Subtypes of Alzheimer's disease: questions, controversy, and meaning
Trends Neurosci. 2022 Feb 25:S0166-2236(22)00033-9. doi: 10.1016/j.tins.2022.02.001. Online ahead of print.ABSTRACTThe distribution of Alzheimer's disease (AD) tau pathology varies systematically and causes a diverse array of syndromes. This forum article provides a brief overview of key controversies in untangling the complexity of AD subtypes, explores potential causes of AD variability in the population, and discusses clinical relevance and future directions of research into AD heterogeneity.PMID:35227519 | DOI:10.1016/j.tins.2022.02.001 (Source: Trends in Neurosciences)
Source: Trends in Neurosciences - March 1, 2022 Category: Neuroscience Authors: Jacob W Vogel Oskar Hansson Source Type: research

Subtypes of Alzheimer's disease: questions, controversy, and meaning
Trends Neurosci. 2022 Feb 25:S0166-2236(22)00033-9. doi: 10.1016/j.tins.2022.02.001. Online ahead of print.ABSTRACTThe distribution of Alzheimer's disease (AD) tau pathology varies systematically and causes a diverse array of syndromes. This forum article provides a brief overview of key controversies in untangling the complexity of AD subtypes, explores potential causes of AD variability in the population, and discusses clinical relevance and future directions of research into AD heterogeneity.PMID:35227519 | DOI:10.1016/j.tins.2022.02.001 (Source: Trends in Neurosciences)
Source: Trends in Neurosciences - March 1, 2022 Category: Neuroscience Authors: Jacob W Vogel Oskar Hansson Source Type: research

The cerebellum on the epilepsy frontline
This study provides insights into how the cerebellum impacts hippocampal activity and opens the way to possible applications for treating temporal lobe epilepsy.PMID:35219523 | DOI:10.1016/j.tins.2022.02.003 (Source: Trends in Neurosciences)
Source: Trends in Neurosciences - February 27, 2022 Category: Neuroscience Authors: Laure Rondi-Reig Source Type: research

The cerebellum on the epilepsy frontline
This study provides insights into how the cerebellum impacts hippocampal activity and opens the way to possible applications for treating temporal lobe epilepsy.PMID:35219523 | DOI:10.1016/j.tins.2022.02.003 (Source: Trends in Neurosciences)
Source: Trends in Neurosciences - February 27, 2022 Category: Neuroscience Authors: Laure Rondi-Reig Source Type: research

How do protein aggregates escape quality control in neurodegeneration?
Trends Neurosci. 2022 Feb 21:S0166-2236(22)00018-2. doi: 10.1016/j.tins.2022.01.006. Online ahead of print.ABSTRACTProtein aggregates are hallmarks of neurodegenerative diseases. The protein quality control (PQC) system normally prevents proteins from misfolding and accumulation; however, proteins somehow escape this control on disease. Here we review advances in the role of PQC in protein aggregation and neurodegeneration. We focus primarily on the protein Tau, which aggregates in Alzheimer's disease (AD) and other tauopathies. We also examine recent advances in amyloid fibril structures and the process of fibril formatio...
Source: Trends in Neurosciences - February 25, 2022 Category: Neuroscience Authors: Margreet B Koopman Luca Ferrari Stefan G D R üdiger Source Type: research

How do protein aggregates escape quality control in neurodegeneration?
Trends Neurosci. 2022 Feb 21:S0166-2236(22)00018-2. doi: 10.1016/j.tins.2022.01.006. Online ahead of print.ABSTRACTProtein aggregates are hallmarks of neurodegenerative diseases. The protein quality control (PQC) system normally prevents proteins from misfolding and accumulation; however, proteins somehow escape this control on disease. Here we review advances in the role of PQC in protein aggregation and neurodegeneration. We focus primarily on the protein Tau, which aggregates in Alzheimer's disease (AD) and other tauopathies. We also examine recent advances in amyloid fibril structures and the process of fibril formatio...
Source: Trends in Neurosciences - February 25, 2022 Category: Neuroscience Authors: Margreet B Koopman Luca Ferrari Stefan G D R üdiger Source Type: research

How do protein aggregates escape quality control in neurodegeneration?
Trends Neurosci. 2022 Feb 21:S0166-2236(22)00018-2. doi: 10.1016/j.tins.2022.01.006. Online ahead of print.ABSTRACTProtein aggregates are hallmarks of neurodegenerative diseases. The protein quality control (PQC) system normally prevents proteins from misfolding and accumulation; however, proteins somehow escape this control on disease. Here we review advances in the role of PQC in protein aggregation and neurodegeneration. We focus primarily on the protein Tau, which aggregates in Alzheimer's disease (AD) and other tauopathies. We also examine recent advances in amyloid fibril structures and the process of fibril formatio...
Source: Trends in Neurosciences - February 25, 2022 Category: Neuroscience Authors: Margreet B Koopman Luca Ferrari Stefan G D R üdiger Source Type: research

Dynamic coupling of oscillatory neural activity and its roles in visual attention
Trends Neurosci. 2022 Feb 18:S0166-2236(22)00015-7. doi: 10.1016/j.tins.2022.01.003. Online ahead of print.ABSTRACTOscillatory neural activity is believed to have a central role in information processing in the mammalian brain. While early studies often focussed on the function of individual frequency bands, there is emerging appreciation for the role of simultaneous activity in many distinct frequency bands and the interactions between them in high-level cognitive functions. Here, we focus on the role of cross-frequency coupling (CFC) in visual attention. First, we propose a framework that reconciles previous contrasting ...
Source: Trends in Neurosciences - February 22, 2022 Category: Neuroscience Authors: Moein Esghaei Stefan Treue Trichur R Vidyasagar Source Type: research

