Editorial Board
Publication date: December 2018Source: Egyptian Journal of Basic and Applied Sciences, Volume 5, Issue 4Author(s): (Source: Egyptian Journal of Basic and Applied Sciences)
Source: Egyptian Journal of Basic and Applied Sciences - December 7, 2018 Category: Science Source Type: research

Corrigendum to “Characterization and applications of exopolysaccharide produced by marine Bacillus altitudinis MSH2014 from Ras Mohamed, Sinai, Egypt” [Egypt. J. Basic Appl. Sci. 5 (2018) 204–209]
Publication date: December 2018Source: Egyptian Journal of Basic and Applied Sciences, Volume 5, Issue 4Author(s): Sahar S. Mohamed, Shaimaa K. Amer, Manal S. Selim, Hala M. Rifaat (Source: Egyptian Journal of Basic and Applied Sciences)
Source: Egyptian Journal of Basic and Applied Sciences - December 7, 2018 Category: Science Source Type: research

Anti-cancer potential of the lipoidal and flavonoidal compounds from Pisum sativum and Vicia faba peels
Publication date: Available online 14 November 2018Source: Egyptian Journal of Basic and Applied SciencesAuthor(s): Amal M. El-Feky, Marwa M. Elbatanony, Marwa M. MounierAbstractFor a long time, plant secondary metabolites have been strongly examined for their antitumor and cytotoxic impacts. These days, there is another pattern of making utilization of the waste products of plants because of their extravagance of numerous phytochemical components and adequacy on human wellbeing. This research work is handling the effect of diversity of lipoidal and phenolic compounds found in the peels of two common edible plants in the M...
Source: Egyptian Journal of Basic and Applied Sciences - November 15, 2018 Category: Science Source Type: research

Ceramide pathway: A novel approach to cancer chemotherapy
Publication date: Available online 28 October 2018Source: Egyptian Journal of Basic and Applied SciencesAuthor(s): Mahdi Mashhadi Akbar Boojar, Masoud Mashhadi Akbar Boojar, Sepide GolmohammadAbstractApoptosis or programmed cell death applies as a protected way to remove unwanted cells and plays a determinative role in many important biological processes such as normal development and tissue homeostasis in multicellular organisms. The main purpose of studies in this field is to focus on understanding the related regulatory mechanisms and novel approaches to the discovery of anticancer drugs. Among the apoptotic messenger m...
Source: Egyptian Journal of Basic and Applied Sciences - October 29, 2018 Category: Science Source Type: research

In silico prediction of anticarcinogenic bioactivities of traditional anti-inflammatory plants used by tribal healers in Sathyamangalam wildlife Sanctuary, India
Publication date: Available online 26 October 2018Source: Egyptian Journal of Basic and Applied SciencesAuthor(s): Pavithra Chinnasamy, Rajendran ArumugamAbstractThe present study was designed to explore ethnopharmacological anti-inflammatory plants in the anti-cancer drug development. From the specialized local herbalists of the study area, who were treating tumors using anti-inflammatory plants by considering as a type of inflammation and explaining the potential of anti-inflammatory plants in prevalence of early stage's cancer. Interaction results obtained from the herbalists, and in silico PASS and CLC-pred prediction ...
Source: Egyptian Journal of Basic and Applied Sciences - October 27, 2018 Category: Science Source Type: research

Structural, IR spectra NBO, TDDFT, AIM calculation, biological activity and docking property of [1,2,4]-triazolo[3,4-b][1,3,4] thiadiazole
Publication date: Available online 25 October 2018Source: Egyptian Journal of Basic and Applied SciencesAuthor(s): Anoop Kumar Pandey, Dharmesh Vikram Shukla, Vijay Singh, Vijay NarayanAbstractIn this paper a complete quantum chemical study of [1,2,4]-triazolo [3,4-b][1,3,4] thiadiazole has been done with the combination of DFT/B3LYP method and 6-311G(d, p) basis set. The vibrational assignments are calculated with the help of PED. By using quantum theory of atoms in the molecule (QTAIM) we have calculated topological parameters at BCP point by which the nature of several intermolecular hydrogen bondings are studied. Elect...
Source: Egyptian Journal of Basic and Applied Sciences - October 26, 2018 Category: Science Source Type: research

Comparison of total phenols, flavonoids and antioxidant potential of local and imported ripe bananas
Publication date: Available online 2 October 2018Source: Egyptian Journal of Basic and Applied SciencesAuthor(s): Fatma Said Al Amri, Mohammad Amzad HossainAbstractBananas are globally used trade crops for nutrition and traditional medicine. The following research aims to study different polarity banana extracts from local and imported ripe bananas and determine the amount of phenols and flavonoids contents, and antioxidant potential by applying various spectroscopic methods. The banana extracts were prepared from the powdered banana samples of Pilipino (Cavendish) and Salalah ripe banana (Somali) by the maceration method ...
Source: Egyptian Journal of Basic and Applied Sciences - October 5, 2018 Category: Science Source Type: research

