Causes and consequences of DNA single-strand breaks
Trends Biochem Sci. 2023 Nov 30:S0968-0004(23)00285-2. doi: 10.1016/j.tibs.2023.11.001. Online ahead of print.ABSTRACTDNA single-strand breaks (SSBs) are among the most common lesions arising in human cells, with tens to hundreds of thousands arising in each cell, each day. Cells have efficient mechanisms for the sensing and repair of these ubiquitous DNA lesions, but the failure of these processes to rapidly remove SSBs can lead to a variety of pathogenic outcomes. The threat posed by unrepaired SSBs is illustrated by the existence of at least six genetic diseases in which SSB repair (SSBR) is defective, all of which are ...
Source: Trends in Biochemical Sciences - December 1, 2023 Category: Biochemistry Authors: Keith W Caldecott Source Type: research
Causes and consequences of DNA single-strand breaks
Trends Biochem Sci. 2023 Nov 30:S0968-0004(23)00285-2. doi: 10.1016/j.tibs.2023.11.001. Online ahead of print.ABSTRACTDNA single-strand breaks (SSBs) are among the most common lesions arising in human cells, with tens to hundreds of thousands arising in each cell, each day. Cells have efficient mechanisms for the sensing and repair of these ubiquitous DNA lesions, but the failure of these processes to rapidly remove SSBs can lead to a variety of pathogenic outcomes. The threat posed by unrepaired SSBs is illustrated by the existence of at least six genetic diseases in which SSB repair (SSBR) is defective, all of which are ...
Source: Trends in Biochemical Sciences - December 1, 2023 Category: Biochemistry Authors: Keith W Caldecott Source Type: research
Causes and consequences of DNA single-strand breaks
Trends Biochem Sci. 2023 Nov 30:S0968-0004(23)00285-2. doi: 10.1016/j.tibs.2023.11.001. Online ahead of print.ABSTRACTDNA single-strand breaks (SSBs) are among the most common lesions arising in human cells, with tens to hundreds of thousands arising in each cell, each day. Cells have efficient mechanisms for the sensing and repair of these ubiquitous DNA lesions, but the failure of these processes to rapidly remove SSBs can lead to a variety of pathogenic outcomes. The threat posed by unrepaired SSBs is illustrated by the existence of at least six genetic diseases in which SSB repair (SSBR) is defective, all of which are ...
Source: Trends in Biochemical Sciences - December 1, 2023 Category: Biochemistry Authors: Keith W Caldecott Source Type: research
Causes and consequences of DNA single-strand breaks
Trends Biochem Sci. 2023 Nov 30:S0968-0004(23)00285-2. doi: 10.1016/j.tibs.2023.11.001. Online ahead of print.ABSTRACTDNA single-strand breaks (SSBs) are among the most common lesions arising in human cells, with tens to hundreds of thousands arising in each cell, each day. Cells have efficient mechanisms for the sensing and repair of these ubiquitous DNA lesions, but the failure of these processes to rapidly remove SSBs can lead to a variety of pathogenic outcomes. The threat posed by unrepaired SSBs is illustrated by the existence of at least six genetic diseases in which SSB repair (SSBR) is defective, all of which are ...
Source: Trends in Biochemical Sciences - December 1, 2023 Category: Biochemistry Authors: Keith W Caldecott Source Type: research
Causes and consequences of DNA single-strand breaks
Trends Biochem Sci. 2023 Nov 30:S0968-0004(23)00285-2. doi: 10.1016/j.tibs.2023.11.001. Online ahead of print.ABSTRACTDNA single-strand breaks (SSBs) are among the most common lesions arising in human cells, with tens to hundreds of thousands arising in each cell, each day. Cells have efficient mechanisms for the sensing and repair of these ubiquitous DNA lesions, but the failure of these processes to rapidly remove SSBs can lead to a variety of pathogenic outcomes. The threat posed by unrepaired SSBs is illustrated by the existence of at least six genetic diseases in which SSB repair (SSBR) is defective, all of which are ...