Dynamic coupling of oscillatory neural activity and its roles in visual attention
Trends Neurosci. 2022 Feb 18:S0166-2236(22)00015-7. doi: 10.1016/j.tins.2022.01.003. Online ahead of print.ABSTRACTOscillatory neural activity is believed to have a central role in information processing in the mammalian brain. While early studies often focussed on the function of individual frequency bands, there is emerging appreciation for the role of simultaneous activity in many distinct frequency bands and the interactions between them in high-level cognitive functions. Here, we focus on the role of cross-frequency coupling (CFC) in visual attention. First, we propose a framework that reconciles previous contrasting ...
Source: Trends in Neurosciences - February 22, 2022 Category: Neuroscience Authors: Moein Esghaei Stefan Treue Trichur R Vidyasagar Source Type: research

Dynamic coupling of oscillatory neural activity and its roles in visual attention
Trends Neurosci. 2022 Feb 18:S0166-2236(22)00015-7. doi: 10.1016/j.tins.2022.01.003. Online ahead of print.ABSTRACTOscillatory neural activity is believed to have a central role in information processing in the mammalian brain. While early studies often focussed on the function of individual frequency bands, there is emerging appreciation for the role of simultaneous activity in many distinct frequency bands and the interactions between them in high-level cognitive functions. Here, we focus on the role of cross-frequency coupling (CFC) in visual attention. First, we propose a framework that reconciles previous contrasting ...
Source: Trends in Neurosciences - February 22, 2022 Category: Neuroscience Authors: Moein Esghaei Stefan Treue Trichur R Vidyasagar Source Type: research

Brain cell type-specific cholesterol metabolism and implications for learning and memory
Trends Neurosci. 2022 Feb 17:S0166-2236(22)00014-5. doi: 10.1016/j.tins.2022.01.002. Online ahead of print.ABSTRACTCholesterol homeostasis is vital for brain function. Brain cholesterol is locally synthesized, with varying synthesis capacities across different cell types. Moreover, brain cholesterol horizontally transfers across various cell types not only to accommodate distinct cholesterol needs, but also to fulfill regulatory functions in target cells. Cholesterol metabolism within individual cell types is essential for brain functioning, and the role of cholesterol-related communication between different cell types is ...
Source: Trends in Neurosciences - February 21, 2022 Category: Neuroscience Authors: Dingfeng Li Juan Zhang Qiang Liu Source Type: research

Spatiotemporally resolved protein synthesis as a molecular framework for memory consolidation
Trends Neurosci. 2022 Feb 17:S0166-2236(22)00016-9. doi: 10.1016/j.tins.2022.01.004. Online ahead of print.ABSTRACTDe novo protein synthesis is required for long-term memory consolidation. Dynamic regulation of protein synthesis occurs via a complex interplay of translation factors and modulators. Many components of the protein synthesis machinery have been targeted either pharmacologically or genetically to establish its requirement for memory. The combination of ligand/light-gating and genetic strategies, that is, chemogenetics and optogenetics, has begun to reveal the spatiotemporal resolution of protein synthesis in sp...
Source: Trends in Neurosciences - February 21, 2022 Category: Neuroscience Authors: Prerana Shrestha Eric Klann Source Type: research

Brain cell type-specific cholesterol metabolism and implications for learning and memory
Trends Neurosci. 2022 Feb 17:S0166-2236(22)00014-5. doi: 10.1016/j.tins.2022.01.002. Online ahead of print.ABSTRACTCholesterol homeostasis is vital for brain function. Brain cholesterol is locally synthesized, with varying synthesis capacities across different cell types. Moreover, brain cholesterol horizontally transfers across various cell types not only to accommodate distinct cholesterol needs, but also to fulfill regulatory functions in target cells. Cholesterol metabolism within individual cell types is essential for brain functioning, and the role of cholesterol-related communication between different cell types is ...
Source: Trends in Neurosciences - February 21, 2022 Category: Neuroscience Authors: Dingfeng Li Juan Zhang Qiang Liu Source Type: research

Spatiotemporally resolved protein synthesis as a molecular framework for memory consolidation
Trends Neurosci. 2022 Feb 17:S0166-2236(22)00016-9. doi: 10.1016/j.tins.2022.01.004. Online ahead of print.ABSTRACTDe novo protein synthesis is required for long-term memory consolidation. Dynamic regulation of protein synthesis occurs via a complex interplay of translation factors and modulators. Many components of the protein synthesis machinery have been targeted either pharmacologically or genetically to establish its requirement for memory. The combination of ligand/light-gating and genetic strategies, that is, chemogenetics and optogenetics, has begun to reveal the spatiotemporal resolution of protein synthesis in sp...
Source: Trends in Neurosciences - February 21, 2022 Category: Neuroscience Authors: Prerana Shrestha Eric Klann Source Type: research

Mechanistic flexibility of the retrosplenial cortex enables its contribution to spatial cognition
Trends Neurosci. 2022 Feb 17:S0166-2236(22)00019-4. doi: 10.1016/j.tins.2022.01.007. Online ahead of print.ABSTRACTThe retrosplenial cortex (RC) is a brain structure crucial for spatial navigation and memory. It contains neurons such as head direction cells, border cells, as well as other cells supporting spatial and contextual encoding. How such complex and diverse neuronal properties are generated by RC microcircuitry and how they jointly orchestrate subsequent behavior remains enigmatic. Here, we consider recent findings that extend current knowledge about how the RC modulates spatial navigation and spatial cognition. W...
Source: Trends in Neurosciences - February 20, 2022 Category: Neuroscience Authors: Martin Stacho Denise Manahan-Vaughan Source Type: research