Lipogenesis inhibition and adipogenesis regulation via PPARγ pathway in 3T3-L1 cells by Zingiber cassumunar Roxb. rhizome extracts
This study aim to investigate the lipolytic and anti-adipogenic activity of crude extracts from ZC on in vitro cultures of the mouse adipocyte cell-model, 3T3-L1. Dry rhizome powder was extracted with absolute ethanol and boiled-water. On the exposed pre-adipocytes to the extracts, cytotoxicity was not detected by using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Lipid content and glycerol release were assessed using Oil Red-O and a commercial Adipolysis Assay kits respectively. The extracts exhibited no significant lipolytic activity on the exposed mature-adipocytes, in serial dilutions r...
Source: Egyptian Journal of Basic and Applied Sciences - September 22, 2018 Category: Science Source Type: research

Changes in the dielectric properties of rat lung tissue following x-irradiation
Publication date: Available online 29 August 2018Source: Egyptian Journal of Basic and Applied SciencesAuthor(s): Abdelrazek B. Abdelrazzak, Ahmad M. Labeeb, Gamal S. El-BahyAbstractThe Dielectric and Fourier Transform Infrared (FTIR) spectroscopy have been used to investigate the effect of low dose (10 cGy) and high dose (2 Gy) X-rays on the lung of whole-body irradiated rats. The dielectric permittivity ε′, dielectric loss ε″, electric modulus M′ and the imaginary part of the electric modulus M″ measured show changes in the molecular dynamics of the cellular membrane following ...
Source: Egyptian Journal of Basic and Applied Sciences - August 31, 2018 Category: Science Source Type: research

Bioactive potential of secondary metabolites derived from medicinal plant endophytes
Publication date: Available online 6 August 2018Source: Egyptian Journal of Basic and Applied SciencesAuthor(s): Prabha Palanichamy, Govindan Krishnamoorthy, Suganya Kannan, Murugan MarudhamuthuAbstractMedicinal plants have been used as an alternative medicine to promote human health and longevity in many regions of the world since ancient times. In recent years, many novel secondary metabolites from higher fungi have been isolated and reported to provide lead compounds for new drug discovery like antimicrobial, antioxidant, and anticancer agents, etc. A total of 42 endophytic fungi were isolated from 11 different medicina...
Source: Egyptian Journal of Basic and Applied Sciences - August 6, 2018 Category: Science Source Type: research

Genetics of congenital cataract, its diagnosis and therapeutics
Publication date: Available online 29 July 2018Source: Egyptian Journal of Basic and Applied SciencesAuthor(s): Luqman Khan, Nargis Shaheen, Qaisar Hanif, Shah Fahad, Muhammad UsmanAbstractCongenital cataract is defined as an opacification of the eye lens appearing at birth or shortly thereafter. Congenital cataract is one of the highest significant causes of blindness or optical impairment in the childhood. Cataract, the cloudiness of the lens is the most frequent reason of blindness worldwide, demonstrating nearly half of all causes of loss of sight worldwide. A significant amount of isolated congenital cataract has mono...
Source: Egyptian Journal of Basic and Applied Sciences - August 4, 2018 Category: Science Source Type: research

Genetics of congenital cataract and its diagnosis and therapeutics
Publication date: Available online 29 July 2018Source: Egyptian Journal of Basic and Applied SciencesAuthor(s): Luqman Khan, Nargis Shaheen, Qaisar Hanif, Shah Fahad, Muhammad UsmanAbstractCongenital cataract is defined as an opacification of the eye lens appearing at birth or shortly thereafter. Congenital cataract is one of the highest significant causes of blindness or optical impairment in the childhood. Cataract, the cloudiness of the lens is the most frequent reason of blindness worldwide, demonstrating nearly half of all causes of loss of sight worldwide. A significant amount of isolated congenital cataract has mono...
Source: Egyptian Journal of Basic and Applied Sciences - July 29, 2018 Category: Science Source Type: research

Visfatin gene expression and oxidative stress in pregnancy induced hypertension
This study was conducted with the aim of evaluating the level of visfatin gene expression in placenta and measuring some oxidative stress parameters. Eighty Egyptian patients of newly diagnosed pregnant hypertensive disorder were selected for the study which was recruited from Mansoura University Hospital, Department of Obstetrics and Gynecology and also normotensive pregnant women were collected. The pregnant women groups were classified into four groups: gestational hypertension (n = 20), mild preeclampsia (n = 16), severe preeclampsia (n = 25), chronic hypertension with superimposed preeclampsia (n = 19)...
Source: Egyptian Journal of Basic and Applied Sciences - July 11, 2018 Category: Science Source Type: research

