Mitochondrial dysfunction as a trigger of programmed axon death
Trends Neurosci. 2021 Nov 29:S0166-2236(21)00214-9. doi: 10.1016/j.tins.2021.10.014. Online ahead of print.ABSTRACTMitochondrial failure has long been associated with programmed axon death (Wallerian degeneration, WD), a widespread and potentially preventable mechanism of axon degeneration. While early findings in axotomised axons indicated that mitochondria are involved during the execution steps of this pathway, recent studies suggest that in addition, mitochondrial dysfunction can initiate programmed axon death without physical injury. As mitochondrial dysfunction is associated with disorders involving early axon loss, ...
Source: Trends in Neurosciences - December 2, 2021 Category: Neuroscience Authors: Elisa Merlini Michael P Coleman Andrea Loreto Source Type: research

Mitochondrial dysfunction as a trigger of programmed axon death
Trends Neurosci. 2021 Nov 29:S0166-2236(21)00214-9. doi: 10.1016/j.tins.2021.10.014. Online ahead of print.ABSTRACTMitochondrial failure has long been associated with programmed axon death (Wallerian degeneration, WD), a widespread and potentially preventable mechanism of axon degeneration. While early findings in axotomised axons indicated that mitochondria are involved during the execution steps of this pathway, recent studies suggest that in addition, mitochondrial dysfunction can initiate programmed axon death without physical injury. As mitochondrial dysfunction is associated with disorders involving early axon loss, ...
Source: Trends in Neurosciences - December 2, 2021 Category: Neuroscience Authors: Elisa Merlini Michael P Coleman Andrea Loreto Source Type: research

The elusive varicose astrocytes
Trends Neurosci. 2021 Nov 22:S0166-2236(21)00230-7. doi: 10.1016/j.tins.2021.11.003. Online ahead of print.ABSTRACTThe evolutionary pattern of different astrocyte types across animal species remains unresolved. In a recent study, Falcone and colleagues revealed that varicose projection astrocytes, a rare form of astrocyte characterized by long varicosities-containing processes, are exclusively found in hominoid brains while being absent from other primate brains.PMID:34823901 | DOI:10.1016/j.tins.2021.11.003 (Source: Trends in Neurosciences)
Source: Trends in Neurosciences - November 26, 2021 Category: Neuroscience Authors: Rune Nguyen Rasmussen Nathan Anthony Smith Source Type: research

The elusive varicose astrocytes
Trends Neurosci. 2021 Nov 22:S0166-2236(21)00230-7. doi: 10.1016/j.tins.2021.11.003. Online ahead of print.ABSTRACTThe evolutionary pattern of different astrocyte types across animal species remains unresolved. In a recent study, Falcone and colleagues revealed that varicose projection astrocytes, a rare form of astrocyte characterized by long varicosities-containing processes, are exclusively found in hominoid brains while being absent from other primate brains.PMID:34823901 | DOI:10.1016/j.tins.2021.11.003 (Source: Trends in Neurosciences)
Source: Trends in Neurosciences - November 26, 2021 Category: Neuroscience Authors: Rune Nguyen Rasmussen Nathan Anthony Smith Source Type: research

The elusive varicose astrocytes
Trends Neurosci. 2021 Nov 22:S0166-2236(21)00230-7. doi: 10.1016/j.tins.2021.11.003. Online ahead of print.ABSTRACTThe evolutionary pattern of different astrocyte types across animal species remains unresolved. In a recent study, Falcone and colleagues revealed that varicose projection astrocytes, a rare form of astrocyte characterized by long varicosities-containing processes, are exclusively found in hominoid brains while being absent from other primate brains.PMID:34823901 | DOI:10.1016/j.tins.2021.11.003 (Source: Trends in Neurosciences)
Source: Trends in Neurosciences - November 26, 2021 Category: Neuroscience Authors: Rune Nguyen Rasmussen Nathan Anthony Smith Source Type: research

The elusive varicose astrocytes
Trends Neurosci. 2021 Nov 22:S0166-2236(21)00230-7. doi: 10.1016/j.tins.2021.11.003. Online ahead of print.ABSTRACTThe evolutionary pattern of different astrocyte types across animal species remains unresolved. In a recent study, Falcone and colleagues revealed that varicose projection astrocytes, a rare form of astrocyte characterized by long varicosities-containing processes, are exclusively found in hominoid brains while being absent from other primate brains.PMID:34823901 | DOI:10.1016/j.tins.2021.11.003 (Source: Trends in Neurosciences)
Source: Trends in Neurosciences - November 26, 2021 Category: Neuroscience Authors: Rune Nguyen Rasmussen Nathan Anthony Smith Source Type: research

The elusive varicose astrocytes
Trends Neurosci. 2021 Nov 22:S0166-2236(21)00230-7. doi: 10.1016/j.tins.2021.11.003. Online ahead of print.ABSTRACTThe evolutionary pattern of different astrocyte types across animal species remains unresolved. In a recent study, Falcone and colleagues revealed that varicose projection astrocytes, a rare form of astrocyte characterized by long varicosities-containing processes, are exclusively found in hominoid brains while being absent from other primate brains.PMID:34823901 | DOI:10.1016/j.tins.2021.11.003 (Source: Trends in Neurosciences)
Source: Trends in Neurosciences - November 26, 2021 Category: Neuroscience Authors: Rune Nguyen Rasmussen Nathan Anthony Smith Source Type: research

