What does preferential viewing tell us about the neurobiology of recognition memory?
Trends Neurosci. 2024 Apr 5:S0166-2236(24)00040-7. doi: 10.1016/j.tins.2024.03.003. Online ahead of print.ABSTRACTThe two tests most widely used in nonhuman primates to assess the neurobiology of recognition memory produce conflicting results. Preferential viewing tests (e.g., visual paired comparison) produce robust impairments following hippocampal lesions, whereas matching tests (e.g., delayed nonmatching-to-sample) often show complete sparing. Here, we review the data, the proposed explanations for this discrepancy, and then critically evaluate those explanations. The most likely explanation is that preferential viewin...
Source: Trends in Neurosciences - April 6, 2024 Category: Neuroscience Authors: Benjamin M Basile Spencer J Waters Elisabeth A Murray Source Type: research
What does preferential viewing tell us about the neurobiology of recognition memory?
Trends Neurosci. 2024 Apr 5:S0166-2236(24)00040-7. doi: 10.1016/j.tins.2024.03.003. Online ahead of print.ABSTRACTThe two tests most widely used in nonhuman primates to assess the neurobiology of recognition memory produce conflicting results. Preferential viewing tests (e.g., visual paired comparison) produce robust impairments following hippocampal lesions, whereas matching tests (e.g., delayed nonmatching-to-sample) often show complete sparing. Here, we review the data, the proposed explanations for this discrepancy, and then critically evaluate those explanations. The most likely explanation is that preferential viewin...
Source: Trends in Neurosciences - April 6, 2024 Category: Neuroscience Authors: Benjamin M Basile Spencer J Waters Elisabeth A Murray Source Type: research
What does preferential viewing tell us about the neurobiology of recognition memory?
Trends Neurosci. 2024 Apr 5:S0166-2236(24)00040-7. doi: 10.1016/j.tins.2024.03.003. Online ahead of print.ABSTRACTThe two tests most widely used in nonhuman primates to assess the neurobiology of recognition memory produce conflicting results. Preferential viewing tests (e.g., visual paired comparison) produce robust impairments following hippocampal lesions, whereas matching tests (e.g., delayed nonmatching-to-sample) often show complete sparing. Here, we review the data, the proposed explanations for this discrepancy, and then critically evaluate those explanations. The most likely explanation is that preferential viewin...
Source: Trends in Neurosciences - April 6, 2024 Category: Neuroscience Authors: Benjamin M Basile Spencer J Waters Elisabeth A Murray Source Type: research
What does preferential viewing tell us about the neurobiology of recognition memory?
Trends Neurosci. 2024 Apr 5:S0166-2236(24)00040-7. doi: 10.1016/j.tins.2024.03.003. Online ahead of print.ABSTRACTThe two tests most widely used in nonhuman primates to assess the neurobiology of recognition memory produce conflicting results. Preferential viewing tests (e.g., visual paired comparison) produce robust impairments following hippocampal lesions, whereas matching tests (e.g., delayed nonmatching-to-sample) often show complete sparing. Here, we review the data, the proposed explanations for this discrepancy, and then critically evaluate those explanations. The most likely explanation is that preferential viewin...
Source: Trends in Neurosciences - April 6, 2024 Category: Neuroscience Authors: Benjamin M Basile Spencer J Waters Elisabeth A Murray Source Type: research
The neuronal cilium - a highly diverse and dynamic organelle involved in sensory detection and neuromodulation
Trends Neurosci. 2024 Apr 4:S0166-2236(24)00041-9. doi: 10.1016/j.tins.2024.03.004. Online ahead of print.ABSTRACTCilia are fascinating organelles that act as cellular antennae, sensing the cellular environment. Cilia gained significant attention in the late 1990s after their dysfunction was linked to genetic diseases known as ciliopathies. Since then, several breakthrough discoveries have uncovered the mechanisms underlying cilia biogenesis and function. Like most cells in the animal kingdom, neurons also harbor cilia, which are enriched in neuromodulatory receptors. Yet, how neuronal cilia modulate neuronal physiology an...
