Lysosomes in retinal health and disease
Trends Neurosci. 2023 Oct 16:S0166-2236(23)00224-2. doi: 10.1016/j.tins.2023.09.006. Online ahead of print.ABSTRACTLysosomes play crucial roles in various cellular processes - including endocytosis, phagocytosis, and autophagy - which are vital for maintaining retinal health. Moreover, these organelles serve as environmental sensors and act as central hubs for multiple signaling pathways. Through communication with other cellular components, such as mitochondria, lysosomes orchestrate the cytoprotective response essential for preserving cellular homeostasis. This coordination is particularly critical in the retina, given i...
Source: Trends in Neurosciences - October 17, 2023 Category: Neuroscience Authors: Patricia Boya Kai Kaarniranta James T Handa Debasish Sinha Source Type: research
Lysosomes in retinal health and disease
Trends Neurosci. 2023 Oct 16:S0166-2236(23)00224-2. doi: 10.1016/j.tins.2023.09.006. Online ahead of print.ABSTRACTLysosomes play crucial roles in various cellular processes - including endocytosis, phagocytosis, and autophagy - which are vital for maintaining retinal health. Moreover, these organelles serve as environmental sensors and act as central hubs for multiple signaling pathways. Through communication with other cellular components, such as mitochondria, lysosomes orchestrate the cytoprotective response essential for preserving cellular homeostasis. This coordination is particularly critical in the retina, given i...
Source: Trends in Neurosciences - October 17, 2023 Category: Neuroscience Authors: Patricia Boya Kai Kaarniranta James T Handa Debasish Sinha Source Type: research
Lysosomes in retinal health and disease
Trends Neurosci. 2023 Oct 16:S0166-2236(23)00224-2. doi: 10.1016/j.tins.2023.09.006. Online ahead of print.ABSTRACTLysosomes play crucial roles in various cellular processes - including endocytosis, phagocytosis, and autophagy - which are vital for maintaining retinal health. Moreover, these organelles serve as environmental sensors and act as central hubs for multiple signaling pathways. Through communication with other cellular components, such as mitochondria, lysosomes orchestrate the cytoprotective response essential for preserving cellular homeostasis. This coordination is particularly critical in the retina, given i...
Source: Trends in Neurosciences - October 17, 2023 Category: Neuroscience Authors: Patricia Boya Kai Kaarniranta James T Handa Debasish Sinha Source Type: research
The endolysosomal pathway and ALS/FTD
Trends Neurosci. 2023 Oct 10:S0166-2236(23)00222-9. doi: 10.1016/j.tins.2023.09.004. Online ahead of print.ABSTRACTAmyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are considered to be part of a disease spectrum that is associated with causative mutations and risk variants in a wide range of genes. Mounting evidence indicates that several of these genes are linked to the endolysosomal system, highlighting the importance of this pathway in ALS/FTD. Although many studies have focused on how disruption of this pathway impacts on autophagy, recent findings reveal that this may not be the whole picture: spe...
Source: Trends in Neurosciences - October 12, 2023 Category: Neuroscience Authors: Tiffany W Todd Wei Shao Yong-Jie Zhang Leonard Petrucelli Source Type: research
The endolysosomal pathway and ALS/FTD
Trends Neurosci. 2023 Oct 10:S0166-2236(23)00222-9. doi: 10.1016/j.tins.2023.09.004. Online ahead of print.ABSTRACTAmyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are considered to be part of a disease spectrum that is associated with causative mutations and risk variants in a wide range of genes. Mounting evidence indicates that several of these genes are linked to the endolysosomal system, highlighting the importance of this pathway in ALS/FTD. Although many studies have focused on how disruption of this pathway impacts on autophagy, recent findings reveal that this may not be the whole picture: spe...
Source: Trends in Neurosciences - October 12, 2023 Category: Neuroscience Authors: Tiffany W Todd Wei Shao Yong-Jie Zhang Leonard Petrucelli Source Type: research
The endolysosomal pathway and ALS/FTD
Trends Neurosci. 2023 Oct 10:S0166-2236(23)00222-9. doi: 10.1016/j.tins.2023.09.004. Online ahead of print.ABSTRACTAmyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are considered to be part of a disease spectrum that is associated with causative mutations and risk variants in a wide range of genes. Mounting evidence indicates that several of these genes are linked to the endolysosomal system, highlighting the importance of this pathway in ALS/FTD. Although many studies have focused on how disruption of this pathway impacts on autophagy, recent findings reveal that this may not be the whole picture: spe...
