Keeping neuronal activity in check: a novel role for α-synuclein serine-129 phosphorylation in the healthy brain
Trends Biochem Sci. 2024 Mar 6:S0968-0004(24)00051-3. doi: 10.1016/j.tibs.2024.02.006. Online ahead of print.ABSTRACTPhosphorylation of α-synuclein protein at serine-129 (Ser129P) is a widely used marker for disease pathology in neurodegenerative disorders termed synucleinopathies. In groundbreaking work by Parra-Rivas, Madhivanan et al., Ser129P was shown to facilitate the normal function of α-synuclein, bearing significant implications for the transition from a physiological to pathological state.PMID:38453543 | DOI:10.1016/j.tibs.2024.02.006 (Source: Trends in Biochemical Sciences)
Source: Trends in Biochemical Sciences - March 7, 2024 Category: Biochemistry Authors: Danielle E Mor Source Type: research
Keeping neuronal activity in check: a novel role for α-synuclein serine-129 phosphorylation in the healthy brain
Trends Biochem Sci. 2024 Mar 6:S0968-0004(24)00051-3. doi: 10.1016/j.tibs.2024.02.006. Online ahead of print.ABSTRACTPhosphorylation of α-synuclein protein at serine-129 (Ser129P) is a widely used marker for disease pathology in neurodegenerative disorders termed synucleinopathies. In groundbreaking work by Parra-Rivas, Madhivanan et al., Ser129P was shown to facilitate the normal function of α-synuclein, bearing significant implications for the transition from a physiological to pathological state.PMID:38453543 | DOI:10.1016/j.tibs.2024.02.006 (Source: Trends in Biochemical Sciences)
Source: Trends in Biochemical Sciences - March 7, 2024 Category: Biochemistry Authors: Danielle E Mor Source Type: research
Keeping neuronal activity in check: a novel role for α-synuclein serine-129 phosphorylation in the healthy brain
Trends Biochem Sci. 2024 Mar 6:S0968-0004(24)00051-3. doi: 10.1016/j.tibs.2024.02.006. Online ahead of print.ABSTRACTPhosphorylation of α-synuclein protein at serine-129 (Ser129P) is a widely used marker for disease pathology in neurodegenerative disorders termed synucleinopathies. In groundbreaking work by Parra-Rivas, Madhivanan et al., Ser129P was shown to facilitate the normal function of α-synuclein, bearing significant implications for the transition from a physiological to pathological state.PMID:38453543 | DOI:10.1016/j.tibs.2024.02.006 (Source: Trends in Biochemical Sciences)
Source: Trends in Biochemical Sciences - March 7, 2024 Category: Biochemistry Authors: Danielle E Mor Source Type: research
Keeping neuronal activity in check: a novel role for α-synuclein serine-129 phosphorylation in the healthy brain
Trends Biochem Sci. 2024 Mar 6:S0968-0004(24)00051-3. doi: 10.1016/j.tibs.2024.02.006. Online ahead of print.ABSTRACTPhosphorylation of α-synuclein protein at serine-129 (Ser129P) is a widely used marker for disease pathology in neurodegenerative disorders termed synucleinopathies. In groundbreaking work by Parra-Rivas, Madhivanan et al., Ser129P was shown to facilitate the normal function of α-synuclein, bearing significant implications for the transition from a physiological to pathological state.PMID:38453543 | DOI:10.1016/j.tibs.2024.02.006 (Source: Trends in Biochemical Sciences)
Source: Trends in Biochemical Sciences - March 7, 2024 Category: Biochemistry Authors: Danielle E Mor Source Type: research
Keeping neuronal activity in check: a novel role for α-synuclein serine-129 phosphorylation in the healthy brain
Trends Biochem Sci. 2024 Mar 6:S0968-0004(24)00051-3. doi: 10.1016/j.tibs.2024.02.006. Online ahead of print.ABSTRACTPhosphorylation of α-synuclein protein at serine-129 (Ser129P) is a widely used marker for disease pathology in neurodegenerative disorders termed synucleinopathies. In groundbreaking work by Parra-Rivas, Madhivanan et al., Ser129P was shown to facilitate the normal function of α-synuclein, bearing significant implications for the transition from a physiological to pathological state.PMID:38453543 | DOI:10.1016/j.tibs.2024.02.006 (Source: Trends in Biochemical Sciences)
Source: Trends in Biochemical Sciences - March 7, 2024 Category: Biochemistry Authors: Danielle E Mor Source Type: research