Quantifying neuronal structural changes over time using dynamic morphometrics
Trends Neurosci. 2021 Nov 20:S0166-2236(21)00211-3. doi: 10.1016/j.tins.2021.10.011. Online ahead of print.ABSTRACTBrain circuit development involves tremendous structural formation and rearrangement of dendrites, axons, and the synaptic connections between them. Direct studies of neuronal morphogenesis are now possible through recent developments in multiple technologies, including single-neuron labeling, time-lapse imaging in intact tissues, and 4D rendering software capable of tracking neural growth over periods spanning minutes to days. These methods allow detailed quantification of structural changes of neurons over t...
Source: Trends in Neurosciences - November 24, 2021 Category: Neuroscience Authors: Peter William Hogg Patrick Coleman Tristan Dellazizzo Toth Kurt Haas Source Type: research

Apart, together: reflections from the Trends editorial team on the COVID-19 pandemic
Trends Neurosci. 2021 Dec;44(12):925-926. doi: 10.1016/j.tins.2021.10.001.NO ABSTRACTPMID:34818516 | PMC:PMC8609657 | DOI:10.1016/j.tins.2021.10.001 (Source: Trends in Neurosciences)
Source: Trends in Neurosciences - November 24, 2021 Category: Neuroscience Authors: Trends editorial team. Electronic address: tins at cell.com Source Type: research

Quantifying neuronal structural changes over time using dynamic morphometrics
Trends Neurosci. 2021 Nov 20:S0166-2236(21)00211-3. doi: 10.1016/j.tins.2021.10.011. Online ahead of print.ABSTRACTBrain circuit development involves tremendous structural formation and rearrangement of dendrites, axons, and the synaptic connections between them. Direct studies of neuronal morphogenesis are now possible through recent developments in multiple technologies, including single-neuron labeling, time-lapse imaging in intact tissues, and 4D rendering software capable of tracking neural growth over periods spanning minutes to days. These methods allow detailed quantification of structural changes of neurons over t...
Source: Trends in Neurosciences - November 24, 2021 Category: Neuroscience Authors: Peter William Hogg Patrick Coleman Tristan Dellazizzo Toth Kurt Haas Source Type: research

Apart, together: reflections from the Trends editorial team on the COVID-19 pandemic
Trends Neurosci. 2021 Dec;44(12):925-926. doi: 10.1016/j.tins.2021.10.001.NO ABSTRACTPMID:34818516 | PMC:PMC8609657 | DOI:10.1016/j.tins.2021.10.001 (Source: Trends in Neurosciences)
Source: Trends in Neurosciences - November 24, 2021 Category: Neuroscience Authors: Trends editorial team. Electronic address: tins at cell.com Source Type: research

Quantifying neuronal structural changes over time using dynamic morphometrics
Trends Neurosci. 2021 Nov 20:S0166-2236(21)00211-3. doi: 10.1016/j.tins.2021.10.011. Online ahead of print.ABSTRACTBrain circuit development involves tremendous structural formation and rearrangement of dendrites, axons, and the synaptic connections between them. Direct studies of neuronal morphogenesis are now possible through recent developments in multiple technologies, including single-neuron labeling, time-lapse imaging in intact tissues, and 4D rendering software capable of tracking neural growth over periods spanning minutes to days. These methods allow detailed quantification of structural changes of neurons over t...
Source: Trends in Neurosciences - November 24, 2021 Category: Neuroscience Authors: Peter William Hogg Patrick Coleman Tristan Dellazizzo Toth Kurt Haas Source Type: research

Neurobiology of the lateral septum: regulation of social behavior
Trends Neurosci. 2021 Nov 19:S0166-2236(21)00210-1. doi: 10.1016/j.tins.2021.10.010. Online ahead of print.ABSTRACTSocial interactions are essential for mammalian life and are regulated by evolutionary conserved neuronal mechanisms. An individual's internal state, experiences, and the nature of the social stimulus are critical for determining apt responses to social situations. The lateral septum (LS) - a structure of the basal forebrain - integrates abundant cortical and subcortical inputs, and projects to multiple downstream regions to generate appropriate behavioral responses. Although incoming cognitive information is ...
Source: Trends in Neurosciences - November 23, 2021 Category: Neuroscience Authors: Rohit Menon Theresa S üß Vin ícius Elias de Moura Oliveira Inga D Neumann Anna Bludau Source Type: research

Neurobiology of the lateral septum: regulation of social behavior
Trends Neurosci. 2021 Nov 19:S0166-2236(21)00210-1. doi: 10.1016/j.tins.2021.10.010. Online ahead of print.ABSTRACTSocial interactions are essential for mammalian life and are regulated by evolutionary conserved neuronal mechanisms. An individual's internal state, experiences, and the nature of the social stimulus are critical for determining apt responses to social situations. The lateral septum (LS) - a structure of the basal forebrain - integrates abundant cortical and subcortical inputs, and projects to multiple downstream regions to generate appropriate behavioral responses. Although incoming cognitive information is ...
Source: Trends in Neurosciences - November 23, 2021 Category: Neuroscience Authors: Rohit Menon Theresa S üß Vin ícius Elias de Moura Oliveira Inga D Neumann Anna Bludau Source Type: research

What can we learn from inactivation studies? Lessons from auditory cortex
Trends Neurosci. 2021 Nov 16:S0166-2236(21)00203-4. doi: 10.1016/j.tins.2021.10.005. Online ahead of print.ABSTRACTInactivation experiments in auditory cortex (AC) produce widely varying results that complicate interpretations regarding the precise role of AC in auditory perception and ensuing behaviour. The advent of optogenetic methods in neuroscience offers previously unachievable insight into the mechanisms transforming brain activity into behaviour. With a view to aiding the design and interpretation of future studies in and outside AC, here we discuss the methodological challenges faced in manipulating neural activit...
Source: Trends in Neurosciences - November 20, 2021 Category: Neuroscience Authors: Zuzanna A Slonina Katarina C Poole Jennifer K Bizley Source Type: research