Enteric glial cells mediate gut immunity and repair
Trends Neurosci. 2021 Dec 29:S0166-2236(21)00249-6. doi: 10.1016/j.tins.2021.12.001. Online ahead of print.ABSTRACTIn the gut, coordinated cell interactions regulate tissue repair and immunity. How enteric glial cells (EGCs) mediate these processes remained elusive. In a recent paper, Progatzky et al. demonstrate that EGCs interact with immune and mesothelial cells under homeostasis and helminth infection, revealing an indispensable role of an interferon-γ (IFNγ)-EGC-CXCL10 axis in tissue repair.PMID:34973845 | DOI:10.1016/j.tins.2021.12.001 (Source: Trends in Neurosciences)
Source: Trends in Neurosciences - January 2, 2022 Category: Neuroscience Authors: Antonia Wallrapp Daping Yang Isaac M Chiu Source Type: research

The tactile sensors of the gut
Trends Neurosci. 2021 Dec 22:S0166-2236(21)00251-4. doi: 10.1016/j.tins.2021.12.003. Online ahead of print.ABSTRACTIn a recent study, Treichel, Finholm et al. showed that the mechanoreceptor Piezo2 enables enteroendocrine cells in the intestinal epithelium to sense luminal contents. Through neuroepithelial signaling, these cells modulate intestinal motility and transit of digestive products.PMID:34953615 | DOI:10.1016/j.tins.2021.12.003 (Source: Trends in Neurosciences)
Source: Trends in Neurosciences - December 26, 2021 Category: Neuroscience Authors: Sarah A Najjar Kara Gross Margolis Source Type: research

The tactile sensors of the gut
Trends Neurosci. 2021 Dec 22:S0166-2236(21)00251-4. doi: 10.1016/j.tins.2021.12.003. Online ahead of print.ABSTRACTIn a recent study, Treichel, Finholm et al. showed that the mechanoreceptor Piezo2 enables enteroendocrine cells in the intestinal epithelium to sense luminal contents. Through neuroepithelial signaling, these cells modulate intestinal motility and transit of digestive products.PMID:34953615 | DOI:10.1016/j.tins.2021.12.003 (Source: Trends in Neurosciences)
Source: Trends in Neurosciences - December 26, 2021 Category: Neuroscience Authors: Sarah A Najjar Kara Gross Margolis Source Type: research

The tactile sensors of the gut
Trends Neurosci. 2021 Dec 22:S0166-2236(21)00251-4. doi: 10.1016/j.tins.2021.12.003. Online ahead of print.ABSTRACTIn a recent study, Treichel, Finholm et al. showed that the mechanoreceptor Piezo2 enables enteroendocrine cells in the intestinal epithelium to sense luminal contents. Through neuroepithelial signaling, these cells modulate intestinal motility and transit of digestive products.PMID:34953615 | DOI:10.1016/j.tins.2021.12.003 (Source: Trends in Neurosciences)
Source: Trends in Neurosciences - December 26, 2021 Category: Neuroscience Authors: Sarah A Najjar Kara Gross Margolis Source Type: research

The tactile sensors of the gut
Trends Neurosci. 2021 Dec 22:S0166-2236(21)00251-4. doi: 10.1016/j.tins.2021.12.003. Online ahead of print.ABSTRACTIn a recent study, Treichel, Finholm et al. showed that the mechanoreceptor Piezo2 enables enteroendocrine cells in the intestinal epithelium to sense luminal contents. Through neuroepithelial signaling, these cells modulate intestinal motility and transit of digestive products.PMID:34953615 | DOI:10.1016/j.tins.2021.12.003 (Source: Trends in Neurosciences)
Source: Trends in Neurosciences - December 26, 2021 Category: Neuroscience Authors: Sarah A Najjar Kara Gross Margolis Source Type: research

