Alzheimer's disease and related tauopathies: disorders of disrupted neuronal identity
Trends Neurosci. 2023 Aug 15:S0166-2236(23)00166-2. doi: 10.1016/j.tins.2023.07.006. Online ahead of print.ABSTRACTPostmitotic neurons require persistently active controls to maintain terminal differentiation. Unlike dividing cells, aberrant cell cycle activation in mature neurons causes apoptosis rather than transformation. In Alzheimer's disease (AD) and related tauopathies, evidence suggests that pathogenic forms of tau drive neurodegeneration via neuronal cell cycle re-entry. Multiple interconnected mechanisms linking tau to cell cycle activation have been identified, including, but not limited to, tau-induced overstab...
Source: Trends in Neurosciences - August 17, 2023 Category: Neuroscience Authors: Bess Frost Source Type: research
Gamma oscillations and episodic memory
Trends Neurosci. 2023 Aug 5:S0166-2236(23)00163-7. doi: 10.1016/j.tins.2023.07.003. Online ahead of print.ABSTRACTEnhanced gamma oscillatory activity (30-80 Hz) accompanies the successful formation and retrieval of episodic memories. While this co-occurrence is well documented, the mechanistic contributions of gamma oscillatory activity to episodic memory remain unclear. Here, we review how gamma oscillatory activity may facilitate spike timing-dependent plasticity, neural communication, and sequence encoding/retrieval, thereby ensuring the successful formation and/or retrieval of an episodic memory. Based on the evidence ...
Source: Trends in Neurosciences - August 7, 2023 Category: Neuroscience Authors: Benjamin J Griffiths Ole Jensen Source Type: research
Gamma oscillations and episodic memory
Trends Neurosci. 2023 Aug 5:S0166-2236(23)00163-7. doi: 10.1016/j.tins.2023.07.003. Online ahead of print.ABSTRACTEnhanced gamma oscillatory activity (30-80 Hz) accompanies the successful formation and retrieval of episodic memories. While this co-occurrence is well documented, the mechanistic contributions of gamma oscillatory activity to episodic memory remain unclear. Here, we review how gamma oscillatory activity may facilitate spike timing-dependent plasticity, neural communication, and sequence encoding/retrieval, thereby ensuring the successful formation and/or retrieval of an episodic memory. Based on the evidence ...
Source: Trends in Neurosciences - August 7, 2023 Category: Neuroscience Authors: Benjamin J Griffiths Ole Jensen Source Type: research
Gamma oscillations and episodic memory
Trends Neurosci. 2023 Aug 5:S0166-2236(23)00163-7. doi: 10.1016/j.tins.2023.07.003. Online ahead of print.ABSTRACTEnhanced gamma oscillatory activity (30-80 Hz) accompanies the successful formation and retrieval of episodic memories. While this co-occurrence is well documented, the mechanistic contributions of gamma oscillatory activity to episodic memory remain unclear. Here, we review how gamma oscillatory activity may facilitate spike timing-dependent plasticity, neural communication, and sequence encoding/retrieval, thereby ensuring the successful formation and/or retrieval of an episodic memory. Based on the evidence ...
Source: Trends in Neurosciences - August 7, 2023 Category: Neuroscience Authors: Benjamin J Griffiths Ole Jensen Source Type: research
Gamma oscillations and episodic memory
Trends Neurosci. 2023 Aug 5:S0166-2236(23)00163-7. doi: 10.1016/j.tins.2023.07.003. Online ahead of print.ABSTRACTEnhanced gamma oscillatory activity (30-80 Hz) accompanies the successful formation and retrieval of episodic memories. While this co-occurrence is well documented, the mechanistic contributions of gamma oscillatory activity to episodic memory remain unclear. Here, we review how gamma oscillatory activity may facilitate spike timing-dependent plasticity, neural communication, and sequence encoding/retrieval, thereby ensuring the successful formation and/or retrieval of an episodic memory. Based on the evidence ...
Source: Trends in Neurosciences - August 7, 2023 Category: Neuroscience Authors: Benjamin J Griffiths Ole Jensen Source Type: research
Gamma oscillations and episodic memory
Trends Neurosci. 2023 Aug 5:S0166-2236(23)00163-7. doi: 10.1016/j.tins.2023.07.003. Online ahead of print.ABSTRACTEnhanced gamma oscillatory activity (30-80 Hz) accompanies the successful formation and retrieval of episodic memories. While this co-occurrence is well documented, the mechanistic contributions of gamma oscillatory activity to episodic memory remain unclear. Here, we review how gamma oscillatory activity may facilitate spike timing-dependent plasticity, neural communication, and sequence encoding/retrieval, thereby ensuring the successful formation and/or retrieval of an episodic memory. Based on the evidence ...
Source: Trends in Neurosciences - August 7, 2023 Category: Neuroscience Authors: Benjamin J Griffiths Ole Jensen Source Type: research
Gamma oscillations and episodic memory
Trends Neurosci. 2023 Aug 5:S0166-2236(23)00163-7. doi: 10.1016/j.tins.2023.07.003. Online ahead of print.ABSTRACTEnhanced gamma oscillatory activity (30-80 Hz) accompanies the successful formation and retrieval of episodic memories. While this co-occurrence is well documented, the mechanistic contributions of gamma oscillatory activity to episodic memory remain unclear. Here, we review how gamma oscillatory activity may facilitate spike timing-dependent plasticity, neural communication, and sequence encoding/retrieval, thereby ensuring the successful formation and/or retrieval of an episodic memory. Based on the evidence ...
