Subdural empyema due to bacterial meningitis
Am J Med Sci. 2024 Apr 4:S0002-9629(24)01158-3. doi: 10.1016/j.amjms.2024.04.003. Online ahead of print.NO ABSTRACTPMID:38582307 | DOI:10.1016/j.amjms.2024.04.003 (Source: The American Journal of the Medical Sciences)
Source: The American Journal of the Medical Sciences - April 6, 2024 Category: General Medicine Authors: Kohei Matsumoto Junpei Komagamine Source Type: research
Factors associated with meningitis vaccine awareness and engagement among Latino men who have sex with men in South Florida
AbstractAwareness and uptake of the meningitis vaccine remains low among marginalized groups, such as Latino men who have sex with men (LMSM), potentially due to structural and psychosocial barriers in accessing preventative healthcare. The current study explored awareness and uptake of meningitis vaccines among a group of LMSM (N = 99) living in South Florida. A three-pronged variable selection approach was utilized prior to conducting regression models (linear and logistic). Overall, 48.5% of the participants reported little to no knowledge about meningitis vaccines, and 20.2% reported being vaccinated. Living with H...
Source: Journal of Behavioral Medicine - April 6, 2024 Category: Psychiatry Source Type: research
Neonatal < em > Elizabethkingia anophelis < /em > meningitis originating from the water reservoir of an automated infant milk dispenser, the Netherlands, February 2024
We report a Dutch case of E. anophelis meningitis in a neonate, clonally related to samples taken from an automated infant milk dispenser located at the family's residence. We inform about the emergence of E. anophelis and suggest molecular surveillance in hospitals and other health settings. This is the first case connecting an automated formula dispenser to an invasive infection in a neonate.PMID:38577802 | DOI:10.2807/1560-7917.ES.2024.29.14.2400177 (Source: Euro Surveill)
Source: Euro Surveill - April 5, 2024 Category: Infectious Diseases Authors: B Ruben Brandsema Ger-Jan Fleurke Sigrid Rosema Eke Mw Schins Jelte Helfferich Erik Bathoorn Source Type: research
Ruxolitinib associated psoas muscle tuberculosis abscess in a primary myelofibrosis woman: A case report and literature review
Medicine (Baltimore). 2024 Apr 5;103(14):e37653. doi: 10.1097/MD.0000000000037653.ABSTRACTRATIONALE: Primary myelofibrosis is a subtype of myeloproliferative neoplasm that leads to bone marrow fibrosis. Historically, the only curative option for primary myelofibrosis was allogeneic hematopoietic stem cell transplant. Ruxolitinib, a Janus kinase inhibitor, is now used for the treatment of primary myelofibrosis and polycythemia vera. It effectively improves symptoms related to splenomegaly and anemia. However, its association with the development of opportunistic infections has been observed in clinical studies and practical...
Source: Herpes - April 5, 2024 Category: Infectious Diseases Authors: Chi-Yu Chen Tun-Chieh Chen Source Type: research
Neonatal < em > Elizabethkingia anophelis < /em > meningitis originating from the water reservoir of an automated infant milk dispenser, the Netherlands, February 2024
We report a Dutch case of E. anophelis meningitis in a neonate, clonally related to samples taken from an automated infant milk dispenser located at the family's residence. We inform about the emergence of E. anophelis and suggest molecular surveillance in hospitals and other health settings. This is the first case connecting an automated formula dispenser to an invasive infection in a neonate.PMID:38577802 | DOI:10.2807/1560-7917.ES.2024.29.14.2400177 (Source: Euro Surveill)
Source: Euro Surveill - April 5, 2024 Category: Infectious Diseases Authors: B Ruben Brandsema Ger-Jan Fleurke Sigrid Rosema Eke Mw Schins Jelte Helfferich Erik Bathoorn Source Type: research
Neonatal < em > Elizabethkingia anophelis < /em > meningitis originating from the water reservoir of an automated infant milk dispenser, the Netherlands, February 2024
We report a Dutch case of E. anophelis meningitis in a neonate, clonally related to samples taken from an automated infant milk dispenser located at the family's residence. We inform about the emergence of E. anophelis and suggest molecular surveillance in hospitals and other health settings. This is the first case connecting an automated formula dispenser to an invasive infection in a neonate.PMID:38577802 | DOI:10.2807/1560-7917.ES.2024.29.14.2400177 (Source: Euro Surveill)