The tactile sensors of the gut
Trends Neurosci. 2021 Dec 22:S0166-2236(21)00251-4. doi: 10.1016/j.tins.2021.12.003. Online ahead of print.ABSTRACTIn a recent study, Treichel, Finholm et al. showed that the mechanoreceptor Piezo2 enables enteroendocrine cells in the intestinal epithelium to sense luminal contents. Through neuroepithelial signaling, these cells modulate intestinal motility and transit of digestive products.PMID:34953615 | DOI:10.1016/j.tins.2021.12.003 (Source: Trends in Neurosciences)
Source: Trends in Neurosciences - December 26, 2021 Category: Neuroscience Authors: Sarah A Najjar Kara Gross Margolis Source Type: research

The tactile sensors of the gut
Trends Neurosci. 2021 Dec 22:S0166-2236(21)00251-4. doi: 10.1016/j.tins.2021.12.003. Online ahead of print.ABSTRACTIn a recent study, Treichel, Finholm et al. showed that the mechanoreceptor Piezo2 enables enteroendocrine cells in the intestinal epithelium to sense luminal contents. Through neuroepithelial signaling, these cells modulate intestinal motility and transit of digestive products.PMID:34953615 | DOI:10.1016/j.tins.2021.12.003 (Source: Trends in Neurosciences)
Source: Trends in Neurosciences - December 26, 2021 Category: Neuroscience Authors: Sarah A Najjar Kara Gross Margolis Source Type: research

Ocular and extraocular roles of neuropsin in vertebrates
Trends Neurosci. 2021 Dec 21:S0166-2236(21)00237-X. doi: 10.1016/j.tins.2021.11.008. Online ahead of print.ABSTRACTThe ability to detect and adapt to different levels of ambient light is critical for animal survival. Light detection is the basis of vision, but light also regulates eye development and drives several non-image-forming functions, including synchronizing circadian rhythms to the daily light/dark cycle, restricting pupils in response to changes in light intensity, and modulating mood in response to light. Until the early 2000s, these functions were thought to be solely mediated by ocular photoreceptors. However...
Source: Trends in Neurosciences - December 25, 2021 Category: Neuroscience Authors: Hugo Calligaro Ouria Dkhissi-Benyahya Satchidananda Panda Source Type: research

Ocular and extraocular roles of neuropsin in vertebrates
Trends Neurosci. 2021 Dec 21:S0166-2236(21)00237-X. doi: 10.1016/j.tins.2021.11.008. Online ahead of print.ABSTRACTThe ability to detect and adapt to different levels of ambient light is critical for animal survival. Light detection is the basis of vision, but light also regulates eye development and drives several non-image-forming functions, including synchronizing circadian rhythms to the daily light/dark cycle, restricting pupils in response to changes in light intensity, and modulating mood in response to light. Until the early 2000s, these functions were thought to be solely mediated by ocular photoreceptors. However...
Source: Trends in Neurosciences - December 25, 2021 Category: Neuroscience Authors: Hugo Calligaro Ouria Dkhissi-Benyahya Satchidananda Panda Source Type: research

Reinforcement learning detuned in addiction: integrative and translational approaches
Trends Neurosci. 2021 Dec 14:S0166-2236(21)00236-8. doi: 10.1016/j.tins.2021.11.007. Online ahead of print.ABSTRACTSuboptimal decision-making strategies have been proposed to contribute to the pathophysiology of addiction. Decision-making, however, arises from a collection of computational components that can independently influence behavior. Disruptions in these different components can lead to decision-making deficits that appear similar behaviorally, but differ at the computational, and likely the neurobiological, level. Here, we discuss recent studies that have used computational approaches to investigate the decision-...
Source: Trends in Neurosciences - December 18, 2021 Category: Neuroscience Authors: Stephanie M Groman Summer L Thompson Daeyeol Lee Jane R Taylor Source Type: research

