PET reporter systems for the brain
Trends Neurosci. 2023 Sep 19:S0166-2236(23)00205-9. doi: 10.1016/j.tins.2023.08.007. Online ahead of print.ABSTRACTPositron emission tomography (PET) can be used as a noninvasive method to longitudinally monitor and quantify the expression of proteins in the brain in vivo. It can be used to monitor changes in biomarkers of mental health disorders, and to assess therapeutic interventions such as stem cell and molecular genetic therapies. The utility of PET monitoring depends on the availability of a radiotracer with good central nervous system (CNS) penetration and high selectivity for the target protein. This review evalua...
Source: Trends in Neurosciences - September 21, 2023 Category: Neuroscience Authors: Sridhar Goud Nerella Michael Michaelides Takafumi Minamimoto Robert B Innis Victor W Pike Mark A G Eldridge Source Type: research
Microglia moonlighting after traumatic brain injury: aging and interferons influence chronic microglia reactivity
Trends Neurosci. 2023 Sep 16:S0166-2236(23)00206-0. doi: 10.1016/j.tins.2023.08.008. Online ahead of print.ABSTRACTMost of the individuals who experience traumatic brain injury (TBI) develop neuropsychiatric and cognitive complications that negatively affect recovery and health span. Activation of multiple inflammatory pathways persists after TBI, but it is unclear how inflammation contributes to long-term behavioral and cognitive deficits. One outcome of TBI is microglial priming and subsequent hyper-reactivity to secondary stressors, injuries, or immune challenges that further augment complications. Additionally, microgl...
Source: Trends in Neurosciences - September 18, 2023 Category: Neuroscience Authors: Lynde M Wangler Jonathan P Godbout Source Type: research
Microglia moonlighting after traumatic brain injury: aging and interferons influence chronic microglia reactivity
Trends Neurosci. 2023 Sep 16:S0166-2236(23)00206-0. doi: 10.1016/j.tins.2023.08.008. Online ahead of print.ABSTRACTMost of the individuals who experience traumatic brain injury (TBI) develop neuropsychiatric and cognitive complications that negatively affect recovery and health span. Activation of multiple inflammatory pathways persists after TBI, but it is unclear how inflammation contributes to long-term behavioral and cognitive deficits. One outcome of TBI is microglial priming and subsequent hyper-reactivity to secondary stressors, injuries, or immune challenges that further augment complications. Additionally, microgl...
Source: Trends in Neurosciences - September 18, 2023 Category: Neuroscience Authors: Lynde M Wangler Jonathan P Godbout Source Type: research
Microglia moonlighting after traumatic brain injury: aging and interferons influence chronic microglia reactivity
Trends Neurosci. 2023 Sep 16:S0166-2236(23)00206-0. doi: 10.1016/j.tins.2023.08.008. Online ahead of print.ABSTRACTMost of the individuals who experience traumatic brain injury (TBI) develop neuropsychiatric and cognitive complications that negatively affect recovery and health span. Activation of multiple inflammatory pathways persists after TBI, but it is unclear how inflammation contributes to long-term behavioral and cognitive deficits. One outcome of TBI is microglial priming and subsequent hyper-reactivity to secondary stressors, injuries, or immune challenges that further augment complications. Additionally, microgl...
Source: Trends in Neurosciences - September 18, 2023 Category: Neuroscience Authors: Lynde M Wangler Jonathan P Godbout Source Type: research
The role of the hippocampus in the consolidation of emotional memories during sleep
Trends Neurosci. 2023 Sep 14:S0166-2236(23)00191-1. doi: 10.1016/j.tins.2023.08.003. Online ahead of print.ABSTRACTEpisodic memory relies on the hippocampus, a heterogeneous brain region with distinct functions. Spatial representations in the dorsal hippocampus (dHPC) are crucial for contextual memory, while the ventral hippocampus (vHPC) is more involved in emotional processing. Here, we review the literature in rodents highlighting the anatomical and functional properties of the hippocampus along its dorsoventral axis that underlie its role in contextual and emotional memory encoding, consolidation, and retrieval. We pro...
