The neuroinvasiveness, neurotropism, and neurovirulence of SARS-CoV-2
Trends Neurosci. 2022 Mar 3:S0166-2236(22)00050-9. doi: 10.1016/j.tins.2022.02.006. Online ahead of print.ABSTRACTSevere acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) infection is associated with a diverse spectrum of neurological complications during the acute and postacute stages. The pathogenesis of these complications is complex and dependent on many factors. For accurate and consistent interpretation of experimental data in this fast-growing field of research, it is essential to use terminology consistently. In this article, we outline the distinctions between neuroinvasiveness, neurotropism, and neurovirulenc...
Source: Trends in Neurosciences - March 13, 2022 Category: Neuroscience Authors: Lisa Bauer Brigitta M Laksono Femke M S de Vrij Steven A Kushner Oliver Harschnitz Debby van Riel Source Type: research

The neuroinvasiveness, neurotropism, and neurovirulence of SARS-CoV-2
Trends Neurosci. 2022 Mar 3:S0166-2236(22)00050-9. doi: 10.1016/j.tins.2022.02.006. Online ahead of print.ABSTRACTSevere acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) infection is associated with a diverse spectrum of neurological complications during the acute and postacute stages. The pathogenesis of these complications is complex and dependent on many factors. For accurate and consistent interpretation of experimental data in this fast-growing field of research, it is essential to use terminology consistently. In this article, we outline the distinctions between neuroinvasiveness, neurotropism, and neurovirulenc...
Source: Trends in Neurosciences - March 13, 2022 Category: Neuroscience Authors: Lisa Bauer Brigitta M Laksono Femke M S de Vrij Steven A Kushner Oliver Harschnitz Debby van Riel Source Type: research

The neuroinvasiveness, neurotropism, and neurovirulence of SARS-CoV-2
Trends Neurosci. 2022 Mar 3:S0166-2236(22)00050-9. doi: 10.1016/j.tins.2022.02.006. Online ahead of print.ABSTRACTSevere acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) infection is associated with a diverse spectrum of neurological complications during the acute and postacute stages. The pathogenesis of these complications is complex and dependent on many factors. For accurate and consistent interpretation of experimental data in this fast-growing field of research, it is essential to use terminology consistently. In this article, we outline the distinctions between neuroinvasiveness, neurotropism, and neurovirulenc...
Source: Trends in Neurosciences - March 13, 2022 Category: Neuroscience Authors: Lisa Bauer Brigitta M Laksono Femke M S de Vrij Steven A Kushner Oliver Harschnitz Debby van Riel Source Type: research

The neuroinvasiveness, neurotropism, and neurovirulence of SARS-CoV-2
Trends Neurosci. 2022 Mar 3:S0166-2236(22)00050-9. doi: 10.1016/j.tins.2022.02.006. Online ahead of print.ABSTRACTSevere acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) infection is associated with a diverse spectrum of neurological complications during the acute and postacute stages. The pathogenesis of these complications is complex and dependent on many factors. For accurate and consistent interpretation of experimental data in this fast-growing field of research, it is essential to use terminology consistently. In this article, we outline the distinctions between neuroinvasiveness, neurotropism, and neurovirulenc...
Source: Trends in Neurosciences - March 13, 2022 Category: Neuroscience Authors: Lisa Bauer Brigitta M Laksono Femke M S de Vrij Steven A Kushner Oliver Harschnitz Debby van Riel Source Type: research

Mitochondria-lysosome contact site dynamics and misregulation in neurodegenerative diseases
Trends Neurosci. 2022 Mar 3:S0166-2236(22)00017-0. doi: 10.1016/j.tins.2022.01.005. Online ahead of print.ABSTRACTNeurons rely heavily on properly regulated mitochondrial and lysosomal homeostasis, with multiple neurodegenerative diseases linked to dysfunction in these two organelles. Interestingly, mitochondria-lysosome membrane contact sites have been identified as a key pathway mediating their crosstalk in neurons. Recent studies have further elucidated the regulation of mitochondria-lysosome contact dynamics via distinct tethering/untethering protein machinery. Moreover, this pathway has been shown to have additional f...
Source: Trends in Neurosciences - March 7, 2022 Category: Neuroscience Authors: Jasmine Cisneros Tayler B Belton George C Shum Catherine G Molakal Yvette C Wong Source Type: research

