A noncoding role of coding mRNA in monogenic olfactory receptor choice
Trends Neurosci. 2024 Feb 19:S0166-2236(24)00020-1. doi: 10.1016/j.tins.2024.02.004. Online ahead of print.ABSTRACTIn a recent study, Pourmorady and colleagues uncovered a noncoding role for olfactory receptor (OR)-coding mRNA in mediating nuclear architecture and singular OR choice. The OR mRNAs reinforce the prevailing enhancer hub and inhibit other competitors, facilitating transition from polygenic to singular OR expression.PMID:38378395 | DOI:10.1016/j.tins.2024.02.004 (Source: Trends in Neurosciences)
Source: Trends in Neurosciences - February 20, 2024 Category: Neuroscience Authors: Yue Hao Kang-Ying Qian Qian Li Source Type: research
A noncoding role of coding mRNA in monogenic olfactory receptor choice
Trends Neurosci. 2024 Feb 19:S0166-2236(24)00020-1. doi: 10.1016/j.tins.2024.02.004. Online ahead of print.ABSTRACTIn a recent study, Pourmorady and colleagues uncovered a noncoding role for olfactory receptor (OR)-coding mRNA in mediating nuclear architecture and singular OR choice. The OR mRNAs reinforce the prevailing enhancer hub and inhibit other competitors, facilitating transition from polygenic to singular OR expression.PMID:38378395 | DOI:10.1016/j.tins.2024.02.004 (Source: Trends in Neurosciences)
Source: Trends in Neurosciences - February 20, 2024 Category: Neuroscience Authors: Yue Hao Kang-Ying Qian Qian Li Source Type: research
Overarching pathomechanisms in inherited peripheral neuropathies, spastic paraplegias, and cerebellar ataxias
Trends Neurosci. 2024 Feb 14:S0166-2236(24)00016-X. doi: 10.1016/j.tins.2024.01.004. Online ahead of print.ABSTRACTInternational consortia collaborating on the genetics of rare diseases have significantly boosted our understanding of inherited neurological disorders. Historical clinical classification boundaries were drawn between disorders with seemingly different etiologies, such as inherited peripheral neuropathies (IPNs), spastic paraplegias, and cerebellar ataxias. These clinically defined borders are being challenged by the identification of mutations in genes displaying wide phenotypic spectra and by shared pathomec...
Source: Trends in Neurosciences - February 15, 2024 Category: Neuroscience Authors: Liedewei Van de Vondel Jonathan De Winter Vincent Timmerman Jonathan Baets Source Type: research
Overarching pathomechanisms in inherited peripheral neuropathies, spastic paraplegias, and cerebellar ataxias
Trends Neurosci. 2024 Feb 14:S0166-2236(24)00016-X. doi: 10.1016/j.tins.2024.01.004. Online ahead of print.ABSTRACTInternational consortia collaborating on the genetics of rare diseases have significantly boosted our understanding of inherited neurological disorders. Historical clinical classification boundaries were drawn between disorders with seemingly different etiologies, such as inherited peripheral neuropathies (IPNs), spastic paraplegias, and cerebellar ataxias. These clinically defined borders are being challenged by the identification of mutations in genes displaying wide phenotypic spectra and by shared pathomec...
Source: Trends in Neurosciences - February 15, 2024 Category: Neuroscience Authors: Liedewei Van de Vondel Jonathan De Winter Vincent Timmerman Jonathan Baets Source Type: research
Overarching pathomechanisms in inherited peripheral neuropathies, spastic paraplegias, and cerebellar ataxias
Trends Neurosci. 2024 Feb 14:S0166-2236(24)00016-X. doi: 10.1016/j.tins.2024.01.004. Online ahead of print.ABSTRACTInternational consortia collaborating on the genetics of rare diseases have significantly boosted our understanding of inherited neurological disorders. Historical clinical classification boundaries were drawn between disorders with seemingly different etiologies, such as inherited peripheral neuropathies (IPNs), spastic paraplegias, and cerebellar ataxias. These clinically defined borders are being challenged by the identification of mutations in genes displaying wide phenotypic spectra and by shared pathomec...