Polyphenon-E encapsulated into chitosan nanoparticles inhibited proliferation and growth of Ehrlich solid tumor in mice
In conclusion, encapsulation of PE into CSNPs provided a good platform for cancer chemotherapy and raised existing application of different polyphenols for nanochemotherapy/prevention.Graphical abstract (Source: Egyptian Journal of Basic and Applied Sciences)
Source: Egyptian Journal of Basic and Applied Sciences - July 11, 2018 Category: Science Source Type: research

Synthesis and evaluation of antimicrobial, antitubercular and anticancer activities of benzimidazole derivatives
Publication date: March 2018Source: Egyptian Journal of Basic and Applied Sciences, Volume 5, Issue 1Author(s): Snehlata Yadav, Balasubramanian Narasimhan, Siong Meng Lim, Kalavathy Ramasamy, Mani Vasudevan, Syed Adnan Ali Shah, Abhishek MathurAbstractA series of benzimidazole derivatives (1–20) was synthesized and evaluated for its in vitro antimicrobial, antitubercular and anticancer activities. Compound 10 was found to be the most active antibacterial agent. The compounds active in in vitro evaluation against M. tuberculosis were further assessed for their in vivo activity in mice and for their capacity to inhibit...
Source: Egyptian Journal of Basic and Applied Sciences - July 11, 2018 Category: Science Source Type: research

Synthesis, characterization and anticancer activity of vincristine loaded folic acid-chitosan conjugated nanoparticles on NCI-H460 non-small cell lung cancer cell line
Publication date: March 2018Source: Egyptian Journal of Basic and Applied Sciences, Volume 5, Issue 1Author(s): Naresh Kumar, Raj Kumar Salar, Minakshi Prasad, Koushlesh RanjanAbstractVincristine is used to treat different type of cancers. But unwanted side effects limit their applications in medicine. To overcome these side effects by targeted drug delivery approach, we synthesized vincristine loaded folic acid-chitosan conjugated nanoparticles by ionic gelation method. The nanoparticles were characterized using Dynamic Light Scattering (DLS), Fourier Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (S...
Source: Egyptian Journal of Basic and Applied Sciences - July 11, 2018 Category: Science Source Type: research

Phytochemical screening, antioxidant, anti-inflammatory and antiangiogenic activities of Lophira procera A. Chev. (Ochnaceae) medicinal plant from Gabon
The objective of this study was to perform phytochemical screening, to determine the content of phenolic compound, to evaluate antioxidant, anti-inflammatory and antiangiogenic activities of ethanol, water-ethanol and water extracts of Lophira procera. Antioxidant activity was determined by 2,2-diphenyl-1-picrylhydrazyl (DPPH) and phosphomolybdenum assay, anti-inflammatory activity by proteins denaturation inhibition and membranes stabilization test and antiangiogenic activity by chicken chorioallantoic membrane (CAM) method. The results showed that this plant is rich in saponins, polyphenols, tannins, total flavonoids, pr...
Source: Egyptian Journal of Basic and Applied Sciences - July 11, 2018 Category: Science Source Type: research

Carob extract attenuates brain and lung injury in rats exposed to waterpipe smoke
Publication date: March 2018Source: Egyptian Journal of Basic and Applied Sciences, Volume 5, Issue 1Author(s): Mona Abdel-Rahman, Amira A. Bauomy, Fatma Elzahraa H. Salem, Mona Ahmed KhalifaAbstractWaterpipe smoking is one of the most popular methods of tobacco consumption world-wide which induces many health problems. In the present study; we evaluated the toxic effects of waterpipe smoke by using amiodarone as a model for lung toxicity in adult male albino rats. Also, the protective and therapeutic effects of carob aqueous extract on these toxicity which produced by daily exposure to waterpipe smoke for 8 weeks. The a...
Source: Egyptian Journal of Basic and Applied Sciences - July 11, 2018 Category: Science Source Type: research

Thioredoxin-1 and MMP-9 as biomarkers in breast cancer metastasis in Egyptian female patients
Publication date: March 2018Source: Egyptian Journal of Basic and Applied Sciences, Volume 5, Issue 1Author(s): Al Shaima G. Abd El Salam, Mohamed A. Ebrahim, Laila A. Eissa, Mamdouh M. El-Shishtawy (Source: Egyptian Journal of Basic and Applied Sciences)
Source: Egyptian Journal of Basic and Applied Sciences - July 11, 2018 Category: Science Source Type: research

