Novel lactic acid-based natural deep eutectic solvents: Efficiency in the ultrasound-assisted extraction of antioxidant polyphenols from common native Greek medicinal plants
Publication date: Available online 25 March 2016 Source:Journal of Applied Research on Medicinal and Aromatic Plants Author(s): Christina Bakirtzi, Katerina Triantafyllidou, Dimitris P. Makris Selected native Greek medicinal plants, including dittany, fennel, marjoram, mint and sage, were used to test the efficiency of some novel lactic acid-based natural deep eutectic solvents (NADES) to extract polyphenolic compounds. Extractions were performed under ultrasonication and the eutectic mixtures, tested as 80% (v/v) aqueous solutions, were lactic acid:choline chloride, lactic acid:sodium acetate, lactic acid:ammoni...
Source: Journal of Applied Research on Medicinal and Aromatic Plants - March 25, 2016 Category: Complementary Medicine Source Type: research
Chemical composition and in vitro evaluation of antioxidant, antimicrobial, cytotoxicity and anti-acetylcholinesterase properties of Tunisian Origanum majorana L. essential oil
This study investigated the chemical composition and evaluated the antioxidant, antimicrobial, cytotoxic and anti-acetylcholinesterase properties of Tunisian Origanum majorana essential oil. The findings showed that the oil exhibited high activity, particularly in terms of reducing power and β-Carotene bleaching, inducing higher IC50 values than BHT. The oil showed an important antimicrobial activity against 25 bacterial and fungal strains. In fact, the IZ, MIC and MBC values recorded for the bacterial strains were in the range of 8±0 -18.33±0.57 mm, 0.097-3.125 and 0.39-6.25 mg/mL, respectively. The IZ, MIC and MFC val...
Source: Microbial Pathogenesis - March 18, 2016 Category: Infectious Diseases Source Type: research
Molecules, Vol. 21, Pages 361: Fumigant Toxicity of Lamiaceae Plant Essential Oils and Blends of Their Constituents against Adult Rice Weevil Sitophilus oryzae
To find a new and safe alternative to conventional insecticides, we evaluated the fumigant toxicity of eight Lamiaceae essential oils and their constituents against the adult rice weevil Sitophilus oryzae. Of the eight species tested, hyssop (Hyssopus offcinalis), majoram (Origanum majorana), and Thymus zygis essential oils showed strong fumigant toxicity against S. oryzae adults at 25 mg/L air concentration. Constituents of active essential oils were analyzed by gas chromatography coupled to flame ionization detector (FID) and gas chromatography-mass spectrometry. A total of 13, 15, and 17 compounds were identified from h...
Source: Molecules - March 16, 2016 Category: Chemistry Authors: Sung-Woong KimHyo-Rim LeeMyeong-Jin JangChan-Sik JungIl-Kwon Park Tags: Article Source Type: research
Antimicrobial Activity of Marjoram (Origanum Majorana) Essential Oil Against the Multidrug‐Resistant Salmonella Enterica Serovar Schwarzengrund Inoculated in Vegetables from Organic Farming
Abstract
Antimicrobial efficacy of the marjoram essential oil (MEO) on organic vegetables inoculated with 4 log/cfu Salmonella enterica serovar Schwarzengrund was evaluated. Previously inoculated samples of smooth lettuce (Lactuva sativa), kale (Brassica oleracea) and arugula (Eruca sativa) were immersed, separately, in three MEO solutions (0.1, 0.3 and 0.5%) for 1 and 2 min. Control groups with sterile phosphate‐buffered saline and sodium hypochlorite (250 ppm) solution were also used. The enumeration of Salmonella was performed for 3 consecutive days, and the essential oil yielded an average reduction in microbial load...
Source: Journal of Food Safety - January 5, 2016 Category: Food Science Authors: Jaqueline Fronza Walker, Palloma de Souza Santos, Cleber Alberto Schmidt, Thereza Cristina Calmon de Bittencourt, Alaíse Gil Guimarães Tags: Original Article Source Type: research
Antimicrobial Activity of Marjoram (Origanum Majorana) Essential Oil Against the Multidrug ‐Resistant Salmonella Enterica Serovar Schwarzengrund Inoculated in Vegetables from Organic Farming
Abstract
Antimicrobial efficacy of the marjoram essential oil (MEO) on organic vegetables inoculated with 4 log/cfu Salmonella enterica serovar Schwarzengrund was evaluated. Previously inoculated samples of smooth lettuce (Lactuva sativa), kale (Brassica oleracea) and arugula (Eruca sativa) were immersed, separately, in three MEO solutions (0.1, 0.3 and 0.5%) for 1 and 2 min. Control groups with sterile phosphate‐buffered saline and sodium hypochlorite (250 ppm) solution were also used. The enumeration of Salmonella was performed for 3 consecutive days, and the essential oil yielded an average reduction in microbial load...
