Contributions by metaplasticity to solving the Catastrophic Forgetting Problem
Trends Neurosci. 2022 Jul 4:S0166-2236(22)00120-5. doi: 10.1016/j.tins.2022.06.002. Online ahead of print.ABSTRACTCatastrophic forgetting (CF) refers to the sudden and severe loss of prior information in learning systems when acquiring new information. CF has been an Achilles heel of standard artificial neural networks (ANNs) when learning multiple tasks sequentially. The brain, by contrast, has solved this problem during evolution. Modellers now use a variety of strategies to overcome CF, many of which have parallels to cellular and circuit functions in the brain. One common strategy, based on metaplasticity phenomena, co...
Source: Trends in Neurosciences - July 7, 2022 Category: Neuroscience Authors: Peter Jedlicka Matus Tomko Anthony Robins Wickliffe C Abraham Source Type: research

Cracking the encoding of human scent in the mosquito brain
Trends Neurosci. 2022 Jun 30:S0166-2236(22)00123-0. doi: 10.1016/j.tins.2022.06.005. Online ahead of print.ABSTRACTIn a recent study, Zhao et al. decipher how the olfactory system encodes human versus animal odors in the mosquito Aedes aegypti. By combining genome engineering, invivo calcium imaging, advanced chemistry, and behavioral analysis, the authors provide compelling evidence that the discriminatory coding of host odors is surprisingly simple - and bridges labeled line with combinatorial coding.PMID:35781173 | DOI:10.1016/j.tins.2022.06.005 (Source: Trends in Neurosciences)
Source: Trends in Neurosciences - July 5, 2022 Category: Neuroscience Authors: Lucia L Prieto-Godino Thomas O Auer Source Type: research

Cracking the encoding of human scent in the mosquito brain
Trends Neurosci. 2022 Jun 30:S0166-2236(22)00123-0. doi: 10.1016/j.tins.2022.06.005. Online ahead of print.ABSTRACTIn a recent study, Zhao et al. decipher how the olfactory system encodes human versus animal odors in the mosquito Aedes aegypti. By combining genome engineering, invivo calcium imaging, advanced chemistry, and behavioral analysis, the authors provide compelling evidence that the discriminatory coding of host odors is surprisingly simple - and bridges labeled line with combinatorial coding.PMID:35781173 | DOI:10.1016/j.tins.2022.06.005 (Source: Trends in Neurosciences)
Source: Trends in Neurosciences - July 5, 2022 Category: Neuroscience Authors: Lucia L Prieto-Godino Thomas O Auer Source Type: research

Cracking the encoding of human scent in the mosquito brain
Trends Neurosci. 2022 Jun 30:S0166-2236(22)00123-0. doi: 10.1016/j.tins.2022.06.005. Online ahead of print.ABSTRACTIn a recent study, Zhao et al. decipher how the olfactory system encodes human versus animal odors in the mosquito Aedes aegypti. By combining genome engineering, invivo calcium imaging, advanced chemistry, and behavioral analysis, the authors provide compelling evidence that the discriminatory coding of host odors is surprisingly simple - and bridges labeled line with combinatorial coding.PMID:35781173 | DOI:10.1016/j.tins.2022.06.005 (Source: Trends in Neurosciences)
Source: Trends in Neurosciences - July 5, 2022 Category: Neuroscience Authors: Lucia L Prieto-Godino Thomas O Auer Source Type: research

Magnetoencephalography with optically pumped magnetometers (OPM-MEG): the next generation of functional neuroimaging
Trends Neurosci. 2022 Jun 29:S0166-2236(22)00102-3. doi: 10.1016/j.tins.2022.05.008. Online ahead of print.ABSTRACTMagnetoencephalography (MEG) measures human brain function via assessment of the magnetic fields generated by electrical activity in neurons. Despite providing high-quality spatiotemporal maps of electrophysiological activity, current MEG instrumentation is limited by cumbersome field sensing technologies, resulting in major barriers to utility. Here, we review a new generation of MEG technology that is beginning to lift many of these barriers. By exploiting quantum sensors, known as optically pumped magnetome...
Source: Trends in Neurosciences - July 2, 2022 Category: Neuroscience Authors: Matthew J Brookes James Leggett Molly Rea Ryan M Hill Niall Holmes Elena Boto Richard Bowtell Source Type: research

