From aversive associations to defensive programs: experience-dependent synaptic modifications in the central amygdala
Trends Neurosci. 2023 Jul 24:S0166-2236(23)00144-3. doi: 10.1016/j.tins.2023.06.006. Online ahead of print.ABSTRACTPlasticity elicited by fear conditioning (FC) is thought to support the storage of aversive associative memories. Although work over the past decade has revealed FC-induced plasticity beyond canonical sites in the basolateral complex of the amygdala (BLA), it is not known whether modifications across distributed circuits make equivalent or distinct contributions to aversive memory. Here, we review evidence demonstrating that experience-dependent synaptic plasticity in the central nucleus of the amygdala (CeA) ...
Source: Trends in Neurosciences - July 26, 2023 Category: Neuroscience Authors: Mario A Penzo Justin M Moscarello Source Type: research
From aversive associations to defensive programs: experience-dependent synaptic modifications in the central amygdala
Trends Neurosci. 2023 Jul 24:S0166-2236(23)00144-3. doi: 10.1016/j.tins.2023.06.006. Online ahead of print.ABSTRACTPlasticity elicited by fear conditioning (FC) is thought to support the storage of aversive associative memories. Although work over the past decade has revealed FC-induced plasticity beyond canonical sites in the basolateral complex of the amygdala (BLA), it is not known whether modifications across distributed circuits make equivalent or distinct contributions to aversive memory. Here, we review evidence demonstrating that experience-dependent synaptic plasticity in the central nucleus of the amygdala (CeA) ...
Source: Trends in Neurosciences - July 26, 2023 Category: Neuroscience Authors: Mario A Penzo Justin M Moscarello Source Type: research
Septo-hippocampal dynamics and the encoding of space and time
Trends Neurosci. 2023 Jul 19:S0166-2236(23)00142-X. doi: 10.1016/j.tins.2023.06.004. Online ahead of print.ABSTRACTEncoding an event in memory requires neural activity to represent multiple dimensions of behavioral experience in space and time. Recent experiments have explored the influence of neural dynamics regulated by the medial septum on the functional encoding of space and time by neurons in the hippocampus and associated structures. This review addresses these dynamics, focusing on the role of theta rhythm, the differential effects of septal inactivation and activation on the functional coding of space and time by i...
Source: Trends in Neurosciences - July 21, 2023 Category: Neuroscience Authors: Jennifer C Robinson Jacob H Wilmot Michael E Hasselmo Source Type: research
Septo-hippocampal dynamics and the encoding of space and time
Trends Neurosci. 2023 Jul 19:S0166-2236(23)00142-X. doi: 10.1016/j.tins.2023.06.004. Online ahead of print.ABSTRACTEncoding an event in memory requires neural activity to represent multiple dimensions of behavioral experience in space and time. Recent experiments have explored the influence of neural dynamics regulated by the medial septum on the functional encoding of space and time by neurons in the hippocampus and associated structures. This review addresses these dynamics, focusing on the role of theta rhythm, the differential effects of septal inactivation and activation on the functional coding of space and time by i...
Source: Trends in Neurosciences - July 21, 2023 Category: Neuroscience Authors: Jennifer C Robinson Jacob H Wilmot Michael E Hasselmo Source Type: research
Septo-hippocampal dynamics and the encoding of space and time
Trends Neurosci. 2023 Jul 19:S0166-2236(23)00142-X. doi: 10.1016/j.tins.2023.06.004. Online ahead of print.ABSTRACTEncoding an event in memory requires neural activity to represent multiple dimensions of behavioral experience in space and time. Recent experiments have explored the influence of neural dynamics regulated by the medial septum on the functional encoding of space and time by neurons in the hippocampus and associated structures. This review addresses these dynamics, focusing on the role of theta rhythm, the differential effects of septal inactivation and activation on the functional coding of space and time by i...