Source: Journal of Food Safety - January 4, 2016 Category: Food Science Authors: Jaqueline Fronza Walker, Palloma de Souza Santos, Cleber Alberto Schmidt, Thereza Cristina Calmon de Bittencourt, Ala íse Gil Guimarães Tags: Original Article Source Type: research
LPS-induced oxidative inflammation and hyperlipidemia in male rats: The protective role of Origanum majorana extract
Publication date: Available online 11 December 2015 Source:Beni-Suef University Journal of Basic and Applied Sciences Author(s): Mayssaa M. Wahby, Galila Yacout, Kamal lKandeel, Doaa Awad The antimicrobicidal activity of the phenolic compounds in the methanolic extract of Origanum majorana was recommended. The present study aimed to investigate the protective effect of Origanum majorana against LPS-induced toxicity in rats. Forty eight male Sprague-Dawely rats were randomly divided into four equal groups; 12 per each. Group C was used as control. While, group E was treated with plant extract orally for 10 days ...
Source: Beni Suef University Journal of Basic and Applied Sciences - December 11, 2015 Category: Science Source Type: research
Effect of cosmetic matrices on the release and odour profiles of the supercritical CO2 extract of Origanum majorana L
ConclusionThe hydrophilic character of the cosmetic matrices strongly influenced the release of the fragrance compounds thus affecting the odour profile of the studied mixtures.This article is protected by copyright. All rights reserved. (Source: International Journal of Cosmetic Science)
Source: International Journal of Cosmetic Science - November 28, 2015 Category: Dermatology Authors: Patrícia Costa, Cristina Verde Velasco, José Miguel Loureiro, Alírio E. Rodrigues Tags: Original Article Source Type: research
Abstract B2-23: A Big Bang model of human colorectal tumor growth
What happens in the early and still undetectable human malignancy is unknown because direct observations are impractical. Here we present a “Big Bang” model, whereby a tumor grows predominantly as a single expansion producing numerous intermixed sub-clones, which are not subject to stringent clonal selection. In this model, both public and most detectable private mutations arise during the earliest phase of tumor growth. Multi-scale genomic profiling of 349 individual glands sampled from 15 colorectal tumors revealed the absence of selective sweeps, uniformly high intra-tumor heterogeneity, and sub-clone mixing in dist...
Source: Cancer Research - November 15, 2015 Category: Cancer & Oncology Authors: Sottoriva, A., Kang, H., Ma, Z., Graham, T. A., Salomon, M., Zhao, J., Marjoram, P., Siegmund, K., Press, M. F., Shibata, D., Curtis, C. Tags: Integrative and Systems Approaches to Elucidating Tumor Progression Source Type: research
al3c: high-performance software for parameter inference using Approximate Bayesian Computation
We present al3c, a C++ framework for implementing ABC-SMC in parallel. By requiring only that users define essential functions such as the simulation model and prior distribution function, al3c abstracts the user from both the complexities of parallel programming and the details of the ABC-SMC algorithm. By using the al3c framework, the user is able to scale the ABC-SMC algorithm in parallel computing environments for his or her specific application, with minimal programming overhead.
Availability and implementation: al3c is offered as a static binary for Linux and OS-X computing environments. The user completes an XML con...
Source: Bioinformatics - October 20, 2015 Category: Bioinformatics Authors: Stram, A. H., Marjoram, P., Chen, G. K. Tags: GENETICS AND POPULATION ANALYSIS Source Type: research
In Vitro Activity of Twenty Commercially Available, Plant-Derived Essential Oils against Selected Dermatophyte Species.
Authors: Nardoni S, Giovanelli S, Pistelli L, Mugnaini L, Profili G, Pisseri F, Mancianti F
Abstract
The in vitro activity of twenty chemically defined essential oils (EOs) obtained from Boswellia sacra, Citrus bergamia, C. limon, C. medica, Cinnamomum zeylanicum, Eucalyptus globulus, Foeniculum vulgare, Helichrysum italicum, Illicium verum, Litsea cubeba, Mentha spicata, Myrtus communis, Ocimum basilicum, Origanum majorana, O. vulgare, Pelargonium graveolens, Rosmarinus officinalis, Santalum album, Satureja montana, and Thymus serpyllum was assayed against clinical animal isolates of Microsporum canis, Tr...
