Midbrain cholinergic neurons signal negative feedback to promote behavioral flexibility
Trends Neurosci. 2022 May 6:S0166-2236(22)00079-0. doi: 10.1016/j.tins.2022.04.005. Online ahead of print.ABSTRACTCholinergic neurons of the pedunculopontine nucleus (PPN) are relevant for adaptive behavior. In a recent study, Ruan et al. revealed that PPN cholinergic neurons signal negative feedback during reward omission after contingency changes, which is necessary for switching to new behavioral strategies.PMID:35534340 | DOI:10.1016/j.tins.2022.04.005 (Source: Trends in Neurosciences)
Source: Trends in Neurosciences - May 9, 2022 Category: Neuroscience Authors: Nadine K Gut Juan Mena-Segovia Source Type: research

Roles of visually evoked and spontaneous activity in the development of retinal direction selectivity maps
Trends Neurosci. 2022 Apr 29:S0166-2236(22)00076-5. doi: 10.1016/j.tins.2022.04.002. Online ahead of print.ABSTRACTDetecting the direction of motion underlies many visually guided behaviors, from reflexive eye movements to identifying and catching moving objects. A subset of motion sensitive cells are direction selective - responding strongly to motion in one direction and weakly to motion in other directions. In mammals, direction-selective cells are found throughout the visual system, including the retina, superior colliculus, and primary visual cortex. Direction selectivity maps are well characterized in the mouse retin...
Source: Trends in Neurosciences - May 1, 2022 Category: Neuroscience Authors: Alexandre Tiriac Marla B Feller Source Type: research

Nonapoptotic caspases in neural development and in anesthesia-induced neurotoxicity
Trends Neurosci. 2022 Apr 21:S0166-2236(22)00058-3. doi: 10.1016/j.tins.2022.03.007. Online ahead of print.ABSTRACTApoptosis, classically initiated by caspase pathway activation, plays a prominent role during normal brain development as well as in neurodegeneration. The noncanonical, nonlethal arm of the caspase pathway is evolutionarily conserved and has also been implicated in both processes, yet is relatively understudied. Dysregulated pathway activation during critical periods of neurodevelopment due to environmental neurotoxins or exposure to compounds such as anesthetics can have detrimental consequences for brain ma...
Source: Trends in Neurosciences - May 1, 2022 Category: Neuroscience Authors: Nemanja Sari ć Kazue Hashimoto-Torii Vesna Jevtovi ć-Todorović Nobuyuki Ishibashi Source Type: research

Roles of visually evoked and spontaneous activity in the development of retinal direction selectivity maps
Trends Neurosci. 2022 Apr 29:S0166-2236(22)00076-5. doi: 10.1016/j.tins.2022.04.002. Online ahead of print.ABSTRACTDetecting the direction of motion underlies many visually guided behaviors, from reflexive eye movements to identifying and catching moving objects. A subset of motion sensitive cells are direction selective - responding strongly to motion in one direction and weakly to motion in other directions. In mammals, direction-selective cells are found throughout the visual system, including the retina, superior colliculus, and primary visual cortex. Direction selectivity maps are well characterized in the mouse retin...
Source: Trends in Neurosciences - May 1, 2022 Category: Neuroscience Authors: Alexandre Tiriac Marla B Feller Source Type: research

Nonapoptotic caspases in neural development and in anesthesia-induced neurotoxicity
Trends Neurosci. 2022 Apr 21:S0166-2236(22)00058-3. doi: 10.1016/j.tins.2022.03.007. Online ahead of print.ABSTRACTApoptosis, classically initiated by caspase pathway activation, plays a prominent role during normal brain development as well as in neurodegeneration. The noncanonical, nonlethal arm of the caspase pathway is evolutionarily conserved and has also been implicated in both processes, yet is relatively understudied. Dysregulated pathway activation during critical periods of neurodevelopment due to environmental neurotoxins or exposure to compounds such as anesthetics can have detrimental consequences for brain ma...
Source: Trends in Neurosciences - May 1, 2022 Category: Neuroscience Authors: Nemanja Sari ć Kazue Hashimoto-Torii Vesna Jevtovi ć-Todorović Nobuyuki Ishibashi Source Type: research

