Hidden variables in stress neurobiology research
Trends Neurosci. 2023 Nov 18:S0166-2236(23)00247-3. doi: 10.1016/j.tins.2023.10.006. Online ahead of print.ABSTRACTAmong the central goals of stress neurobiology research is to understand the mechanisms by which stressors change neural circuit function to precipitate or exacerbate psychiatric symptoms. Yet despite decades of effort, psychiatric medications that target the biological substrates of the stress response are largely lacking. We propose that the clinical advancement of stress response-based therapeutics for psychiatric disorders may be hindered by 'hidden variables' in stress research, including considerations o...
Source: Trends in Neurosciences - November 20, 2023 Category: Neuroscience Authors: Ashley L Holloway Talia N Lerner Source Type: research
Epigenetic mechanisms underlying sex differences in the brain and behavior
Trends Neurosci. 2023 Nov 13:S0166-2236(23)00225-4. doi: 10.1016/j.tins.2023.09.007. Online ahead of print.ABSTRACTSex differences are found across brain regions, behaviors, and brain diseases. Sexual differentiation of the brain is initiated prenatally but it continues throughout life, as a result of the interaction of three major factors: gonadal hormones, sex chromosomes, and the environment. These factors are thought to act, in part, via epigenetic mechanisms which control chromatin and transcriptional states in brain cells. In this review, we discuss evidence that epigenetic mechanisms underlie sex-specific neurobehav...
Source: Trends in Neurosciences - November 15, 2023 Category: Neuroscience Authors: Marija Kundakovic Maria Tickerhoof Source Type: research
Epigenetic mechanisms underlying sex differences in the brain and behavior
Trends Neurosci. 2023 Nov 13:S0166-2236(23)00225-4. doi: 10.1016/j.tins.2023.09.007. Online ahead of print.ABSTRACTSex differences are found across brain regions, behaviors, and brain diseases. Sexual differentiation of the brain is initiated prenatally but it continues throughout life, as a result of the interaction of three major factors: gonadal hormones, sex chromosomes, and the environment. These factors are thought to act, in part, via epigenetic mechanisms which control chromatin and transcriptional states in brain cells. In this review, we discuss evidence that epigenetic mechanisms underlie sex-specific neurobehav...
Source: Trends in Neurosciences - November 15, 2023 Category: Neuroscience Authors: Marija Kundakovic Maria Tickerhoof Source Type: research
Epigenetic mechanisms underlying sex differences in the brain and behavior
Trends Neurosci. 2023 Nov 13:S0166-2236(23)00225-4. doi: 10.1016/j.tins.2023.09.007. Online ahead of print.ABSTRACTSex differences are found across brain regions, behaviors, and brain diseases. Sexual differentiation of the brain is initiated prenatally but it continues throughout life, as a result of the interaction of three major factors: gonadal hormones, sex chromosomes, and the environment. These factors are thought to act, in part, via epigenetic mechanisms which control chromatin and transcriptional states in brain cells. In this review, we discuss evidence that epigenetic mechanisms underlie sex-specific neurobehav...
Source: Trends in Neurosciences - November 15, 2023 Category: Neuroscience Authors: Marija Kundakovic Maria Tickerhoof Source Type: research
Epigenetic mechanisms underlying sex differences in the brain and behavior
Trends Neurosci. 2023 Nov 13:S0166-2236(23)00225-4. doi: 10.1016/j.tins.2023.09.007. Online ahead of print.ABSTRACTSex differences are found across brain regions, behaviors, and brain diseases. Sexual differentiation of the brain is initiated prenatally but it continues throughout life, as a result of the interaction of three major factors: gonadal hormones, sex chromosomes, and the environment. These factors are thought to act, in part, via epigenetic mechanisms which control chromatin and transcriptional states in brain cells. In this review, we discuss evidence that epigenetic mechanisms underlie sex-specific neurobehav...
Source: Trends in Neurosciences - November 15, 2023 Category: Neuroscience Authors: Marija Kundakovic Maria Tickerhoof Source Type: research
Capturing postpandemic changes in research participants
This article aims to initiate a conversation regarding difficult-to-capture outcomes of the pandemic that are relevant to researchers who test human participants. These considerations encourage collection of additional measures when assessing pre- versus postpandemic patterns of behavior.PMID:37953185 | DOI:10.1016/j.tins.2023.10.005 (Source: Trends in Neurosciences)
Source: Trends in Neurosciences - November 12, 2023 Category: Neuroscience Authors: Marian E Berryhill Source Type: research
Capturing postpandemic changes in research participants
This article aims to initiate a conversation regarding difficult-to-capture outcomes of the pandemic that are relevant to researchers who test human participants. These considerations encourage collection of additional measures when assessing pre- versus postpandemic patterns of behavior.PMID:37953185 | DOI:10.1016/j.tins.2023.10.005 (Source: Trends in Neurosciences)
Source: Trends in Neurosciences - November 12, 2023 Category: Neuroscience Authors: Marian E Berryhill Source Type: research
Capturing postpandemic changes in research participants
This article aims to initiate a conversation regarding difficult-to-capture outcomes of the pandemic that are relevant to researchers who test human participants. These considerations encourage collection of additional measures when assessing pre- versus postpandemic patterns of behavior.PMID:37953185 | DOI:10.1016/j.tins.2023.10.005 (Source: Trends in Neurosciences)
Source: Trends in Neurosciences - November 12, 2023 Category: Neuroscience Authors: Marian E Berryhill Source Type: research
Curiosity-driven exploration: foundations in neuroscience and computational modeling
Trends Neurosci. 2023 Nov 2:S0166-2236(23)00240-0. doi: 10.1016/j.tins.2023.10.002. Online ahead of print.ABSTRACTCuriosity refers to the intrinsic desire of humans and animals to explore the unknown, even when there is no apparent reason to do so. Thus far, no single, widely accepted definition or framework for curiosity has emerged, but there is growing consensus that curious behavior is not goal-directed but related to seeking or reacting to information. In this review, we take a phenomenological approach and group behavioral and neurophysiological studies which meet these criteria into three categories according to the...
