The making of a proprioceptor: a tale of two identities
Trends Neurosci. 2023 Oct 17:S0166-2236(23)00226-6. doi: 10.1016/j.tins.2023.09.008. Online ahead of print.ABSTRACTProprioception, the sense of body position in space, has a critical role in the control of posture and movement. Aside from skin and joint receptors, the main sources of proprioceptive information in tetrapods are mechanoreceptive end organs in skeletal muscle: muscle spindles (MSs) and Golgi tendon organs (GTOs). The sensory neurons that innervate these receptors are divided into subtypes that detect discrete aspects of sensory information from muscles with different biomechanical functions. Despite the impor...
Source: Trends in Neurosciences - October 20, 2023 Category: Neuroscience Authors: Joriene C de Nooij Niccol ò Zampieri Source Type: research
The feasibility of artificial consciousness through the lens of neuroscience
Trends Neurosci. 2023 Oct 18:S0166-2236(23)00227-8. doi: 10.1016/j.tins.2023.09.009. Online ahead of print.ABSTRACTInteractions with large language models (LLMs) have led to the suggestion that these models may soon be conscious. From the perspective of neuroscience, this position is difficult to defend. For one, the inputs to LLMs lack the embodied, embedded information content characteristic of our sensory contact with the world around us. Secondly, the architectures of present-day artificial intelligence algorithms are missing key features of the thalamocortical system that have been linked to conscious awareness in mam...
Source: Trends in Neurosciences - October 20, 2023 Category: Neuroscience Authors: Jaan Aru Matthew E Larkum James M Shine Source Type: research
Targeting LRRK2 mRNA stability in Parkinson's disease
Trends Neurosci. 2023 Oct 17:S0166-2236(23)00244-8. doi: 10.1016/j.tins.2023.10.003. Online ahead of print.ABSTRACTIn a recent study, Liu and colleagues demonstrated a role for the purine biosynthesis enzyme ATIC and its substrate in regulating the protein levels of the Parkinson's disease kinase LRRK2, which rescues neurodegeneration and neuroinflammation in distinct animal models. This work highlights a novel avenue to target LRRK2 protein levels as a strategy to prevent neurodegeneration in Parkinson's disease.PMID:37858439 | DOI:10.1016/j.tins.2023.10.003 (Source: Trends in Neurosciences)
Source: Trends in Neurosciences - October 20, 2023 Category: Neuroscience Authors: Rachel Fasiczka Sabine Hilfiker Source Type: research
The making of a proprioceptor: a tale of two identities
Trends Neurosci. 2023 Oct 17:S0166-2236(23)00226-6. doi: 10.1016/j.tins.2023.09.008. Online ahead of print.ABSTRACTProprioception, the sense of body position in space, has a critical role in the control of posture and movement. Aside from skin and joint receptors, the main sources of proprioceptive information in tetrapods are mechanoreceptive end organs in skeletal muscle: muscle spindles (MSs) and Golgi tendon organs (GTOs). The sensory neurons that innervate these receptors are divided into subtypes that detect discrete aspects of sensory information from muscles with different biomechanical functions. Despite the impor...
Source: Trends in Neurosciences - October 20, 2023 Category: Neuroscience Authors: Joriene C de Nooij Niccol ò Zampieri Source Type: research
The feasibility of artificial consciousness through the lens of neuroscience
Trends Neurosci. 2023 Oct 18:S0166-2236(23)00227-8. doi: 10.1016/j.tins.2023.09.009. Online ahead of print.ABSTRACTInteractions with large language models (LLMs) have led to the suggestion that these models may soon be conscious. From the perspective of neuroscience, this position is difficult to defend. For one, the inputs to LLMs lack the embodied, embedded information content characteristic of our sensory contact with the world around us. Secondly, the architectures of present-day artificial intelligence algorithms are missing key features of the thalamocortical system that have been linked to conscious awareness in mam...