Source: Natural Product Communications - October 7, 2015 Category: Biochemistry Tags: Nat Prod Commun Source Type: research
Using Magnets and Magnetic Beads to Dissect Signaling Pathways Activated by Mechanical Tension Applied to Cells
Publication date: Available online 30 September 2015 Source:Methods Author(s): R.J. Marjoram, C. Guilluy, K. Burridge Cellular tension has implications in normal biology and pathology. Membrane adhesion receptors serve as conduits for mechanotransduction that lead to cellular responses. Ligand-conjugated magnetic beads are a useful tool in the study of how cells sense and respond to tension. Here we detail methods for their use in applying tension to cells and strategies for analyzing the results. We demonstrate the methods by analyzing mechanotransduction through VE-cadherin on endothelial cells using both perma...
Source: Methods - October 2, 2015 Category: Molecular Biology Source Type: research
Antifungal Effect of Essential Oils against Fusarium Keratitis Isolates
Planta MedDOI: 10.1055/s-0035-1546272The present study was carried out to investigate the antifungal effects of Cinnamomum zeylanicum, Citrus limon, Juniperus communis, Eucalyptus citriodora, Gaultheria procumbens, Melaleuca alternifolia, Origanum majorana, Salvia sclarea, and Thymus vulgaris essential oils against Fusarium species, the most common etiologic agents of filamentous fungal keratitis in South India. C. zeylanicum essential oil showed strong anti-Fusarium activity, whereas all the other tested essential oils proved to be less effective. The main component of C. zeylanicum essential oil, trans-cinnamaldehyde, wa...
Source: Planta Medica - July 30, 2015 Category: Drugs & Pharmacology Authors: Homa, MónikaFekete, Ildikó PálmaBöszörményi, AndreaSingh, Yendrembam Randhir BabuSelvam, Kanesan PanneerShobana, Coimbatore SubramanianManikandan, PalanisamyKredics, LászlóVágvölgyi, CsabaGalgóczy, László Tags: Original Papers Source Type: research
Many Private Mutations Originate From The First Few Divisions Of A Human Colorectal Adenoma
Abstract
Intratumoral mutational heterogeneity (ITH) or the presence of different private mutations in different parts of the same tumor is commonly observed in human tumors. The mechanisms generating such ITH are uncertain. Here we find ITH can be remarkably well‐structured by measuring point mutations, chromosome copy numbers and DNA passenger methylation from opposite sides and individual glands of a 6 cm human colorectal adenoma. ITH was present between tumor sides and individual glands, but the private mutations were side specific and subdivided the adenoma into two major subclones. Furthermore, ITH disappeared with...
Source: The Journal of Pathology - June 29, 2015 Category: Pathology Authors: Haeyoun Kang, Matthew P. Salomon, Andrea Sottoriva, Junsong Zhao, Morgan Toy, Michael F. Press, Christina Curtis, Paul Marjoram, Kimberly Siegmund, Darryl Shibata Tags: Original Paper Source Type: research
Preventing male infertility by marjoram and sage essential oils through modulating testicular lipid accumulation and androgens biosynthesis disruption in a rat model of dietary obesity
This study aimed to investigate reproductive disorders caused by obesity and the possible prevention through the use of marjoram and sage oil extracts. Obesity was achieved in adult male rats by feeding high fat diet (HFD) for 12 weeks, while marjoram (0.16 ml/kg b.wt) and sage (0.05 ml/kg b.wt) oils were given orally for the same duration. HFD-fed rats exhibited marked obesity features indicated by increased adiposity index, with higher weight gain compared to control rats. This goes with increased lipid accumulation in testis and serum of the obese rats. Increased serum levels of leptin, prolactinL (PRL) and estrogen...
Source: Egyptian Journal of Basic and Applied Sciences - May 31, 2015 Category: Science Source Type: research
A Bayesian Approach to Social Structure Uncovers Cryptic Regulation of Group Dynamics in Drosophila melanogaster.
Abstract
Understanding the mechanisms that give rise to social structure is central to predicting the evolutionary and ecological outcomes of social interactions. Modeling this process is challenging, because all individuals simultaneously behave in ways that shape their social environments-a process called social niche construction (SNC). In earlier work, we demonstrated that aggression acts as an SNC trait in fruit flies (Drosophila melanogaster), but the mechanisms of that process remained cryptic. Here, we analyze how individual social group preferences generate overall social structure. We use a combi...
Source: The American Naturalist - May 25, 2015 Category: Biology Authors: Foley BR, Saltz JB, Nuzhdin SV, Marjoram P Tags: Am Nat Source Type: research
