Immune-related neurodegeneration in the midbrain causes pulmonary dysfunction in murine cryptococcal IRIS
Trends Neurosci. 2023 Oct 6:S0166-2236(23)00223-0. doi: 10.1016/j.tins.2023.09.005. Online ahead of print.ABSTRACTCryptococcal immune reconstitution inflammatory syndrome (C-IRIS) is a condition that affects immunosuppressed individuals recruited to antiretroviral therapy. In a recent publication, Kawano and colleagues used a mouse model to demonstrate that pulmonary dysfunction, one of the fatal complications of C-IRIS, is caused by T cell-driven neurodegeneration in a vital medullary nucleus of the brain responsible for respiratory control.PMID:37806831 | DOI:10.1016/j.tins.2023.09.005 (Source: Trends in Neurosciences)
Source: Trends in Neurosciences - October 8, 2023 Category: Neuroscience Authors: Rachael Dangarembizi Rebecca Drummond Source Type: research
Immune-related neurodegeneration in the midbrain causes pulmonary dysfunction in murine cryptococcal IRIS
Trends Neurosci. 2023 Oct 6:S0166-2236(23)00223-0. doi: 10.1016/j.tins.2023.09.005. Online ahead of print.ABSTRACTCryptococcal immune reconstitution inflammatory syndrome (C-IRIS) is a condition that affects immunosuppressed individuals recruited to antiretroviral therapy. In a recent publication, Kawano and colleagues used a mouse model to demonstrate that pulmonary dysfunction, one of the fatal complications of C-IRIS, is caused by T cell-driven neurodegeneration in a vital medullary nucleus of the brain responsible for respiratory control.PMID:37806831 | DOI:10.1016/j.tins.2023.09.005 (Source: Trends in Neurosciences)
Source: Trends in Neurosciences - October 8, 2023 Category: Neuroscience Authors: Rachael Dangarembizi Rebecca Drummond Source Type: research
Immune-related neurodegeneration in the midbrain causes pulmonary dysfunction in murine cryptococcal IRIS
Trends Neurosci. 2023 Oct 6:S0166-2236(23)00223-0. doi: 10.1016/j.tins.2023.09.005. Online ahead of print.ABSTRACTCryptococcal immune reconstitution inflammatory syndrome (C-IRIS) is a condition that affects immunosuppressed individuals recruited to antiretroviral therapy. In a recent publication, Kawano and colleagues used a mouse model to demonstrate that pulmonary dysfunction, one of the fatal complications of C-IRIS, is caused by T cell-driven neurodegeneration in a vital medullary nucleus of the brain responsible for respiratory control.PMID:37806831 | DOI:10.1016/j.tins.2023.09.005 (Source: Trends in Neurosciences)
Source: Trends in Neurosciences - October 8, 2023 Category: Neuroscience Authors: Rachael Dangarembizi Rebecca Drummond Source Type: research
Disrupted circadian rhythms in the plateau pika
Trends Neurosci. 2023 Oct 4:S0166-2236(23)00221-7. doi: 10.1016/j.tins.2023.09.003. Online ahead of print.ABSTRACTThe plateau pika (Ochotona curzoniae) is the most populous mammal on the 'third pole', the Qinghai-Tibet Plateau, and is presumed to have inhabited the region before the plateau rose up from sea level. Herein we discuss the disrupted circadian rhythm in the plateau pika and the gene polymorphism behind this phenotype, placing these findings in the broader context of circadian rhythms under extreme conditions.PMID:37802756 | DOI:10.1016/j.tins.2023.09.003 (Source: Trends in Neurosciences)
Source: Trends in Neurosciences - October 6, 2023 Category: Neuroscience Authors: Ziqing Yu Eric Erquan Zhang Source Type: research
Disrupted circadian rhythms in the plateau pika
Trends Neurosci. 2023 Oct 4:S0166-2236(23)00221-7. doi: 10.1016/j.tins.2023.09.003. Online ahead of print.ABSTRACTThe plateau pika (Ochotona curzoniae) is the most populous mammal on the 'third pole', the Qinghai-Tibet Plateau, and is presumed to have inhabited the region before the plateau rose up from sea level. Herein we discuss the disrupted circadian rhythm in the plateau pika and the gene polymorphism behind this phenotype, placing these findings in the broader context of circadian rhythms under extreme conditions.PMID:37802756 | DOI:10.1016/j.tins.2023.09.003 (Source: Trends in Neurosciences)