Source: Trends in Neurosciences - July 21, 2023 Category: Neuroscience Authors: Jennifer C Robinson Jacob H Wilmot Michael E Hasselmo Source Type: research
Septo-hippocampal dynamics and the encoding of space and time
Trends Neurosci. 2023 Jul 19:S0166-2236(23)00142-X. doi: 10.1016/j.tins.2023.06.004. Online ahead of print.ABSTRACTEncoding an event in memory requires neural activity to represent multiple dimensions of behavioral experience in space and time. Recent experiments have explored the influence of neural dynamics regulated by the medial septum on the functional encoding of space and time by neurons in the hippocampus and associated structures. This review addresses these dynamics, focusing on the role of theta rhythm, the differential effects of septal inactivation and activation on the functional coding of space and time by i...
Source: Trends in Neurosciences - July 21, 2023 Category: Neuroscience Authors: Jennifer C Robinson Jacob H Wilmot Michael E Hasselmo Source Type: research
More than just risk for Alzheimer's disease: APOE ε4's impact on the aging brain
Trends Neurosci. 2023 Jul 15:S0166-2236(23)00141-8. doi: 10.1016/j.tins.2023.06.003. Online ahead of print.ABSTRACTThe apolipoprotein ε4 (APOE ε4) allele is most commonly associated with increased risk for late-onset Alzheimer's disease (AD). However, recent longitudinal studies suggest that these risks are overestimated; most ε4 carriers will not develop dementia in their lifetime. In this article, we review new evidence regarding the impact of APOE ε4 on cognition among healthy older adults. We discuss emerging work from animal models suggesting that ε4 impacts brain structure and function in multiple ways that may ...
Source: Trends in Neurosciences - July 17, 2023 Category: Neuroscience Authors: Justin M Palmer Matthew Huentelman Lee Ryan Source Type: research
More than just risk for Alzheimer's disease: APOE ε4's impact on the aging brain
Trends Neurosci. 2023 Jul 15:S0166-2236(23)00141-8. doi: 10.1016/j.tins.2023.06.003. Online ahead of print.ABSTRACTThe apolipoprotein ε4 (APOE ε4) allele is most commonly associated with increased risk for late-onset Alzheimer's disease (AD). However, recent longitudinal studies suggest that these risks are overestimated; most ε4 carriers will not develop dementia in their lifetime. In this article, we review new evidence regarding the impact of APOE ε4 on cognition among healthy older adults. We discuss emerging work from animal models suggesting that ε4 impacts brain structure and function in multiple ways that may ...
Source: Trends in Neurosciences - July 17, 2023 Category: Neuroscience Authors: Justin M Palmer Matthew Huentelman Lee Ryan Source Type: research
More than just risk for Alzheimer's disease: APOE ε4's impact on the aging brain
Trends Neurosci. 2023 Jul 15:S0166-2236(23)00141-8. doi: 10.1016/j.tins.2023.06.003. Online ahead of print.ABSTRACTThe apolipoprotein ε4 (APOE ε4) allele is most commonly associated with increased risk for late-onset Alzheimer's disease (AD). However, recent longitudinal studies suggest that these risks are overestimated; most ε4 carriers will not develop dementia in their lifetime. In this article, we review new evidence regarding the impact of APOE ε4 on cognition among healthy older adults. We discuss emerging work from animal models suggesting that ε4 impacts brain structure and function in multiple ways that may ...
Source: Trends in Neurosciences - July 17, 2023 Category: Neuroscience Authors: Justin M Palmer Matthew Huentelman Lee Ryan Source Type: research
More than just risk for Alzheimer's disease: APOE ε4's impact on the aging brain
Trends Neurosci. 2023 Jul 15:S0166-2236(23)00141-8. doi: 10.1016/j.tins.2023.06.003. Online ahead of print.ABSTRACTThe apolipoprotein ε4 (APOE ε4) allele is most commonly associated with increased risk for late-onset Alzheimer's disease (AD). However, recent longitudinal studies suggest that these risks are overestimated; most ε4 carriers will not develop dementia in their lifetime. In this article, we review new evidence regarding the impact of APOE ε4 on cognition among healthy older adults. We discuss emerging work from animal models suggesting that ε4 impacts brain structure and function in multiple ways that may ...