Source: Trends in Neurosciences - November 4, 2023 Category: Neuroscience Authors: Alireza Modirshanechi Kacper Kondrakiewicz Wulfram Gerstner Sebastian Haesler Source Type: research
Curiosity-driven exploration: foundations in neuroscience and computational modeling
Trends Neurosci. 2023 Nov 2:S0166-2236(23)00240-0. doi: 10.1016/j.tins.2023.10.002. Online ahead of print.ABSTRACTCuriosity refers to the intrinsic desire of humans and animals to explore the unknown, even when there is no apparent reason to do so. Thus far, no single, widely accepted definition or framework for curiosity has emerged, but there is growing consensus that curious behavior is not goal-directed but related to seeking or reacting to information. In this review, we take a phenomenological approach and group behavioral and neurophysiological studies which meet these criteria into three categories according to the...
Source: Trends in Neurosciences - November 4, 2023 Category: Neuroscience Authors: Alireza Modirshanechi Kacper Kondrakiewicz Wulfram Gerstner Sebastian Haesler Source Type: research
Curiosity-driven exploration: foundations in neuroscience and computational modeling
Trends Neurosci. 2023 Nov 2:S0166-2236(23)00240-0. doi: 10.1016/j.tins.2023.10.002. Online ahead of print.ABSTRACTCuriosity refers to the intrinsic desire of humans and animals to explore the unknown, even when there is no apparent reason to do so. Thus far, no single, widely accepted definition or framework for curiosity has emerged, but there is growing consensus that curious behavior is not goal-directed but related to seeking or reacting to information. In this review, we take a phenomenological approach and group behavioral and neurophysiological studies which meet these criteria into three categories according to the...
Source: Trends in Neurosciences - November 4, 2023 Category: Neuroscience Authors: Alireza Modirshanechi Kacper Kondrakiewicz Wulfram Gerstner Sebastian Haesler Source Type: research
Curiosity-driven exploration: foundations in neuroscience and computational modeling
Trends Neurosci. 2023 Nov 2:S0166-2236(23)00240-0. doi: 10.1016/j.tins.2023.10.002. Online ahead of print.ABSTRACTCuriosity refers to the intrinsic desire of humans and animals to explore the unknown, even when there is no apparent reason to do so. Thus far, no single, widely accepted definition or framework for curiosity has emerged, but there is growing consensus that curious behavior is not goal-directed but related to seeking or reacting to information. In this review, we take a phenomenological approach and group behavioral and neurophysiological studies which meet these criteria into three categories according to the...
Source: Trends in Neurosciences - November 4, 2023 Category: Neuroscience Authors: Alireza Modirshanechi Kacper Kondrakiewicz Wulfram Gerstner Sebastian Haesler Source Type: research
Curiosity-driven exploration: foundations in neuroscience and computational modeling
Trends Neurosci. 2023 Nov 2:S0166-2236(23)00240-0. doi: 10.1016/j.tins.2023.10.002. Online ahead of print.ABSTRACTCuriosity refers to the intrinsic desire of humans and animals to explore the unknown, even when there is no apparent reason to do so. Thus far, no single, widely accepted definition or framework for curiosity has emerged, but there is growing consensus that curious behavior is not goal-directed but related to seeking or reacting to information. In this review, we take a phenomenological approach and group behavioral and neurophysiological studies which meet these criteria into three categories according to the...
Source: Trends in Neurosciences - November 4, 2023 Category: Neuroscience Authors: Alireza Modirshanechi Kacper Kondrakiewicz Wulfram Gerstner Sebastian Haesler Source Type: research
Curiosity-driven exploration: foundations in neuroscience and computational modeling
Trends Neurosci. 2023 Nov 2:S0166-2236(23)00240-0. doi: 10.1016/j.tins.2023.10.002. Online ahead of print.ABSTRACTCuriosity refers to the intrinsic desire of humans and animals to explore the unknown, even when there is no apparent reason to do so. Thus far, no single, widely accepted definition or framework for curiosity has emerged, but there is growing consensus that curious behavior is not goal-directed but related to seeking or reacting to information. In this review, we take a phenomenological approach and group behavioral and neurophysiological studies which meet these criteria into three categories according to the...
Source: Trends in Neurosciences - November 4, 2023 Category: Neuroscience Authors: Alireza Modirshanechi Kacper Kondrakiewicz Wulfram Gerstner Sebastian Haesler Source Type: research
Curiosity-driven exploration: foundations in neuroscience and computational modeling
Trends Neurosci. 2023 Nov 2:S0166-2236(23)00240-0. doi: 10.1016/j.tins.2023.10.002. Online ahead of print.ABSTRACTCuriosity refers to the intrinsic desire of humans and animals to explore the unknown, even when there is no apparent reason to do so. Thus far, no single, widely accepted definition or framework for curiosity has emerged, but there is growing consensus that curious behavior is not goal-directed but related to seeking or reacting to information. In this review, we take a phenomenological approach and group behavioral and neurophysiological studies which meet these criteria into three categories according to the...
Source: Trends in Neurosciences - November 4, 2023 Category: Neuroscience Authors: Alireza Modirshanechi Kacper Kondrakiewicz Wulfram Gerstner Sebastian Haesler Source Type: research
