Origanum majorana essential oil decreases lung tumor growth and metastasis in vitro and in vivo
Biomed Pharmacother. 2022 Sep 28;155:113762. doi: 10.1016/j.biopha.2022.113762. Online ahead of print.ABSTRACTCurrent targeted- and immuno-therapies have prolonged the overall survival of non-small cell lung cancer (NSCLC) patients by few months in a small percentage of patients responding to these treatments. This situation has prompted us to investigate the anticancer potential of the Origanum majorana Essential Oil (OMEO). In this pre-clinical study and using two major human NSCLC, namely A549 and LNM35, we demonstrated that OMEO significantly decreases the viability of these cells and the growth of their pre-formed col...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - October 1, 2022 Category: Drugs & Pharmacology Authors: Kholoud Arafat Shahrazad Sulaiman Aya Mudhafar Al-Azawi Javed Yasin Subi Sugathan Abderrahim Nemmar Sherif Karam Samir Attoub Source Type: research
Origanum majorana essential oil decreases lung tumor growth and metastasis in vitro and in vivo
Biomed Pharmacother. 2022 Sep 28;155:113762. doi: 10.1016/j.biopha.2022.113762. Online ahead of print.ABSTRACTCurrent targeted- and immuno-therapies have prolonged the overall survival of non-small cell lung cancer (NSCLC) patients by few months in a small percentage of patients responding to these treatments. This situation has prompted us to investigate the anticancer potential of the Origanum majorana Essential Oil (OMEO). In this pre-clinical study and using two major human NSCLC, namely A549 and LNM35, we demonstrated that OMEO significantly decreases the viability of these cells and the growth of their pre-formed col...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - October 1, 2022 Category: Drugs & Pharmacology Authors: Kholoud Arafat Shahrazad Sulaiman Aya Mudhafar Al-Azawi Javed Yasin Subi Sugathan Abderrahim Nemmar Sherif Karam Samir Attoub Source Type: research
Origanum majorana essential oil decreases lung tumor growth and metastasis in vitro and in vivo
Biomed Pharmacother. 2022 Sep 28;155:113762. doi: 10.1016/j.biopha.2022.113762. Online ahead of print.ABSTRACTCurrent targeted- and immuno-therapies have prolonged the overall survival of non-small cell lung cancer (NSCLC) patients by few months in a small percentage of patients responding to these treatments. This situation has prompted us to investigate the anticancer potential of the Origanum majorana Essential Oil (OMEO). In this pre-clinical study and using two major human NSCLC, namely A549 and LNM35, we demonstrated that OMEO significantly decreases the viability of these cells and the growth of their pre-formed col...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - October 1, 2022 Category: Drugs & Pharmacology Authors: Kholoud Arafat Shahrazad Sulaiman Aya Mudhafar Al-Azawi Javed Yasin Subi Sugathan Abderrahim Nemmar Sherif Karam Samir Attoub Source Type: research
Origanum majorana essential oil decreases lung tumor growth and metastasis in vitro and in vivo
Biomed Pharmacother. 2022 Sep 28;155:113762. doi: 10.1016/j.biopha.2022.113762. Online ahead of print.ABSTRACTCurrent targeted- and immuno-therapies have prolonged the overall survival of non-small cell lung cancer (NSCLC) patients by few months in a small percentage of patients responding to these treatments. This situation has prompted us to investigate the anticancer potential of the Origanum majorana Essential Oil (OMEO). In this pre-clinical study and using two major human NSCLC, namely A549 and LNM35, we demonstrated that OMEO significantly decreases the viability of these cells and the growth of their pre-formed col...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - October 1, 2022 Category: Drugs & Pharmacology Authors: Kholoud Arafat Shahrazad Sulaiman Aya Mudhafar Al-Azawi Javed Yasin Subi Sugathan Abderrahim Nemmar Sherif Karam Samir Attoub Source Type: research
In Vitro and In Silico Evaluation of ACE2 and LOX Inhibitory Activity of Origanum Essential Oils and Carvacrol
In this study, commercially Origanum majorana, O. minutiflorum, O. vulgare, and O. onites essential oils, and their prominent constituent carvacrol was evaluated for their in vitro and in silico angiotensin-converting enzyme 2 (ACE2) and lipoxygenase (LOX) enzyme inhibitory potentials. The essential oils were analysed by GC-FID and GC/MS, where carvacrol was identified as the major component (62–81%), confirming the quality. In vitro enzyme inhibition assays were conducted both with the essential oils (20 µg/mL) and with carvacrol (5 µg/mL). The comparative values of ACE2 percent inhibition for O. majorana, O. minutifl...