Source: Trends in Neurosciences - October 20, 2023 Category: Neuroscience Authors: Jaan Aru Matthew E Larkum James M Shine Source Type: research
Targeting LRRK2 mRNA stability in Parkinson's disease
Trends Neurosci. 2023 Oct 17:S0166-2236(23)00244-8. doi: 10.1016/j.tins.2023.10.003. Online ahead of print.ABSTRACTIn a recent study, Liu and colleagues demonstrated a role for the purine biosynthesis enzyme ATIC and its substrate in regulating the protein levels of the Parkinson's disease kinase LRRK2, which rescues neurodegeneration and neuroinflammation in distinct animal models. This work highlights a novel avenue to target LRRK2 protein levels as a strategy to prevent neurodegeneration in Parkinson's disease.PMID:37858439 | DOI:10.1016/j.tins.2023.10.003 (Source: Trends in Neurosciences)
Source: Trends in Neurosciences - October 20, 2023 Category: Neuroscience Authors: Rachel Fasiczka Sabine Hilfiker Source Type: research
The making of a proprioceptor: a tale of two identities
Trends Neurosci. 2023 Oct 17:S0166-2236(23)00226-6. doi: 10.1016/j.tins.2023.09.008. Online ahead of print.ABSTRACTProprioception, the sense of body position in space, has a critical role in the control of posture and movement. Aside from skin and joint receptors, the main sources of proprioceptive information in tetrapods are mechanoreceptive end organs in skeletal muscle: muscle spindles (MSs) and Golgi tendon organs (GTOs). The sensory neurons that innervate these receptors are divided into subtypes that detect discrete aspects of sensory information from muscles with different biomechanical functions. Despite the impor...
Source: Trends in Neurosciences - October 20, 2023 Category: Neuroscience Authors: Joriene C de Nooij Niccol ò Zampieri Source Type: research
The feasibility of artificial consciousness through the lens of neuroscience
Trends Neurosci. 2023 Oct 18:S0166-2236(23)00227-8. doi: 10.1016/j.tins.2023.09.009. Online ahead of print.ABSTRACTInteractions with large language models (LLMs) have led to the suggestion that these models may soon be conscious. From the perspective of neuroscience, this position is difficult to defend. For one, the inputs to LLMs lack the embodied, embedded information content characteristic of our sensory contact with the world around us. Secondly, the architectures of present-day artificial intelligence algorithms are missing key features of the thalamocortical system that have been linked to conscious awareness in mam...
Source: Trends in Neurosciences - October 20, 2023 Category: Neuroscience Authors: Jaan Aru Matthew E Larkum James M Shine Source Type: research
Targeting LRRK2 mRNA stability in Parkinson's disease
Trends Neurosci. 2023 Oct 17:S0166-2236(23)00244-8. doi: 10.1016/j.tins.2023.10.003. Online ahead of print.ABSTRACTIn a recent study, Liu and colleagues demonstrated a role for the purine biosynthesis enzyme ATIC and its substrate in regulating the protein levels of the Parkinson's disease kinase LRRK2, which rescues neurodegeneration and neuroinflammation in distinct animal models. This work highlights a novel avenue to target LRRK2 protein levels as a strategy to prevent neurodegeneration in Parkinson's disease.PMID:37858439 | DOI:10.1016/j.tins.2023.10.003 (Source: Trends in Neurosciences)
Source: Trends in Neurosciences - October 20, 2023 Category: Neuroscience Authors: Rachel Fasiczka Sabine Hilfiker Source Type: research
The making of a proprioceptor: a tale of two identities
Trends Neurosci. 2023 Oct 17:S0166-2236(23)00226-6. doi: 10.1016/j.tins.2023.09.008. Online ahead of print.ABSTRACTProprioception, the sense of body position in space, has a critical role in the control of posture and movement. Aside from skin and joint receptors, the main sources of proprioceptive information in tetrapods are mechanoreceptive end organs in skeletal muscle: muscle spindles (MSs) and Golgi tendon organs (GTOs). The sensory neurons that innervate these receptors are divided into subtypes that detect discrete aspects of sensory information from muscles with different biomechanical functions. Despite the impor...
