Shared gustatory sensor for acids and ammonium

Trends Neurosci. 2023 Dec 8:S0166-2236(23)00271-0. doi: 10.1016/j.tins.2023.11.009. Online ahead of print.ABSTRACTIn a recent study, Liang, Wilson, and colleagues demonstrated that the H+-selective ion channel OTOP1, responsible for sour taste transduction, also functions as a gustatory sensor for ammonium in mice. Additionally, this research revealed a novel mode of channel activation by intracellular alkalinization, which is conserved across vertebrate species.PMID:38071122 | DOI:10.1016/j.tins.2023.11.009
Source: Trends in Neurosciences - Category: Neuroscience Authors: Source Type: research