A comparative study on larvicidal potential of selected medicinal plants over green synthesized silver nano particles
Publication date: March 2018Source: Egyptian Journal of Basic and Applied Sciences, Volume 5, Issue 1Author(s): Syed Zameer Ahmed Khader, Sidhra Syed Zameer Ahmed, Jagadeeswari Sathyan, Mohamed Rafi Mahboob, Kisore P. Venkatesh, Kishore RameshAbstractLarvicidal activity was assessed for alcoholic extracts of Phyllanthus amarus, Annona squamosa, Coccinia grandis and Eclipta prostrata extracted using solvents of various polarity. Third instar stage larvae of Dengue-vector, Aedes aegypti and Japanese encephalitis (JE) causing mosquito Culex tritaeniorhynchus were subjected to larvicidal bioassay at various concentrations (100...
Source: Egyptian Journal of Basic and Applied Sciences - July 11, 2018 Category: Science Source Type: research

Cancer preventive and therapeutic effects of EGCG, the major polyphenol in green tea
Publication date: March 2018Source: Egyptian Journal of Basic and Applied Sciences, Volume 5, Issue 1Author(s): Islam Rady, Hadir Mohamed, Mohamad Rady, Imtiaz A. Siddiqui, Hasan MukhtarAbstract(-)-epigallocatechin-3-gallate (EGCG), the major bioactive catechin in green tea (GT) has been studied for almost past thirty years as an agent initially for its cancer chemoprevention effects and then for its cancer chemotherapeutic ability. This agent has shown considerable anti-cancer effects in a variety of preclinical cell culture and animal model systems. However, its clinical application to human patients is hampered by a var...
Source: Egyptian Journal of Basic and Applied Sciences - July 11, 2018 Category: Science Source Type: research

Analysis of efficiency of different antennas for microwave ablation using simulation and experimental methods
The objective of this study is to analyze the efficiency of different antennas proposed for microwave ablation therapy using numerical simulation and experimental approach. The simulation was done with COMSOL MULTIPHYSICS® software to design antenna prototypes and evaluate its reflection coefficient, power dissipation distribution, power dissipation density, specific absorption rate and temperature distribution in tissue. Antennas were fabricated from a 50 Ω RG405/U semi-rigid coaxial cable to match the geometric prototypes generated during simulation. Ex vivo bovine livers were ablated with the fabricated ante...
Source: Egyptian Journal of Basic and Applied Sciences - July 11, 2018 Category: Science Source Type: research

Molecular docking and QSAR analysis of a few Gama amino butyric acid aminotransferase inhibitors
Publication date: March 2018Source: Egyptian Journal of Basic and Applied Sciences, Volume 5, Issue 1Author(s): Usman Abdulfatai, Adamu Uzairu, Sani UbaAbstractMolecular docking and quantitative structure–activity relationship (QSAR) studies were carried out on 37 anticonvulsant compounds to develop a robust model for the prediction of anticonvulsant activities against Gama amino butyric acid aminotransferase (GABAAT) and to determine the dominant structural amino acid residues responsible for the binding affinity of the ligand-GABAAT complex. AutoDock Vina of PyRx virtual screening software was used to perform the m...
Source: Egyptian Journal of Basic and Applied Sciences - July 11, 2018 Category: Science Source Type: research

The vasorelaxant effect of Canarium odontophyllum Miq. (Dabai) extract in rat thoracic aorta
ConclusionThis study suggests that the vasorelaxant effect of aqueous extract from CO leaves was endothelium-independent and was possibly mediated through the blockade of voltage-dependent calcium channel and receptor-operated calcium channel. (Source: Egyptian Journal of Basic and Applied Sciences)
Source: Egyptian Journal of Basic and Applied Sciences - July 11, 2018 Category: Science Source Type: research

Antimicrobial activity of silver nanoparticles biosynthesised by Rhodotorula sp. strain ATL72
In conclusion, the pink yeast Rhodotorula sp., strain ATL72 isolated from Egypt is a promising new biological source for the synthesis of silver nanoparticles having a potent antimicrobial activity against a wide range of pathogenic bacteria and fungi. (Source: Egyptian Journal of Basic and Applied Sciences)
Source: Egyptian Journal of Basic and Applied Sciences - July 11, 2018 Category: Science Source Type: research

6-(2-Morpholinoethyl)-thiazolo[3,2-a]pyrimidin-5-one: A novel scaffold for the synthesis of potential PI3kα inhibitors
Publication date: June 2018Source: Egyptian Journal of Basic and Applied Sciences, Volume 5, Issue 2Author(s): Ahmed R. Ali, Eman R. El-Bendary, Mariam A. Ghaly, Ihsan A. ShehataAbstractThe present study involves the development of certain thiazolo[3,2-a]pyrimidin-5-ones linked through an ethylene bridge to various amines. The newly synthesized compounds 4–6(a–c) were subjected to in vitro anticancer evaluation using NCI antitumor screening. The target compounds showed observed activity against Renal UO-31 cancer cell line with cell growth promotion 52.72–64.52%. COMPARE analyses revealed compounds 4a and...
Source: Egyptian Journal of Basic and Applied Sciences - July 11, 2018 Category: Science Source Type: research