Source: Trends in Neurosciences - February 15, 2024 Category: Neuroscience Authors: Liedewei Van de Vondel Jonathan De Winter Vincent Timmerman Jonathan Baets Source Type: research
Overarching pathomechanisms in inherited peripheral neuropathies, spastic paraplegias, and cerebellar ataxias
Trends Neurosci. 2024 Feb 14:S0166-2236(24)00016-X. doi: 10.1016/j.tins.2024.01.004. Online ahead of print.ABSTRACTInternational consortia collaborating on the genetics of rare diseases have significantly boosted our understanding of inherited neurological disorders. Historical clinical classification boundaries were drawn between disorders with seemingly different etiologies, such as inherited peripheral neuropathies (IPNs), spastic paraplegias, and cerebellar ataxias. These clinically defined borders are being challenged by the identification of mutations in genes displaying wide phenotypic spectra and by shared pathomec...
Source: Trends in Neurosciences - February 15, 2024 Category: Neuroscience Authors: Liedewei Van de Vondel Jonathan De Winter Vincent Timmerman Jonathan Baets Source Type: research
Overarching pathomechanisms in inherited peripheral neuropathies, spastic paraplegias, and cerebellar ataxias
Trends Neurosci. 2024 Feb 14:S0166-2236(24)00016-X. doi: 10.1016/j.tins.2024.01.004. Online ahead of print.ABSTRACTInternational consortia collaborating on the genetics of rare diseases have significantly boosted our understanding of inherited neurological disorders. Historical clinical classification boundaries were drawn between disorders with seemingly different etiologies, such as inherited peripheral neuropathies (IPNs), spastic paraplegias, and cerebellar ataxias. These clinically defined borders are being challenged by the identification of mutations in genes displaying wide phenotypic spectra and by shared pathomec...
Source: Trends in Neurosciences - February 15, 2024 Category: Neuroscience Authors: Liedewei Van de Vondel Jonathan De Winter Vincent Timmerman Jonathan Baets Source Type: research
Protein-protein interactions regulating α-synuclein pathology
Trends Neurosci. 2024 Feb 13:S0166-2236(24)00014-6. doi: 10.1016/j.tins.2024.01.002. Online ahead of print.ABSTRACTParkinson's disease (PD) is a neurodegenerative disease characterized by the degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNpc) and the formation of Lewy bodies (LBs). The main proteinaceous component of LBs is aggregated α-synuclein (α-syn). However, the mechanisms underlying α-syn aggregation are not yet fully understood. Converging lines of evidence indicate that, under certain pathological conditions, various proteins can interact with α-syn and regulate its aggregation. ...
Source: Trends in Neurosciences - February 14, 2024 Category: Neuroscience Authors: Jiannan Wang Lijun Dai Sichun Chen Zhaohui Zhang Xin Fang Zhentao Zhang Source Type: research
Contiguity in perception: origins in cellular associative computations
Trends Neurosci. 2024 Feb 2:S0166-2236(24)00001-8. doi: 10.1016/j.tins.2024.01.001. Online ahead of print.ABSTRACTOur brains are good at detecting and learning associative structures; according to some linguistic theories, this capacity even constitutes a prerequisite for the development of syntax and compositionality in language and verbalized thought. I will argue that the search for associative motifs in input patterns is an evolutionary old brain function that enables contiguity in sensory perception and orientation in time and space. It has its origins in an elementary material property of cells that is particularly e...
Source: Trends in Neurosciences - February 3, 2024 Category: Neuroscience Authors: Christian Hansel Source Type: research
Tuning neural circuits and behaviors by microglia in the adult brain
Trends Neurosci. 2024 Jan 19:S0166-2236(23)00290-4. doi: 10.1016/j.tins.2023.12.003. Online ahead of print.ABSTRACTMicroglia are the primary immune cells of the CNS, contributing to both inflammatory damage and tissue repair in neurological disorder. In addition, emerging evidence highlights the role of homeostatic microglia in regulating neuronal activity, interacting with synapses, tuning neural circuits, and modulating behaviors. Herein, we review how microglia sense and regulate neuronal activity through synaptic interactions, thereby directly engaging with neural networks and behaviors. We discuss current studies util...