Source: Planta Medica - September 22, 2022 Category: Drugs & Pharmacology Authors: Demirci, Fatih Terali, Kerem Karada ğ, Ayşe Esra Biltekin, Sevde Nur Ak Sakall ı, Ezgi Ko şar, Müberra Demirci, Bet ül Baser, Kemal Husnu Can Tags: Original Papers Source Type: research
Molecules, Vol. 27, Pages 6136: Chemical Composition, Enantiomeric Distribution, Antimicrobial and Antioxidant Activities of Origanum majorana L. Essential Oil from Nepal
This study was conducted to examine the chemical constituents of Origanum majorana L. essential oils (EOs) that originate in Nepal, as well as their biological activities, antioxidant properties, and enantiomeric compositions. The EOs were extracted by the hydro-distillation method using a Clevenger-type apparatus and their chemical compositions were determined through gas chromatography and mass spectrometry (GC-MS). Chiral GC-MS was used to evaluate the enantiomeric compositions of EOs. The minimum inhibitory concentrations (MICs) of the essential oils were determined by the micro-broth dilution method, and the antioxida...
Source: Molecules - September 19, 2022 Category: Chemistry Authors: Prem Narayan Paudel Prabodh Satyal Rakesh Satyal William N. Setzer Rajendra Gyawali Tags: Article Source Type: research
Modulatory Impact of Lamiaceae Metabolites on Apoptosis of Human Leukemia Cells
Lamiaceae species are rich sources of biologically active compounds which have been applied in medicine since ancient times. Especially their antineoplastic properties have been thoroughly studied with respect to their putative application in chemoprevention and adjuvant therapy of cancer. However, the most known biological effects of Lamiaceae have been ascribed to their essential oil fractions, whereas their (poly)phenolic metabolites being also abundant in these plants, are much less recognized, nevertheless contributing to their beneficial properties, such as anti-cancer actions. The aim of this study was to evaluate t...
Source: Frontiers in Pharmacology - June 15, 2022 Category: Drugs & Pharmacology Source Type: research
The immune modulatory role of marjoram extract on imidacloprid induced toxic effects in thymus and spleen of adult rats
Conclusion, Marjoram has a protective role to reverse IMID immune toxic effects in thymus and spleen tissues of rats by its antioxidant, anti-inflammatory and immunomodulatory defense mechanisms.PMID:35398170 | DOI:10.1016/j.tox.2022.153174 (Source: Toxicology)
Source: Toxicology - April 10, 2022 Category: Toxicology Authors: Eman El-Sayed Khayal Mohamed Ali Alabiad Mahmoud Ramadan Elkholy Amany Mohamed Shalaby Yousef Nosery Arwa A El-Sheikh Source Type: research
Molecules, Vol. 27, Pages 663: Antifungal and Anti-Virulent Activity of Origanum majorana L. Essential Oil on Candida albicans and In Vivo Toxicity in the Galleria mellonella Larval Model
Ivan Kosalec
The aim of this study was to investigate and compare in detail both the antifungal activity in vitro (with planktonic and biofilm-forming cells) and the essential oil composition (EOs) of naturally growing (OMN) and cultivated (OMC) samples of Origanum majorana L. (marjoram). The essential oil composition was analyzed using GC-MS. The major constituent of both EOs was carvacrol: 75.3% and 84%, respectively. Both essential oils showed high antifungal activity against clinically relevant Candida spp. with IC50 and IC90 less than or equal to 0.5 µg mL−1 and inhibition of biofilm ...
