Clinical course and peculiarities of Parechovirus and Enterovirus central nervous system infections in newborns: a single-center experience

Conclusion: EV and HpEV CNS infections are not easily distinguishable by clinical features. In both cases, brain MRI abnormalities are not uncommon, and a severe course of the disease is possible. Hyper-ferritinemia may represent an additional diagnostic clue for HpEV infection, and its monitoring is recommended to intercept HLH early and initiate immunomodulatory treatment. Larger studies are needed to confirm our findings.What is Known:• Parechovirus and Enteroviruses are the most common viral pathogens responsible for sepsis and meningoencephalitis in neonates and young infants.• The clinical course and distinguishing features of Parechovirus and Enterovirus central nervous system infections are not well described.What is New:• Severe disease course, brain MRI abnormalities, and complications are not uncommon in newborns with Parechovirus and Enteroviruses central nervous system infections.• Hyper-ferritinemia may represent an additional diagnostic clue for Parechovirus infection and its monitoring is recommended.
Source: European Journal of Pediatrics - Category: Pediatrics Source Type: research