Source: Trends in Neurosciences - April 5, 2024 Category: Neuroscience Authors: Nathalie Jurisch-Yaksi Dagmar Wachten Jay Gopalakrishnan Source Type: research
The neuronal cilium - a highly diverse and dynamic organelle involved in sensory detection and neuromodulation
Trends Neurosci. 2024 Apr 4:S0166-2236(24)00041-9. doi: 10.1016/j.tins.2024.03.004. Online ahead of print.ABSTRACTCilia are fascinating organelles that act as cellular antennae, sensing the cellular environment. Cilia gained significant attention in the late 1990s after their dysfunction was linked to genetic diseases known as ciliopathies. Since then, several breakthrough discoveries have uncovered the mechanisms underlying cilia biogenesis and function. Like most cells in the animal kingdom, neurons also harbor cilia, which are enriched in neuromodulatory receptors. Yet, how neuronal cilia modulate neuronal physiology an...
Source: Trends in Neurosciences - April 5, 2024 Category: Neuroscience Authors: Nathalie Jurisch-Yaksi Dagmar Wachten Jay Gopalakrishnan Source Type: research
Infant neuroscience: how to measure brain activity in the youngest minds
Trends Neurosci. 2024 Apr 2:S0166-2236(24)00019-5. doi: 10.1016/j.tins.2024.02.003. Online ahead of print.ABSTRACTThe functional properties of the infant brain are poorly understood. Recent advances in cognitive neuroscience are opening new avenues for measuring brain activity in human infants. These include novel uses of existing technologies such as electroencephalography (EEG) and magnetoencephalography (MEG), the availability of newer technologies including functional near-infrared spectroscopy (fNIRS) and optically pumped magnetometry (OPM), and innovative applications of functional magnetic resonance imaging (fMRI) i...
Source: Trends in Neurosciences - April 3, 2024 Category: Neuroscience Authors: Nicholas B Turk-Browne Richard N Aslin Source Type: research
Infant neuroscience: how to measure brain activity in the youngest minds
Trends Neurosci. 2024 Apr 2:S0166-2236(24)00019-5. doi: 10.1016/j.tins.2024.02.003. Online ahead of print.ABSTRACTThe functional properties of the infant brain are poorly understood. Recent advances in cognitive neuroscience are opening new avenues for measuring brain activity in human infants. These include novel uses of existing technologies such as electroencephalography (EEG) and magnetoencephalography (MEG), the availability of newer technologies including functional near-infrared spectroscopy (fNIRS) and optically pumped magnetometry (OPM), and innovative applications of functional magnetic resonance imaging (fMRI) i...
Source: Trends in Neurosciences - April 3, 2024 Category: Neuroscience Authors: Nicholas B Turk-Browne Richard N Aslin Source Type: research
CRISPR-based identification of N-terminal acetylation in synucleinopathies
Trends Neurosci. 2024 Mar 28:S0166-2236(24)00043-2. doi: 10.1016/j.tins.2024.03.006. Online ahead of print.ABSTRACTA recent study by Kumar et al. identified several biological pathways that regulate the levels of endogenous alpha-synuclein (α-synuclein). They specifically highlighted the N-terminal acetylation (NTA) pathway as an important factor in maintaining the stability of endogenous α-synuclein, suggesting targeting the NTA pathway as a potential therapeutic approach.PMID:38553385 | DOI:10.1016/j.tins.2024.03.006 (Source: Trends in Neurosciences)
Source: Trends in Neurosciences - March 29, 2024 Category: Neuroscience Authors: Eun-Jin Bae Seung-Jae Lee Source Type: research
CRISPR-based identification of N-terminal acetylation in synucleinopathies
Trends Neurosci. 2024 Mar 28:S0166-2236(24)00043-2. doi: 10.1016/j.tins.2024.03.006. Online ahead of print.ABSTRACTA recent study by Kumar et al. identified several biological pathways that regulate the levels of endogenous alpha-synuclein (α-synuclein). They specifically highlighted the N-terminal acetylation (NTA) pathway as an important factor in maintaining the stability of endogenous α-synuclein, suggesting targeting the NTA pathway as a potential therapeutic approach.PMID:38553385 | DOI:10.1016/j.tins.2024.03.006 (Source: Trends in Neurosciences)