Isolation, structure characterization and prediction of antioxidant activity of two new compounds from the leaves of Dodonaea viscosa native to the Sultanate of Oman
Publication date: June 2018Source: Egyptian Journal of Basic and Applied Sciences, Volume 5, Issue 2Author(s): Asila Ahmed Salim Al Habsi, Mohammad Amzad HossainAbstractTraditionally, Dodonaea viscosa (D. viscosa) is used worldwide for the treatment of different chronic diseases. The current investigation involves the isolation, structure characterization and prediction of antioxidant compounds from the leaves of D. viscosa, which was collected from AL-Hamra, Sultanate of Oman. The leaves samples were used for the extraction of plant constituents with methanol by using hot extraction method. The methanol solvent was evapor...
Source: Egyptian Journal of Basic and Applied Sciences - July 11, 2018 Category: Science Source Type: research

Microwave-assisted spent black tea leaves as cost-effective and powerful green adsorbent for the efficient removal of Eriochrome black T from aqueous solutions
Publication date: June 2018Source: Egyptian Journal of Basic and Applied Sciences, Volume 5, Issue 2Author(s): Ayub Khan, Xiangke Wang, Kashif Gul, Fazli Khuda, Zaynab Aly, A.M. ElsemanAbstractIn this work, microwave-assisted spent black tea leaves (MASTL) were used as effective low-cost green adsorbents for the removal of Eriochrome Black T (EBT) from aqueous solutions and adequately characterized. The pHpzc of MASTL was found to be 4.6. The experimental conditions, such as pH, contact time, temperature, adsorbent dose and EBT concentration, were optimized to evaluate the interaction of EBT with MASTL. The adsorption isot...
Source: Egyptian Journal of Basic and Applied Sciences - July 11, 2018 Category: Science Source Type: research

Spectrophotometic determination of Lorazepam in pharmaceutical tablets using batch and reverse flow injection methods
Publication date: June 2018Source: Egyptian Journal of Basic and Applied Sciences, Volume 5, Issue 2Author(s): Maryam Jamal, Hind HadiAbstractA reverse flow injection analysis (RFIA) spectrophotometric method have been developed and compared with batch method for the determination of lorazepam (LOR) at the microgram level in pure and pharmaceutical dosage forms. The methods are based on the reaction of LOR with 3-methyl-2-benzothiazolinone hydrazone hydrochloride (MBTH) in the presence of ferric chloride in aqueous medium. The water soluble green color product was measured at λmax 659 nm. Under the optimum conditi...
Source: Egyptian Journal of Basic and Applied Sciences - July 11, 2018 Category: Science Source Type: research

Antifungal activity of fabricated mesoporous silica nanoparticles against early blight of tomato
In this study, we described synthesis and evaluation of the direct antifungal activity of mesoporous silica nanoparticles (MSN) compared to metalaxyl (recommended fungicide) against A. solani under laboratory and greenhouse conditions. The structural features of MSN such as high porosity, small particle size and suitable shape contributed to its high antifungal efficacy against Alternaria solani. Laboratory synthesized MSN showed marked increase in tomato growth parameters compared to untreated control. Our study presents promising results of the use of MSN as an effective and safe alternative of fungicides for managing to...
Source: Egyptian Journal of Basic and Applied Sciences - July 11, 2018 Category: Science Source Type: research

Role of CdSe quantum dots in the structure and antibacterial activity of chitosan/poly ɛ-caprolactone thin films
Publication date: June 2018Source: Egyptian Journal of Basic and Applied Sciences, Volume 5, Issue 2Author(s): M.S. Meikhail, A.M. Abdelghany, W.M. AwadAbstractChitosan/polycaprolactone (Ch/PCL) semi-natural polymeric blend containing gradient concentrations of CdSe quantum dots (QDs) dopant were synthesized via hot injection method. Synthesized samples containing different concentration of CdSe QDs were characterized by X-ray diffraction and FTIR absorption spectroscopy. FTIR experimental data of synthesized samples shows the maintenance of characteristic vibrational band with a marginal variation in both intensity and po...
Source: Egyptian Journal of Basic and Applied Sciences - July 11, 2018 Category: Science Source Type: research

Diphyllin: An effective anticandidal agent isolated from Cleistanthus collinus leaf extract
In this study, diphyllin [9-(1,3-benzodioxol-5-yl)-4-hydroxy-6,7-dimethoxynaphtho[2,3-c]furan-1(3H)-one] was isolated from Cleistanthus collinus leaf extract. The isolated compound and leaf extract were evaluated for their in vitro anticandidal activity against Candida strains such as Candida albicans, C. tropicalis, and C. glabrata. Diphyllin was found to possess higher anticandidal activity against various Candida species with the Minimal Fungicidal Concentration (MFC) of 85–145 μg and inhibition zone of 9.5 ± 0.5–13.5 ± 0.5 mm at 200 μg concentration against the yeast pathog...
Source: Egyptian Journal of Basic and Applied Sciences - July 11, 2018 Category: Science Source Type: research