Keeping neuronal activity in check: a novel role for α-synuclein serine-129 phosphorylation in the healthy brain
Trends Biochem Sci. 2024 Mar 6:S0968-0004(24)00051-3. doi: 10.1016/j.tibs.2024.02.006. Online ahead of print.ABSTRACTPhosphorylation of α-synuclein protein at serine-129 (Ser129P) is a widely used marker for disease pathology in neurodegenerative disorders termed synucleinopathies. In groundbreaking work by Parra-Rivas, Madhivanan et al., Ser129P was shown to facilitate the normal function of α-synuclein, bearing significant implications for the transition from a physiological to pathological state.PMID:38453543 | DOI:10.1016/j.tibs.2024.02.006 (Source: Trends in Biochemical Sciences)
Source: Trends in Biochemical Sciences - March 7, 2024 Category: Biochemistry Authors: Danielle E Mor Source Type: research
Spray-type modifications: an emerging paradigm in post-translational modifications
Trends Biochem Sci. 2024 Feb 28:S0968-0004(24)00023-9. doi: 10.1016/j.tibs.2024.01.008. Online ahead of print.ABSTRACTA post-translational modification (PTM) occurs when a nucleophilic residue (e.g., lysine of a target protein) attacks electrophilic substrate molecules (e.g., acyl-AMP), involving writer enzymes or even occurring spontaneously. Traditionally, this phenomenon was thought to be sequence specific; however, recent research suggests that PTMs can also occur in a non-sequence-specific manner confined to a specific location in a cell. In this Opinion, we compile the accumulated evidence of spray-type PTMs and prop...
Source: Trends in Biochemical Sciences - March 5, 2024 Category: Biochemistry Authors: Yun-Bin Lee Hyun-Woo Rhee Source Type: research
Spray-type modifications: an emerging paradigm in post-translational modifications
Trends Biochem Sci. 2024 Feb 28:S0968-0004(24)00023-9. doi: 10.1016/j.tibs.2024.01.008. Online ahead of print.ABSTRACTA post-translational modification (PTM) occurs when a nucleophilic residue (e.g., lysine of a target protein) attacks electrophilic substrate molecules (e.g., acyl-AMP), involving writer enzymes or even occurring spontaneously. Traditionally, this phenomenon was thought to be sequence specific; however, recent research suggests that PTMs can also occur in a non-sequence-specific manner confined to a specific location in a cell. In this Opinion, we compile the accumulated evidence of spray-type PTMs and prop...
Source: Trends in Biochemical Sciences - March 5, 2024 Category: Biochemistry Authors: Yun-Bin Lee Hyun-Woo Rhee Source Type: research
TrkB transmembrane domain: bridging structural understanding with therapeutic strategy
Trends Biochem Sci. 2024 Mar 2:S0968-0004(24)00037-9. doi: 10.1016/j.tibs.2024.02.001. Online ahead of print.ABSTRACTTrkB (neuronal receptor tyrosine kinase-2, NTRK2) is the receptor for brain-derived neurotrophic factor (BDNF) and is a critical regulator of activity-dependent neuronal plasticity. The past few years have witnessed an increasing understanding of the structure and function of TrkB, including its transmembrane domain (TMD). TrkB interacts with membrane cholesterol, which bidirectionally regulates TrkB signaling. Additionally, TrkB has recently been recognized as a binding target of antidepressant drugs. A var...
Source: Trends in Biochemical Sciences - March 3, 2024 Category: Biochemistry Authors: Giray Enkavi Mykhailo Girych Rafael Moliner Ilpo Vattulainen Eero Castr én Source Type: research
TrkB transmembrane domain: bridging structural understanding with therapeutic strategy
Trends Biochem Sci. 2024 Mar 2:S0968-0004(24)00037-9. doi: 10.1016/j.tibs.2024.02.001. Online ahead of print.ABSTRACTTrkB (neuronal receptor tyrosine kinase-2, NTRK2) is the receptor for brain-derived neurotrophic factor (BDNF) and is a critical regulator of activity-dependent neuronal plasticity. The past few years have witnessed an increasing understanding of the structure and function of TrkB, including its transmembrane domain (TMD). TrkB interacts with membrane cholesterol, which bidirectionally regulates TrkB signaling. Additionally, TrkB has recently been recognized as a binding target of antidepressant drugs. A var...
