Antiepileptic Strategies for Patients with Primary and Metastatic Brain Tumors
Curr Treat Options Oncol. 2024 Feb 14. doi: 10.1007/s11864-024-01182-8. Online ahead of print.ABSTRACTSeizure activity is common in patients with primary and metastatic brain tumors, affecting more than 50% of cases over the course of their disease. Several mechanisms contribute to brain tumor-related epilepsy (BTRE), including a pro-inflammatory environment, excessive secretion of glutamate and an increase in neuronal excitatory tone, reduction of GABAergic inhibitory activity, and an increase in 2-hydroxygluturate production in isocitrate dehydrogenase mutant tumors. After a verified seizure in a brain tumor patient, the...
Source: Epilepsy Curr - February 14, 2024 Category: Neurology Authors: Herbert B Newton Jenna Wojkowski Source Type: research
Antiepileptic Strategies for Patients with Primary and Metastatic Brain Tumors
Curr Treat Options Oncol. 2024 Feb 14. doi: 10.1007/s11864-024-01182-8. Online ahead of print.ABSTRACTSeizure activity is common in patients with primary and metastatic brain tumors, affecting more than 50% of cases over the course of their disease. Several mechanisms contribute to brain tumor-related epilepsy (BTRE), including a pro-inflammatory environment, excessive secretion of glutamate and an increase in neuronal excitatory tone, reduction of GABAergic inhibitory activity, and an increase in 2-hydroxygluturate production in isocitrate dehydrogenase mutant tumors. After a verified seizure in a brain tumor patient, the...
Source: Epilepsy Curr - February 14, 2024 Category: Neurology Authors: Herbert B Newton Jenna Wojkowski Source Type: research
Antiepileptic Strategies for Patients with Primary and Metastatic Brain Tumors
Opinion statementSeizure activity is common in patients with primary and metastatic brain tumors, affecting more than 50% of cases over the course of their disease. Several mechanisms contribute to brain tumor –related epilepsy (BTRE), including a pro-inflammatory environment, excessive secretion of glutamate and an increase in neuronal excitatory tone, reduction of GABAergic inhibitory activity, and an increase in 2-hydroxygluturate production in isocitrate dehydrogenase mutant tumors. After a verified seizure in a brain tumor patient, the consensus is that BTRE has developed, and it is necessary to initiate an antiepil...
Source: Current Treatment Options in Oncology - February 14, 2024 Category: Cancer & Oncology Source Type: research
Exploring the impact of pharmacogenetics on personalized medicine: A systematic review
CONCLUSION: The studies analyzed in this review suggest a strong correlation between genetic variability and individual drug responses, supporting the use of pharmacogenetics for treatment optimization. However, for certain drugs like metformin or quetiapine, the influence of genotype on their response remains unclear. More studies with larger sample sizes, greater ethnic diversity, and consideration of non-genetic factors are needed. The lack of standardization in analysis methods and accessibility to genetic testing are significant challenges in this field. As a conclusion, pharmacogenetics shows immense potential in per...
Source: Farmacia Hospitalaria - February 10, 2024 Category: Drugs & Pharmacology Authors: Laura Amaro- Álvarez Jaime Cordero-Ramos Miguel Ángel Calleja-Hernández Source Type: research
Exploring the impact of pharmacogenetics on personalized medicine: A systematic review
CONCLUSION: The studies analyzed in this review suggest a strong correlation between genetic variability and individual drug responses, supporting the use of pharmacogenetics for treatment optimization. However, for certain drugs like metformin or quetiapine, the influence of genotype on their response remains unclear. More studies with larger sample sizes, greater ethnic diversity, and consideration of non-genetic factors are needed. The lack of standardization in analysis methods and accessibility to genetic testing are significant challenges in this field. As a conclusion, pharmacogenetics shows immense potential in per...