Fatty acids and survival of bacteria in Hammam Pharaon springs, Egypt
Publication date: June 2018Source: Egyptian Journal of Basic and Applied Sciences, Volume 5, Issue 2Author(s): Yehia A. Osman, Mahmud Mokhtar Gbr, Ahmed Abdelrazak, Amr M. MowafyAbstractA great lack of knowledge of Hammam Pharaon's microbial community; the most famous hot spring in Sinai, Egypt, derived this work. Three different hyperthermophilic bacterial were isolated from vents in the area, where the temperature was above 80 °C. Response Surface Methodology algorithm such as Central Composite Design determined the optimum cultivation conditions for these isolates. Accordingly, the best growth conditions were at 7...
Source: Egyptian Journal of Basic and Applied Sciences - July 11, 2018 Category: Science Source Type: research

Therapeutic challenges in ocular delivery of lipid based emulsion
Publication date: June 2018Source: Egyptian Journal of Basic and Applied Sciences, Volume 5, Issue 2Author(s): Rahul Tiwari, Vikas Pandey, Saket Asati, Vandana Soni, Dharmendra JainAbstractIn the last decade, lipid based emulsions (LEs) have emerged as a novel tool in ophthalmic drug delivery from the aspect of improved bioavailability (BA). Recent research is focuses on two main approaches for BA improvement i.e., by enhancing the corneal permeability and increasing the retention time of drug on the ocular surface. The LEs have great potential to delivery hydrophobic drug because drug molecules get dissolve in oil globule...
Source: Egyptian Journal of Basic and Applied Sciences - July 11, 2018 Category: Science Source Type: research

The aqueous extract of Ocimum gratissimum leaves ameliorates acetic acid-induced colitis via improving antioxidant status and hematological parameters in male Wistar rats
This study investigated the protective effects of aqueous extract of Ocimum gratissimum leaves (AEOGL) on acetic acid induced colitis in male rats. Twenty male Wistar rats, 100–180 g were divided into four groups as follows: Group 1 (control) (n = 5) received 2 ml/kg of distilled water for 21 consecutive days. Group 2 (n = 5) received 2 ml of 6% acetic acid solution once intra rectally for induction of colitis. Group 3 and 4 (n = 5 each) were treated as group 2 and thereafter received AEOGL orally at 200 and 400 mg/kg/day respectively for 20 consecutive days. All the animals from each group were s...
Source: Egyptian Journal of Basic and Applied Sciences - July 11, 2018 Category: Science Source Type: research

Screening and identification of novel inhibitors against human 4-aminobutyrate-aminotransferase: A computational approach
Publication date: Available online 6 June 2018Source: Egyptian Journal of Basic and Applied SciencesAuthor(s): S. Vijayakumar, G. Kasthuri, S. Prabhu, P. Manogar, N. ParameswariAbstract4-Aminobutyrate aminotransferase (GABA) receptors are the key mediators of quick inhibitory synaptic transmission in the midpoint of the nervous system in mammalian. Dysfunction of GABA receptors contributes the genetic disorders and chronic neurological disorders include childhood absence epilepsy, juvenile myoclonic epilepsy, adolescent myoclonic epilepsy, and seizures. They get affected by mutations of GABA subunit genes from the brain. T...
Source: Egyptian Journal of Basic and Applied Sciences - July 11, 2018 Category: Science Source Type: research

Malignant pleural mesothelioma: Presentation of a case report
Publication date: Available online 7 June 2018Source: Egyptian Journal of Basic and Applied SciencesAuthor(s): Munir Ahmad, Muhammad Omer Aamir, Khurram Minhas, Khwaja Ajmal, Iftikhar AhmadAbstractMalignant pleural mesothelioma (MPM) is a rare and highly aggressive intrathoracic neoplasm that typically offer poor prognosis. In general, development of MPM is linked with a history of asbestos exposure. Herein we report a 56-year-old female patient with MPM, who presented with complains of chest pain, cough, shortness of breath and weight loss. The patient’s radiological work-up demonstrated right sided plural effusion ...
Source: Egyptian Journal of Basic and Applied Sciences - July 11, 2018 Category: Science Source Type: research

Characterization and applications of exopolysaccharide produced by marine Bacillus altitudinis MSH2014 from Ras Mohamed, Sinai, Egypt
Publication date: Available online 8 June 2018Source: Egyptian Journal of Basic and Applied SciencesAuthor(s): Sahar S. Mohamed, Shaimaa K. Amer, Manal S. Selim, Hala M. RifaatAbstractThe present study aims to survey exopolysaccharides (EPSs) production in 29 bacterial strains isolated from the sediments around the mangrove trees in Ras Mohamed area, Red Sea Coast, Sinai Peninsula, Egypt. Two of the strains were able to produce EPSs. A higher yield of EPS was obtained from isolate No. 12. Strain identification resulted in a close similarity with Bacillus altitudinis. The produced EPS was characterised as a heteropolysaccha...
Source: Egyptian Journal of Basic and Applied Sciences - July 11, 2018 Category: Science Source Type: research