Source: Euro Surveill - April 5, 2024 Category: Infectious Diseases Authors: B Ruben Brandsema Ger-Jan Fleurke Sigrid Rosema Eke Mw Schins Jelte Helfferich Erik Bathoorn Source Type: research
Neonatal < em > Elizabethkingia anophelis < /em > meningitis originating from the water reservoir of an automated infant milk dispenser, the Netherlands, February 2024
We report a Dutch case of E. anophelis meningitis in a neonate, clonally related to samples taken from an automated infant milk dispenser located at the family's residence. We inform about the emergence of E. anophelis and suggest molecular surveillance in hospitals and other health settings. This is the first case connecting an automated formula dispenser to an invasive infection in a neonate.PMID:38577802 | PMC:PMC11004591 | DOI:10.2807/1560-7917.ES.2024.29.14.2400177 (Source: Euro Surveill)
Source: Euro Surveill - April 5, 2024 Category: Infectious Diseases Authors: B Ruben Brandsema Ger-Jan Fleurke Sigrid Rosema Eke Mw Schins Jelte Helfferich Erik Bathoorn Source Type: research
Neonatal < em > Elizabethkingia anophelis < /em > meningitis originating from the water reservoir of an automated infant milk dispenser, the Netherlands, February 2024
We report a Dutch case of E. anophelis meningitis in a neonate, clonally related to samples taken from an automated infant milk dispenser located at the family's residence. We inform about the emergence of E. anophelis and suggest molecular surveillance in hospitals and other health settings. This is the first case connecting an automated formula dispenser to an invasive infection in a neonate.PMID:38577802 | PMC:PMC11004591 | DOI:10.2807/1560-7917.ES.2024.29.14.2400177 (Source: Euro Surveill)
Source: Euro Surveill - April 5, 2024 Category: Infectious Diseases Authors: B Ruben Brandsema Ger-Jan Fleurke Sigrid Rosema Eke Mw Schins Jelte Helfferich Erik Bathoorn Source Type: research
CNS Viral Infections —What to Consider for Improving Drug Treatment: A Plea for Using Mathematical Modeling Approaches
AbstractNeurotropic viruses may cause meningitis, myelitis, encephalitis, or meningoencephalitis. These inflammatory conditions of the central nervous system (CNS) may have serious and devastating consequences if not treated adequately. In this review, we first summarize how neurotropic viruses can enter the CNS by (1) crossing the blood-brain barrier or blood-cerebrospinal fluid barrier; (2) invading the nose via the olfactory route; or (3) invading the peripheral nervous system. Neurotropic viruses may then enter the intracellular space of brain cells via endocytosis and/or membrane fusion. Antiviral drugs are currently ...
Source: CNS Drugs - April 5, 2024 Category: Neurology Source Type: research
Safety and Efficacy of Pegcetacoplan in Adult Patients with Paroxysmal Nocturnal Hemoglobinuria over 48 Weeks: 307 Open-Label Extension Study
CONCLUSION: Pegcetacoplan sustained long-term improvements in hemoglobin concentrations, fatigue reduction, and transfusion burden. Long-term safety findings corroborate the favorable profile established for pegcetacoplan.TRIAL REGISTRATION: ClinicalTrials.gov identifier, NCT03531255.PMID:38573482 | DOI:10.1007/s12325-024-02827-8 (Source: Adv Data)
Source: Adv Data - April 4, 2024 Category: Epidemiology Authors: Christopher J Patriquin Andrija Bogdanovic Morag Griffin Richard J Kelly Jaroslaw P Maciejewski Brian Mulherin R égis Peffault de Latour Alexander R öth Veena Selvaratnam Jeffrey Szer Mohammed Al-Adhami Regina Horneff Lisa Tan Michael Yeh Jens Panse Source Type: research
Acute demyelinating encephalomyelitis in a child with pulmonary tuberculosis
Paediatr Int Child Health. 2024 Apr 3:1-3. doi: 10.1080/20469047.2024.2335422. Online ahead of print.ABSTRACTTuberculosis is a leading cause of mortality in children worldwide. One of the greatest challenges in its management is the difficulty of diagnosis as the manifestations are non-specific and often mimic other illnesses. Neurological infection occurs in approximately 1% of patients diagnosed with tuberculosis, and usually takes the form of tuberculous meningitis or tuberculoma. An 11-year-old girl who was diagnosed with acute disseminated encephalomyelitis, a rare immunological manifestation of tuberculosis, is prese...