Source: Trends in Neurosciences - October 12, 2023 Category: Neuroscience Authors: Tiffany W Todd Wei Shao Yong-Jie Zhang Leonard Petrucelli Source Type: research
The endolysosomal pathway and ALS/FTD
Trends Neurosci. 2023 Oct 10:S0166-2236(23)00222-9. doi: 10.1016/j.tins.2023.09.004. Online ahead of print.ABSTRACTAmyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are considered to be part of a disease spectrum that is associated with causative mutations and risk variants in a wide range of genes. Mounting evidence indicates that several of these genes are linked to the endolysosomal system, highlighting the importance of this pathway in ALS/FTD. Although many studies have focused on how disruption of this pathway impacts on autophagy, recent findings reveal that this may not be the whole picture: spe...
Source: Trends in Neurosciences - October 12, 2023 Category: Neuroscience Authors: Tiffany W Todd Wei Shao Yong-Jie Zhang Leonard Petrucelli Source Type: research
Immune-related neurodegeneration in the midbrain causes pulmonary dysfunction in murine cryptococcal IRIS
Trends Neurosci. 2023 Oct 6:S0166-2236(23)00223-0. doi: 10.1016/j.tins.2023.09.005. Online ahead of print.ABSTRACTCryptococcal immune reconstitution inflammatory syndrome (C-IRIS) is a condition that affects immunosuppressed individuals recruited to antiretroviral therapy. In a recent publication, Kawano and colleagues used a mouse model to demonstrate that pulmonary dysfunction, one of the fatal complications of C-IRIS, is caused by T cell-driven neurodegeneration in a vital medullary nucleus of the brain responsible for respiratory control.PMID:37806831 | DOI:10.1016/j.tins.2023.09.005 (Source: Trends in Neurosciences)
Source: Trends in Neurosciences - October 8, 2023 Category: Neuroscience Authors: Rachael Dangarembizi Rebecca Drummond Source Type: research
Immune-related neurodegeneration in the midbrain causes pulmonary dysfunction in murine cryptococcal IRIS
Trends Neurosci. 2023 Oct 6:S0166-2236(23)00223-0. doi: 10.1016/j.tins.2023.09.005. Online ahead of print.ABSTRACTCryptococcal immune reconstitution inflammatory syndrome (C-IRIS) is a condition that affects immunosuppressed individuals recruited to antiretroviral therapy. In a recent publication, Kawano and colleagues used a mouse model to demonstrate that pulmonary dysfunction, one of the fatal complications of C-IRIS, is caused by T cell-driven neurodegeneration in a vital medullary nucleus of the brain responsible for respiratory control.PMID:37806831 | DOI:10.1016/j.tins.2023.09.005 (Source: Trends in Neurosciences)
Source: Trends in Neurosciences - October 8, 2023 Category: Neuroscience Authors: Rachael Dangarembizi Rebecca Drummond Source Type: research
Immune-related neurodegeneration in the midbrain causes pulmonary dysfunction in murine cryptococcal IRIS
Trends Neurosci. 2023 Oct 6:S0166-2236(23)00223-0. doi: 10.1016/j.tins.2023.09.005. Online ahead of print.ABSTRACTCryptococcal immune reconstitution inflammatory syndrome (C-IRIS) is a condition that affects immunosuppressed individuals recruited to antiretroviral therapy. In a recent publication, Kawano and colleagues used a mouse model to demonstrate that pulmonary dysfunction, one of the fatal complications of C-IRIS, is caused by T cell-driven neurodegeneration in a vital medullary nucleus of the brain responsible for respiratory control.PMID:37806831 | DOI:10.1016/j.tins.2023.09.005 (Source: Trends in Neurosciences)
Source: Trends in Neurosciences - October 8, 2023 Category: Neuroscience Authors: Rachael Dangarembizi Rebecca Drummond Source Type: research
Immune-related neurodegeneration in the midbrain causes pulmonary dysfunction in murine cryptococcal IRIS
