Delayed diagnosis of serious paediatric conditions in 13 regional emergency departments
Conclusion
Delayed diagnosis was uncommon across 13 regional EDs but was more likely among children with Hispanic ethnicity, CCCs or normal vital signs. Delays were associated with a higher risk of complications. (Source: BMJ Quality and Safety)
Source: BMJ Quality and Safety - April 24, 2024 Category: General Medicine Authors: Michelson, K. A., McGarghan, F. L. E., Patterson, E. E., Samuels-Kalow, M. E., Waltzman, M. L., Greco, K. F. Tags: Original research Source Type: research
Cochlear implantation in patients with < em > Streptococcus suis < /em > meningitis: clinical characteristics and postoperative evaluation
CONCLUSIONS AND SIGNIFICANCE: It is recommended for S. suis meningitis CI candidates to undergo CI promptly after controlling infection, preferably within four to six weeks. CI users with S. suis meningitis tend to exhibit suboptimal hearing rehabilitation outcomes, possibly associated with the more severe damage on spiral ganglion cells after S. suis meningitis.PMID:38651889 | DOI:10.1080/00016489.2024.2323650 (Source: Acta Oto-Laryngologica)
Source: Acta Oto-Laryngologica - April 23, 2024 Category: ENT & OMF Authors: Zhuoyi Chen Minqian Gao Xiaying Huang Xianghui Li Xiaotong Huang Yongkang Ou Yiqing Zheng Haidi Yang Source Type: research
Temporal variations in the serogroup distribution of invasive meningococcal disease in Quebec, Canada, due to emerging unique clade of serogroup Y strain belonging to the Sequence Type-23 clonal complex.
To identify recent trends in invasive meningococcal diseases (IMD) in Quebec, Canada, with a focus on MenY cases and MenY strains. (Source: Journal of Infection)
Source: Journal of Infection - April 23, 2024 Category: Infectious Diseases Authors: Raymond S.W. Tsang, Genevieve Deceuninck, Courtney Meilleur, Jianwei Zhou, Brigitte Lefebvre, Philippe De Wals Tags: Bacteria and Bacterial Diseases Source Type: research
Angiostrongylus cantonensis induces energy imbalance and dyskinesia in mice by reducing the expression of melanin-concentrating hormone
Infection with Angiostrongylus cantonensis (AC) in humans or mice can lead to severe eosinophilic meningitis or encephalitis, resulting in various neurological impairments. Developing effective neuroprotective dr... (Source: Parasites and Vectors)
Source: Parasites and Vectors - April 23, 2024 Category: Microbiology Authors: Hui Huang, Zhongyuan Zhang, Mengdan Xing, Zihan Jin, Yue Hu, Minyu Zhou, Hang Wei, Yiwen Liang and Zhiyue Lv Tags: Research Source Type: research
A Retrospective Analysis of Central and Peripheral Metabolic Characteristics in Patients with Cryptococcal Meningitis
ConclusionMetabolic and structural alterations in the brain may be associated with peripheral metabolic changes. (Source: Neurology and Therapy)
Source: Neurology and Therapy - April 20, 2024 Category: Neurology Source Type: research
Use of the Pfizer Pentavalent Meningococcal Vaccine Among Persons Aged ≥10 Years: Recommendations of the Advisory Committee on Immunization Practices - United States, 2023
This report summarizes evidence considered for these recommendations and provides clinical guidance for the use of MenACWY-TT/MenB-FHbp.PMID:38635488 | DOI:10.15585/mmwr.mm7315a4 (Source: MMWR Morb Mortal Wkl...)
Source: MMWR Morb Mortal Wkl... - April 18, 2024 Category: Epidemiology Authors: Jennifer P Collins Samuel J Crowe Ismael R Ortega-Sanchez Lynn Bahta Doug Campos-Outcalt Jamie Loehr Rebecca L Morgan Katherine A Poehling Lucy A McNamara Source Type: research
Secondary normal pressure hydrocephalus following pituitary apoplexy: A case report
CONCLUSION: This case suggests that sNPH can develop even after a small subarachnoid hemorrhage caused by a pituitary apoplexy in LOVA patients. If the aqueduct of Sylvius is open, sNPH with a LOVA background can be successfully treated with LPS placement.PMID:38628523 | PMC:PMC11021090 | DOI:10.25259/SNI_32_2024 (Source: Surgical Neurology International)
Source: Surgical Neurology International - April 17, 2024 Category: Neurosurgery Authors: Yusuke Tomita Shoichi Fukuda Aiko Kobashi Yoshihiro Okada Keigo Makino Naoya Kidani Kenichiro Muraoka Nobuyuki Hirotsune Shigeki Nishino Source Type: research
Gold Nanoparticle-Based Drug Delivery System for the Diagnosis and Treatment of Bacterial Meningitis
Curr Drug Deliv. 2024 Apr 16. doi: 10.2174/0115672018278607240405060054. Online ahead of print.ABSTRACTManaging bacterial pathogens in the central nervous system is an immense issue for researchers all around the globe. The problem of these infections remains throughout the population, regardless of the discovery of several possible medicines. The major obstacle to drug delivery is the BBB, but only a few medicines that fulfill demanding requirements can penetrate it. Considering inadequate antibiotic alternatives and the increasing development of resistance, it is more important than ever to find new approaches to address...