Source: Trends in Neurosciences - October 6, 2023 Category: Neuroscience Authors: Ziqing Yu Eric Erquan Zhang Source Type: research
Visual attention and processing in jumping spiders
Trends Neurosci. 2023 Oct 3:S0166-2236(23)00220-5. doi: 10.1016/j.tins.2023.09.002. Online ahead of print.ABSTRACTJumping spiders have extraordinary vision. Using multiple, specialized eyes, these spiders selectively gather and integrate disparate streams of information about motion, color, and spatial detail. The saccadic movements of a forward-facing pair of eyes allow spiders to inspect their surroundings and identify objects. Here, we discuss the jumping spider visual system and how visual information is attended to and processed.PMID:37798203 | DOI:10.1016/j.tins.2023.09.002 (Source: Trends in Neurosciences)
Source: Trends in Neurosciences - October 5, 2023 Category: Neuroscience Authors: Alex M Winsor Luke Remage-Healey Ronald R Hoy Elizabeth M Jakob Source Type: research
Visual attention and processing in jumping spiders
Trends Neurosci. 2023 Oct 3:S0166-2236(23)00220-5. doi: 10.1016/j.tins.2023.09.002. Online ahead of print.ABSTRACTJumping spiders have extraordinary vision. Using multiple, specialized eyes, these spiders selectively gather and integrate disparate streams of information about motion, color, and spatial detail. The saccadic movements of a forward-facing pair of eyes allow spiders to inspect their surroundings and identify objects. Here, we discuss the jumping spider visual system and how visual information is attended to and processed.PMID:37798203 | DOI:10.1016/j.tins.2023.09.002 (Source: Trends in Neurosciences)
Source: Trends in Neurosciences - October 5, 2023 Category: Neuroscience Authors: Alex M Winsor Luke Remage-Healey Ronald R Hoy Elizabeth M Jakob Source Type: research
A thalamocortical pathway controlling impulsive behavior
Trends Neurosci. 2023 Sep 29:S0166-2236(23)00219-9. doi: 10.1016/j.tins.2023.09.001. Online ahead of print.ABSTRACTPlanning and anticipating motor actions enables movements to be quickly and accurately executed. However, if anticipation is not properly controlled, it can lead to premature impulsive actions. Impulsive behavior is defined as actions that are poorly conceived and are often risky and inappropriate. Historically, impulsive behavior was thought to be primarily controlled by the frontal cortex and basal ganglia. More recently, two additional brain regions, the ventromedial (VM) thalamus and the anterior lateral m...
Source: Trends in Neurosciences - October 1, 2023 Category: Neuroscience Authors: Robertas Guzulaitis Lucy M Palmer Source Type: research
A thalamocortical pathway controlling impulsive behavior
Trends Neurosci. 2023 Sep 29:S0166-2236(23)00219-9. doi: 10.1016/j.tins.2023.09.001. Online ahead of print.ABSTRACTPlanning and anticipating motor actions enables movements to be quickly and accurately executed. However, if anticipation is not properly controlled, it can lead to premature impulsive actions. Impulsive behavior is defined as actions that are poorly conceived and are often risky and inappropriate. Historically, impulsive behavior was thought to be primarily controlled by the frontal cortex and basal ganglia. More recently, two additional brain regions, the ventromedial (VM) thalamus and the anterior lateral m...
Source: Trends in Neurosciences - October 1, 2023 Category: Neuroscience Authors: Robertas Guzulaitis Lucy M Palmer Source Type: research
A thalamocortical pathway controlling impulsive behavior
Trends Neurosci. 2023 Sep 29:S0166-2236(23)00219-9. doi: 10.1016/j.tins.2023.09.001. Online ahead of print.ABSTRACTPlanning and anticipating motor actions enables movements to be quickly and accurately executed. However, if anticipation is not properly controlled, it can lead to premature impulsive actions. Impulsive behavior is defined as actions that are poorly conceived and are often risky and inappropriate. Historically, impulsive behavior was thought to be primarily controlled by the frontal cortex and basal ganglia. More recently, two additional brain regions, the ventromedial (VM) thalamus and the anterior lateral m...