Mitochondria-lysosome contact site dynamics and misregulation in neurodegenerative diseases
Trends Neurosci. 2022 Mar 3:S0166-2236(22)00017-0. doi: 10.1016/j.tins.2022.01.005. Online ahead of print.ABSTRACTNeurons rely heavily on properly regulated mitochondrial and lysosomal homeostasis, with multiple neurodegenerative diseases linked to dysfunction in these two organelles. Interestingly, mitochondria-lysosome membrane contact sites have been identified as a key pathway mediating their crosstalk in neurons. Recent studies have further elucidated the regulation of mitochondria-lysosome contact dynamics via distinct tethering/untethering protein machinery. Moreover, this pathway has been shown to have additional f...
Source: Trends in Neurosciences - March 7, 2022 Category: Neuroscience Authors: Jasmine Cisneros Tayler B Belton George C Shum Catherine G Molakal Yvette C Wong Source Type: research

Mitochondria-lysosome contact site dynamics and misregulation in neurodegenerative diseases
Trends Neurosci. 2022 Mar 3:S0166-2236(22)00017-0. doi: 10.1016/j.tins.2022.01.005. Online ahead of print.ABSTRACTNeurons rely heavily on properly regulated mitochondrial and lysosomal homeostasis, with multiple neurodegenerative diseases linked to dysfunction in these two organelles. Interestingly, mitochondria-lysosome membrane contact sites have been identified as a key pathway mediating their crosstalk in neurons. Recent studies have further elucidated the regulation of mitochondria-lysosome contact dynamics via distinct tethering/untethering protein machinery. Moreover, this pathway has been shown to have additional f...
Source: Trends in Neurosciences - March 7, 2022 Category: Neuroscience Authors: Jasmine Cisneros Tayler B Belton George C Shum Catherine G Molakal Yvette C Wong Source Type: research

Mitochondria-lysosome contact site dynamics and misregulation in neurodegenerative diseases
Trends Neurosci. 2022 Mar 3:S0166-2236(22)00017-0. doi: 10.1016/j.tins.2022.01.005. Online ahead of print.ABSTRACTNeurons rely heavily on properly regulated mitochondrial and lysosomal homeostasis, with multiple neurodegenerative diseases linked to dysfunction in these two organelles. Interestingly, mitochondria-lysosome membrane contact sites have been identified as a key pathway mediating their crosstalk in neurons. Recent studies have further elucidated the regulation of mitochondria-lysosome contact dynamics via distinct tethering/untethering protein machinery. Moreover, this pathway has been shown to have additional f...
Source: Trends in Neurosciences - March 7, 2022 Category: Neuroscience Authors: Jasmine Cisneros Tayler B Belton George C Shum Catherine G Molakal Yvette C Wong Source Type: research

Mitochondria-lysosome contact site dynamics and misregulation in neurodegenerative diseases
Trends Neurosci. 2022 Mar 3:S0166-2236(22)00017-0. doi: 10.1016/j.tins.2022.01.005. Online ahead of print.ABSTRACTNeurons rely heavily on properly regulated mitochondrial and lysosomal homeostasis, with multiple neurodegenerative diseases linked to dysfunction in these two organelles. Interestingly, mitochondria-lysosome membrane contact sites have been identified as a key pathway mediating their crosstalk in neurons. Recent studies have further elucidated the regulation of mitochondria-lysosome contact dynamics via distinct tethering/untethering protein machinery. Moreover, this pathway has been shown to have additional f...
Source: Trends in Neurosciences - March 7, 2022 Category: Neuroscience Authors: Jasmine Cisneros Tayler B Belton George C Shum Catherine G Molakal Yvette C Wong Source Type: research

Mitochondria-lysosome contact site dynamics and misregulation in neurodegenerative diseases
Trends Neurosci. 2022 Mar 3:S0166-2236(22)00017-0. doi: 10.1016/j.tins.2022.01.005. Online ahead of print.ABSTRACTNeurons rely heavily on properly regulated mitochondrial and lysosomal homeostasis, with multiple neurodegenerative diseases linked to dysfunction in these two organelles. Interestingly, mitochondria-lysosome membrane contact sites have been identified as a key pathway mediating their crosstalk in neurons. Recent studies have further elucidated the regulation of mitochondria-lysosome contact dynamics via distinct tethering/untethering protein machinery. Moreover, this pathway has been shown to have additional f...
Source: Trends in Neurosciences - March 7, 2022 Category: Neuroscience Authors: Jasmine Cisneros Tayler B Belton George C Shum Catherine G Molakal Yvette C Wong Source Type: research