Source: Farmacia Hospitalaria - February 10, 2024 Category: Drugs & Pharmacology Authors: Laura Amaro- Álvarez Jaime Cordero-Ramos Miguel Ángel Calleja-Hernández Source Type: research
Exploring the impact of pharmacogenetics on personalized medicine: A systematic review
CONCLUSION: The studies analyzed in this review suggest a strong correlation between genetic variability and individual drug responses, supporting the use of pharmacogenetics for treatment optimization. However, for certain drugs like metformin or quetiapine, the influence of genotype on their response remains unclear. More studies with larger sample sizes, greater ethnic diversity, and consideration of non-genetic factors are needed. The lack of standardization in analysis methods and accessibility to genetic testing are significant challenges in this field. As a conclusion, pharmacogenetics shows immense potential in per...
Source: Farmacia Hospitalaria - February 10, 2024 Category: Drugs & Pharmacology Authors: Laura Amaro- Álvarez Jaime Cordero-Ramos Miguel Ángel Calleja-Hernández Source Type: research
Exploring the impact of pharmacogenetics on personalized medicine: A systematic review
CONCLUSION: The studies analyzed in this review suggest a strong correlation between genetic variability and individual drug responses, supporting the use of pharmacogenetics for treatment optimization. However, for certain drugs like metformin or quetiapine, the influence of genotype on their response remains unclear. More studies with larger sample sizes, greater ethnic diversity, and consideration of non-genetic factors are needed. The lack of standardization in analysis methods and accessibility to genetic testing are significant challenges in this field. As a conclusion, pharmacogenetics shows immense potential in per...
Source: Farmacia Hospitalaria - February 10, 2024 Category: Drugs & Pharmacology Authors: Laura Amaro- Álvarez Jaime Cordero-Ramos Miguel Ángel Calleja-Hernández Source Type: research
Exploring the impact of pharmacogenetics on personalized medicine: A systematic review
CONCLUSION: The studies analyzed in this review suggest a strong correlation between genetic variability and individual drug responses, supporting the use of pharmacogenetics for treatment optimization. However, for certain drugs like metformin or quetiapine, the influence of genotype on their response remains unclear. More studies with larger sample sizes, greater ethnic diversity, and consideration of non-genetic factors are needed. The lack of standardization in analysis methods and accessibility to genetic testing are significant challenges in this field. As a conclusion, pharmacogenetics shows immense potential in per...
Source: Farmacia Hospitalaria - February 10, 2024 Category: Drugs & Pharmacology Authors: Laura Amaro- Álvarez Jaime Cordero-Ramos Miguel Ángel Calleja-Hernández Source Type: research
Exploring the impact of pharmacogenetics on personalized medicine: A systematic review
CONCLUSION: The studies analyzed in this review suggest a strong correlation between genetic variability and individual drug responses, supporting the use of pharmacogenetics for treatment optimization. However, for certain drugs like metformin or quetiapine, the influence of genotype on their response remains unclear. More studies with larger sample sizes, greater ethnic diversity, and consideration of non-genetic factors are needed. The lack of standardization in analysis methods and accessibility to genetic testing are significant challenges in this field. As a conclusion, pharmacogenetics shows immense potential in per...
Source: Farmacia Hospitalaria - February 10, 2024 Category: Drugs & Pharmacology Authors: Laura Amaro- Álvarez Jaime Cordero-Ramos Miguel Ángel Calleja-Hernández Source Type: research
Exploring the impact of pharmacogenetics on personalized medicine: A systematic review
CONCLUSION: The studies analyzed in this review suggest a strong correlation between genetic variability and individual drug responses, supporting the use of pharmacogenetics for treatment optimization. However, for certain drugs like metformin or quetiapine, the influence of genotype on their response remains unclear. More studies with larger sample sizes, greater ethnic diversity, and consideration of non-genetic factors are needed. The lack of standardization in analysis methods and accessibility to genetic testing are significant challenges in this field. As a conclusion, pharmacogenetics shows immense potential in per...