Magnetoencephalography with optically pumped magnetometers (OPM-MEG): the next generation of functional neuroimaging
Trends Neurosci. 2022 Jun 29:S0166-2236(22)00102-3. doi: 10.1016/j.tins.2022.05.008. Online ahead of print.ABSTRACTMagnetoencephalography (MEG) measures human brain function via assessment of the magnetic fields generated by electrical activity in neurons. Despite providing high-quality spatiotemporal maps of electrophysiological activity, current MEG instrumentation is limited by cumbersome field sensing technologies, resulting in major barriers to utility. Here, we review a new generation of MEG technology that is beginning to lift many of these barriers. By exploiting quantum sensors, known as optically pumped magnetome...
Source: Trends in Neurosciences - July 2, 2022 Category: Neuroscience Authors: Matthew J Brookes James Leggett Molly Rea Ryan M Hill Niall Holmes Elena Boto Richard Bowtell Source Type: research

BET-ting on histone proteomics in schizophrenia
Trends Neurosci. 2022 Jun 16:S0166-2236(22)00119-9. doi: 10.1016/j.tins.2022.06.001. Online ahead of print.ABSTRACTIn a recent study, Farrelly, Zheng, and colleagues used a histone proteomics approach and patient-derived neurons to show increase in histone variant H2A.Z acetylation associated with schizophrenia (SCZ). They identified the bromo- and extraterminal (BET) protein BRD4 as an H2A.Z acetylation 'reader', and showed that a BRD4 inhibitor ameliorated the SCZ-associated transcriptional signature, revealing a new candidate target for treatment.PMID:35718601 | DOI:10.1016/j.tins.2022.06.001 (Source: Trends in Neurosciences)
Source: Trends in Neurosciences - June 19, 2022 Category: Neuroscience Authors: Marija Kundakovic Source Type: research

BET-ting on histone proteomics in schizophrenia
Trends Neurosci. 2022 Jun 16:S0166-2236(22)00119-9. doi: 10.1016/j.tins.2022.06.001. Online ahead of print.ABSTRACTIn a recent study, Farrelly, Zheng, and colleagues used a histone proteomics approach and patient-derived neurons to show increase in histone variant H2A.Z acetylation associated with schizophrenia (SCZ). They identified the bromo- and extraterminal (BET) protein BRD4 as an H2A.Z acetylation 'reader', and showed that a BRD4 inhibitor ameliorated the SCZ-associated transcriptional signature, revealing a new candidate target for treatment.PMID:35718601 | DOI:10.1016/j.tins.2022.06.001 (Source: Trends in Neurosciences)
Source: Trends in Neurosciences - June 19, 2022 Category: Neuroscience Authors: Marija Kundakovic Source Type: research

BET-ting on histone proteomics in schizophrenia
Trends Neurosci. 2022 Jun 16:S0166-2236(22)00119-9. doi: 10.1016/j.tins.2022.06.001. Online ahead of print.ABSTRACTIn a recent study, Farrelly, Zheng, and colleagues used a histone proteomics approach and patient-derived neurons to show increase in histone variant H2A.Z acetylation associated with schizophrenia (SCZ). They identified the bromo- and extraterminal (BET) protein BRD4 as an H2A.Z acetylation 'reader', and showed that a BRD4 inhibitor ameliorated the SCZ-associated transcriptional signature, revealing a new candidate target for treatment.PMID:35718601 | DOI:10.1016/j.tins.2022.06.001 (Source: Trends in Neurosciences)
Source: Trends in Neurosciences - June 19, 2022 Category: Neuroscience Authors: Marija Kundakovic Source Type: research

BET-ting on histone proteomics in schizophrenia
Trends Neurosci. 2022 Jun 16:S0166-2236(22)00119-9. doi: 10.1016/j.tins.2022.06.001. Online ahead of print.ABSTRACTIn a recent study, Farrelly, Zheng, and colleagues used a histone proteomics approach and patient-derived neurons to show increase in histone variant H2A.Z acetylation associated with schizophrenia (SCZ). They identified the bromo- and extraterminal (BET) protein BRD4 as an H2A.Z acetylation 'reader', and showed that a BRD4 inhibitor ameliorated the SCZ-associated transcriptional signature, revealing a new candidate target for treatment.PMID:35718601 | DOI:10.1016/j.tins.2022.06.001 (Source: Trends in Neurosciences)
Source: Trends in Neurosciences - June 19, 2022 Category: Neuroscience Authors: Marija Kundakovic Source Type: research

