Construction of complex memories via parallel distributed cortical-subcortical iterative integration
Trends Neurosci. 2022 May 19:S0166-2236(22)00080-7. doi: 10.1016/j.tins.2022.04.006. Online ahead of print.ABSTRACTThe construction of complex engrams requires hippocampal-cortical interactions. These include both direct interactions and ones via often-overlooked subcortical loops. Here, we review the anatomical organization of a hierarchy of parallel 'Papez' loops through the hypothalamus that are homologous in mammals from rats to humans. These hypothalamic loops supplement direct hippocampal-cortical connections with iterative reprocessing paced by theta rhythmicity. We couple existing anatomy and lesion data with theor...
Source: Trends in Neurosciences - May 22, 2022 Category: Neuroscience Authors: Neil McNaughton Seralynne D Vann Source Type: research

Interplay between metabolic energy regulation and memory pathways in Drosophila
Trends Neurosci. 2022 May 18:S0166-2236(22)00081-9. doi: 10.1016/j.tins.2022.04.007. Online ahead of print.ABSTRACTRegulating energy metabolism is critical to maintain homeostasis of cellular and systemic functions. In the brain, specialised centres for energy storage regulation finely communicate with the periphery and integrate signals about internal states. As a result, the behavioural responses can be directly adjusted accordingly to the energetic demands. In the fruit fly Drosophila melanogaster, one of these regulatory centres is the mushroom bodies (MBs), a brain region involved in olfactory memory. The integration ...
Source: Trends in Neurosciences - May 21, 2022 Category: Neuroscience Authors: Noemi Sgammeglia Simon G Sprecher Source Type: research

Interplay between metabolic energy regulation and memory pathways in Drosophila
Trends Neurosci. 2022 May 18:S0166-2236(22)00081-9. doi: 10.1016/j.tins.2022.04.007. Online ahead of print.ABSTRACTRegulating energy metabolism is critical to maintain homeostasis of cellular and systemic functions. In the brain, specialised centres for energy storage regulation finely communicate with the periphery and integrate signals about internal states. As a result, the behavioural responses can be directly adjusted accordingly to the energetic demands. In the fruit fly Drosophila melanogaster, one of these regulatory centres is the mushroom bodies (MBs), a brain region involved in olfactory memory. The integration ...
Source: Trends in Neurosciences - May 21, 2022 Category: Neuroscience Authors: Noemi Sgammeglia Simon G Sprecher Source Type: research

Functional interplay between central and autonomic nervous systems in human fear conditioning
Trends Neurosci. 2022 May 13:S0166-2236(22)00077-7. doi: 10.1016/j.tins.2022.04.003. Online ahead of print.ABSTRACTHistorically, studies on the neural basis of fear conditioning have emphasized the role of the central nervous system. However, there is growing evidence for the role of the autonomic nervous system in human fear conditioning. Here, we provide an overview of the sophisticated anatomical-functional interplay between the prefrontal cortex and heart-related dynamics in human fear conditioning and propose a theoretical model to conceptualize these psychophysiological processes, the neurovisceral integration model ...
Source: Trends in Neurosciences - May 16, 2022 Category: Neuroscience Authors: Simone Battaglia Julian F Thayer Source Type: research

Reassessing synaptic adhesion pathways
Trends Neurosci. 2022 May 13:S0166-2236(22)00078-9. doi: 10.1016/j.tins.2022.04.004. Online ahead of print.ABSTRACTMultiple synaptic adhesion proteins are thought to collectively define the properties of specific synapses and thereby shape the architectures of neural circuits. Growing evidence supports a molecular model in which a set of central hub proteins interacts with a vast number of other proteins to organize multifarious synaptic adhesion pathways. However, several fundamental open questions remain, partly owing to drawbacks in current approaches and interpretations. In this opinion, we provide an overview of synap...
Source: Trends in Neurosciences - May 16, 2022 Category: Neuroscience Authors: Dongseok Lim Dongwook Kim Ji Won Um Jaewon Ko Source Type: research