Interbrain synchrony: on wavy ground
Trends Neurosci. 2022 Feb 28:S0166-2236(22)00036-4. doi: 10.1016/j.tins.2022.02.002. Online ahead of print.ABSTRACTIn recent years the study of dynamic, between-brain coupling mechanisms has taken social neuroscience by storm. In particular, interbrain synchrony (IBS) is a putative neural mechanism said to promote social interactions by enabling the functional integration of multiple brains. In this article, I argue that this research is beset with three pervasive and interrelated problems. First, the field lacks a widely accepted definition of IBS. Second, IBS wants for theories that can guide the design and interpretatio...
Source: Trends in Neurosciences - March 3, 2022 Category: Neuroscience Authors: Clay B Holroyd Source Type: research

Interbrain synchrony: on wavy ground
Trends Neurosci. 2022 Feb 28:S0166-2236(22)00036-4. doi: 10.1016/j.tins.2022.02.002. Online ahead of print.ABSTRACTIn recent years the study of dynamic, between-brain coupling mechanisms has taken social neuroscience by storm. In particular, interbrain synchrony (IBS) is a putative neural mechanism said to promote social interactions by enabling the functional integration of multiple brains. In this article, I argue that this research is beset with three pervasive and interrelated problems. First, the field lacks a widely accepted definition of IBS. Second, IBS wants for theories that can guide the design and interpretatio...
Source: Trends in Neurosciences - March 3, 2022 Category: Neuroscience Authors: Clay B Holroyd Source Type: research

Interbrain synchrony: on wavy ground
Trends Neurosci. 2022 Feb 28:S0166-2236(22)00036-4. doi: 10.1016/j.tins.2022.02.002. Online ahead of print.ABSTRACTIn recent years the study of dynamic, between-brain coupling mechanisms has taken social neuroscience by storm. In particular, interbrain synchrony (IBS) is a putative neural mechanism said to promote social interactions by enabling the functional integration of multiple brains. In this article, I argue that this research is beset with three pervasive and interrelated problems. First, the field lacks a widely accepted definition of IBS. Second, IBS wants for theories that can guide the design and interpretatio...
Source: Trends in Neurosciences - March 3, 2022 Category: Neuroscience Authors: Clay B Holroyd Source Type: research

Interbrain synchrony: on wavy ground
Trends Neurosci. 2022 Feb 28:S0166-2236(22)00036-4. doi: 10.1016/j.tins.2022.02.002. Online ahead of print.ABSTRACTIn recent years the study of dynamic, between-brain coupling mechanisms has taken social neuroscience by storm. In particular, interbrain synchrony (IBS) is a putative neural mechanism said to promote social interactions by enabling the functional integration of multiple brains. In this article, I argue that this research is beset with three pervasive and interrelated problems. First, the field lacks a widely accepted definition of IBS. Second, IBS wants for theories that can guide the design and interpretatio...
Source: Trends in Neurosciences - March 3, 2022 Category: Neuroscience Authors: Clay B Holroyd Source Type: research

Tau talk - synaptic and mitochondrial proteins interact with Tau in human neurons
Trends Neurosci. 2022 Feb 26:S0166-2236(22)00038-8. doi: 10.1016/j.tins.2022.02.004. Online ahead of print.ABSTRACTIn a recent study, Tracy et al. observed that Tau interacts with mitochondrial and presynaptic vesicle proteins in human iPSC-derived neurons. Tau with mutations that cause neurodegeneration has decreased mitochondrial interactions. This elegant interactome mapping with supporting human brain data paves the way to a better understanding of Tau pathology and future Tau-directed therapeutics.PMID:35232606 | DOI:10.1016/j.tins.2022.02.004 (Source: Trends in Neurosciences)
Source: Trends in Neurosciences - March 2, 2022 Category: Neuroscience Authors: Declan King Tara L Spires-Jones Source Type: research