesarean Delivery
This study was aimed to evaluate success rates of (1) external cephalic version (ECV) among women with one prior cesarean delivery (CD) and (2) maternal and neonatal outcomes after ECV among women with prior CD. Study Design Two linked studies using U.S. Natality Database were performed. First we performed a retrospective cohort comparing ECV success rates of women with prior CD and women without prior CD. Then we compared the outcomes of TOLACs (trial of labor after cesarean delivery) that occurred after ECV with those that occurred without ECV. Multivariable logistic regression analysis was used to estimate adver...
Source: American Journal of Perinatology Reports - November 28, 2018 Category: Perinatology & Neonatology Authors: McLaren, Rodney A. Atallah, Fouad Fisher, Nelli Minkoff, Howard Tags: Original Article Source Type: research

Maternal and Fetal Outcomes in Pregnancies affected by Bone and Soft Tissue Tumors
Conclusion Pregnant women with bone and soft tissue tumors are candidates for standard surgical management during pregnancy. Other treatments, such as chemotherapy and radiotherapy must be evaluated for each woman on a case-by-case basis. Iatrogenic prematurity was common in our findings. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - November 28, 2018 Category: Perinatology & Neonatology Authors: Figueiro-Filho, Ernesto Antonio Al-Sum, Hythem Parrish, Jacqueline Wunder, Jay S. Maxwell, Cynthia Tags: Case Report Source Type: research

Bromocriptine Use in Peripartum Cardiomyopathy: Review of Cases
Conclusion Bromocriptine seems to be a promising treatment, there is currently insufficient evidence for universal utilization of bromocriptine for all patients with PPCMP. Addition of bromocriptine to the standard heart failure therapy should be individualized. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - November 21, 2018 Category: Perinatology & Neonatology Authors: Simon, Rebecca Yang, Sophia Hameed, Afshan B. Tags: Case Report Source Type: research

Heterogeneous Presentation of Neonatal Hemochromatosis in Dichorionic Twins
We present a pair of dichorionic twin who had a diverse clinical presentation of NH. One twin passed away despite medical treatment with exchange transfusion and intravenous immunoglobulin (IVIg), whereas the other twin suffered from only mildly deranged liver function, which normalized spontaneously. Early identification of liver failure and clinical awareness of this disease entity are essential to its timely diagnosis and treatment. Antenatal management using IVIg prevents the recurrence of NH in subsequent pregnancies. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJourna...
Source: American Journal of Perinatology Reports - November 20, 2018 Category: Perinatology & Neonatology Authors: Chee, Yee Yuet Wong, Siu Chun Mabel Wong, Ming Sum Rosanna Tags: Case Report Source Type: research

Mermaid Syndrome: A Case Report of a Rare Congenital Anomaly in Full-Term Neonate with Thumb Deformity
AJP Rep 2018; 08: e328-e331 DOI: 10.1055/s-0038-1669943The mermaid syndrome (sirenomelia) is an extremely rare anomaly, an incidence of 1 in 100,000 births, in which a newborn born with legs joined together featuring a mermaid-like appearance (head and trunk like humans and tail like fish), and in most cases die shortly after birth. Gastrointestinal and urogenital anomalies and single umbilical artery are clinical outcome of this syndrome. There are two important hypotheses for pathogenesis of mermaid syndrome: vitelline artery steal hypothesis and defective blastogenesis hypothesis. The cause of the mermaid syndrome is un...
Source: American Journal of Perinatology Reports - November 14, 2018 Category: Perinatology & Neonatology Authors: Taee, Nadereh Tarhani, Fariba Goodarzi, Mojgan Faraji Safdari, Mohammad Bajelan, Amir Tags: Case Report Source Type: research

Use of a Fibrin Sealant Patch at Cesarean for Conservative Management of Morbidly Adherent Placenta
Conclusion Postpartum hemorrhage is an ongoing leading source of maternal morbidity and mortality. A case is presented in which a fibrin sealant patch provided control of focal placental bed bleeding, allowing removal of a focal morbidly adherent placenta and avoidance of hysterectomy. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - November 14, 2018 Category: Perinatology & Neonatology Authors: Greenberg, James A. Robinson, Julian N. Carabuena, Jean M. Farber, Michaela K. Carusi, Daniela A. Tags: Case Report Source Type: research

Recurrent Cholangiocarcinoma in Pregnancy: A Case Report
AJP Rep 2018; 08: e261-e263 DOI: 10.1055/s-0038-1675376Hepatobiliary malignancies during pregnancy are extremely rare and portend a poor prognosis. There are only seven published cases of cholangiocarcinoma in an obstetrical patient, all are cases of primary cholangiocarcinoma (1–7). Herein, we describe the first case of recurrent cholangiocarcinoma during pregnancy. The patient did not receive chemotherapy during pregnancy and required prolonged hospitalizations for nutritional and intensive medical support. She delivered preterm, at 30 2/7 weeks gestation, after developing pre-eclampsia with severe features. The in...
Source: American Journal of Perinatology Reports - November 12, 2018 Category: Perinatology & Neonatology Authors: Francis, Antonia P. Chang, Michelle Dolin, Cara D. Chervenak, Judith Cardonick, Elyce Tags: Case Report Source Type: research