Source: Trends in Biochemical Sciences - March 3, 2024 Category: Biochemistry Authors: Giray Enkavi Mykhailo Girych Rafael Moliner Ilpo Vattulainen Eero Castr én Source Type: research
TrkB transmembrane domain: bridging structural understanding with therapeutic strategy
Trends Biochem Sci. 2024 Mar 2:S0968-0004(24)00037-9. doi: 10.1016/j.tibs.2024.02.001. Online ahead of print.ABSTRACTTrkB (neuronal receptor tyrosine kinase-2, NTRK2) is the receptor for brain-derived neurotrophic factor (BDNF) and is a critical regulator of activity-dependent neuronal plasticity. The past few years have witnessed an increasing understanding of the structure and function of TrkB, including its transmembrane domain (TMD). TrkB interacts with membrane cholesterol, which bidirectionally regulates TrkB signaling. Additionally, TrkB has recently been recognized as a binding target of antidepressant drugs. A var...
Source: Trends in Biochemical Sciences - March 3, 2024 Category: Biochemistry Authors: Giray Enkavi Mykhailo Girych Rafael Moliner Ilpo Vattulainen Eero Castr én Source Type: research
Glucocorticoid receptor signaling: intricacies and therapeutic opportunities
Trends Biochem Sci. 2024 Feb 29:S0968-0004(24)00032-X. doi: 10.1016/j.tibs.2024.01.012. Online ahead of print.ABSTRACTThe glucocorticoid receptor (GR) is a major nuclear receptor (NR) drug target for the treatment of inflammatory disorders and several cancers. Despite the effectiveness of GR ligands, their systemic action triggers a plethora of side effects, limiting long-term use. Here, we discuss new concepts of and insights into GR mechanisms of action to assist in the identification of routes toward enhanced therapeutic benefits. We zoom in on the communication between different GR domains and how this is influenced by...
Source: Trends in Biochemical Sciences - March 1, 2024 Category: Biochemistry Authors: Dorien Clarisse Laura Van Moortel Chlo é Van Leene Kris Gevaert Karolien De Bosscher Source Type: research
Glucocorticoid receptor signaling: intricacies and therapeutic opportunities
Trends Biochem Sci. 2024 Feb 29:S0968-0004(24)00032-X. doi: 10.1016/j.tibs.2024.01.012. Online ahead of print.ABSTRACTThe glucocorticoid receptor (GR) is a major nuclear receptor (NR) drug target for the treatment of inflammatory disorders and several cancers. Despite the effectiveness of GR ligands, their systemic action triggers a plethora of side effects, limiting long-term use. Here, we discuss new concepts of and insights into GR mechanisms of action to assist in the identification of routes toward enhanced therapeutic benefits. We zoom in on the communication between different GR domains and how this is influenced by...
Source: Trends in Biochemical Sciences - March 1, 2024 Category: Biochemistry Authors: Dorien Clarisse Laura Van Moortel Chlo é Van Leene Kris Gevaert Karolien De Bosscher Source Type: research
Oxytocin and vasopressin signaling in health and disease
Trends Biochem Sci. 2024 Feb 27:S0968-0004(24)00030-6. doi: 10.1016/j.tibs.2024.01.010. Online ahead of print.ABSTRACTNeurohypophysial peptides are ancient and evolutionarily highly conserved neuropeptides that regulate many crucial physiological functions in vertebrates and invertebrates. The human neurohypophysial oxytocin/vasopressin (OT/VP) signaling system with its four receptors has become an attractive drug target for a variety of diseases, including cancer, pain, cardiovascular indications, and neurological disorders. Despite its promise, drug development faces hurdles, including signaling complexity, selectivity a...
Source: Trends in Biochemical Sciences - February 28, 2024 Category: Biochemistry Authors: Monika Perisic Katrina Woolcock Anke Hering Helen Mendel Markus Muttenthaler Source Type: research
Oxytocin and vasopressin signaling in health and disease
Trends Biochem Sci. 2024 Feb 27:S0968-0004(24)00030-6. doi: 10.1016/j.tibs.2024.01.010. Online ahead of print.ABSTRACTNeurohypophysial peptides are ancient and evolutionarily highly conserved neuropeptides that regulate many crucial physiological functions in vertebrates and invertebrates. The human neurohypophysial oxytocin/vasopressin (OT/VP) signaling system with its four receptors has become an attractive drug target for a variety of diseases, including cancer, pain, cardiovascular indications, and neurological disorders. Despite its promise, drug development faces hurdles, including signaling complexity, selectivity a...
Source: Trends in Biochemical Sciences - February 28, 2024 Category: Biochemistry Authors: Monika Perisic Katrina Woolcock Anke Hering Helen Mendel Markus Muttenthaler Source Type: research