Functional interplay between central and autonomic nervous systems in human fear conditioning
Trends Neurosci. 2022 May 13:S0166-2236(22)00077-7. doi: 10.1016/j.tins.2022.04.003. Online ahead of print.ABSTRACTHistorically, studies on the neural basis of fear conditioning have emphasized the role of the central nervous system. However, there is growing evidence for the role of the autonomic nervous system in human fear conditioning. Here, we provide an overview of the sophisticated anatomical-functional interplay between the prefrontal cortex and heart-related dynamics in human fear conditioning and propose a theoretical model to conceptualize these psychophysiological processes, the neurovisceral integration model ...
Source: Trends in Neurosciences - May 16, 2022 Category: Neuroscience Authors: Simone Battaglia Julian F Thayer Source Type: research

Reassessing synaptic adhesion pathways
Trends Neurosci. 2022 May 13:S0166-2236(22)00078-9. doi: 10.1016/j.tins.2022.04.004. Online ahead of print.ABSTRACTMultiple synaptic adhesion proteins are thought to collectively define the properties of specific synapses and thereby shape the architectures of neural circuits. Growing evidence supports a molecular model in which a set of central hub proteins interacts with a vast number of other proteins to organize multifarious synaptic adhesion pathways. However, several fundamental open questions remain, partly owing to drawbacks in current approaches and interpretations. In this opinion, we provide an overview of synap...
Source: Trends in Neurosciences - May 16, 2022 Category: Neuroscience Authors: Dongseok Lim Dongwook Kim Ji Won Um Jaewon Ko Source Type: research

Functional interplay between central and autonomic nervous systems in human fear conditioning
Trends Neurosci. 2022 May 13:S0166-2236(22)00077-7. doi: 10.1016/j.tins.2022.04.003. Online ahead of print.ABSTRACTHistorically, studies on the neural basis of fear conditioning have emphasized the role of the central nervous system. However, there is growing evidence for the role of the autonomic nervous system in human fear conditioning. Here, we provide an overview of the sophisticated anatomical-functional interplay between the prefrontal cortex and heart-related dynamics in human fear conditioning and propose a theoretical model to conceptualize these psychophysiological processes, the neurovisceral integration model ...
Source: Trends in Neurosciences - May 16, 2022 Category: Neuroscience Authors: Simone Battaglia Julian F Thayer Source Type: research

Reassessing synaptic adhesion pathways
Trends Neurosci. 2022 May 13:S0166-2236(22)00078-9. doi: 10.1016/j.tins.2022.04.004. Online ahead of print.ABSTRACTMultiple synaptic adhesion proteins are thought to collectively define the properties of specific synapses and thereby shape the architectures of neural circuits. Growing evidence supports a molecular model in which a set of central hub proteins interacts with a vast number of other proteins to organize multifarious synaptic adhesion pathways. However, several fundamental open questions remain, partly owing to drawbacks in current approaches and interpretations. In this opinion, we provide an overview of synap...
Source: Trends in Neurosciences - May 16, 2022 Category: Neuroscience Authors: Dongseok Lim Dongwook Kim Ji Won Um Jaewon Ko Source Type: research

Functional interplay between central and autonomic nervous systems in human fear conditioning
Trends Neurosci. 2022 May 13:S0166-2236(22)00077-7. doi: 10.1016/j.tins.2022.04.003. Online ahead of print.ABSTRACTHistorically, studies on the neural basis of fear conditioning have emphasized the role of the central nervous system. However, there is growing evidence for the role of the autonomic nervous system in human fear conditioning. Here, we provide an overview of the sophisticated anatomical-functional interplay between the prefrontal cortex and heart-related dynamics in human fear conditioning and propose a theoretical model to conceptualize these psychophysiological processes, the neurovisceral integration model ...
Source: Trends in Neurosciences - May 16, 2022 Category: Neuroscience Authors: Simone Battaglia Julian F Thayer Source Type: research

