Impact of different fixed flow sampling protocols on flow ‐independent exhaled nitric oxide parameter estimates using the Bayesian dynamic two‐compartment model
A recently developed Bayesian dynamic two ‐compartment model of FeNO uses flow‐concentration data from the entire exhalation, which permits estimation of CawNO and CANO from a wide variety of protocols. We compare estimation under single and multiple fixed expiratory flow protocols to demonstrate the gains in precision of multiple flow protocols and the feasibility of estimation with multiple 50 ml/s maneuvers informing, respectively, future study designs and the re‐analysis of archived online FeNO data. AbstractExhaled nitric oxide (FeNO) is an established respiratory biomarker with clinical applications in the dia...
Source: Physiological Reports - January 20, 2020 Category: Physiology Authors: Patrick Muchmore,
Shujing Xu,
Paul Marjoram,
Edward B. Rappaport,
Jingying Weng,
Noa Molshatzki,
Sandrah P. Eckel Tags: ORIGINAL RESEARCH Source Type: research
Anti- < i > Escherichia coli < /i > O157:H7 as Natural Preservative to Control and Prevent Food Contamination in Meat and Fish Products.
CONCLUSION: This study suggests that the use of herbal extracts provide antibacterial potentials against food pathogens in meat and fish products.
PMID: 32363824 [PubMed - in process] (Source: Pakistan Journal of Biological Sciences: PJBS)
Source: Pakistan Journal of Biological Sciences: PJBS - December 31, 2019 Category: Biomedical Science Authors: M Hamad G, Abdelmotilib NM, Mostafa Abdel-Fattah S, M Zeitoun A Tags: Pak J Biol Sci Source Type: research
Mutational signatures in colon cancer
Recently, many tumor sequencing studies have inferred and reported on mutational signatures, short nucleotide patterns at which particular somatic base substitutions appear more often. A number of signatures r... (Source: BMC Research Notes)
Source: BMC Research Notes - December 3, 2019 Category: Research Authors: Priyatama Pandey, Zhi Yang, Darryl Shibata, Paul Marjoram and Kimberly D. Siegmund Tags: Research note Source Type: research
Molecules, Vol. 24, Pages 4030: Evaluation of the Anti-Diabetic Activity of Some Common Herbs and Spices: Providing New Insights with Inverse Virtual Screening
In this study, a library of over 2300 compounds derived from 30 common herbs and spices were screened in silico with the DIA-DB web server against 18 known diabetes drug targets. Over 900 compounds from the herbs and spices library were observed to have potential anti-diabetic activity and liquorice, hops, fennel, rosemary, and fenugreek were observed to be particularly enriched with potential anti-diabetic compounds. A large percentage of the compounds were observed to be potential polypharmacological agents regulating three or more anti-diabetic drug targets and included compounds such as achillin B from yarrow, asparasa...
Source: Molecules - November 6, 2019 Category: Chemistry Authors: Andreia S.P. Pereira Antonio J. Banegas-Luna Jorge Pe ña-García Horacio P érez-Sánchez Zeno Apostolides Tags: Article Source Type: research
Activity and reproductive capability of Meloidogyne incognita and sunflower growth response as influenced by root exudates of some medicinal plants
Publication date: Available online 6 November 2019Source: Biocatalysis and Agricultural BiotechnologyAuthor(s): A.A. Abdel-Rahman, H.H. Kesba, A.A. Al-SayedAbstractTwo experiments were separately conducted to test the effect of root exudates of seventeen medicinal plant species on hatching and survival of the root-knot nematode, Meloidogyne incognita, in-vitro and in-vivo on infected sunflower cv. Giza 102. In vitro tests, rosemary and marjoram root exudates were the best treatments for inhibiting egg hatch at all concentrations. Nematicidal and nematistatic effects of exudates were concentration-dependent, as the anesthet...
Source: Biocatalysis and Agricultural Biotechnology - November 6, 2019 Category: Biotechnology Source Type: research
Molecules, Vol. 24, Pages 4021: Chemical Composition and Antimicrobial Activity of Artemisia herba-alba and Origanum majorana Essential Oils from Morocco
This study was carried out to study the chemical composition and the antimicrobial effects of Artemisia herba-alba and Origanum majorana essential oils against some Gram-positive and Gram-negative bacteria, and a fungal strain isolated from spoiled butter. The plants were collected in the region Azzemour of South West Morocco and the EOs, extracted by hydrodistillation, were analyzed by GC-MS. The antimicrobial activity was determined using the agar paper disc method. The main components of A. herba-alba EO were cis-thujone, trans-thujone and vanillyl alcohol; in O. majorana EO terpinen-4-ol, isopulegol and &beta;-...
Source: Molecules - November 5, 2019 Category: Chemistry Authors: Amor Caputo La Storia De Feo Mauriello Fechtali Tags: Article Source Type: research
IJERPH, Vol. 16, Pages 4185: Effects of Aromatherapy Combined with Music Therapy on Anxiety, Stress, and Fundamental Nursing Skills in Nursing Students: A Randomized Controlled Trial
Conclusions: The results suggest that nursing education that includes aromatherapy combined with music therapy may be effective for improving the performance of fundamental nursing skills and reducing anxiety and stress among nursing students. (Source: International Journal of Environmental Research and Public Health)
Source: International Journal of Environmental Research and Public Health - October 28, 2019 Category: Environmental Health Authors: Hae Kyoung Son Wi-Young So Myoungsuk Kim Tags: Article Source Type: research
In vivo protection of the marjoram (Origanum majorana Linn.) essential oil in the cutaneous sporotrichosis by Sporothrix brasiliensis.
