Neurodevelopmental outcomes after prenatal exposure to lamotrigine monotherapy in women with epilepsy: a systematic review and meta-analysis
Lamotrigine has become one of the most commonly prescribed antiseizure medications (ASM) in epileptic women during pregnancy and therefore requires regular updates regarding its safety. The aim of this study w... (Source: BMC Pregnancy and Childbirth)
Source: BMC Pregnancy and Childbirth - February 2, 2024 Category: OBGYN Authors: Audrey Peron, Cyndie Picot, Lucie Jurek, Mika ïl Nourredine, Emmanuelle Ripoche, Priscilla Ajiji, Michel Cucherat and Judith Cottin Tags: Research Source Type: research
Where Does Lamotrigine Fit in the Pharmacotherapy of Mood Disorders? An Evidence-Based Appraisal
J Clin Psychiatry. 2024 Jan 31;85(1):23ac15219. doi: 10.4088/JCP.23ac15219.NO ABSTRACTPMID:38301185 | DOI:10.4088/JCP.23ac15219 (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - February 1, 2024 Category: Psychiatry Authors: Joseph F Goldberg Source Type: research
To examine or not to examine, this is not the question: a diagnostic exclusion of 32-year-old virgo intacta presented with advanced non-hpv related cervical cancer and ovarian metastases
Introduction and aims of the study: A 32-year-old woman with schizophrenia and obesity presented with heavy vaginal bleeding and lower abdominal pain. She denied any sexual activity and her progressively heavy menstruations were falsely associated with lamotrigine use. Over 3 years she started having a vaginal discharge with a strong odor. Due to an intact hymen, she wasn ’t examined vaginally. (Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology)
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - February 1, 2024 Category: OBGYN Authors: Marcin Śniadecki, Paulina Jaworek, Dagmara Klasa-Mazurkiewicz, Wojciech Biernat, Bartosz Regent, Dariusz Wydra Source Type: research
Molecules, Vol. 29, Pages 676: Direct Immersion & ndash;Solid Phase Microextraction for Therapeutic Drug Monitoring of Patients with Mood Disorders
This article discusses a new method for monitoring drug concentrations in blood samples from patients with mood disorders. The method uses solid-phase microextraction to extract analytes directly from blood samples. It has been adapted to identify the most commonly used drugs in mood disorders, including amitriptyline, citalopram, fluoxetine, paroxetine, sertraline, trazodone, duloxetine, venlafaxine, lamotrigine, quetiapine, olanzapine, and mirtazapine. The analysis is carried out using high-performance liquid chromatography coupled with mass spectroscopy. The proposed DI-SPME/LC-MS method allows for a simple and quick sc...
Source: Molecules - January 31, 2024 Category: Chemistry Authors: Magdalena Świądro-Piętoń Dominika Dudek Renata Wietecha-Pos łuszny Tags: Article Source Type: research
Retention Rates and Successful Treatment with Antiseizure Medications in Newly-Diagnosed Epilepsy Patients
CONCLUSION: Second-generation ASMs have the advantage of more successful treatment with fewer ASM regimen changes compared with first-generation drugs. Various comorbid conditions as well as age and sex should be considered when selecting ASMs.PMID:38288649 | PMC:PMC10827640 | DOI:10.3349/ymj.2022.0539 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - January 30, 2024 Category: Universities & Medical Training Authors: Sungeun Hwang Hyungmi An Dong Woo Shin Hyang Woon Lee Source Type: research
Retention Rates and Successful Treatment with Antiseizure Medications in Newly-Diagnosed Epilepsy Patients
CONCLUSION: Second-generation ASMs have the advantage of more successful treatment with fewer ASM regimen changes compared with first-generation drugs. Various comorbid conditions as well as age and sex should be considered when selecting ASMs.PMID:38288649 | PMC:PMC10827640 | DOI:10.3349/ymj.2022.0539 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - January 30, 2024 Category: Universities & Medical Training Authors: Sungeun Hwang Hyungmi An Dong Woo Shin Hyang Woon Lee Source Type: research
Retention Rates and Successful Treatment with Antiseizure Medications in Newly-Diagnosed Epilepsy Patients
CONCLUSION: Second-generation ASMs have the advantage of more successful treatment with fewer ASM regimen changes compared with first-generation drugs. Various comorbid conditions as well as age and sex should be considered when selecting ASMs.PMID:38288649 | PMC:PMC10827640 | DOI:10.3349/ymj.2022.0539 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - January 30, 2024 Category: Universities & Medical Training Authors: Sungeun Hwang Hyungmi An Dong Woo Shin Hyang Woon Lee Source Type: research
Retention Rates and Successful Treatment with Antiseizure Medications in Newly-Diagnosed Epilepsy Patients
CONCLUSION: Second-generation ASMs have the advantage of more successful treatment with fewer ASM regimen changes compared with first-generation drugs. Various comorbid conditions as well as age and sex should be considered when selecting ASMs.PMID:38288649 | PMC:PMC10827640 | DOI:10.3349/ymj.2022.0539 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - January 30, 2024 Category: Universities & Medical Training Authors: Sungeun Hwang Hyungmi An Dong Woo Shin Hyang Woon Lee Source Type: research