Source: Trends in Neurosciences - July 17, 2023 Category: Neuroscience Authors: Justin M Palmer Matthew Huentelman Lee Ryan Source Type: research
Motor neural networks in the leech
Trends Neurosci. 2023 Jul 6:S0166-2236(23)00140-6. doi: 10.1016/j.tins.2023.06.002. Online ahead of print.ABSTRACTLeeches display robust motor patterns and exhibit a relatively simple nervous system where neurons are unambiguously identified. This brief article focuses on Hirudo verbana and summarizes how research in this organism has contributed to insights in the field of motor control, where networks have been studied from population down to individual neuron perspectives.PMID:37422418 | DOI:10.1016/j.tins.2023.06.002 (Source: Trends in Neurosciences)
Source: Trends in Neurosciences - July 8, 2023 Category: Neuroscience Authors: Lidia Szczupak Source Type: research
Motor neural networks in the leech
Trends Neurosci. 2023 Jul 6:S0166-2236(23)00140-6. doi: 10.1016/j.tins.2023.06.002. Online ahead of print.ABSTRACTLeeches display robust motor patterns and exhibit a relatively simple nervous system where neurons are unambiguously identified. This brief article focuses on Hirudo verbana and summarizes how research in this organism has contributed to insights in the field of motor control, where networks have been studied from population down to individual neuron perspectives.PMID:37422418 | DOI:10.1016/j.tins.2023.06.002 (Source: Trends in Neurosciences)
Source: Trends in Neurosciences - July 8, 2023 Category: Neuroscience Authors: Lidia Szczupak Source Type: research
Motor neural networks in the leech
Trends Neurosci. 2023 Jul 6:S0166-2236(23)00140-6. doi: 10.1016/j.tins.2023.06.002. Online ahead of print.ABSTRACTLeeches display robust motor patterns and exhibit a relatively simple nervous system where neurons are unambiguously identified. This brief article focuses on Hirudo verbana and summarizes how research in this organism has contributed to insights in the field of motor control, where networks have been studied from population down to individual neuron perspectives.PMID:37422418 | DOI:10.1016/j.tins.2023.06.002 (Source: Trends in Neurosciences)
Source: Trends in Neurosciences - July 8, 2023 Category: Neuroscience Authors: Lidia Szczupak Source Type: research
Motor neural networks in the leech
Trends Neurosci. 2023 Jul 6:S0166-2236(23)00140-6. doi: 10.1016/j.tins.2023.06.002. Online ahead of print.ABSTRACTLeeches display robust motor patterns and exhibit a relatively simple nervous system where neurons are unambiguously identified. This brief article focuses on Hirudo verbana and summarizes how research in this organism has contributed to insights in the field of motor control, where networks have been studied from population down to individual neuron perspectives.PMID:37422418 | DOI:10.1016/j.tins.2023.06.002 (Source: Trends in Neurosciences)
Source: Trends in Neurosciences - July 8, 2023 Category: Neuroscience Authors: Lidia Szczupak Source Type: research
Motor neural networks in the leech
Trends Neurosci. 2023 Jul 6:S0166-2236(23)00140-6. doi: 10.1016/j.tins.2023.06.002. Online ahead of print.ABSTRACTLeeches display robust motor patterns and exhibit a relatively simple nervous system where neurons are unambiguously identified. This brief article focuses on Hirudo verbana and summarizes how research in this organism has contributed to insights in the field of motor control, where networks have been studied from population down to individual neuron perspectives.PMID:37422418 | DOI:10.1016/j.tins.2023.06.002 (Source: Trends in Neurosciences)
Source: Trends in Neurosciences - July 8, 2023 Category: Neuroscience Authors: Lidia Szczupak Source Type: research
