Molecules, Vol. 28, Pages 7830: Simple HPLC-UV Method for Therapeutic Drug Monitoring of 12 Antiepileptic Drugs and Their Main Metabolites in Human Plasma
The objective of the present report was to develop and validate a simple, selective, and reproducible high-performance liquid chromatography method with UV detection suitable for routine therapeutic drug monitoring of the most commonly used antiepileptic drugs and some of their metabolites. Simple precipitation of plasma proteins with acetonitrile was used for sample preparation. 10,11-dihydrocarbamazepine was used as an internal standard. Chromatographic separation of the analytes was achieved by gradient elution on a Phenyl–Hexyl column at 40 °C, using methanol and potassium phosphate buffer (25...
Source: Molecules - November 28, 2023 Category: Chemistry Authors: Daniela Milosheska Robert Ro škar Tags: Article Source Type: research
Epilepsy and inequality: demographic description and analysis of the difficulty in accessing advanced resources in a population in a small health area
CONCLUSIONS: This study demonstrates that epilepsy inequality continues to be a problem, especially in certain geographical areas, with a lack of access to advanced care for patients who need it most. The solution can be achieved by increasing human and material resources to improve overall patient care, thus strengthening both referral hospitals and epilepsy units.PMID:38010783 | DOI:10.33588/rn.7711.2023262 (Source: Revista de Neurologia)
Source: Revista de Neurologia - November 27, 2023 Category: Neurology Authors: V M P érez-Navarro M C ánovas-Iniesta B Palaz ón-Cabanes M Navarro-Lozano Source Type: research
Epilepsy and inequality: demographic description and analysis of the difficulty in accessing advanced resources in a population in a small health area
CONCLUSIONS: This study demonstrates that epilepsy inequality continues to be a problem, especially in certain geographical areas, with a lack of access to advanced care for patients who need it most. The solution can be achieved by increasing human and material resources to improve overall patient care, thus strengthening both referral hospitals and epilepsy units.PMID:38010783 | DOI:10.33588/rn.7711.2023262 (Source: Revista de Neurologia)
Source: Revista de Neurologia - November 27, 2023 Category: Neurology Authors: V M P érez-Navarro M C ánovas-Iniesta B Palaz ón-Cabanes M Navarro-Lozano Source Type: research
Epilepsy and inequality: demographic description and analysis of the difficulty in accessing advanced resources in a population in a small health area
CONCLUSIONS: This study demonstrates that epilepsy inequality continues to be a problem, especially in certain geographical areas, with a lack of access to advanced care for patients who need it most. The solution can be achieved by increasing human and material resources to improve overall patient care, thus strengthening both referral hospitals and epilepsy units.PMID:38010783 | DOI:10.33588/rn.7711.2023262 (Source: Revista de Neurologia)
Source: Revista de Neurologia - November 27, 2023 Category: Neurology Authors: V M P érez-Navarro M C ánovas-Iniesta B Palaz ón-Cabanes M Navarro-Lozano Source Type: research
Characterising people with focal drug-resistant epilepsy: A retrospective cohort study
Epilepsy Behav. 2023 Nov 24;149:109540. doi: 10.1016/j.yebeh.2023.109540. Online ahead of print.ABSTRACTOBJECTIVES: To describe the demographics, clinical characteristics, drug treatment outcomes, healthcare resource utilization, and injuries among people with focal drug-resistant epilepsy (F-DRE) analysed separately for six European countries.METHODS: We used electronic medical record data from six European (Belgium, Spain, Italy, France, UK and Germany) primary care/specialist care databases to identify antiseizure medication (ASM) treatment-naïve people (aged ≥ 18 years at F-DRE diagnosis). They were followed from th...
Source: Epilepsy and Behaviour - November 25, 2023 Category: Neurology Authors: Caroline Benoist Simona Boccaletti John Paul Leach Agnese Cattaneo Anna Chaplin Luis Antunes Franca Heiman Josemir W Sander Source Type: research
Combination of multivariate data analysis and mixing modelling to assess tracer potential of contaminants of emerging concern in aquifers
In this study, we present an approach that incorporates multivariate statistical analysis (principal component analysis (PCA) and Kohonen's Self-Organizing Map method (SOM)) and mixing modelling to identify the most suitable CECs to be employed as anthropogenic tracers. The study area is located in the Besòs River Delta (Barcelona, NE Spain) and represents the highly mixed aquifer system. A one-year monthly based monitoring campaign was performed to collect the information about the concentrations of 105 CECs as well as major and minor ions in the river and along the groundwater flow. The dimensionality of the obtained da...
Source: Environmental Pollution - November 25, 2023 Category: Environmental Health Authors: Olha Nikolenko Francesc Labad Estanislao Pujades Laura Scheiber Sandra P érez Antoni Ginebreda Anna Jurado Source Type: research
Characterising people with focal drug-resistant epilepsy: A retrospective cohort study
Epilepsy Behav. 2023 Nov 24;149:109540. doi: 10.1016/j.yebeh.2023.109540. Online ahead of print.ABSTRACTOBJECTIVES: To describe the demographics, clinical characteristics, drug treatment outcomes, healthcare resource utilization, and injuries among people with focal drug-resistant epilepsy (F-DRE) analysed separately for six European countries.METHODS: We used electronic medical record data from six European (Belgium, Spain, Italy, France, UK and Germany) primary care/specialist care databases to identify antiseizure medication (ASM) treatment-naïve people (aged ≥ 18 years at F-DRE diagnosis). They were followed from th...
