Unlocking the biosynthesis of psychedelic-inspired indolethylamines
Trends Biochem Sci. 2023 Dec 29:S0968-0004(23)00313-4. doi: 10.1016/j.tibs.2023.12.009. Online ahead of print.ABSTRACTA recent report by Chen et al. describes the discovery of RmNMT, a highly active and promiscuous tryptamine N-methyltransferase from the cane toad, Rhinella marina. N,N-dimethyltryptamine derivatives produced by this enzyme were then evaluated for their potential to serve as next-generation treatments for mental health disorders.PMID:38160063 | DOI:10.1016/j.tibs.2023.12.009 (Source: Trends in Biochemical Sciences)
Source: Trends in Biochemical Sciences - December 30, 2023 Category: Biochemistry Authors: Abhishek K Sen J Andrew Jones Source Type: research
Creative approaches using proximity labeling to gain new biological insights
Trends Biochem Sci. 2023 Dec 29:S0968-0004(23)00300-6. doi: 10.1016/j.tibs.2023.12.005. Online ahead of print.ABSTRACTAt its most fundamental level, life is a collection of synchronized cellular processes driven by interactions among biomolecules. Proximity labeling has emerged as a powerful technique to capture these interactions in native settings, revealing previously unexplored elements of biology. This review highlights recent developments in proximity labeling, focusing on methods that push the fundamental technologies beyond the classic bait-prey paradigm, such as RNA-protein interactions, ligand/small-molecule-prot...
Source: Trends in Biochemical Sciences - December 30, 2023 Category: Biochemistry Authors: Ryan R Milione Bin-Bin Schell Cameron J Douglas Ciaran P Seath Source Type: research
Unlocking the biosynthesis of psychedelic-inspired indolethylamines
Trends Biochem Sci. 2023 Dec 29:S0968-0004(23)00313-4. doi: 10.1016/j.tibs.2023.12.009. Online ahead of print.ABSTRACTA recent report by Chen et al. describes the discovery of RmNMT, a highly active and promiscuous tryptamine N-methyltransferase from the cane toad, Rhinella marina. N,N-dimethyltryptamine derivatives produced by this enzyme were then evaluated for their potential to serve as next-generation treatments for mental health disorders.PMID:38160063 | DOI:10.1016/j.tibs.2023.12.009 (Source: Trends in Biochemical Sciences)
Source: Trends in Biochemical Sciences - December 30, 2023 Category: Biochemistry Authors: Abhishek K Sen J Andrew Jones Source Type: research
Creative approaches using proximity labeling to gain new biological insights
Trends Biochem Sci. 2023 Dec 29:S0968-0004(23)00300-6. doi: 10.1016/j.tibs.2023.12.005. Online ahead of print.ABSTRACTAt its most fundamental level, life is a collection of synchronized cellular processes driven by interactions among biomolecules. Proximity labeling has emerged as a powerful technique to capture these interactions in native settings, revealing previously unexplored elements of biology. This review highlights recent developments in proximity labeling, focusing on methods that push the fundamental technologies beyond the classic bait-prey paradigm, such as RNA-protein interactions, ligand/small-molecule-prot...