Source: Molecules - January 20, 2022 Category: Chemistry Authors: Banu Kaskatepe Sinem Aslan Erdem Sukran Ozturk Zehra Safi Oz Eldan Subasi Mehmet Koyuncu Josipa Vlaini ć Ivan Kosalec Tags: Article Source Type: research
Effect of mung bean protein isolate/pullulan films containing marjoram (Origanum majorana L.) essential oil on chemical and microbial properties of minced beef meat
In this study, the effect of marjoram essential oil (MEO) on the mechanical, barrier, antioxidant and antimicrobial properties of mung bean protein isolate (MPI)/pullulan (PU) composite films and its influence on the quality of minced beef meat during 14 days storage at 4 °C was studied. The Fourier transform infrared (FT-IR) spectroscopy, X-ray diffraction (XRD) and scanning electron microscopy (SEM) results confirmed the compatibility between components. Also, depend on the different ratios of combination of MEO and MPI/PU, tensile strength (TS) and elongation at break (EAB) were varied. The results showed that an incre...
Source: International Journal of Biological Macromolecules - January 13, 2022 Category: Biochemistry Authors: Negar Haghighatpanah Maedeh Omar-Aziz Mohammad Gharaghani Faramarz Khodaiyan Seyed Saeid Hosseini John F Kennedy Source Type: research
The efficacy of < em > Origanum majorana < /em > nanocubosomal systems in ameliorating submandibular salivary gland alterations in streptozotocin-induced diabetic rats
In conclusion, OE-loaded NC enhanced the anti-hyperglycemic effect of OE and ameliorated diabetic gland alterations compared to conventional OE. Thus, cubosomal nano-systems could be anticipated as potential carriers for the best outcome with OE.PMID:34964423 | DOI:10.1080/10717544.2021.2018522 (Source: Drug Delivery)
Source: Drug Delivery - December 29, 2021 Category: Drugs & Pharmacology Authors: Dina B E Farag Carol Yousry Abdulaziz Mohsen Al-Mahallawi Hesham I El-Askary Meselhy R Meselhy Nermeen AbuBakr Source Type: research
Anti-Inflammatory and Antimicrobial Volatile Oils: Fennel and Cumin Inhibit Neutrophilic Inflammation via Regulating Calcium and MAPKs
Neutrophilic inflammatory diseases, such as chronic obstructive pulmonary disease (COPD), acute respiratory distress syndrome (ARDS), or psoriasis, exert a huge burden on the global health system due to the lack of safe and effective treatments. Volatile oils from terrestrial plants showed impressive therapeutic effects against disorders of the skin, digestive system, lungs, liver, metabolism, and nervous system. However, their effect on the immune system and neutrophil function is still elusive. Fennel, cumin, marjoram, lavender, caraway, and anise are the common nutraceuticals that are widely used in the Mediterranean di...
Source: Frontiers in Pharmacology - October 11, 2021 Category: Drugs & Pharmacology Source Type: research
Aqueous Extract of Origanum majorana at Low Temperature (0 °C) Promotes Mitochondrial Fusion and Contributes to Induced Apoptosis in Human Breast Cancer Cells
Asian Pac J Cancer Prev. 2021 Sep 1;22(9):2959-2967. doi: 10.31557/APJCP.2021.22.9.2959.ABSTRACTMarjoram plants have varied pharmacological properties because they contain antioxidants. In the present study, to evaluate the effect of Origanum majorana, gathered from Abha, Saudi Arabia, on the growth of human breast cancer cells using MCF7. Fresh aerial parts from Origanum majorana were extracted at a low temperature (0 ℃/6 hours). Human MCF7 breast cancer cells were then treated with 4 separate fluctuated concentrations of 0, 50, 150, 200 and 350 µg/mL for 24 and 48 hours. The findings showed that Origanum majorana aque...
Source: Asian Pacific Journal of Cancer Prevention - September 28, 2021 Category: Cancer & Oncology Authors: Asma Algebaly Qwait AlGabbani Wedad Refaiea Al-Otaibi Amani Mohammed Alotaibi Fatimah Gh Albani Ibtesam Sanad ALanazi Gadah Albasher Abdul Qader Saeed Alqahtani Wedad Saeed Al-Qahtani Source Type: research