Source: Epilepsy and Behaviour - November 25, 2023 Category: Neurology Authors: Caroline Benoist Simona Boccaletti John Paul Leach Agnese Cattaneo Anna Chaplin Luis Antunes Franca Heiman Josemir W Sander Source Type: research
Combination of multivariate data analysis and mixing modelling to assess tracer potential of contaminants of emerging concern in aquifers
In this study, we present an approach that incorporates multivariate statistical analysis (principal component analysis (PCA) and Kohonen's Self-Organizing Map method (SOM)) and mixing modelling to identify the most suitable CECs to be employed as anthropogenic tracers. The study area is located in the Besòs River Delta (Barcelona, NE Spain) and represents the highly mixed aquifer system. A one-year monthly based monitoring campaign was performed to collect the information about the concentrations of 105 CECs as well as major and minor ions in the river and along the groundwater flow. The dimensionality of the obtained da...
Source: Environmental Pollution - November 25, 2023 Category: Environmental Health Authors: Olha Nikolenko Francesc Labad Estanislao Pujades Laura Scheiber Sandra P érez Antoni Ginebreda Anna Jurado Source Type: research
Time-course changes in lamotrigine concentration after addition of valproate and the safety and long-term tolerability of lamotrigine-valproate combination therapy
Biol Pharm Bull. 2023 Nov 10. doi: 10.1248/bpb.b23-00608. Online ahead of print.ABSTRACTThe aim of this study was to evaluate the time-course changes in lamotrigine (LTG) concentration after addition of valproate (VPA) and the safety and tolerability of the combination therapy.We reviewed our therapeutic drug monitoring (TDM) database and found 345 patients on LTG who received add-on therapy with VPA. VPA had been added at least 12 weeks after patients finished stepwise LTG titration. Also, we retrospectively evaluated the LTG concentration after addition of VPA and the safety and long-term tolerability of LTG-VPA combinat...
Source: Biological and Pharmaceutical Bulletin - November 12, 2023 Category: Drugs & Pharmacology Authors: Yoshiaki Yamamoto Naotaka Usui Yoshiyuki Kagawa Katsumi Imai Source Type: research
Time-course changes in lamotrigine concentration after addition of valproate and the safety and long-term tolerability of lamotrigine-valproate combination therapy
Biol Pharm Bull. 2023 Nov 10. doi: 10.1248/bpb.b23-00608. Online ahead of print.ABSTRACTThe aim of this study was to evaluate the time-course changes in lamotrigine (LTG) concentration after addition of valproate (VPA) and the safety and tolerability of the combination therapy.We reviewed our therapeutic drug monitoring (TDM) database and found 345 patients on LTG who received add-on therapy with VPA. VPA had been added at least 12 weeks after patients finished stepwise LTG titration. Also, we retrospectively evaluated the LTG concentration after addition of VPA and the safety and long-term tolerability of LTG-VPA combinat...
Source: Biological and Pharmaceutical Bulletin - November 12, 2023 Category: Drugs & Pharmacology Authors: Yoshiaki Yamamoto Naotaka Usui Yoshiyuki Kagawa Katsumi Imai Source Type: research
Time-course changes in lamotrigine concentration after addition of valproate and the safety and long-term tolerability of lamotrigine-valproate combination therapy
Biol Pharm Bull. 2023 Nov 10. doi: 10.1248/bpb.b23-00608. Online ahead of print.ABSTRACTThe aim of this study was to evaluate the time-course changes in lamotrigine (LTG) concentration after addition of valproate (VPA) and the safety and tolerability of the combination therapy.We reviewed our therapeutic drug monitoring (TDM) database and found 345 patients on LTG who received add-on therapy with VPA. VPA had been added at least 12 weeks after patients finished stepwise LTG titration. Also, we retrospectively evaluated the LTG concentration after addition of VPA and the safety and long-term tolerability of LTG-VPA combinat...
Source: Biological and Pharmaceutical Bulletin - November 12, 2023 Category: Drugs & Pharmacology Authors: Yoshiaki Yamamoto Naotaka Usui Yoshiyuki Kagawa Katsumi Imai Source Type: research
Development of a UPLC-MS/MS method for the determination of lacosamide and its metabolite and its application to drug-drug interaction
Lacosamide, a third-generation novel antiepileptic drug, was first approved in 2008 as an adjunct to partial seizures. In 2014, the U.S. Food and Drug Administration (FDA) approved it as a single agent for partial seizures. Since epilepsy is a chronic condition, most patients need long-term antiepileptic medicinal products, so it is even more important to consider the drug-drug interactions (DDIs). For the purpose of this experiment, an ultra performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) assay with accuracy and simplicity was optimized and fully validated for the simultaneous quantitative determin...
Source: Frontiers in Pharmacology - November 10, 2023 Category: Drugs & Pharmacology Source Type: research