Source: Trends in Neurosciences - March 29, 2024 Category: Neuroscience Authors: Eun-Jin Bae Seung-Jae Lee Source Type: research
CRISPR-based identification of N-terminal acetylation in synucleinopathies
Trends Neurosci. 2024 Mar 28:S0166-2236(24)00043-2. doi: 10.1016/j.tins.2024.03.006. Online ahead of print.ABSTRACTA recent study by Kumar et al. identified several biological pathways that regulate the levels of endogenous alpha-synuclein (α-synuclein). They specifically highlighted the N-terminal acetylation (NTA) pathway as an important factor in maintaining the stability of endogenous α-synuclein, suggesting targeting the NTA pathway as a potential therapeutic approach.PMID:38553385 | DOI:10.1016/j.tins.2024.03.006 (Source: Trends in Neurosciences)
Source: Trends in Neurosciences - March 29, 2024 Category: Neuroscience Authors: Eun-Jin Bae Seung-Jae Lee Source Type: research
CRISPR-based identification of N-terminal acetylation in synucleinopathies
Trends Neurosci. 2024 Mar 28:S0166-2236(24)00043-2. doi: 10.1016/j.tins.2024.03.006. Online ahead of print.ABSTRACTA recent study by Kumar et al. identified several biological pathways that regulate the levels of endogenous alpha-synuclein (α-synuclein). They specifically highlighted the N-terminal acetylation (NTA) pathway as an important factor in maintaining the stability of endogenous α-synuclein, suggesting targeting the NTA pathway as a potential therapeutic approach.PMID:38553385 | DOI:10.1016/j.tins.2024.03.006 (Source: Trends in Neurosciences)
Source: Trends in Neurosciences - March 29, 2024 Category: Neuroscience Authors: Eun-Jin Bae Seung-Jae Lee Source Type: research
Balancing neuronal activity to fight neurodevelopmental disorders
Trends Neurosci. 2024 Mar 22:S0166-2236(24)00039-0. doi: 10.1016/j.tins.2024.03.002. Online ahead of print.ABSTRACTIn a recent study, Rylaarsdam and colleagues revealed that mutant PACS1 gene, which causes a rare neurodevelopmental syndrome, affects the firing ability of human neurons without dysregulating the cellular architecture of brain organoids. These findings suggest aberrant neuronal electrophysiology as a possible interventional target for pediatric diseases impairing brain development.PMID:38521709 | DOI:10.1016/j.tins.2024.03.002 (Source: Trends in Neurosciences)
Source: Trends in Neurosciences - March 23, 2024 Category: Neuroscience Authors: Stephanie Le Carmen Menacho Alessandro Prigione Source Type: research
Astrocytes in selective vulnerability to neurodegenerative disease
Trends Neurosci. 2024 Mar 22:S0166-2236(24)00024-9. doi: 10.1016/j.tins.2024.02.008. Online ahead of print.ABSTRACTSelective vulnerability of specific brain regions and cell populations is a hallmark of neurodegenerative disorders. Mechanisms of selective vulnerability involve neuronal heterogeneity, functional specializations, and differential sensitivities to stressors and pathogenic factors. In this review we discuss the growing body of literature suggesting that, like neurons, astrocytes are heterogeneous and specialized, respond to and integrate diverse inputs, and induce selective effects on brain function. In diseas...
Source: Trends in Neurosciences - March 23, 2024 Category: Neuroscience Authors: Till S Zimmer Adam L Orr Anna G Orr Source Type: research
Balancing neuronal activity to fight neurodevelopmental disorders
Trends Neurosci. 2024 Mar 22:S0166-2236(24)00039-0. doi: 10.1016/j.tins.2024.03.002. Online ahead of print.ABSTRACTIn a recent study, Rylaarsdam and colleagues revealed that mutant PACS1 gene, which causes a rare neurodevelopmental syndrome, affects the firing ability of human neurons without dysregulating the cellular architecture of brain organoids. These findings suggest aberrant neuronal electrophysiology as a possible interventional target for pediatric diseases impairing brain development.PMID:38521709 | DOI:10.1016/j.tins.2024.03.002 (Source: Trends in Neurosciences)
Source: Trends in Neurosciences - March 23, 2024 Category: Neuroscience Authors: Stephanie Le Carmen Menacho Alessandro Prigione Source Type: research