Source: Trends in Neurosciences - January 20, 2024 Category: Neuroscience Authors: Shunyi Zhao Anthony D Umpierre Long-Jun Wu Source Type: research
An integrative view on the cell-type-specific mechanisms of ketamine's antidepressant actions
Trends Neurosci. 2024 Jan 13:S0166-2236(23)00291-6. doi: 10.1016/j.tins.2023.12.004. Online ahead of print.ABSTRACTOver the past six decades, the use of ketamine has evolved from an anesthetic and recreational drug to the first non-monoaminergic antidepressant approved for treatment-resistant major depressive disorder (MDD). Subanesthetic doses of ketamine and its enantiomer (S)-ketamine (esketamine) directly bind to several neurotransmitter receptors [including N-methyl-d-aspartic acid receptor (NMDAR), κ and μ opioid receptor (KOR and MOR)] widely distributed in the brain and across different cell types, implicating se...
Source: Trends in Neurosciences - January 14, 2024 Category: Neuroscience Authors: Vern Lewis Gareth Rurak Natalina Salmaso Argel Aguilar-Valles Source Type: research
Latent-state and model-based learning in PTSD
Trends Neurosci. 2024 Feb;47(2):150-162. doi: 10.1016/j.tins.2023.12.002. Epub 2024 Jan 11.ABSTRACTPost-traumatic stress disorder (PTSD) is characterized by altered emotional and behavioral responding following a traumatic event. In this article, we review the concepts of latent-state and model-based learning (i.e., learning and inferring abstract task representations) and discuss their relevance for clinical and neuroscience models of PTSD. Recent data demonstrate evidence for brain and behavioral biases in these learning processes in PTSD. These new data potentially recast excessive fear towards trauma cues as a problem ...
Source: Trends in Neurosciences - January 11, 2024 Category: Neuroscience Authors: Josh M Cisler Joseph E Dunsmoor Gregory A Fonzo Charles B Nemeroff Source Type: research
The pulvinar as a hub of visual processing and cortical integration
Trends Neurosci. 2024 Feb;47(2):120-134. doi: 10.1016/j.tins.2023.11.008. Epub 2023 Dec 24.ABSTRACTThe pulvinar nucleus of the thalamus is a crucial component of the visual system and plays significant roles in sensory processing and cognitive integration. The pulvinar's extensive connectivity with cortical regions allows for bidirectional communication, contributing to the integration of sensory information across the visual hierarchy. Recent findings underscore the pulvinar's involvement in attentional modulation, feature binding, and predictive coding. In this review, we highlight recent advances in clarifying the pulvi...
Source: Trends in Neurosciences - December 24, 2023 Category: Neuroscience Authors: Nelson Cortes Hugo J Ladret Reza Abbas-Farishta Christian Casanova Source Type: research
The pulvinar as a hub of visual processing and cortical integration
Trends Neurosci. 2023 Dec 23:S0166-2236(23)00270-9. doi: 10.1016/j.tins.2023.11.008. Online ahead of print.ABSTRACTThe pulvinar nucleus of the thalamus is a crucial component of the visual system and plays significant roles in sensory processing and cognitive integration. The pulvinar's extensive connectivity with cortical regions allows for bidirectional communication, contributing to the integration of sensory information across the visual hierarchy. Recent findings underscore the pulvinar's involvement in attentional modulation, feature binding, and predictive coding. In this review, we highlight recent advances in clar...
Source: Trends in Neurosciences - December 24, 2023 Category: Neuroscience Authors: Nelson Cortes Hugo J Ladret Reza Abbas-Farishta Christian Casanova Source Type: research
The pulvinar as a hub of visual processing and cortical integration
Trends Neurosci. 2023 Dec 23:S0166-2236(23)00270-9. doi: 10.1016/j.tins.2023.11.008. Online ahead of print.ABSTRACTThe pulvinar nucleus of the thalamus is a crucial component of the visual system and plays significant roles in sensory processing and cognitive integration. The pulvinar's extensive connectivity with cortical regions allows for bidirectional communication, contributing to the integration of sensory information across the visual hierarchy. Recent findings underscore the pulvinar's involvement in attentional modulation, feature binding, and predictive coding. In this review, we highlight recent advances in clar...
Source: Trends in Neurosciences - December 24, 2023 Category: Neuroscience Authors: Nelson Cortes Hugo J Ladret Reza Abbas-Farishta Christian Casanova Source Type: research