Source: Trends in Neurosciences - September 15, 2023 Category: Neuroscience Authors: Éléonore Pronier Juan Facundo Morici Gabrielle Girardeau Source Type: research
The role of the hippocampus in the consolidation of emotional memories during sleep
Trends Neurosci. 2023 Sep 14:S0166-2236(23)00191-1. doi: 10.1016/j.tins.2023.08.003. Online ahead of print.ABSTRACTEpisodic memory relies on the hippocampus, a heterogeneous brain region with distinct functions. Spatial representations in the dorsal hippocampus (dHPC) are crucial for contextual memory, while the ventral hippocampus (vHPC) is more involved in emotional processing. Here, we review the literature in rodents highlighting the anatomical and functional properties of the hippocampus along its dorsoventral axis that underlie its role in contextual and emotional memory encoding, consolidation, and retrieval. We pro...
Source: Trends in Neurosciences - September 15, 2023 Category: Neuroscience Authors: Éléonore Pronier Juan Facundo Morici Gabrielle Girardeau Source Type: research
The role of the hippocampus in the consolidation of emotional memories during sleep
Trends Neurosci. 2023 Sep 14:S0166-2236(23)00191-1. doi: 10.1016/j.tins.2023.08.003. Online ahead of print.ABSTRACTEpisodic memory relies on the hippocampus, a heterogeneous brain region with distinct functions. Spatial representations in the dorsal hippocampus (dHPC) are crucial for contextual memory, while the ventral hippocampus (vHPC) is more involved in emotional processing. Here, we review the literature in rodents highlighting the anatomical and functional properties of the hippocampus along its dorsoventral axis that underlie its role in contextual and emotional memory encoding, consolidation, and retrieval. We pro...
Source: Trends in Neurosciences - September 15, 2023 Category: Neuroscience Authors: Éléonore Pronier Juan Facundo Morici Gabrielle Girardeau Source Type: research
Synaptic crossroads: navigating the circuits of movement
Trends Neurosci. 2023 Sep 8:S0166-2236(23)00204-7. doi: 10.1016/j.tins.2023.08.006. Online ahead of print.ABSTRACTThe anterior lateral motor area (ALM) is crucial in preparing and executing voluntary movements through its diverse neuronal subpopulations that target different subcortical areas. A recent study by Xu et al. utilized an elaborate viral tracing strategy in mice to provide comprehensive whole-brain maps of monosynaptic inputs to the major descending pathways of ALM.PMID:37690954 | DOI:10.1016/j.tins.2023.08.006 (Source: Trends in Neurosciences)
Source: Trends in Neurosciences - September 10, 2023 Category: Neuroscience Authors: Eduardo Maristany de Las Casas Naoya Takahashi Source Type: research
Synaptic crossroads: navigating the circuits of movement
Trends Neurosci. 2023 Sep 8:S0166-2236(23)00204-7. doi: 10.1016/j.tins.2023.08.006. Online ahead of print.ABSTRACTThe anterior lateral motor area (ALM) is crucial in preparing and executing voluntary movements through its diverse neuronal subpopulations that target different subcortical areas. A recent study by Xu et al. utilized an elaborate viral tracing strategy in mice to provide comprehensive whole-brain maps of monosynaptic inputs to the major descending pathways of ALM.PMID:37690954 | DOI:10.1016/j.tins.2023.08.006 (Source: Trends in Neurosciences)
Source: Trends in Neurosciences - September 10, 2023 Category: Neuroscience Authors: Eduardo Maristany de Las Casas Naoya Takahashi Source Type: research
Synaptic crossroads: navigating the circuits of movement
Trends Neurosci. 2023 Sep 8:S0166-2236(23)00204-7. doi: 10.1016/j.tins.2023.08.006. Online ahead of print.ABSTRACTThe anterior lateral motor area (ALM) is crucial in preparing and executing voluntary movements through its diverse neuronal subpopulations that target different subcortical areas. A recent study by Xu et al. utilized an elaborate viral tracing strategy in mice to provide comprehensive whole-brain maps of monosynaptic inputs to the major descending pathways of ALM.PMID:37690954 | DOI:10.1016/j.tins.2023.08.006 (Source: Trends in Neurosciences)