Roles of visually evoked and spontaneous activity in the development of retinal direction selectivity maps
Trends Neurosci. 2022 Apr 29:S0166-2236(22)00076-5. doi: 10.1016/j.tins.2022.04.002. Online ahead of print.ABSTRACTDetecting the direction of motion underlies many visually guided behaviors, from reflexive eye movements to identifying and catching moving objects. A subset of motion sensitive cells are direction selective - responding strongly to motion in one direction and weakly to motion in other directions. In mammals, direction-selective cells are found throughout the visual system, including the retina, superior colliculus, and primary visual cortex. Direction selectivity maps are well characterized in the mouse retin...
Source: Trends in Neurosciences - May 1, 2022 Category: Neuroscience Authors: Alexandre Tiriac Marla B Feller Source Type: research

Nonapoptotic caspases in neural development and in anesthesia-induced neurotoxicity
Trends Neurosci. 2022 Apr 21:S0166-2236(22)00058-3. doi: 10.1016/j.tins.2022.03.007. Online ahead of print.ABSTRACTApoptosis, classically initiated by caspase pathway activation, plays a prominent role during normal brain development as well as in neurodegeneration. The noncanonical, nonlethal arm of the caspase pathway is evolutionarily conserved and has also been implicated in both processes, yet is relatively understudied. Dysregulated pathway activation during critical periods of neurodevelopment due to environmental neurotoxins or exposure to compounds such as anesthetics can have detrimental consequences for brain ma...
Source: Trends in Neurosciences - May 1, 2022 Category: Neuroscience Authors: Nemanja Sari ć Kazue Hashimoto-Torii Vesna Jevtovi ć-Todorović Nobuyuki Ishibashi Source Type: research

Roles of visually evoked and spontaneous activity in the development of retinal direction selectivity maps
Trends Neurosci. 2022 Apr 29:S0166-2236(22)00076-5. doi: 10.1016/j.tins.2022.04.002. Online ahead of print.ABSTRACTDetecting the direction of motion underlies many visually guided behaviors, from reflexive eye movements to identifying and catching moving objects. A subset of motion sensitive cells are direction selective - responding strongly to motion in one direction and weakly to motion in other directions. In mammals, direction-selective cells are found throughout the visual system, including the retina, superior colliculus, and primary visual cortex. Direction selectivity maps are well characterized in the mouse retin...
Source: Trends in Neurosciences - May 1, 2022 Category: Neuroscience Authors: Alexandre Tiriac Marla B Feller Source Type: research

Nonapoptotic caspases in neural development and in anesthesia-induced neurotoxicity
Trends Neurosci. 2022 Apr 21:S0166-2236(22)00058-3. doi: 10.1016/j.tins.2022.03.007. Online ahead of print.ABSTRACTApoptosis, classically initiated by caspase pathway activation, plays a prominent role during normal brain development as well as in neurodegeneration. The noncanonical, nonlethal arm of the caspase pathway is evolutionarily conserved and has also been implicated in both processes, yet is relatively understudied. Dysregulated pathway activation during critical periods of neurodevelopment due to environmental neurotoxins or exposure to compounds such as anesthetics can have detrimental consequences for brain ma...
Source: Trends in Neurosciences - May 1, 2022 Category: Neuroscience Authors: Nemanja Sari ć Kazue Hashimoto-Torii Vesna Jevtovi ć-Todorović Nobuyuki Ishibashi Source Type: research

Roles of visually evoked and spontaneous activity in the development of retinal direction selectivity maps
Trends Neurosci. 2022 Apr 29:S0166-2236(22)00076-5. doi: 10.1016/j.tins.2022.04.002. Online ahead of print.ABSTRACTDetecting the direction of motion underlies many visually guided behaviors, from reflexive eye movements to identifying and catching moving objects. A subset of motion sensitive cells are direction selective - responding strongly to motion in one direction and weakly to motion in other directions. In mammals, direction-selective cells are found throughout the visual system, including the retina, superior colliculus, and primary visual cortex. Direction selectivity maps are well characterized in the mouse retin...
Source: Trends in Neurosciences - May 1, 2022 Category: Neuroscience Authors: Alexandre Tiriac Marla B Feller Source Type: research