Retention Rates and Successful Treatment with Antiseizure Medications in Newly-Diagnosed Epilepsy Patients
CONCLUSION: Second-generation ASMs have the advantage of more successful treatment with fewer ASM regimen changes compared with first-generation drugs. Various comorbid conditions as well as age and sex should be considered when selecting ASMs.PMID:38288649 | PMC:PMC10827640 | DOI:10.3349/ymj.2022.0539 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - January 30, 2024 Category: Universities & Medical Training Authors: Sungeun Hwang Hyungmi An Dong Woo Shin Hyang Woon Lee Source Type: research
Greater need for treatment optimization in patients with epilepsy initiating adjunctive therapy: Results of a retrospective claims analysis of antiseizure medication drug load in the United States
CONCLUSION: Concomitant ASM drug load increased prior to addition of new ASM, with higher increases observed among patients starting branded vs unbranded ASMs, followed by slight decreases thereafter. Total drug load increased linearly among all patients. These findings underscore the need for ongoing ASM regimen evaluation and treatment optimization in patients with epilepsy.PMID:38277849 | DOI:10.1016/j.yebeh.2024.109649 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - January 26, 2024 Category: Neurology Authors: Gregory S Connor David M Labiner Vernon F Schabert Mindl Weingarten Clarence T Wade Sean Stern Danielle A Becker Source Type: research
Age-Dependent Phenomena of 6-Hz Corneal Kindling Model in Mice
This study investigates the impact of aging on 6-Hz corneal kindling in young-adult mice and middle-aged mice. We found that the kindling acquisition of the 6-Hz corneal kindling model was delayed in middle-aged mice when compared to young-adult mice. While the seizure stage and incidence of generalized seizures (GS) were similar between the two age groups, the duration of GS in the kindled middle-aged mice was shorter than that in the kindled young-adult mice. Besides, all kindled mice, regardless of age, were resistant to phenytoin sodium (PHT), valproate sodium (VPA), and lamotrigine (LGT), whereas middle-aged mice exhi...
Source: Molecular Neurobiology - January 12, 2024 Category: Neurology Source Type: research
Long-term protective effects of lamotrigine in a rat ovarian ischemia-reperfusion model
In this study, we aimed to investigate the long-term anatomical, histological and biochemical protective effects of lamotrigine in ovariums in the ischemia - reperfusion (I-R) model created experimentally in rats. A total of 40 female Sprague-Dawley rats, 14 weeks old, weighing 220-270 g were used in the study. The subjects were randomly distributed to form 4 groups named SHAM group, I - R group, I - R + Lamotrigine (LTG) group and R + LTG group. Under general anesthesia, the ovaries of the rats were reached and ischemia was created for 3 h with vascular clamps. 20 mg / kg LTG was administered intraperitoneally (ip.) to gr...
Source: Tissue and Cell - January 9, 2024 Category: Cytology Authors: Riza Aktepe Yilmaz Ucuncu Levent Tumkaya Tolga Mercantepe Atilla Topcu Huseyin Avni Uydu Mehtap Atak Source Type: research
How to handle a missed or delayed dose of lacosamide in pediatric patients with epilepsy? a mode-informed individual dosing
This study aims to investigate the effects on the pharmacokinetic (PK) of lacosamide (LCM), and to guide the individual dosing regimens for children and ones with poor medication adherence. Population PK research was performed based on 164 plasma samples of 113 pediatric patients aged from 1.75 to 14.42 years old. The PK characteristic of LCM was developed by a one-compartment model with first-order elimination. The typical value of apparent clearance (CL) and apparent volume of distribution (Vd) was 1.91 L·h-1 and 56.53 L respectively. In the final model, the variability of CL was significantly associated with the body s...
Source: Epilepsy and Behaviour - January 9, 2024 Category: Neurology Authors: Jun Wang Yan Mei Song Liang Si-Chan Li Chen Chen Gang Nie Ya-Li Tuo Dan Sun Yang Wang Source Type: research
Long-term protective effects of lamotrigine in a rat ovarian ischemia-reperfusion model
In this study, we aimed to investigate the long-term anatomical, histological and biochemical protective effects of lamotrigine in ovariums in the ischemia - reperfusion (I-R) model created experimentally in rats. A total of 40 female Sprague-Dawley rats, 14 weeks old, weighing 220-270 g were used in the study. The subjects were randomly distributed to form 4 groups named SHAM group, I - R group, I - R + Lamotrigine (LTG) group and R + LTG group. Under general anesthesia, the ovaries of the rats were reached and ischemia was created for 3 h with vascular clamps. 20 mg / kg LTG was administered intraperitoneally (ip.) to gr...
Source: Tissue and Cell - January 9, 2024 Category: Cytology Authors: Riza Aktepe Yilmaz Ucuncu Levent Tumkaya Tolga Mercantepe Atilla Topcu Huseyin Avni Uydu Mehtap Atak Source Type: research
Efficacy of lamotrigine in migralepsy: a case report
(Source: Neurological Sciences)
Source: Neurological Sciences - January 2, 2024 Category: Neurology Source Type: research