Source: Trends in Neurosciences - August 7, 2023 Category: Neuroscience Authors: Benjamin J Griffiths Ole Jensen Source Type: research
Gamma oscillations and episodic memory
Trends Neurosci. 2023 Aug 5:S0166-2236(23)00163-7. doi: 10.1016/j.tins.2023.07.003. Online ahead of print.ABSTRACTEnhanced gamma oscillatory activity (30-80 Hz) accompanies the successful formation and retrieval of episodic memories. While this co-occurrence is well documented, the mechanistic contributions of gamma oscillatory activity to episodic memory remain unclear. Here, we review how gamma oscillatory activity may facilitate spike timing-dependent plasticity, neural communication, and sequence encoding/retrieval, thereby ensuring the successful formation and/or retrieval of an episodic memory. Based on the evidence ...
Source: Trends in Neurosciences - August 7, 2023 Category: Neuroscience Authors: Benjamin J Griffiths Ole Jensen Source Type: research
Gamma oscillations and episodic memory
Trends Neurosci. 2023 Aug 5:S0166-2236(23)00163-7. doi: 10.1016/j.tins.2023.07.003. Online ahead of print.ABSTRACTEnhanced gamma oscillatory activity (30-80 Hz) accompanies the successful formation and retrieval of episodic memories. While this co-occurrence is well documented, the mechanistic contributions of gamma oscillatory activity to episodic memory remain unclear. Here, we review how gamma oscillatory activity may facilitate spike timing-dependent plasticity, neural communication, and sequence encoding/retrieval, thereby ensuring the successful formation and/or retrieval of an episodic memory. Based on the evidence ...
Source: Trends in Neurosciences - August 7, 2023 Category: Neuroscience Authors: Benjamin J Griffiths Ole Jensen Source Type: research
Nonsense-mediated mRNA decay in neuronal physiology and neurodegeneration
Trends Neurosci. 2023 Aug 3:S0166-2236(23)00161-3. doi: 10.1016/j.tins.2023.07.001. Online ahead of print.ABSTRACTThe processes of mRNA export from the nucleus and subsequent mRNA translation in the cytoplasm are of particular relevance in eukaryotic cells. In highly polarised cells such as neurons, finely-tuned molecular regulation of these processes serves to safeguard the spatiotemporal fidelity of gene expression. Nonsense-mediated mRNA decay (NMD) is a cytoplasmic translation-dependent quality control process that regulates gene expression in a wide range of scenarios in the nervous system, including neurodevelopment,...
Source: Trends in Neurosciences - August 5, 2023 Category: Neuroscience Authors: Marija Petri ć Howe Rickie Patani Source Type: research
Nonsense-mediated mRNA decay in neuronal physiology and neurodegeneration
Trends Neurosci. 2023 Aug 3:S0166-2236(23)00161-3. doi: 10.1016/j.tins.2023.07.001. Online ahead of print.ABSTRACTThe processes of mRNA export from the nucleus and subsequent mRNA translation in the cytoplasm are of particular relevance in eukaryotic cells. In highly polarised cells such as neurons, finely-tuned molecular regulation of these processes serves to safeguard the spatiotemporal fidelity of gene expression. Nonsense-mediated mRNA decay (NMD) is a cytoplasmic translation-dependent quality control process that regulates gene expression in a wide range of scenarios in the nervous system, including neurodevelopment,...
Source: Trends in Neurosciences - August 5, 2023 Category: Neuroscience Authors: Marija Petri ć Howe Rickie Patani Source Type: research
Neuroscience of cognitive control in crows
This article presents a brief overview of cognitive control functions and their neuronal foundation in crows.PMID:37524636 | DOI:10.1016/j.tins.2023.07.002 (Source: Trends in Neurosciences)
Source: Trends in Neurosciences - July 31, 2023 Category: Neuroscience Authors: Andreas Nieder Source Type: research
Neuroscience of cognitive control in crows
This article presents a brief overview of cognitive control functions and their neuronal foundation in crows.PMID:37524636 | DOI:10.1016/j.tins.2023.07.002 (Source: Trends in Neurosciences)
Source: Trends in Neurosciences - July 31, 2023 Category: Neuroscience Authors: Andreas Nieder Source Type: research
Neuroscience of cognitive control in crows
This article presents a brief overview of cognitive control functions and their neuronal foundation in crows.PMID:37524636 | DOI:10.1016/j.tins.2023.07.002 (Source: Trends in Neurosciences)
Source: Trends in Neurosciences - July 31, 2023 Category: Neuroscience Authors: Andreas Nieder Source Type: research
Neuroscience of cognitive control in crows
This article presents a brief overview of cognitive control functions and their neuronal foundation in crows.PMID:37524636 | DOI:10.1016/j.tins.2023.07.002 (Source: Trends in Neurosciences)
Source: Trends in Neurosciences - July 31, 2023 Category: Neuroscience Authors: Andreas Nieder Source Type: research
