CRISPR-based identification of N-terminal acetylation in synucleinopathies

Trends Neurosci. 2024 Mar 28:S0166-2236(24)00043-2. doi: 10.1016/j.tins.2024.03.006. Online ahead of print.ABSTRACTA recent study by Kumar et al. identified several biological pathways that regulate the levels of endogenous alpha-synuclein (α-synuclein). They specifically highlighted the N-terminal acetylation (NTA) pathway as an important factor in maintaining the stability of endogenous α-synuclein, suggesting targeting the NTA pathway as a potential therapeutic approach.PMID:38553385 | DOI:10.1016/j.tins.2024.03.006

Source: Trends in Neurosciences - March 29, 2024 Category: Neuroscience Authors: Eun-Jin Bae Seung-Jae Lee Source Type: research