Source: Trends in Neurosciences - September 10, 2023 Category: Neuroscience Authors: Eduardo Maristany de Las Casas Naoya Takahashi Source Type: research
Synaptic crossroads: navigating the circuits of movement
Trends Neurosci. 2023 Sep 8:S0166-2236(23)00204-7. doi: 10.1016/j.tins.2023.08.006. Online ahead of print.ABSTRACTThe anterior lateral motor area (ALM) is crucial in preparing and executing voluntary movements through its diverse neuronal subpopulations that target different subcortical areas. A recent study by Xu et al. utilized an elaborate viral tracing strategy in mice to provide comprehensive whole-brain maps of monosynaptic inputs to the major descending pathways of ALM.PMID:37690954 | DOI:10.1016/j.tins.2023.08.006 (Source: Trends in Neurosciences)
Source: Trends in Neurosciences - September 10, 2023 Category: Neuroscience Authors: Eduardo Maristany de Las Casas Naoya Takahashi Source Type: research
Synaptic crossroads: navigating the circuits of movement
Trends Neurosci. 2023 Sep 8:S0166-2236(23)00204-7. doi: 10.1016/j.tins.2023.08.006. Online ahead of print.ABSTRACTThe anterior lateral motor area (ALM) is crucial in preparing and executing voluntary movements through its diverse neuronal subpopulations that target different subcortical areas. A recent study by Xu et al. utilized an elaborate viral tracing strategy in mice to provide comprehensive whole-brain maps of monosynaptic inputs to the major descending pathways of ALM.PMID:37690954 | DOI:10.1016/j.tins.2023.08.006 (Source: Trends in Neurosciences)
Source: Trends in Neurosciences - September 10, 2023 Category: Neuroscience Authors: Eduardo Maristany de Las Casas Naoya Takahashi Source Type: research
The neuropathogenesis of highly pathogenic avian influenza H5Nx viruses in mammalian species including humans
Trends Neurosci. 2023 Sep 6:S0166-2236(23)00190-X. doi: 10.1016/j.tins.2023.08.002. Online ahead of print.ABSTRACTCirculation of highly pathogenic avian influenza (HPAI) H5Nx viruses of the A/Goose/Guangdong/1/96 lineage in birds regularly causes infections of mammals, including humans. In many mammalian species, infections are associated with severe neurological disease, a unique feature of HPAI H5Nx viruses compared with other influenza A viruses. Here, we provide an overview of the neuropathogenesis of HPAI H5Nx virus infection in mammals, centered on three aspects: neuroinvasion, neurotropism, and neurovirulence. We fo...
Source: Trends in Neurosciences - September 8, 2023 Category: Neuroscience Authors: Lisa Bauer Feline F W Benavides Edwin J B Veldhuis Kroeze Emmie de Wit Debby van Riel Source Type: research
The neuropathogenesis of highly pathogenic avian influenza H5Nx viruses in mammalian species including humans
Trends Neurosci. 2023 Sep 6:S0166-2236(23)00190-X. doi: 10.1016/j.tins.2023.08.002. Online ahead of print.ABSTRACTCirculation of highly pathogenic avian influenza (HPAI) H5Nx viruses of the A/Goose/Guangdong/1/96 lineage in birds regularly causes infections of mammals, including humans. In many mammalian species, infections are associated with severe neurological disease, a unique feature of HPAI H5Nx viruses compared with other influenza A viruses. Here, we provide an overview of the neuropathogenesis of HPAI H5Nx virus infection in mammals, centered on three aspects: neuroinvasion, neurotropism, and neurovirulence. We fo...
Source: Trends in Neurosciences - September 8, 2023 Category: Neuroscience Authors: Lisa Bauer Feline F W Benavides Edwin J B Veldhuis Kroeze Emmie de Wit Debby van Riel Source Type: research
Cold blooded vertebrates help unveil a heat-dependent trigger
This study highlights the importance of considering natural diversity and comparative biology when approaching biophysical questions.PMID:37652839 | DOI:10.1016/j.tins.2023.08.005 (Source: Trends in Neurosciences)
Source: Trends in Neurosciences - August 31, 2023 Category: Neuroscience Authors: Sebastian E Brauchi Source Type: research