Source: Trends in Neurosciences - October 20, 2023 Category: Neuroscience Authors: Joriene C de Nooij Niccol ò Zampieri Source Type: research
The feasibility of artificial consciousness through the lens of neuroscience
Trends Neurosci. 2023 Oct 18:S0166-2236(23)00227-8. doi: 10.1016/j.tins.2023.09.009. Online ahead of print.ABSTRACTInteractions with large language models (LLMs) have led to the suggestion that these models may soon be conscious. From the perspective of neuroscience, this position is difficult to defend. For one, the inputs to LLMs lack the embodied, embedded information content characteristic of our sensory contact with the world around us. Secondly, the architectures of present-day artificial intelligence algorithms are missing key features of the thalamocortical system that have been linked to conscious awareness in mam...
Source: Trends in Neurosciences - October 20, 2023 Category: Neuroscience Authors: Jaan Aru Matthew E Larkum James M Shine Source Type: research
Targeting LRRK2 mRNA stability in Parkinson's disease
Trends Neurosci. 2023 Oct 17:S0166-2236(23)00244-8. doi: 10.1016/j.tins.2023.10.003. Online ahead of print.ABSTRACTIn a recent study, Liu and colleagues demonstrated a role for the purine biosynthesis enzyme ATIC and its substrate in regulating the protein levels of the Parkinson's disease kinase LRRK2, which rescues neurodegeneration and neuroinflammation in distinct animal models. This work highlights a novel avenue to target LRRK2 protein levels as a strategy to prevent neurodegeneration in Parkinson's disease.PMID:37858439 | DOI:10.1016/j.tins.2023.10.003 (Source: Trends in Neurosciences)
Source: Trends in Neurosciences - October 20, 2023 Category: Neuroscience Authors: Rachel Fasiczka Sabine Hilfiker Source Type: research
The making of a proprioceptor: a tale of two identities
Trends Neurosci. 2023 Oct 17:S0166-2236(23)00226-6. doi: 10.1016/j.tins.2023.09.008. Online ahead of print.ABSTRACTProprioception, the sense of body position in space, has a critical role in the control of posture and movement. Aside from skin and joint receptors, the main sources of proprioceptive information in tetrapods are mechanoreceptive end organs in skeletal muscle: muscle spindles (MSs) and Golgi tendon organs (GTOs). The sensory neurons that innervate these receptors are divided into subtypes that detect discrete aspects of sensory information from muscles with different biomechanical functions. Despite the impor...
Source: Trends in Neurosciences - October 20, 2023 Category: Neuroscience Authors: Joriene C de Nooij Niccol ò Zampieri Source Type: research
The feasibility of artificial consciousness through the lens of neuroscience
Trends Neurosci. 2023 Oct 18:S0166-2236(23)00227-8. doi: 10.1016/j.tins.2023.09.009. Online ahead of print.ABSTRACTInteractions with large language models (LLMs) have led to the suggestion that these models may soon be conscious. From the perspective of neuroscience, this position is difficult to defend. For one, the inputs to LLMs lack the embodied, embedded information content characteristic of our sensory contact with the world around us. Secondly, the architectures of present-day artificial intelligence algorithms are missing key features of the thalamocortical system that have been linked to conscious awareness in mam...
Source: Trends in Neurosciences - October 20, 2023 Category: Neuroscience Authors: Jaan Aru Matthew E Larkum James M Shine Source Type: research
Targeting LRRK2 mRNA stability in Parkinson's disease
Trends Neurosci. 2023 Oct 17:S0166-2236(23)00244-8. doi: 10.1016/j.tins.2023.10.003. Online ahead of print.ABSTRACTIn a recent study, Liu and colleagues demonstrated a role for the purine biosynthesis enzyme ATIC and its substrate in regulating the protein levels of the Parkinson's disease kinase LRRK2, which rescues neurodegeneration and neuroinflammation in distinct animal models. This work highlights a novel avenue to target LRRK2 protein levels as a strategy to prevent neurodegeneration in Parkinson's disease.PMID:37858439 | DOI:10.1016/j.tins.2023.10.003 (Source: Trends in Neurosciences)
Source: Trends in Neurosciences - October 20, 2023 Category: Neuroscience Authors: Rachel Fasiczka Sabine Hilfiker Source Type: research