Source: Farmacia Hospitalaria - February 10, 2024 Category: Drugs & Pharmacology Authors: Laura Amaro- Álvarez Jaime Cordero-Ramos Miguel Ángel Calleja-Hernández Source Type: research
Exploring the impact of pharmacogenetics on personalized medicine: A systematic review
CONCLUSION: The studies analyzed in this review suggest a strong correlation between genetic variability and individual drug responses, supporting the use of pharmacogenetics for treatment optimization. However, for certain drugs like metformin or quetiapine, the influence of genotype on their response remains unclear. More studies with larger sample sizes, greater ethnic diversity, and consideration of non-genetic factors are needed. The lack of standardization in analysis methods and accessibility to genetic testing are significant challenges in this field. As a conclusion, pharmacogenetics shows immense potential in per...
Source: Farmacia Hospitalaria - February 10, 2024 Category: Drugs & Pharmacology Authors: Laura Amaro- Álvarez Jaime Cordero-Ramos Miguel Ángel Calleja-Hernández Source Type: research
Exploring the impact of pharmacogenetics on personalized medicine: A systematic review
CONCLUSION: The studies analyzed in this review suggest a strong correlation between genetic variability and individual drug responses, supporting the use of pharmacogenetics for treatment optimization. However, for certain drugs like metformin or quetiapine, the influence of genotype on their response remains unclear. More studies with larger sample sizes, greater ethnic diversity, and consideration of non-genetic factors are needed. The lack of standardization in analysis methods and accessibility to genetic testing are significant challenges in this field. As a conclusion, pharmacogenetics shows immense potential in per...
Source: Farmacia Hospitalaria - February 10, 2024 Category: Drugs & Pharmacology Authors: Laura Amaro- Álvarez Jaime Cordero-Ramos Miguel Ángel Calleja-Hernández Source Type: research
Exploring the impact of pharmacogenetics on personalized medicine: A systematic review
CONCLUSION: The studies analyzed in this review suggest a strong correlation between genetic variability and individual drug responses, supporting the use of pharmacogenetics for treatment optimization. However, for certain drugs like metformin or quetiapine, the influence of genotype on their response remains unclear. More studies with larger sample sizes, greater ethnic diversity, and consideration of non-genetic factors are needed. The lack of standardization in analysis methods and accessibility to genetic testing are significant challenges in this field. As a conclusion, pharmacogenetics shows immense potential in per...
Source: Farmacia Hospitalaria - February 10, 2024 Category: Drugs & Pharmacology Authors: Laura Amaro- Álvarez Jaime Cordero-Ramos Miguel Ángel Calleja-Hernández Source Type: research
Exploring the impact of pharmacogenetics on personalized medicine: A systematic review
CONCLUSION: The studies analyzed in this review suggest a strong correlation between genetic variability and individual drug responses, supporting the use of pharmacogenetics for treatment optimization. However, for certain drugs like metformin or quetiapine, the influence of genotype on their response remains unclear. More studies with larger sample sizes, greater ethnic diversity, and consideration of non-genetic factors are needed. The lack of standardization in analysis methods and accessibility to genetic testing are significant challenges in this field. As a conclusion, pharmacogenetics shows immense potential in per...
Source: Farmacia Hospitalaria - February 10, 2024 Category: Drugs & Pharmacology Authors: Laura Amaro- Álvarez Jaime Cordero-Ramos Miguel Ángel Calleja-Hernández Source Type: research
Biochemical evaluation and ligand binding studies on glycerophosphodiester phosphodiesterase from Staphylococcus aureus using STD-NMR spectroscopy and molecular docking analysis
In this study, competent E. coli BL21(DE3)pLysS expression cells were used to express the GDPD enzyme from vancomycin-resistant Staphylococcus aureus (VRSA), which was then purified using size exclusion and anion exchange chromatography. The hydrolytic activity of GDPD was evaluated on the non-physiological substrate bis(p-nitrophenyl) phosphate (BpNPP), which indicated functional activity of the enzyme. 79 drugs were evaluated for their inhibitory potential against GDPD enzyme by the colorimetric assay. Out of 79 drugs, 13 drugs, including tenofovir (1), adenosine (2), clioquinol (11), bromazepam (12), lamotrigine (13), s...
Source: Bioorganic Chemistry - February 9, 2024 Category: Chemistry Authors: Uzma Salar None Atia-Tul-Wahab M Iqbal Choudhary Source Type: research
