Balancing neuronal activity to fight neurodevelopmental disorders

Trends Neurosci. 2024 Mar 22:S0166-2236(24)00039-0. doi: 10.1016/j.tins.2024.03.002. Online ahead of print.ABSTRACTIn a recent study, Rylaarsdam and colleagues revealed that mutant PACS1 gene, which causes a rare neurodevelopmental syndrome, affects the firing ability of human neurons without dysregulating the cellular architecture of brain organoids. These findings suggest aberrant neuronal electrophysiology as a possible interventional target for pediatric diseases impairing brain development.PMID:38521709 | DOI:10.1016/j.tins.2024.03.002
Source: Trends in Neurosciences - Category: Neuroscience Authors: Source Type: research