Column chromatography and HPLC analysis of phenolic compounds in the fractions of Salvinia molesta mitchell
In this study the active fractions of the fern extract were separated using column chromatography and phenolic compounds present in the active fractions were determined by RP-HPLC. Ethyl acetate extract was found to possess significant pharmacological activity when compared to other extracts under study and therefore an attempt was made to fractionate ethyl acetate extract. The analysis was performed through two different mobile phases involving solvent A (acetonitrile) and solvent B (0.1% phosphoric acid in water) and solvent A (methanol) and Solvent B (4% acetic acid). HPLC analysis indicated the presence of phenolic com...
Source: Egyptian Journal of Basic and Applied Sciences - July 11, 2018 Category: Science Source Type: research

Molecular structure investigation towards pharmacodynamic activity and QSAR analysis on hypoxanthine using experimental and computational tools
Publication date: Available online 14 June 2018Source: Egyptian Journal of Basic and Applied SciencesAuthor(s): G. Susithra, S. Ramalingam, S. Periandy, R. AarthiAbstractThe structural properties of Hypoxanthine compound related to molecular dynamic activity have been ornately interpreted in this methodical research work. The FT-IR, FT-Raman, NMR and UV–Visible spectral analysis has been carried out and the obtained results were validated using theoretical tools. The tautomerism of the compound has been monitored while analyzing the molecular structure regarding to describe unknown properties and applications. The di...
Source: Egyptian Journal of Basic and Applied Sciences - July 11, 2018 Category: Science Source Type: research

Protective effect of Spirulina against cyclophosphamide-induced urotoxicity in mice
Publication date: Available online 27 June 2018Source: Egyptian Journal of Basic and Applied SciencesAuthor(s): Fatma M. Eltantawy, Mohamed A. Ali Sobh, Ahmed M. EL-Waseef, Rehab-Allah A. Ibrahim, Mohamed A.A. SaadAbstractCyclophosphamide (CP) is an anti-neoplastic drug, which is widely used for treating cancer and non-malignant tumors. One of the major side effects of CP is hemorrhagic cystitis. Spirulina (Arthrospira platensis; Sp) is a blue-green algae with the ability to attenuate oxidative stress, which may be utilized for alleviating side effects of chemotherapeutic drugs in the clinic. The aim of the present study w...
Source: Egyptian Journal of Basic and Applied Sciences - July 11, 2018 Category: Science Source Type: research

Visfatin gene expression and oxidative stress in pregnancy induced hypertension
This study was conducted with the aim of evaluating the level of visfatin gene expression in placenta and measuring some oxidative stress parameters. Eighty Egyptian patients of newly diagnosed pregnant hypertensive disorder were selected for the study which was recruited from Mansoura University Hospital, Department of Obstetrics and Gynecology and also normotensive pregnant women were collected. The pregnant women groups were classified into four groups: gestational hypertension (n = 20), mild preeclampsia (n = 16), severe preeclampsia (n = 25), chronic hypertension with superimposed preeclampsia (n = 19)...
Source: Egyptian Journal of Basic and Applied Sciences - July 5, 2018 Category: Science Source Type: research

Polyphenon-E encapsulated into chitosan nanoparticles inhibited proliferation and growth of Ehrlich solid tumor in mice
In conclusion, encapsulation of PE into CSNPs provided a good platform for cancer chemotherapy and raised existing application of different polyphenols for nanochemotherapy/prevention.Graphical abstract (Source: Egyptian Journal of Basic and Applied Sciences)
Source: Egyptian Journal of Basic and Applied Sciences - July 5, 2018 Category: Science Source Type: research

Synthesis and evaluation of antimicrobial, antitubercular and anticancer activities of benzimidazole derivatives
Publication date: March 2018Source: Egyptian Journal of Basic and Applied Sciences, Volume 5, Issue 1Author(s): Snehlata Yadav, Balasubramanian Narasimhan, Siong Meng Lim, Kalavathy Ramasamy, Mani Vasudevan, Syed Adnan Ali Shah, Abhishek MathurAbstractA series of benzimidazole derivatives (1–20) was synthesized and evaluated for its in vitro antimicrobial, antitubercular and anticancer activities. Compound 10 was found to be the most active antibacterial agent. The compounds active in in vitro evaluation against M. tuberculosis were further assessed for their in vivo activity in mice and for their capacity to inhibit...
Source: Egyptian Journal of Basic and Applied Sciences - July 5, 2018 Category: Science Source Type: research