Source: Trends in Biochemical Sciences - December 30, 2023 Category: Biochemistry Authors: Ryan R Milione Bin-Bin Schell Cameron J Douglas Ciaran P Seath Source Type: research
Unlocking the biosynthesis of psychedelic-inspired indolethylamines
Trends Biochem Sci. 2023 Dec 29:S0968-0004(23)00313-4. doi: 10.1016/j.tibs.2023.12.009. Online ahead of print.ABSTRACTA recent report by Chen et al. describes the discovery of RmNMT, a highly active and promiscuous tryptamine N-methyltransferase from the cane toad, Rhinella marina. N,N-dimethyltryptamine derivatives produced by this enzyme were then evaluated for their potential to serve as next-generation treatments for mental health disorders.PMID:38160063 | DOI:10.1016/j.tibs.2023.12.009 (Source: Trends in Biochemical Sciences)
Source: Trends in Biochemical Sciences - December 30, 2023 Category: Biochemistry Authors: Abhishek K Sen J Andrew Jones Source Type: research
Creative approaches using proximity labeling to gain new biological insights
Trends Biochem Sci. 2023 Dec 29:S0968-0004(23)00300-6. doi: 10.1016/j.tibs.2023.12.005. Online ahead of print.ABSTRACTAt its most fundamental level, life is a collection of synchronized cellular processes driven by interactions among biomolecules. Proximity labeling has emerged as a powerful technique to capture these interactions in native settings, revealing previously unexplored elements of biology. This review highlights recent developments in proximity labeling, focusing on methods that push the fundamental technologies beyond the classic bait-prey paradigm, such as RNA-protein interactions, ligand/small-molecule-prot...
Source: Trends in Biochemical Sciences - December 30, 2023 Category: Biochemistry Authors: Ryan R Milione Bin-Bin Schell Cameron J Douglas Ciaran P Seath Source Type: research
Structural insights into membrane adenylyl cyclases, initiators of cAMP signaling
Trends Biochem Sci. 2023 Dec 28:S0968-0004(23)00297-9. doi: 10.1016/j.tibs.2023.12.002. Online ahead of print.ABSTRACTMembrane adenylyl cyclases (ACs) catalyze the conversion of ATP to the ubiquitous second messenger cAMP. As effector proteins of G protein-coupled receptors and other signaling pathways, ACs receive and amplify signals from the cell surface, translating them into biochemical reactions in the intracellular space and integrating different signaling pathways. Despite their importance in signal transduction and physiology, our knowledge about the structure, function, regulation, and molecular interactions of AC...
Source: Trends in Biochemical Sciences - December 29, 2023 Category: Biochemistry Authors: Dina Schuster Basavraj Khanppnavar Ilayda Kantarci Ved Mehta Volodymyr M Korkhov Source Type: research
Revealing eEF-2 kinase: recent structural insights into function
We describe recent structural insights into this unique activation process and examine the effects of specific regulatory signals on this mechanism. We also highlight key unanswered questions to guide future structure-function studies. These include structural mechanisms which enable eEF-2K to interact with upstream/downstream partners and facilitate its integration of diverse inputs, including Ca2+ transients, phosphorylation mediated by energy/nutrient-sensing pathways, pH changes, and metabolites. Answering these questions is key to establishing how eEF-2K harmonizes translation with cellular requirements within the bou...
Source: Trends in Biochemical Sciences - December 16, 2023 Category: Biochemistry Authors: Andrea Piserchio Kevin N Dalby Ranajeet Ghose Source Type: research
Revealing eEF-2 kinase: recent structural insights into function
We describe recent structural insights into this unique activation process and examine the effects of specific regulatory signals on this mechanism. We also highlight key unanswered questions to guide future structure-function studies. These include structural mechanisms which enable eEF-2K to interact with upstream/downstream partners and facilitate its integration of diverse inputs, including Ca2+ transients, phosphorylation mediated by energy/nutrient-sensing pathways, pH changes, and metabolites. Answering these questions is key to establishing how eEF-2K harmonizes translation with cellular requirements within the bou...
Source: Trends in Biochemical Sciences - December 16, 2023 Category: Biochemistry Authors: Andrea Piserchio Kevin N Dalby Ranajeet Ghose Source Type: research
Revealing eEF-2 kinase: recent structural insights into function
We describe recent structural insights into this unique activation process and examine the effects of specific regulatory signals on this mechanism. We also highlight key unanswered questions to guide future structure-function studies. These include structural mechanisms which enable eEF-2K to interact with upstream/downstream partners and facilitate its integration of diverse inputs, including Ca2+ transients, phosphorylation mediated by energy/nutrient-sensing pathways, pH changes, and metabolites. Answering these questions is key to establishing how eEF-2K harmonizes translation with cellular requirements within the bou...