Abstract
Thirty Wistar rats subcutaneously infected by an itraconazole-resistant Sporothrix brasiliensis received the oral daily treatment (n = 10, each) of control (CTL, saline solution), itraconazole (ITZ, 10 mg/kg) and marjoram essential oil (MRJ, 80 mg/kg) for 30 days. Weekly, the clinical evaluation and euthanasia for histopathology and fungal burden were performed. Only animals from MRJ evolved to the remission of the cutaneous lesion with a mild to absent presence of yeasts in footpad, besides decreased the fungal burden in the systemic organs compared to CTL and ITZ (p < 0.05), pre...
Source: Natural Product Research - October 16, 2019 Category: Biochemistry Authors: Waller SB, Cleff MB, de Mattos CB, da Silva CC, Giordani C, Dalla Lana DF, Fuentefria AM, Freitag RA, Viegas Sallis ES, de Mello JRB, de Faria RO, Meireles MCA Tags: Nat Prod Res Source Type: research
Molecules, Vol. 24, Pages 3532: Effect of the Chemical Composition of Free-Terpene Hydrocarbons Essential Oils on Antifungal Activity
This study highlights that separation under reduced pressure is a simple green method to obtain fractions or to isolate compounds with higher biological activity useful for pharmaceutical products or natural additives in formulations. (Source: Molecules)
Source: Molecules - September 28, 2019 Category: Chemistry Authors: Ben Salha Herrera D íaz Lengliz Abderrabba Labidi Tags: Article Source Type: research
Development and characterization of pectin films activated by nanoemulsion and Pickering emulsion stabilized marjoram (Origanum majorana L.) essential oil
In conclusion, the fabricated active pectin film containing Pickering emulsion showed great potential for active food packaging.Graphical abstract (Source: Food Hydrocolloids)
Source: Food Hydrocolloids - August 28, 2019 Category: Food Science Source Type: research
[Research Articles] Treating murine inflammatory diseases with an anti-erythrocyte antibody
Treatment of autoimmune and inflammatory diseases typically involves immune suppression. In an opposite strategy, we show that administration of the highly inflammatory erythrocyte-specific antibody Ter119 into mice remodels the monocyte cellular landscape, leading to resolution of inflammatory disease. Ter119 with intact Fc function was unexpectedly therapeutic in the K/BxN serum transfer model of arthritis. Similarly, it rapidly reversed clinical disease progression in collagen antibody-induced arthritis (CAIA) and collagen-induced arthritis and completely corrected CAIA-induced increase in monocyte Fc receptor II/III ex...
Source: Science Translational Medicine - August 20, 2019 Category: Biomedical Science Authors: Crow, A. R., Kapur, R., Koernig, S., Campbell, I. K., Jen, C.-C., Mott, P. J., Marjoram, D., Khan, R., Kim, M., Brasseit, J., Cruz-Leal, Y., Amash, A., Kahlon, S., Yougbare, I., Ni, H., Zuercher, A. W., Käsermann, F., Semple, J. W., Lazarus, A. H. Tags: Research Articles Source Type: research
Origanum majorana Ethanolic Extract Promotes Colorectal Cancer Cell Death by Triggering Abortive Autophagy and Activation of the Extrinsic Apoptotic Pathway
Colorectal cancer is the third leading cause of cancer-related death worldwide. We have previously shown that Origanum majorana ethanolic extract (OME) promoted mitotic arrest, induced apoptosis and inhibited migration, metastasis and tumor growth of triple negative breast cancer. Here, we investigated the potential anticancer effect and the molecular mechanism of Origanum majoran ethanolic extract against human colorectal cancer cells. Our results showed that OME exhibited strong anti-proliferative activity against colorectal cancer cells (HT-29 and Caco-2) in a concentration- and time-dependent manner. OME inhibited cell...
Source: Frontiers in Oncology - August 20, 2019 Category: Cancer & Oncology Source Type: research
Phenolic compound by MALDI-TOF and essential composition oil by GC-MS during three development stage of Origanum majorana L.
This study aimed to investigate the effect of the maturation process of sweet marjoram (Origanum majorana L.) on essential oil composition, phenolic profile of ethanolic extract and their antioxidant capacities. The essential oil composition was studied at three stages of maturity by GC-MS. Thirty compounds were detected representing 100 % of the total essential oil. p-menth-1-en-4-ol was the major compound (37.15-76.94 %) followed by Cyclohexanol 3,3,5trimethyl (5.41-15.99 %) and α- terpineol (0.94 - 11.34 %). During maturation process, an accumulation of oxygenated monoterpenes was observed. The phenolic composition was...
Source: Biomedical Chromatography : BMC - July 23, 2019 Category: Biomedical Science Authors: Khadhri A, Bouali I, Aouadhi C, Lagel MC, Masson E, Pizzi A Tags: Biomed Chromatogr Source Type: research