BET-ting on histone proteomics in schizophrenia
Trends Neurosci. 2022 Jun 16:S0166-2236(22)00119-9. doi: 10.1016/j.tins.2022.06.001. Online ahead of print.ABSTRACTIn a recent study, Farrelly, Zheng, and colleagues used a histone proteomics approach and patient-derived neurons to show increase in histone variant H2A.Z acetylation associated with schizophrenia (SCZ). They identified the bromo- and extraterminal (BET) protein BRD4 as an H2A.Z acetylation 'reader', and showed that a BRD4 inhibitor ameliorated the SCZ-associated transcriptional signature, revealing a new candidate target for treatment.PMID:35718601 | DOI:10.1016/j.tins.2022.06.001 (Source: Trends in Neurosciences)
Source: Trends in Neurosciences - June 19, 2022 Category: Neuroscience Authors: Marija Kundakovic Source Type: research

BET-ting on histone proteomics in schizophrenia
Trends Neurosci. 2022 Jun 16:S0166-2236(22)00119-9. doi: 10.1016/j.tins.2022.06.001. Online ahead of print.ABSTRACTIn a recent study, Farrelly, Zheng, and colleagues used a histone proteomics approach and patient-derived neurons to show increase in histone variant H2A.Z acetylation associated with schizophrenia (SCZ). They identified the bromo- and extraterminal (BET) protein BRD4 as an H2A.Z acetylation 'reader', and showed that a BRD4 inhibitor ameliorated the SCZ-associated transcriptional signature, revealing a new candidate target for treatment.PMID:35718601 | DOI:10.1016/j.tins.2022.06.001 (Source: Trends in Neurosciences)
Source: Trends in Neurosciences - June 19, 2022 Category: Neuroscience Authors: Marija Kundakovic Source Type: research

BET-ting on histone proteomics in schizophrenia
Trends Neurosci. 2022 Jun 16:S0166-2236(22)00119-9. doi: 10.1016/j.tins.2022.06.001. Online ahead of print.ABSTRACTIn a recent study, Farrelly, Zheng, and colleagues used a histone proteomics approach and patient-derived neurons to show increase in histone variant H2A.Z acetylation associated with schizophrenia (SCZ). They identified the bromo- and extraterminal (BET) protein BRD4 as an H2A.Z acetylation 'reader', and showed that a BRD4 inhibitor ameliorated the SCZ-associated transcriptional signature, revealing a new candidate target for treatment.PMID:35718601 | DOI:10.1016/j.tins.2022.06.001 (Source: Trends in Neurosciences)
Source: Trends in Neurosciences - June 19, 2022 Category: Neuroscience Authors: Marija Kundakovic Source Type: research

BET-ting on histone proteomics in schizophrenia
Trends Neurosci. 2022 Jun 16:S0166-2236(22)00119-9. doi: 10.1016/j.tins.2022.06.001. Online ahead of print.ABSTRACTIn a recent study, Farrelly, Zheng, and colleagues used a histone proteomics approach and patient-derived neurons to show increase in histone variant H2A.Z acetylation associated with schizophrenia (SCZ). They identified the bromo- and extraterminal (BET) protein BRD4 as an H2A.Z acetylation 'reader', and showed that a BRD4 inhibitor ameliorated the SCZ-associated transcriptional signature, revealing a new candidate target for treatment.PMID:35718601 | DOI:10.1016/j.tins.2022.06.001 (Source: Trends in Neurosciences)
Source: Trends in Neurosciences - June 19, 2022 Category: Neuroscience Authors: Marija Kundakovic Source Type: research

BET-ting on histone proteomics in schizophrenia
Trends Neurosci. 2022 Jun 16:S0166-2236(22)00119-9. doi: 10.1016/j.tins.2022.06.001. Online ahead of print.ABSTRACTIn a recent study, Farrelly, Zheng, and colleagues used a histone proteomics approach and patient-derived neurons to show increase in histone variant H2A.Z acetylation associated with schizophrenia (SCZ). They identified the bromo- and extraterminal (BET) protein BRD4 as an H2A.Z acetylation 'reader', and showed that a BRD4 inhibitor ameliorated the SCZ-associated transcriptional signature, revealing a new candidate target for treatment.PMID:35718601 | DOI:10.1016/j.tins.2022.06.001 (Source: Trends in Neurosciences)
Source: Trends in Neurosciences - June 19, 2022 Category: Neuroscience Authors: Marija Kundakovic Source Type: research