Toward identifying key mechanisms of progression in multiple sclerosis
Trends Neurosci. 2023 Dec 14:S0166-2236(23)00265-5. doi: 10.1016/j.tins.2023.11.005. Online ahead of print.ABSTRACTA major therapeutic goal in the treatment of multiple sclerosis (MS) is to prevent the accumulation of disability over an often decades-long disease course. Disability progression can result from acute relapses as well as from CNS intrinsic parenchymal disintegration without de novo CNS lesion formation. Research focus has shifted to progression not associated with acute inflammation, as it is not sufficiently controlled by currently available treatments. This review outlines how recent advances in the underst...
Source: Trends in Neurosciences - December 15, 2023 Category: Neuroscience Authors: Leila Husseini Anastasia Geladaris Martin S Weber Source Type: research
The locus coeruleus as a global model failure system
Trends Neurosci. 2023 Dec 14:S0166-2236(23)00268-0. doi: 10.1016/j.tins.2023.11.006. Online ahead of print.ABSTRACTPredictive processing models posit that brains constantly attempt to predict their sensory inputs. Prediction errors signal when these predictions are incorrect and are thought to be instructive signals that drive corrective plasticity. Recent findings support the idea that the locus coeruleus (LC) - a brain-wide neuromodulatory system - signals several types of prediction error. I discuss how these findings support models proposing that the LC signals global model failures: instances where predictions about t...
Source: Trends in Neurosciences - December 15, 2023 Category: Neuroscience Authors: Rebecca Jordan Source Type: research
Toward identifying key mechanisms of progression in multiple sclerosis
Trends Neurosci. 2023 Dec 14:S0166-2236(23)00265-5. doi: 10.1016/j.tins.2023.11.005. Online ahead of print.ABSTRACTA major therapeutic goal in the treatment of multiple sclerosis (MS) is to prevent the accumulation of disability over an often decades-long disease course. Disability progression can result from acute relapses as well as from CNS intrinsic parenchymal disintegration without de novo CNS lesion formation. Research focus has shifted to progression not associated with acute inflammation, as it is not sufficiently controlled by currently available treatments. This review outlines how recent advances in the underst...
Source: Trends in Neurosciences - December 15, 2023 Category: Neuroscience Authors: Leila Husseini Anastasia Geladaris Martin S Weber Source Type: research
The locus coeruleus as a global model failure system
Trends Neurosci. 2023 Dec 14:S0166-2236(23)00268-0. doi: 10.1016/j.tins.2023.11.006. Online ahead of print.ABSTRACTPredictive processing models posit that brains constantly attempt to predict their sensory inputs. Prediction errors signal when these predictions are incorrect and are thought to be instructive signals that drive corrective plasticity. Recent findings support the idea that the locus coeruleus (LC) - a brain-wide neuromodulatory system - signals several types of prediction error. I discuss how these findings support models proposing that the LC signals global model failures: instances where predictions about t...
Source: Trends in Neurosciences - December 15, 2023 Category: Neuroscience Authors: Rebecca Jordan Source Type: research
Shared gustatory sensor for acids and ammonium
Trends Neurosci. 2023 Dec 8:S0166-2236(23)00271-0. doi: 10.1016/j.tins.2023.11.009. Online ahead of print.ABSTRACTIn a recent study, Liang, Wilson, and colleagues demonstrated that the H+-selective ion channel OTOP1, responsible for sour taste transduction, also functions as a gustatory sensor for ammonium in mice. Additionally, this research revealed a novel mode of channel activation by intracellular alkalinization, which is conserved across vertebrate species.PMID:38071122 | DOI:10.1016/j.tins.2023.11.009 (Source: Trends in Neurosciences)
Source: Trends in Neurosciences - December 9, 2023 Category: Neuroscience Authors: Akiyuki Taruno Source Type: research
Ontogeny of the circadian system: a multiscale process throughout development
Trends Neurosci. 2023 Dec 8:S0166-2236(23)00264-3. doi: 10.1016/j.tins.2023.11.004. Online ahead of print.ABSTRACTThe 24 h (circadian) timing system develops in mammals during the perinatal period. It carries out the essential task of anticipating daily recurring environmental changes to identify the best time of day for each molecular, cellular, and systemic process. Although significant knowledge has been acquired about the organization and function of the adult circadian system, relatively little is known about its ontogeny. During the perinatal period, the circadian system progressively gains functionality under the in...
Source: Trends in Neurosciences - December 9, 2023 Category: Neuroscience Authors: Maria Comas Davide De Pietri Tonelli Luca Berdondini Mariana Astiz Source Type: research
Shared gustatory sensor for acids and ammonium
Trends Neurosci. 2023 Dec 8:S0166-2236(23)00271-0. doi: 10.1016/j.tins.2023.11.009. Online ahead of print.ABSTRACTIn a recent study, Liang, Wilson, and colleagues demonstrated that the H+-selective ion channel OTOP1, responsible for sour taste transduction, also functions as a gustatory sensor for ammonium in mice. Additionally, this research revealed a novel mode of channel activation by intracellular alkalinization, which is conserved across vertebrate species.PMID:38071122 | DOI:10.1016/j.tins.2023.11.009 (Source: Trends in Neurosciences)
Source: Trends in Neurosciences - December 9, 2023 Category: Neuroscience Authors: Akiyuki Taruno Source Type: research
Ontogeny of the circadian system: a multiscale process throughout development
Trends Neurosci. 2023 Dec 8:S0166-2236(23)00264-3. doi: 10.1016/j.tins.2023.11.004. Online ahead of print.ABSTRACTThe 24 h (circadian) timing system develops in mammals during the perinatal period. It carries out the essential task of anticipating daily recurring environmental changes to identify the best time of day for each molecular, cellular, and systemic process. Although significant knowledge has been acquired about the organization and function of the adult circadian system, relatively little is known about its ontogeny. During the perinatal period, the circadian system progressively gains functionality under the in...