Reinforcement learning detuned in addiction: integrative and translational approaches
Trends Neurosci. 2021 Dec 14:S0166-2236(21)00236-8. doi: 10.1016/j.tins.2021.11.007. Online ahead of print.ABSTRACTSuboptimal decision-making strategies have been proposed to contribute to the pathophysiology of addiction. Decision-making, however, arises from a collection of computational components that can independently influence behavior. Disruptions in these different components can lead to decision-making deficits that appear similar behaviorally, but differ at the computational, and likely the neurobiological, level. Here, we discuss recent studies that have used computational approaches to investigate the decision-...
Source: Trends in Neurosciences - December 18, 2021 Category: Neuroscience Authors: Stephanie M Groman Summer L Thompson Daeyeol Lee Jane R Taylor Source Type: research

Reinforcement learning detuned in addiction: integrative and translational approaches
Trends Neurosci. 2021 Dec 14:S0166-2236(21)00236-8. doi: 10.1016/j.tins.2021.11.007. Online ahead of print.ABSTRACTSuboptimal decision-making strategies have been proposed to contribute to the pathophysiology of addiction. Decision-making, however, arises from a collection of computational components that can independently influence behavior. Disruptions in these different components can lead to decision-making deficits that appear similar behaviorally, but differ at the computational, and likely the neurobiological, level. Here, we discuss recent studies that have used computational approaches to investigate the decision-...
Source: Trends in Neurosciences - December 18, 2021 Category: Neuroscience Authors: Stephanie M Groman Summer L Thompson Daeyeol Lee Jane R Taylor Source Type: research

Reinforcement learning detuned in addiction: integrative and translational approaches
Trends Neurosci. 2021 Dec 14:S0166-2236(21)00236-8. doi: 10.1016/j.tins.2021.11.007. Online ahead of print.ABSTRACTSuboptimal decision-making strategies have been proposed to contribute to the pathophysiology of addiction. Decision-making, however, arises from a collection of computational components that can independently influence behavior. Disruptions in these different components can lead to decision-making deficits that appear similar behaviorally, but differ at the computational, and likely the neurobiological, level. Here, we discuss recent studies that have used computational approaches to investigate the decision-...
Source: Trends in Neurosciences - December 18, 2021 Category: Neuroscience Authors: Stephanie M Groman Summer L Thompson Daeyeol Lee Jane R Taylor Source Type: research

Reinforcement learning detuned in addiction: integrative and translational approaches
Trends Neurosci. 2021 Dec 14:S0166-2236(21)00236-8. doi: 10.1016/j.tins.2021.11.007. Online ahead of print.ABSTRACTSuboptimal decision-making strategies have been proposed to contribute to the pathophysiology of addiction. Decision-making, however, arises from a collection of computational components that can independently influence behavior. Disruptions in these different components can lead to decision-making deficits that appear similar behaviorally, but differ at the computational, and likely the neurobiological, level. Here, we discuss recent studies that have used computational approaches to investigate the decision-...
Source: Trends in Neurosciences - December 18, 2021 Category: Neuroscience Authors: Stephanie M Groman Summer L Thompson Daeyeol Lee Jane R Taylor Source Type: research

Reinforcement learning detuned in addiction: integrative and translational approaches
Trends Neurosci. 2021 Dec 14:S0166-2236(21)00236-8. doi: 10.1016/j.tins.2021.11.007. Online ahead of print.ABSTRACTSuboptimal decision-making strategies have been proposed to contribute to the pathophysiology of addiction. Decision-making, however, arises from a collection of computational components that can independently influence behavior. Disruptions in these different components can lead to decision-making deficits that appear similar behaviorally, but differ at the computational, and likely the neurobiological, level. Here, we discuss recent studies that have used computational approaches to investigate the decision-...
Source: Trends in Neurosciences - December 18, 2021 Category: Neuroscience Authors: Stephanie M Groman Summer L Thompson Daeyeol Lee Jane R Taylor Source Type: research