Source: Paediatrics and international child health - April 4, 2024 Category: Pediatrics Authors: Jasmine Singh Pallavi Sharma Shivani Randev Narinder Kaur Pankaj Kumar Vishal Guglani Source Type: research
An all-inclusive model for predicting invasive bacterial infection in febrile infants age 7-60 days
CONCLUSION: A machine learning model (XGBoost) demonstrated the best performance in predicting a rare outcome among febrile infants, including those excluded from existing algorithms.IMPACT: Several models for the risk stratification of febrile infants have been developed. There is a need for a preferred comprehensive model free from limitations and algorithm exclusions that accurately predicts IBIs. This is the first study to derive an all-inclusive predictive model for febrile infants aged 7-60 days in a community ED sample with IBI as a primary outcome. This machine learning model demonstrates potential for clinical uti...
Source: Pediatric Research - April 4, 2024 Category: Pediatrics Authors: Dustin W Ballard Jie Huang Adam L Sharp Dustin G Mark Tran H P Nguyen Beverly R Young David R Vinson Patrick Van Winkle Mamata V Kene Adina S Rauchwerger Jennifer Y Zhang Stacy J Park Mary E Reed Tara L Greenhow Source Type: research
Safety and Efficacy of Pegcetacoplan in Adult Patients with Paroxysmal Nocturnal Hemoglobinuria over 48 Weeks: 307 Open-Label Extension Study
CONCLUSION: Pegcetacoplan sustained long-term improvements in hemoglobin concentrations, fatigue reduction, and transfusion burden. Long-term safety findings corroborate the favorable profile established for pegcetacoplan.TRIAL REGISTRATION: ClinicalTrials.gov identifier, NCT03531255.PMID:38573482 | DOI:10.1007/s12325-024-02827-8 (Source: Adv Data)
Source: Adv Data - April 4, 2024 Category: Epidemiology Authors: Christopher J Patriquin Andrija Bogdanovic Morag Griffin Richard J Kelly Jaroslaw P Maciejewski Brian Mulherin R égis Peffault de Latour Alexander R öth Veena Selvaratnam Jeffrey Szer Mohammed Al-Adhami Regina Horneff Lisa Tan Michael Yeh Jens Panse Source Type: research
Acute demyelinating encephalomyelitis in a child with pulmonary tuberculosis
Paediatr Int Child Health. 2024 Apr 3:1-3. doi: 10.1080/20469047.2024.2335422. Online ahead of print.ABSTRACTTuberculosis is a leading cause of mortality in children worldwide. One of the greatest challenges in its management is the difficulty of diagnosis as the manifestations are non-specific and often mimic other illnesses. Neurological infection occurs in approximately 1% of patients diagnosed with tuberculosis, and usually takes the form of tuberculous meningitis or tuberculoma. An 11-year-old girl who was diagnosed with acute disseminated encephalomyelitis, a rare immunological manifestation of tuberculosis, is prese...
Source: Paediatrics and international child health - April 4, 2024 Category: Pediatrics Authors: Jasmine Singh Pallavi Sharma Shivani Randev Narinder Kaur Pankaj Kumar Vishal Guglani Source Type: research
An all-inclusive model for predicting invasive bacterial infection in febrile infants age 7-60 days
CONCLUSION: A machine learning model (XGBoost) demonstrated the best performance in predicting a rare outcome among febrile infants, including those excluded from existing algorithms.IMPACT: Several models for the risk stratification of febrile infants have been developed. There is a need for a preferred comprehensive model free from limitations and algorithm exclusions that accurately predicts IBIs. This is the first study to derive an all-inclusive predictive model for febrile infants aged 7-60 days in a community ED sample with IBI as a primary outcome. This machine learning model demonstrates potential for clinical uti...
Source: Pediatric Research - April 4, 2024 Category: Pediatrics Authors: Dustin W Ballard Jie Huang Adam L Sharp Dustin G Mark Tran H P Nguyen Beverly R Young David R Vinson Patrick Van Winkle Mamata V Kene Adina S Rauchwerger Jennifer Y Zhang Stacy J Park Mary E Reed Tara L Greenhow Source Type: research