Nonapoptotic caspases in neural development and in anesthesia-induced neurotoxicity
Trends Neurosci. 2022 Apr 21:S0166-2236(22)00058-3. doi: 10.1016/j.tins.2022.03.007. Online ahead of print.ABSTRACTApoptosis, classically initiated by caspase pathway activation, plays a prominent role during normal brain development as well as in neurodegeneration. The noncanonical, nonlethal arm of the caspase pathway is evolutionarily conserved and has also been implicated in both processes, yet is relatively understudied. Dysregulated pathway activation during critical periods of neurodevelopment due to environmental neurotoxins or exposure to compounds such as anesthetics can have detrimental consequences for brain ma...
Source: Trends in Neurosciences - May 1, 2022 Category: Neuroscience Authors: Nemanja Sari ć Kazue Hashimoto-Torii Vesna Jevtovi ć-Todorović Nobuyuki Ishibashi Source Type: research

Roles of visually evoked and spontaneous activity in the development of retinal direction selectivity maps
Trends Neurosci. 2022 Apr 29:S0166-2236(22)00076-5. doi: 10.1016/j.tins.2022.04.002. Online ahead of print.ABSTRACTDetecting the direction of motion underlies many visually guided behaviors, from reflexive eye movements to identifying and catching moving objects. A subset of motion sensitive cells are direction selective - responding strongly to motion in one direction and weakly to motion in other directions. In mammals, direction-selective cells are found throughout the visual system, including the retina, superior colliculus, and primary visual cortex. Direction selectivity maps are well characterized in the mouse retin...
Source: Trends in Neurosciences - May 1, 2022 Category: Neuroscience Authors: Alexandre Tiriac Marla B Feller Source Type: research

Nonapoptotic caspases in neural development and in anesthesia-induced neurotoxicity
Trends Neurosci. 2022 Apr 21:S0166-2236(22)00058-3. doi: 10.1016/j.tins.2022.03.007. Online ahead of print.ABSTRACTApoptosis, classically initiated by caspase pathway activation, plays a prominent role during normal brain development as well as in neurodegeneration. The noncanonical, nonlethal arm of the caspase pathway is evolutionarily conserved and has also been implicated in both processes, yet is relatively understudied. Dysregulated pathway activation during critical periods of neurodevelopment due to environmental neurotoxins or exposure to compounds such as anesthetics can have detrimental consequences for brain ma...
Source: Trends in Neurosciences - May 1, 2022 Category: Neuroscience Authors: Nemanja Sari ć Kazue Hashimoto-Torii Vesna Jevtovi ć-Todorović Nobuyuki Ishibashi Source Type: research

Roles of visually evoked and spontaneous activity in the development of retinal direction selectivity maps
Trends Neurosci. 2022 Apr 29:S0166-2236(22)00076-5. doi: 10.1016/j.tins.2022.04.002. Online ahead of print.ABSTRACTDetecting the direction of motion underlies many visually guided behaviors, from reflexive eye movements to identifying and catching moving objects. A subset of motion sensitive cells are direction selective - responding strongly to motion in one direction and weakly to motion in other directions. In mammals, direction-selective cells are found throughout the visual system, including the retina, superior colliculus, and primary visual cortex. Direction selectivity maps are well characterized in the mouse retin...
Source: Trends in Neurosciences - May 1, 2022 Category: Neuroscience Authors: Alexandre Tiriac Marla B Feller Source Type: research

Nonapoptotic caspases in neural development and in anesthesia-induced neurotoxicity
Trends Neurosci. 2022 Apr 21:S0166-2236(22)00058-3. doi: 10.1016/j.tins.2022.03.007. Online ahead of print.ABSTRACTApoptosis, classically initiated by caspase pathway activation, plays a prominent role during normal brain development as well as in neurodegeneration. The noncanonical, nonlethal arm of the caspase pathway is evolutionarily conserved and has also been implicated in both processes, yet is relatively understudied. Dysregulated pathway activation during critical periods of neurodevelopment due to environmental neurotoxins or exposure to compounds such as anesthetics can have detrimental consequences for brain ma...
Source: Trends in Neurosciences - May 1, 2022 Category: Neuroscience Authors: Nemanja Sari ć Kazue Hashimoto-Torii Vesna Jevtovi ć-Todorović Nobuyuki Ishibashi Source Type: research