Source: Trends in Biochemical Sciences - December 1, 2023 Category: Biochemistry Authors: Keith W Caldecott Source Type: research
Hypoxia Inducible Factor pathway proteins in high-altitude mammals
Trends Biochem Sci. 2023 Nov 29:S0968-0004(23)00286-4. doi: 10.1016/j.tibs.2023.11.002. Online ahead of print.ABSTRACTHumans and other mammals inhabit hypoxic high-altitude locales. In many of these species, genes under positive selection include ones in the Hypoxia Inducible Factor (HIF) pathway. One is PHD2 (EGLN1), which encodes for a key oxygen sensor. Another is HIF2A (EPAS1), which encodes for a PHD2-regulated transcription factor. Recent studies have provided insights into mechanisms for these high-altitude alleles. These studies have (i) shown that selection can occur on nonconserved, unstructured regions of protei...
Source: Trends in Biochemical Sciences - November 30, 2023 Category: Biochemistry Authors: Frank S Lee Source Type: research
Hypoxia Inducible Factor pathway proteins in high-altitude mammals
Trends Biochem Sci. 2023 Nov 29:S0968-0004(23)00286-4. doi: 10.1016/j.tibs.2023.11.002. Online ahead of print.ABSTRACTHumans and other mammals inhabit hypoxic high-altitude locales. In many of these species, genes under positive selection include ones in the Hypoxia Inducible Factor (HIF) pathway. One is PHD2 (EGLN1), which encodes for a key oxygen sensor. Another is HIF2A (EPAS1), which encodes for a PHD2-regulated transcription factor. Recent studies have provided insights into mechanisms for these high-altitude alleles. These studies have (i) shown that selection can occur on nonconserved, unstructured regions of protei...
Source: Trends in Biochemical Sciences - November 30, 2023 Category: Biochemistry Authors: Frank S Lee Source Type: research
Elucidating the novel mechanisms of molecular chaperones by single-molecule technologies
Trends Biochem Sci. 2023 Nov 16:S0968-0004(23)00281-5. doi: 10.1016/j.tibs.2023.10.009. Online ahead of print.ABSTRACTMolecular chaperones play central roles in sustaining protein homeostasis and preventing protein aggregation. Most studies of these systems have been performed in bulk, providing averaged measurements, though recent single-molecule approaches have provided an in-depth understanding of the molecular mechanisms of their activities and structural rearrangements during substrate recognition. Chaperone activities have been observed to be substrate specific, with some associated with ATP-dependent structural dyna...
Source: Trends in Biochemical Sciences - November 18, 2023 Category: Biochemistry Authors: Ayush Chandrakant Mistry Debojyoti Chowdhury Soham Chakraborty Shubhasis Haldar Source Type: research
The ART of RNAylation: covalent RNA-protein linkage in bacteriophage infection
Trends Biochem Sci. 2023 Nov 16:S0968-0004(23)00284-0. doi: 10.1016/j.tibs.2023.10.011. Online ahead of print.ABSTRACTBacteriophages have been a treasure trove for the discovery of fundamental biological principles and the expansion of our enzymatic toolkit since the dawn of molecular biology. In a recent study by Wolfram-Schauerte et al. these ubiquitous bacteria-infecting viruses reveal yet another new biological concept: post-translational modification through covalent RNA-protein linkages.PMID:37980188 | DOI:10.1016/j.tibs.2023.10.011 (Source: Trends in Biochemical Sciences)
Source: Trends in Biochemical Sciences - November 18, 2023 Category: Biochemistry Authors: Sophie M Korn Sunny Sharma Anna-Lena Steckelberg Source Type: research
Elucidating the novel mechanisms of molecular chaperones by single-molecule technologies
Trends Biochem Sci. 2023 Nov 16:S0968-0004(23)00281-5. doi: 10.1016/j.tibs.2023.10.009. Online ahead of print.ABSTRACTMolecular chaperones play central roles in sustaining protein homeostasis and preventing protein aggregation. Most studies of these systems have been performed in bulk, providing averaged measurements, though recent single-molecule approaches have provided an in-depth understanding of the molecular mechanisms of their activities and structural rearrangements during substrate recognition. Chaperone activities have been observed to be substrate specific, with some associated with ATP-dependent structural dyna...
