Development of a UPLC-MS/MS method for the determination of lacosamide and its metabolite and its application to drug-drug interaction
Lacosamide, a third-generation novel antiepileptic drug, was first approved in 2008 as an adjunct to partial seizures. In 2014, the U.S. Food and Drug Administration (FDA) approved it as a single agent for partial seizures. Since epilepsy is a chronic condition, most patients need long-term antiepileptic medicinal products, so it is even more important to consider the drug-drug interactions (DDIs). For the purpose of this experiment, an ultra performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) assay with accuracy and simplicity was optimized and fully validated for the simultaneous quantitative determin...
Source: Frontiers in Pharmacology - November 10, 2023 Category: Drugs & Pharmacology Source Type: research
Leukopenia associated with lamotrigine initiation after COVID-19 vaccine booster: A case report and literature review
Int J Clin Pharmacol Ther. 2023 Nov 9. doi: 10.5414/CP204452. Online ahead of print.ABSTRACTAdverse lamotrigine effects are more likely with concomitant use of antiepileptic drugs, rapid dose titration, and multiple drug use, highlighting the importance of measuring its concentration. Here, lamotrigine was administered the day after the third mRNA vaccination to a 20-year-old bipolar woman with these risk factors. Leukopenia occurred on day 12 without rapid concentration increase, but leukocytes gradually recovered after 22 weeks without discontinuation of lamotrigine. The second mRNA vaccination did not induce leukopenia....
Source: International Journal of Clinical Pharmacology and Therapeutics - November 9, 2023 Category: Drugs & Pharmacology Authors: Tsukasa Murata Katsuaki Uno Miki Ito Takahiko Nagamine Source Type: research
Management of Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis: A Case Report and Literature Review
DISCUSSION: This literature review highlights how SJS/TEN may present differently in patients on immune checkpoint inhibitors. Treatments in these cases may vary from those with classic SJS/TEN. Specifically, etanercept given days late into the disease course is effective in speeding re-epithelialization and tapering of already given corticosteroids in classic SJS/TEN. J Drugs Dermatol. 2023;22(11):e24-e28 doi:10.36849/JDD.6999e.PMID:37943271 | DOI:10.36849/JDD.6999 (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - November 9, 2023 Category: Dermatology Authors: Shannon Meledathu Michael Gordon Mason Thornton Robin Ashinoff Source Type: research
Leukopenia associated with lamotrigine initiation after COVID-19 vaccine booster: A case report and literature review
Int J Clin Pharmacol Ther. 2023 Nov 9. doi: 10.5414/CP204452. Online ahead of print.ABSTRACTAdverse lamotrigine effects are more likely with concomitant use of antiepileptic drugs, rapid dose titration, and multiple drug use, highlighting the importance of measuring its concentration. Here, lamotrigine was administered the day after the third mRNA vaccination to a 20-year-old bipolar woman with these risk factors. Leukopenia occurred on day 12 without rapid concentration increase, but leukocytes gradually recovered after 22 weeks without discontinuation of lamotrigine. The second mRNA vaccination did not induce leukopenia....
Source: Clinical Pharmacology and Therapeutics - November 9, 2023 Category: Drugs & Pharmacology Authors: Tsukasa Murata Katsuaki Uno Miki Ito Takahiko Nagamine Source Type: research
Management of Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis: A Case Report and Literature Review
DISCUSSION: This literature review highlights how SJS/TEN may present differently in patients on immune checkpoint inhibitors. Treatments in these cases may vary from those with classic SJS/TEN. Specifically, etanercept given days late into the disease course is effective in speeding re-epithelialization and tapering of already given corticosteroids in classic SJS/TEN. J Drugs Dermatol. 2023;22(11):e24-e28 doi:10.36849/JDD.6999e.PMID:37943271 | DOI:10.36849/JDD.6999 (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - November 9, 2023 Category: Dermatology Authors: Shannon Meledathu Michael Gordon Mason Thornton Robin Ashinoff Source Type: research
Leukopenia associated with lamotrigine initiation after COVID-19 vaccine booster: A case report and literature review
Int J Clin Pharmacol Ther. 2023 Nov 9. doi: 10.5414/CP204452. Online ahead of print.ABSTRACTAdverse lamotrigine effects are more likely with concomitant use of antiepileptic drugs, rapid dose titration, and multiple drug use, highlighting the importance of measuring its concentration. Here, lamotrigine was administered the day after the third mRNA vaccination to a 20-year-old bipolar woman with these risk factors. Leukopenia occurred on day 12 without rapid concentration increase, but leukocytes gradually recovered after 22 weeks without discontinuation of lamotrigine. The second mRNA vaccination did not induce leukopenia....