Reassessing synaptic adhesion pathways
Trends Neurosci. 2022 May 13:S0166-2236(22)00078-9. doi: 10.1016/j.tins.2022.04.004. Online ahead of print.ABSTRACTMultiple synaptic adhesion proteins are thought to collectively define the properties of specific synapses and thereby shape the architectures of neural circuits. Growing evidence supports a molecular model in which a set of central hub proteins interacts with a vast number of other proteins to organize multifarious synaptic adhesion pathways. However, several fundamental open questions remain, partly owing to drawbacks in current approaches and interpretations. In this opinion, we provide an overview of synap...
Source: Trends in Neurosciences - May 16, 2022 Category: Neuroscience Authors: Dongseok Lim Dongwook Kim Ji Won Um Jaewon Ko Source Type: research

Neurofeedback through the lens of reinforcement learning
Trends Neurosci. 2022 May 9:S0166-2236(22)00059-5. doi: 10.1016/j.tins.2022.03.008. Online ahead of print.ABSTRACTDespite decades of experimental and clinical practice, the neuropsychological mechanisms underlying neurofeedback (NF) training remain obscure. NF is a unique form of reinforcement learning (RL) task, during which participants are provided with rewarding feedback regarding desired changes in neural patterns. However, key RL considerations - including choices during practice, prediction errors, credit-assignment problems, or the exploration-exploitation tradeoff - have infrequently been considered in the context...
Source: Trends in Neurosciences - May 13, 2022 Category: Neuroscience Authors: Nitzan Lubianiker Christian Paret Peter Dayan Talma Hendler Source Type: research

Neurofeedback through the lens of reinforcement learning
Trends Neurosci. 2022 May 9:S0166-2236(22)00059-5. doi: 10.1016/j.tins.2022.03.008. Online ahead of print.ABSTRACTDespite decades of experimental and clinical practice, the neuropsychological mechanisms underlying neurofeedback (NF) training remain obscure. NF is a unique form of reinforcement learning (RL) task, during which participants are provided with rewarding feedback regarding desired changes in neural patterns. However, key RL considerations - including choices during practice, prediction errors, credit-assignment problems, or the exploration-exploitation tradeoff - have infrequently been considered in the context...
Source: Trends in Neurosciences - May 13, 2022 Category: Neuroscience Authors: Nitzan Lubianiker Christian Paret Peter Dayan Talma Hendler Source Type: research

Neurofeedback through the lens of reinforcement learning
Trends Neurosci. 2022 May 9:S0166-2236(22)00059-5. doi: 10.1016/j.tins.2022.03.008. Online ahead of print.ABSTRACTDespite decades of experimental and clinical practice, the neuropsychological mechanisms underlying neurofeedback (NF) training remain obscure. NF is a unique form of reinforcement learning (RL) task, during which participants are provided with rewarding feedback regarding desired changes in neural patterns. However, key RL considerations - including choices during practice, prediction errors, credit-assignment problems, or the exploration-exploitation tradeoff - have infrequently been considered in the context...
Source: Trends in Neurosciences - May 13, 2022 Category: Neuroscience Authors: Nitzan Lubianiker Christian Paret Peter Dayan Talma Hendler Source Type: research

Neurofeedback through the lens of reinforcement learning
Trends Neurosci. 2022 May 9:S0166-2236(22)00059-5. doi: 10.1016/j.tins.2022.03.008. Online ahead of print.ABSTRACTDespite decades of experimental and clinical practice, the neuropsychological mechanisms underlying neurofeedback (NF) training remain obscure. NF is a unique form of reinforcement learning (RL) task, during which participants are provided with rewarding feedback regarding desired changes in neural patterns. However, key RL considerations - including choices during practice, prediction errors, credit-assignment problems, or the exploration-exploitation tradeoff - have infrequently been considered in the context...
Source: Trends in Neurosciences - May 13, 2022 Category: Neuroscience Authors: Nitzan Lubianiker Christian Paret Peter Dayan Talma Hendler Source Type: research