Source: Trends in Biochemical Sciences - December 16, 2023 Category: Biochemistry Authors: Andrea Piserchio Kevin N Dalby Ranajeet Ghose Source Type: research
Revealing eEF-2 kinase: recent structural insights into function
We describe recent structural insights into this unique activation process and examine the effects of specific regulatory signals on this mechanism. We also highlight key unanswered questions to guide future structure-function studies. These include structural mechanisms which enable eEF-2K to interact with upstream/downstream partners and facilitate its integration of diverse inputs, including Ca2+ transients, phosphorylation mediated by energy/nutrient-sensing pathways, pH changes, and metabolites. Answering these questions is key to establishing how eEF-2K harmonizes translation with cellular requirements within the bou...
Source: Trends in Biochemical Sciences - December 16, 2023 Category: Biochemistry Authors: Andrea Piserchio Kevin N Dalby Ranajeet Ghose Source Type: research
Revealing eEF-2 kinase: recent structural insights into function
We describe recent structural insights into this unique activation process and examine the effects of specific regulatory signals on this mechanism. We also highlight key unanswered questions to guide future structure-function studies. These include structural mechanisms which enable eEF-2K to interact with upstream/downstream partners and facilitate its integration of diverse inputs, including Ca2+ transients, phosphorylation mediated by energy/nutrient-sensing pathways, pH changes, and metabolites. Answering these questions is key to establishing how eEF-2K harmonizes translation with cellular requirements within the bou...
Source: Trends in Biochemical Sciences - December 16, 2023 Category: Biochemistry Authors: Andrea Piserchio Kevin N Dalby Ranajeet Ghose Source Type: research
Revealing eEF-2 kinase: recent structural insights into function
We describe recent structural insights into this unique activation process and examine the effects of specific regulatory signals on this mechanism. We also highlight key unanswered questions to guide future structure-function studies. These include structural mechanisms which enable eEF-2K to interact with upstream/downstream partners and facilitate its integration of diverse inputs, including Ca2+ transients, phosphorylation mediated by energy/nutrient-sensing pathways, pH changes, and metabolites. Answering these questions is key to establishing how eEF-2K harmonizes translation with cellular requirements within the bou...
Source: Trends in Biochemical Sciences - December 16, 2023 Category: Biochemistry Authors: Andrea Piserchio Kevin N Dalby Ranajeet Ghose Source Type: research
Revealing eEF-2 kinase: recent structural insights into function
We describe recent structural insights into this unique activation process and examine the effects of specific regulatory signals on this mechanism. We also highlight key unanswered questions to guide future structure-function studies. These include structural mechanisms which enable eEF-2K to interact with upstream/downstream partners and facilitate its integration of diverse inputs, including Ca2+ transients, phosphorylation mediated by energy/nutrient-sensing pathways, pH changes, and metabolites. Answering these questions is key to establishing how eEF-2K harmonizes translation with cellular requirements within the bou...
Source: Trends in Biochemical Sciences - December 16, 2023 Category: Biochemistry Authors: Andrea Piserchio Kevin N Dalby Ranajeet Ghose Source Type: research
Revealing eEF-2 kinase: recent structural insights into function
We describe recent structural insights into this unique activation process and examine the effects of specific regulatory signals on this mechanism. We also highlight key unanswered questions to guide future structure-function studies. These include structural mechanisms which enable eEF-2K to interact with upstream/downstream partners and facilitate its integration of diverse inputs, including Ca2+ transients, phosphorylation mediated by energy/nutrient-sensing pathways, pH changes, and metabolites. Answering these questions is key to establishing how eEF-2K harmonizes translation with cellular requirements within the bou...
Source: Trends in Biochemical Sciences - December 16, 2023 Category: Biochemistry Authors: Andrea Piserchio Kevin N Dalby Ranajeet Ghose Source Type: research