Synthesis, characterization and anticancer activity of vincristine loaded folic acid-chitosan conjugated nanoparticles on NCI-H460 non-small cell lung cancer cell line
Publication date: March 2018Source: Egyptian Journal of Basic and Applied Sciences, Volume 5, Issue 1Author(s): Naresh Kumar, Raj Kumar Salar, Minakshi Prasad, Koushlesh RanjanAbstractVincristine is used to treat different type of cancers. But unwanted side effects limit their applications in medicine. To overcome these side effects by targeted drug delivery approach, we synthesized vincristine loaded folic acid-chitosan conjugated nanoparticles by ionic gelation method. The nanoparticles were characterized using Dynamic Light Scattering (DLS), Fourier Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (S...
Source: Egyptian Journal of Basic and Applied Sciences - July 5, 2018 Category: Science Source Type: research

Phytochemical screening, antioxidant, anti-inflammatory and antiangiogenic activities of Lophira procera A. Chev. (Ochnaceae) medicinal plant from Gabon
The objective of this study was to perform phytochemical screening, to determine the content of phenolic compound, to evaluate antioxidant, anti-inflammatory and antiangiogenic activities of ethanol, water-ethanol and water extracts of Lophira procera. Antioxidant activity was determined by 2,2-diphenyl-1-picrylhydrazyl (DPPH) and phosphomolybdenum assay, anti-inflammatory activity by proteins denaturation inhibition and membranes stabilization test and antiangiogenic activity by chicken chorioallantoic membrane (CAM) method. The results showed that this plant is rich in saponins, polyphenols, tannins, total flavonoids, pr...
Source: Egyptian Journal of Basic and Applied Sciences - July 5, 2018 Category: Science Source Type: research

Carob extract attenuates brain and lung injury in rats exposed to waterpipe smoke
Publication date: March 2018Source: Egyptian Journal of Basic and Applied Sciences, Volume 5, Issue 1Author(s): Mona Abdel-Rahman, Amira A. Bauomy, Fatma Elzahraa H. Salem, Mona Ahmed KhalifaAbstractWaterpipe smoking is one of the most popular methods of tobacco consumption world-wide which induces many health problems. In the present study; we evaluated the toxic effects of waterpipe smoke by using amiodarone as a model for lung toxicity in adult male albino rats. Also, the protective and therapeutic effects of carob aqueous extract on these toxicity which produced by daily exposure to waterpipe smoke for 8 weeks. The a...
Source: Egyptian Journal of Basic and Applied Sciences - July 5, 2018 Category: Science Source Type: research

Thioredoxin-1 and MMP-9 as biomarkers in breast cancer metastasis in Egyptian female patients
Publication date: March 2018Source: Egyptian Journal of Basic and Applied Sciences, Volume 5, Issue 1Author(s): Al Shaima G. Abd El Salam, Mohamed A. Ebrahim, Laila A. Eissa, Mamdouh M. El-Shishtawy (Source: Egyptian Journal of Basic and Applied Sciences)
Source: Egyptian Journal of Basic and Applied Sciences - July 5, 2018 Category: Science Source Type: research

A comparative study on larvicidal potential of selected medicinal plants over green synthesized silver nano particles
Publication date: March 2018Source: Egyptian Journal of Basic and Applied Sciences, Volume 5, Issue 1Author(s): Syed Zameer Ahmed Khader, Sidhra Syed Zameer Ahmed, Jagadeeswari Sathyan, Mohamed Rafi Mahboob, Kisore P. Venkatesh, Kishore RameshAbstractLarvicidal activity was assessed for alcoholic extracts of Phyllanthus amarus, Annona squamosa, Coccinia grandis and Eclipta prostrata extracted using solvents of various polarity. Third instar stage larvae of Dengue-vector, Aedes aegypti and Japanese encephalitis (JE) causing mosquito Culex tritaeniorhynchus were subjected to larvicidal bioassay at various concentrations (100...
Source: Egyptian Journal of Basic and Applied Sciences - July 5, 2018 Category: Science Source Type: research

Cancer preventive and therapeutic effects of EGCG, the major polyphenol in green tea
Publication date: March 2018Source: Egyptian Journal of Basic and Applied Sciences, Volume 5, Issue 1Author(s): Islam Rady, Hadir Mohamed, Mohamad Rady, Imtiaz A. Siddiqui, Hasan MukhtarAbstract(-)-epigallocatechin-3-gallate (EGCG), the major bioactive catechin in green tea (GT) has been studied for almost past thirty years as an agent initially for its cancer chemoprevention effects and then for its cancer chemotherapeutic ability. This agent has shown considerable anti-cancer effects in a variety of preclinical cell culture and animal model systems. However, its clinical application to human patients is hampered by a var...
Source: Egyptian Journal of Basic and Applied Sciences - July 5, 2018 Category: Science Source Type: research