Source: Current Drug Delivery - April 17, 2024 Category: Drugs & Pharmacology Authors: Darsh Gautam Vinay Pandit Sanjay Kumar Poonam Talwan Tarun Sharma Source Type: research
Secondary normal pressure hydrocephalus following pituitary apoplexy: A case report
CONCLUSION: This case suggests that sNPH can develop even after a small subarachnoid hemorrhage caused by a pituitary apoplexy in LOVA patients. If the aqueduct of Sylvius is open, sNPH with a LOVA background can be successfully treated with LPS placement.PMID:38628523 | PMC:PMC11021090 | DOI:10.25259/SNI_32_2024 (Source: Surgical Neurology International)
Source: Surgical Neurology International - April 17, 2024 Category: Neurosurgery Authors: Yusuke Tomita Shoichi Fukuda Aiko Kobashi Yoshihiro Okada Keigo Makino Naoya Kidani Kenichiro Muraoka Nobuyuki Hirotsune Shigeki Nishino Source Type: research
Gold Nanoparticle-Based Drug Delivery System for the Diagnosis and Treatment of Bacterial Meningitis
Curr Drug Deliv. 2024 Apr 16. doi: 10.2174/0115672018278607240405060054. Online ahead of print.ABSTRACTManaging bacterial pathogens in the central nervous system is an immense issue for researchers all around the globe. The problem of these infections remains throughout the population, regardless of the discovery of several possible medicines. The major obstacle to drug delivery is the BBB, but only a few medicines that fulfill demanding requirements can penetrate it. Considering inadequate antibiotic alternatives and the increasing development of resistance, it is more important than ever to find new approaches to address...
Source: Current Drug Delivery - April 17, 2024 Category: Drugs & Pharmacology Authors: Darsh Gautam Vinay Pandit Sanjay Kumar Poonam Talwan Tarun Sharma Source Type: research
Biphasic Clinical Trajectory in Pneumococcal Meningitis from Cerebral Infarcts
(Source: Neurocritical Care)
Source: Neurocritical Care - April 17, 2024 Category: Neurology Source Type: research
Neurologic Emergencies in Pregnancy
Obstet Gynecol. 2024 Apr 16. doi: 10.1097/AOG.0000000000005575. Online ahead of print.ABSTRACTNeurologic emergencies in pregnancy require prompt evaluation and early, focused intervention to improve neurologic outcomes for the affected person and to avoid further injury. Neurologic events in pregnancy, although rare, present a time of extreme risk of permanent injury for the person who is pregnant. Therefore, obstetric clinicians should be well versed in the risk factors for potential neurologic events and understand the symptoms and events that should prompt evaluation for a neurologic event. In addition, they should supp...
Source: Obstetrics and Gynecology - April 16, 2024 Category: OBGYN Authors: Shaun R Wesley G Edward Vates Loralei L Thornburg Source Type: research
Neurologic Emergencies in Pregnancy
Obstet Gynecol. 2024 Apr 16. doi: 10.1097/AOG.0000000000005575. Online ahead of print.ABSTRACTNeurologic emergencies in pregnancy require prompt evaluation and early, focused intervention to improve neurologic outcomes for the affected person and to avoid further injury. Neurologic events in pregnancy, although rare, present a time of extreme risk of permanent injury for the person who is pregnant. Therefore, obstetric clinicians should be well versed in the risk factors for potential neurologic events and understand the symptoms and events that should prompt evaluation for a neurologic event. In addition, they should supp...
Source: Obstetrics and Gynecology - April 16, 2024 Category: OBGYN Authors: Shaun R Wesley G Edward Vates Loralei L Thornburg Source Type: research
Neurologic Emergencies in Pregnancy
Obstet Gynecol. 2024 Apr 16. doi: 10.1097/AOG.0000000000005575. Online ahead of print.ABSTRACTNeurologic emergencies in pregnancy require prompt evaluation and early, focused intervention to improve neurologic outcomes for the affected person and to avoid further injury. Neurologic events in pregnancy, although rare, present a time of extreme risk of permanent injury for the person who is pregnant. Therefore, obstetric clinicians should be well versed in the risk factors for potential neurologic events and understand the symptoms and events that should prompt evaluation for a neurologic event. In addition, they should supp...
Source: Obstetrics and Gynecology - April 16, 2024 Category: OBGYN Authors: Shaun R Wesley G Edward Vates Loralei L Thornburg Source Type: research
Multicentre double-blind randomised placebo-controlled trial evaluating the efficacy of the meningococcal B vaccine, 4CMenB (Bexsero), against Neisseria gonorrhoeae infection in men who have sex with men: the GoGoVax study protocol
This study will evaluate the efficacy of 4CMenB against N. gonorrhoeae infection in men (cis and trans), transwomen and non-binary people who have sex with men (hereafter referred to as GBM+).
Methods and analysis
This is a double-blind, randomised placebo-controlled trial in GBM+, either HIV-negative on pre-exposure prophylaxis against HIV or living with HIV (CD4 count >350 cells/mm3), who have had a diagnosis of gonorrhoea or infectious syphilis in the last 18 months (a key characteristic associated with a high risk of N. gonorrhoeae infection). Participants are randomised 1:1 to receive two doses of 4CMenB or placeb...
Source: BMJ Open - April 16, 2024 Category: General Medicine Authors: Seib, K. L., Donovan, B., Thng, C., Lewis, D. A., McNulty, A., Fairley, C. K., Yeung, B., Jin, F., Fraser, D., Bavinton, B. R., Law, M., Chen, M. Y., Chow, E. P. F., Whiley, D. M., Mackie, B., Jennings, M. P., Jennison, A. V., Lahra, M. M., Grulich, A. E. Tags: Open access, Infectious diseases Source Type: research