Trends Neurosci. 2023 Oct 6:S0166-2236(23)00223-0. doi: 10.1016/j.tins.2023.09.005. Online ahead of print.ABSTRACTCryptococcal immune reconstitution inflammatory syndrome (C-IRIS) is a condition that affects immunosuppressed individuals recruited to antiretroviral therapy. In a recent publication, Kawano and colleagues used a mouse model to demonstrate that pulmonary dysfunction, one of the fatal complications of C-IRIS, is caused by T cell-driven neurodegeneration in a vital medullary nucleus of the brain responsible for respiratory control.PMID:37806831 | DOI:10.1016/j.tins.2023.09.005 (Source: Trends in Neurosciences)
Source: Trends in Neurosciences - October 8, 2023 Category: Neuroscience Authors: Rachael Dangarembizi Rebecca Drummond Source Type: research
Disrupted circadian rhythms in the plateau pika
Trends Neurosci. 2023 Oct 4:S0166-2236(23)00221-7. doi: 10.1016/j.tins.2023.09.003. Online ahead of print.ABSTRACTThe plateau pika (Ochotona curzoniae) is the most populous mammal on the 'third pole', the Qinghai-Tibet Plateau, and is presumed to have inhabited the region before the plateau rose up from sea level. Herein we discuss the disrupted circadian rhythm in the plateau pika and the gene polymorphism behind this phenotype, placing these findings in the broader context of circadian rhythms under extreme conditions.PMID:37802756 | DOI:10.1016/j.tins.2023.09.003 (Source: Trends in Neurosciences)
Source: Trends in Neurosciences - October 6, 2023 Category: Neuroscience Authors: Ziqing Yu Eric Erquan Zhang Source Type: research
Disrupted circadian rhythms in the plateau pika
Trends Neurosci. 2023 Oct 4:S0166-2236(23)00221-7. doi: 10.1016/j.tins.2023.09.003. Online ahead of print.ABSTRACTThe plateau pika (Ochotona curzoniae) is the most populous mammal on the 'third pole', the Qinghai-Tibet Plateau, and is presumed to have inhabited the region before the plateau rose up from sea level. Herein we discuss the disrupted circadian rhythm in the plateau pika and the gene polymorphism behind this phenotype, placing these findings in the broader context of circadian rhythms under extreme conditions.PMID:37802756 | DOI:10.1016/j.tins.2023.09.003 (Source: Trends in Neurosciences)
Source: Trends in Neurosciences - October 6, 2023 Category: Neuroscience Authors: Ziqing Yu Eric Erquan Zhang Source Type: research
Visual attention and processing in jumping spiders
Trends Neurosci. 2023 Oct 3:S0166-2236(23)00220-5. doi: 10.1016/j.tins.2023.09.002. Online ahead of print.ABSTRACTJumping spiders have extraordinary vision. Using multiple, specialized eyes, these spiders selectively gather and integrate disparate streams of information about motion, color, and spatial detail. The saccadic movements of a forward-facing pair of eyes allow spiders to inspect their surroundings and identify objects. Here, we discuss the jumping spider visual system and how visual information is attended to and processed.PMID:37798203 | DOI:10.1016/j.tins.2023.09.002 (Source: Trends in Neurosciences)
Source: Trends in Neurosciences - October 5, 2023 Category: Neuroscience Authors: Alex M Winsor Luke Remage-Healey Ronald R Hoy Elizabeth M Jakob Source Type: research
Visual attention and processing in jumping spiders
Trends Neurosci. 2023 Oct 3:S0166-2236(23)00220-5. doi: 10.1016/j.tins.2023.09.002. Online ahead of print.ABSTRACTJumping spiders have extraordinary vision. Using multiple, specialized eyes, these spiders selectively gather and integrate disparate streams of information about motion, color, and spatial detail. The saccadic movements of a forward-facing pair of eyes allow spiders to inspect their surroundings and identify objects. Here, we discuss the jumping spider visual system and how visual information is attended to and processed.PMID:37798203 | DOI:10.1016/j.tins.2023.09.002 (Source: Trends in Neurosciences)
Source: Trends in Neurosciences - October 5, 2023 Category: Neuroscience Authors: Alex M Winsor Luke Remage-Healey Ronald R Hoy Elizabeth M Jakob Source Type: research