Source: Trends in Neurosciences - December 9, 2023 Category: Neuroscience Authors: Maria Comas Davide De Pietri Tonelli Luca Berdondini Mariana Astiz Source Type: research
Shared gustatory sensor for acids and ammonium
Trends Neurosci. 2023 Dec 8:S0166-2236(23)00271-0. doi: 10.1016/j.tins.2023.11.009. Online ahead of print.ABSTRACTIn a recent study, Liang, Wilson, and colleagues demonstrated that the H+-selective ion channel OTOP1, responsible for sour taste transduction, also functions as a gustatory sensor for ammonium in mice. Additionally, this research revealed a novel mode of channel activation by intracellular alkalinization, which is conserved across vertebrate species.PMID:38071122 | DOI:10.1016/j.tins.2023.11.009 (Source: Trends in Neurosciences)
Source: Trends in Neurosciences - December 9, 2023 Category: Neuroscience Authors: Akiyuki Taruno Source Type: research
Ontogeny of the circadian system: a multiscale process throughout development
Trends Neurosci. 2023 Dec 8:S0166-2236(23)00264-3. doi: 10.1016/j.tins.2023.11.004. Online ahead of print.ABSTRACTThe 24 h (circadian) timing system develops in mammals during the perinatal period. It carries out the essential task of anticipating daily recurring environmental changes to identify the best time of day for each molecular, cellular, and systemic process. Although significant knowledge has been acquired about the organization and function of the adult circadian system, relatively little is known about its ontogeny. During the perinatal period, the circadian system progressively gains functionality under the in...
Source: Trends in Neurosciences - December 9, 2023 Category: Neuroscience Authors: Maria Comas Davide De Pietri Tonelli Luca Berdondini Mariana Astiz Source Type: research
Shared gustatory sensor for acids and ammonium
Trends Neurosci. 2023 Dec 8:S0166-2236(23)00271-0. doi: 10.1016/j.tins.2023.11.009. Online ahead of print.ABSTRACTIn a recent study, Liang, Wilson, and colleagues demonstrated that the H+-selective ion channel OTOP1, responsible for sour taste transduction, also functions as a gustatory sensor for ammonium in mice. Additionally, this research revealed a novel mode of channel activation by intracellular alkalinization, which is conserved across vertebrate species.PMID:38071122 | DOI:10.1016/j.tins.2023.11.009 (Source: Trends in Neurosciences)
Source: Trends in Neurosciences - December 9, 2023 Category: Neuroscience Authors: Akiyuki Taruno Source Type: research
Ontogeny of the circadian system: a multiscale process throughout development
Trends Neurosci. 2023 Dec 8:S0166-2236(23)00264-3. doi: 10.1016/j.tins.2023.11.004. Online ahead of print.ABSTRACTThe 24 h (circadian) timing system develops in mammals during the perinatal period. It carries out the essential task of anticipating daily recurring environmental changes to identify the best time of day for each molecular, cellular, and systemic process. Although significant knowledge has been acquired about the organization and function of the adult circadian system, relatively little is known about its ontogeny. During the perinatal period, the circadian system progressively gains functionality under the in...
Source: Trends in Neurosciences - December 9, 2023 Category: Neuroscience Authors: Maria Comas Davide De Pietri Tonelli Luca Berdondini Mariana Astiz Source Type: research
Shared gustatory sensor for acids and ammonium
Trends Neurosci. 2023 Dec 8:S0166-2236(23)00271-0. doi: 10.1016/j.tins.2023.11.009. Online ahead of print.ABSTRACTIn a recent study, Liang, Wilson, and colleagues demonstrated that the H+-selective ion channel OTOP1, responsible for sour taste transduction, also functions as a gustatory sensor for ammonium in mice. Additionally, this research revealed a novel mode of channel activation by intracellular alkalinization, which is conserved across vertebrate species.PMID:38071122 | DOI:10.1016/j.tins.2023.11.009 (Source: Trends in Neurosciences)
Source: Trends in Neurosciences - December 9, 2023 Category: Neuroscience Authors: Akiyuki Taruno Source Type: research
Ontogeny of the circadian system: a multiscale process throughout development
Trends Neurosci. 2023 Dec 8:S0166-2236(23)00264-3. doi: 10.1016/j.tins.2023.11.004. Online ahead of print.ABSTRACTThe 24 h (circadian) timing system develops in mammals during the perinatal period. It carries out the essential task of anticipating daily recurring environmental changes to identify the best time of day for each molecular, cellular, and systemic process. Although significant knowledge has been acquired about the organization and function of the adult circadian system, relatively little is known about its ontogeny. During the perinatal period, the circadian system progressively gains functionality under the in...
Source: Trends in Neurosciences - December 9, 2023 Category: Neuroscience Authors: Maria Comas Davide De Pietri Tonelli Luca Berdondini Mariana Astiz Source Type: research
White matter injury across neurodegenerative disease
Trends Neurosci. 2023 Dec 4:S0166-2236(23)00263-1. doi: 10.1016/j.tins.2023.11.003. Online ahead of print.ABSTRACTOligodendrocytes (OLs), the myelin-generating cells of the central nervous system (CNS), are active players in shaping neuronal circuitry and function. It has become increasingly apparent that injury to cells within the OL lineage plays a central role in neurodegeneration. In this review, we focus primarily on three degenerative disorders in which white matter loss is well documented: Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS). We discuss clinical data implicatin...
Source: Trends in Neurosciences - December 5, 2023 Category: Neuroscience Authors: Lindsay K Festa Judith B Grinspan Kelly L Jordan-Sciutto Source Type: research