Source: International Journal of Clinical Pharmacology and Therapeutics - November 9, 2023 Category: Drugs & Pharmacology Authors: Tsukasa Murata Katsuaki Uno Miki Ito Takahiko Nagamine Source Type: research
Management of Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis: A Case Report and Literature Review
DISCUSSION: This literature review highlights how SJS/TEN may present differently in patients on immune checkpoint inhibitors. Treatments in these cases may vary from those with classic SJS/TEN. Specifically, etanercept given days late into the disease course is effective in speeding re-epithelialization and tapering of already given corticosteroids in classic SJS/TEN. J Drugs Dermatol. 2023;22(11):e24-e28 doi:10.36849/JDD.6999e.PMID:37943271 | DOI:10.36849/JDD.6999 (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - November 9, 2023 Category: Dermatology Authors: Shannon Meledathu Michael Gordon Mason Thornton Robin Ashinoff Source Type: research
Leukopenia associated with lamotrigine initiation after COVID-19 vaccine booster: A case report and literature review
Int J Clin Pharmacol Ther. 2023 Nov 9. doi: 10.5414/CP204452. Online ahead of print.ABSTRACTAdverse lamotrigine effects are more likely with concomitant use of antiepileptic drugs, rapid dose titration, and multiple drug use, highlighting the importance of measuring its concentration. Here, lamotrigine was administered the day after the third mRNA vaccination to a 20-year-old bipolar woman with these risk factors. Leukopenia occurred on day 12 without rapid concentration increase, but leukocytes gradually recovered after 22 weeks without discontinuation of lamotrigine. The second mRNA vaccination did not induce leukopenia....
Source: International Journal of Clinical Pharmacology and Therapeutics - November 9, 2023 Category: Drugs & Pharmacology Authors: Tsukasa Murata Katsuaki Uno Miki Ito Takahiko Nagamine Source Type: research
Management of Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis: A Case Report and Literature Review
DISCUSSION: This literature review highlights how SJS/TEN may present differently in patients on immune checkpoint inhibitors. Treatments in these cases may vary from those with classic SJS/TEN. Specifically, etanercept given days late into the disease course is effective in speeding re-epithelialization and tapering of already given corticosteroids in classic SJS/TEN. J Drugs Dermatol. 2023;22(11):e24-e28 doi:10.36849/JDD.6999e.PMID:37943271 | DOI:10.36849/JDD.6999 (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - November 9, 2023 Category: Dermatology Authors: Shannon Meledathu Michael Gordon Mason Thornton Robin Ashinoff Source Type: research
Leukopenia associated with lamotrigine initiation after COVID-19 vaccine booster: A case report and literature review
Int J Clin Pharmacol Ther. 2023 Nov 9. doi: 10.5414/CP204452. Online ahead of print.ABSTRACTAdverse lamotrigine effects are more likely with concomitant use of antiepileptic drugs, rapid dose titration, and multiple drug use, highlighting the importance of measuring its concentration. Here, lamotrigine was administered the day after the third mRNA vaccination to a 20-year-old bipolar woman with these risk factors. Leukopenia occurred on day 12 without rapid concentration increase, but leukocytes gradually recovered after 22 weeks without discontinuation of lamotrigine. The second mRNA vaccination did not induce leukopenia....
Source: International Journal of Clinical Pharmacology and Therapeutics - November 9, 2023 Category: Drugs & Pharmacology Authors: Tsukasa Murata Katsuaki Uno Miki Ito Takahiko Nagamine Source Type: research
Management of Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis: A Case Report and Literature Review
DISCUSSION: This literature review highlights how SJS/TEN may present differently in patients on immune checkpoint inhibitors. Treatments in these cases may vary from those with classic SJS/TEN. Specifically, etanercept given days late into the disease course is effective in speeding re-epithelialization and tapering of already given corticosteroids in classic SJS/TEN. J Drugs Dermatol. 2023;22(11):e24-e28 doi:10.36849/JDD.6999e.PMID:37943271 | DOI:10.36849/JDD.6999 (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - November 9, 2023 Category: Dermatology Authors: Shannon Meledathu Michael Gordon Mason Thornton Robin Ashinoff Source Type: research
Leukopenia associated with lamotrigine initiation after COVID-19 vaccine booster: A case report and literature review
Int J Clin Pharmacol Ther. 2023 Nov 9. doi: 10.5414/CP204452. Online ahead of print.ABSTRACTAdverse lamotrigine effects are more likely with concomitant use of antiepileptic drugs, rapid dose titration, and multiple drug use, highlighting the importance of measuring its concentration. Here, lamotrigine was administered the day after the third mRNA vaccination to a 20-year-old bipolar woman with these risk factors. Leukopenia occurred on day 12 without rapid concentration increase, but leukocytes gradually recovered after 22 weeks without discontinuation of lamotrigine. The second mRNA vaccination did not induce leukopenia....
Source: International Journal of Clinical Pharmacology and Therapeutics - November 9, 2023 Category: Drugs & Pharmacology Authors: Tsukasa Murata Katsuaki Uno Miki Ito Takahiko Nagamine Source Type: research
Management of Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis: A Case Report and Literature Review
DISCUSSION: This literature review highlights how SJS/TEN may present differently in patients on immune checkpoint inhibitors. Treatments in these cases may vary from those with classic SJS/TEN. Specifically, etanercept given days late into the disease course is effective in speeding re-epithelialization and tapering of already given corticosteroids in classic SJS/TEN. J Drugs Dermatol. 2023;22(11):e24-e28 doi:10.36849/JDD.6999e.PMID:37943271 | DOI:10.36849/JDD.6999 (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - November 9, 2023 Category: Dermatology Authors: Shannon Meledathu Michael Gordon Mason Thornton Robin Ashinoff Source Type: research