Source: Trends in Neurosciences - October 1, 2023 Category: Neuroscience Authors: Robertas Guzulaitis Lucy M Palmer Source Type: research
A thalamocortical pathway controlling impulsive behavior
Trends Neurosci. 2023 Sep 29:S0166-2236(23)00219-9. doi: 10.1016/j.tins.2023.09.001. Online ahead of print.ABSTRACTPlanning and anticipating motor actions enables movements to be quickly and accurately executed. However, if anticipation is not properly controlled, it can lead to premature impulsive actions. Impulsive behavior is defined as actions that are poorly conceived and are often risky and inappropriate. Historically, impulsive behavior was thought to be primarily controlled by the frontal cortex and basal ganglia. More recently, two additional brain regions, the ventromedial (VM) thalamus and the anterior lateral m...
Source: Trends in Neurosciences - October 1, 2023 Category: Neuroscience Authors: Robertas Guzulaitis Lucy M Palmer Source Type: research
Air pollution, glymphatic impairment, and Alzheimer's disease
Trends Neurosci. 2023 Sep 28:S0166-2236(23)00210-2. doi: 10.1016/j.tins.2023.08.010. Online ahead of print.ABSTRACTEpidemiological evidence demonstrates a link between air pollution exposure and the onset and progression of cognitive impairment and Alzheimer's disease (AD). However, current understanding of the underlying pathophysiological mechanisms is limited. This opinion article examines the hypothesis that air pollution-induced impairment of glymphatic clearance represents a crucial etiological event in the development of AD. Exposure to airborne particulate matter (PM) leads to systemic inflammation and neuroinflamm...
Source: Trends in Neurosciences - September 30, 2023 Category: Neuroscience Authors: Rashad Hussain Uschi Graham Alison Elder Maiken Nedergaard Source Type: research
Air pollution, glymphatic impairment, and Alzheimer's disease
Trends Neurosci. 2023 Sep 28:S0166-2236(23)00210-2. doi: 10.1016/j.tins.2023.08.010. Online ahead of print.ABSTRACTEpidemiological evidence demonstrates a link between air pollution exposure and the onset and progression of cognitive impairment and Alzheimer's disease (AD). However, current understanding of the underlying pathophysiological mechanisms is limited. This opinion article examines the hypothesis that air pollution-induced impairment of glymphatic clearance represents a crucial etiological event in the development of AD. Exposure to airborne particulate matter (PM) leads to systemic inflammation and neuroinflamm...
Source: Trends in Neurosciences - September 30, 2023 Category: Neuroscience Authors: Rashad Hussain Uschi Graham Alison Elder Maiken Nedergaard Source Type: research
Internal models of self-motion: neural computations by the vestibular cerebellum
Trends Neurosci. 2023 Sep 20:S0166-2236(23)00207-2. doi: 10.1016/j.tins.2023.08.009. Online ahead of print.ABSTRACTThe vestibular cerebellum plays an essential role in maintaining our balance and ensuring perceptual stability during activities of daily living. Here I examine three key regions of the vestibular cerebellum: the floccular lobe, anterior vermis (lobules I-V), and nodulus and ventral uvula (lobules X-IX of the posterior vermis). These cerebellar regions encode vestibular information and combine it with extravestibular signals to create internal models of eye, head, and body movements, as well as their spatial o...
Source: Trends in Neurosciences - September 22, 2023 Category: Neuroscience Authors: Kathleen E Cullen Source Type: research
Internal models of self-motion: neural computations by the vestibular cerebellum
Trends Neurosci. 2023 Sep 20:S0166-2236(23)00207-2. doi: 10.1016/j.tins.2023.08.009. Online ahead of print.ABSTRACTThe vestibular cerebellum plays an essential role in maintaining our balance and ensuring perceptual stability during activities of daily living. Here I examine three key regions of the vestibular cerebellum: the floccular lobe, anterior vermis (lobules I-V), and nodulus and ventral uvula (lobules X-IX of the posterior vermis). These cerebellar regions encode vestibular information and combine it with extravestibular signals to create internal models of eye, head, and body movements, as well as their spatial o...
Source: Trends in Neurosciences - September 22, 2023 Category: Neuroscience Authors: Kathleen E Cullen Source Type: research