Source: Trends in Biochemical Sciences - November 18, 2023 Category: Biochemistry Authors: Ayush Chandrakant Mistry Debojyoti Chowdhury Soham Chakraborty Shubhasis Haldar Source Type: research
The ART of RNAylation: covalent RNA-protein linkage in bacteriophage infection
Trends Biochem Sci. 2023 Nov 16:S0968-0004(23)00284-0. doi: 10.1016/j.tibs.2023.10.011. Online ahead of print.ABSTRACTBacteriophages have been a treasure trove for the discovery of fundamental biological principles and the expansion of our enzymatic toolkit since the dawn of molecular biology. In a recent study by Wolfram-Schauerte et al. these ubiquitous bacteria-infecting viruses reveal yet another new biological concept: post-translational modification through covalent RNA-protein linkages.PMID:37980188 | DOI:10.1016/j.tibs.2023.10.011 (Source: Trends in Biochemical Sciences)
Source: Trends in Biochemical Sciences - November 18, 2023 Category: Biochemistry Authors: Sophie M Korn Sunny Sharma Anna-Lena Steckelberg Source Type: research
Elucidating the novel mechanisms of molecular chaperones by single-molecule technologies
Trends Biochem Sci. 2023 Nov 16:S0968-0004(23)00281-5. doi: 10.1016/j.tibs.2023.10.009. Online ahead of print.ABSTRACTMolecular chaperones play central roles in sustaining protein homeostasis and preventing protein aggregation. Most studies of these systems have been performed in bulk, providing averaged measurements, though recent single-molecule approaches have provided an in-depth understanding of the molecular mechanisms of their activities and structural rearrangements during substrate recognition. Chaperone activities have been observed to be substrate specific, with some associated with ATP-dependent structural dyna...
Source: Trends in Biochemical Sciences - November 18, 2023 Category: Biochemistry Authors: Ayush Chandrakant Mistry Debojyoti Chowdhury Soham Chakraborty Shubhasis Haldar Source Type: research
The ART of RNAylation: covalent RNA-protein linkage in bacteriophage infection
Trends Biochem Sci. 2023 Nov 16:S0968-0004(23)00284-0. doi: 10.1016/j.tibs.2023.10.011. Online ahead of print.ABSTRACTBacteriophages have been a treasure trove for the discovery of fundamental biological principles and the expansion of our enzymatic toolkit since the dawn of molecular biology. In a recent study by Wolfram-Schauerte et al. these ubiquitous bacteria-infecting viruses reveal yet another new biological concept: post-translational modification through covalent RNA-protein linkages.PMID:37980188 | DOI:10.1016/j.tibs.2023.10.011 (Source: Trends in Biochemical Sciences)
Source: Trends in Biochemical Sciences - November 18, 2023 Category: Biochemistry Authors: Sophie M Korn Sunny Sharma Anna-Lena Steckelberg Source Type: research
Elucidating the novel mechanisms of molecular chaperones by single-molecule technologies
Trends Biochem Sci. 2023 Nov 16:S0968-0004(23)00281-5. doi: 10.1016/j.tibs.2023.10.009. Online ahead of print.ABSTRACTMolecular chaperones play central roles in sustaining protein homeostasis and preventing protein aggregation. Most studies of these systems have been performed in bulk, providing averaged measurements, though recent single-molecule approaches have provided an in-depth understanding of the molecular mechanisms of their activities and structural rearrangements during substrate recognition. Chaperone activities have been observed to be substrate specific, with some associated with ATP-dependent structural dyna...
Source: Trends in Biochemical Sciences - November 18, 2023 Category: Biochemistry Authors: Ayush Chandrakant Mistry Debojyoti Chowdhury Soham Chakraborty Shubhasis Haldar Source Type: research
The ART of RNAylation: covalent RNA-protein linkage in bacteriophage infection
Trends Biochem Sci. 2023 Nov 16:S0968-0004(23)00284-0. doi: 10.1016/j.tibs.2023.10.011. Online ahead of print.ABSTRACTBacteriophages have been a treasure trove for the discovery of fundamental biological principles and the expansion of our enzymatic toolkit since the dawn of molecular biology. In a recent study by Wolfram-Schauerte et al. these ubiquitous bacteria-infecting viruses reveal yet another new biological concept: post-translational modification through covalent RNA-protein linkages.PMID:37980188 | DOI:10.1016/j.tibs.2023.10.011 (Source: Trends in Biochemical Sciences)
Source: Trends in Biochemical Sciences - November 18, 2023 Category: Biochemistry Authors: Sophie M Korn Sunny Sharma Anna-Lena Steckelberg Source Type: research
