Keeping neuronal activity in check: a novel role for α-synuclein serine-129 phosphorylation in the healthy brain

Trends Biochem Sci. 2024 Mar 6:S0968-0004(24)00051-3. doi: 10.1016/j.tibs.2024.02.006. Online ahead of print.ABSTRACTPhosphorylation of α-synuclein protein at serine-129 (Ser129P) is a widely used marker for disease pathology in neurodegenerative disorders termed synucleinopathies. In groundbreaking work by Parra-Rivas, Madhivanan et al., Ser129P was shown to facilitate the normal function of α-synuclein, bearing significant implications for the transition from a physiological to pathological state.PMID:38453543 | DOI:10.1016/j.tibs.2024.02.006
Source: Trends in Biochemical Sciences - Category: Biochemistry Authors: Source Type: research