Integrating lipids into figures
Trends Biochem Sci. 2023 Oct;48(10):829-831. doi: 10.1016/j.tibs.2023.07.004.NO ABSTRACTPMID:37714138 | DOI:10.1016/j.tibs.2023.07.004 (Source: Trends in Biochemical Sciences)
Source: Trends in Biochemical Sciences - September 15, 2023 Category: Biochemistry Authors: Xinyu Li Ye Tian Xiaochun Li Sarah R Barger Source Type: research

Discordant skeletal muscle gene and protein responses to exercise
Trends Biochem Sci. 2023 Sep 12:S0968-0004(23)00208-6. doi: 10.1016/j.tibs.2023.08.005. Online ahead of print.ABSTRACTThe ability of skeletal muscle to adapt to repeated contractile stimuli is one of the most intriguing aspects of physiology. The molecular bases underpinning these adaptations involve increased protein activity and/or expression, mediated by an array of pre- and post-transcriptional processes, as well as translational and post-translational control. A longstanding dogma assumes a direct relationship between exercise-induced increases in mRNA levels and subsequent changes in the abundance of the proteins the...
Source: Trends in Biochemical Sciences - September 14, 2023 Category: Biochemistry Authors: David J Bishop Nolan J Hoffman Dale F Taylor Nicholas J Saner Matthew J-C Lee John A Hawley Source Type: research

Discordant skeletal muscle gene and protein responses to exercise
Trends Biochem Sci. 2023 Sep 12:S0968-0004(23)00208-6. doi: 10.1016/j.tibs.2023.08.005. Online ahead of print.ABSTRACTThe ability of skeletal muscle to adapt to repeated contractile stimuli is one of the most intriguing aspects of physiology. The molecular bases underpinning these adaptations involve increased protein activity and/or expression, mediated by an array of pre- and post-transcriptional processes, as well as translational and post-translational control. A longstanding dogma assumes a direct relationship between exercise-induced increases in mRNA levels and subsequent changes in the abundance of the proteins the...
Source: Trends in Biochemical Sciences - September 14, 2023 Category: Biochemistry Authors: David J Bishop Nolan J Hoffman Dale F Taylor Nicholas J Saner Matthew J-C Lee John A Hawley Source Type: research

Using light to drive energy transduction in metazoan aging
Trends Biochem Sci. 2023 Sep 11:S0968-0004(23)00213-X. doi: 10.1016/j.tibs.2023.08.010. Online ahead of print.ABSTRACTMitochondrial dysfunction is a central hallmark of aging and energy transduction is a promising target for longevity interventions. New research suggests that interventions in how energy is transduced could benefit healthy longevity. Here, we propose using light as an alternative energy source to fuel mitochondria and increase metazoan lifespan.PMID:37704489 | DOI:10.1016/j.tibs.2023.08.010 (Source: Trends in Biochemical Sciences)
Source: Trends in Biochemical Sciences - September 13, 2023 Category: Biochemistry Authors: Vaibhav Tiwary Anne-Marie Galow Andrew P Wojtovich Shahaf Peleg Source Type: research

Multifaceted control of T cell differentiation by STIM1
Trends Biochem Sci. 2023 Sep 9:S0968-0004(23)00209-8. doi: 10.1016/j.tibs.2023.08.006. Online ahead of print.ABSTRACTIn T cells, stromal interaction molecule (STIM) and Orai are dispensable for conventional T cell development, but critical for activation and differentiation. This review focuses on novel STIM-dependent mechanisms for control of Ca2+ signals during T cell activation and its impact on mitochondrial function and transcriptional activation for control of T cell differentiation and function. We highlight areas that require further work including the roles of plasma membrane Ca2+ ATPase (PMCA) and partner of STIM...
Source: Trends in Biochemical Sciences - September 11, 2023 Category: Biochemistry Authors: Scott Gross Lauren Womer Dietmar J Kappes Jonathan Soboloff Source Type: research

Multifaceted control of T cell differentiation by STIM1
Trends Biochem Sci. 2023 Sep 9:S0968-0004(23)00209-8. doi: 10.1016/j.tibs.2023.08.006. Online ahead of print.ABSTRACTIn T cells, stromal interaction molecule (STIM) and Orai are dispensable for conventional T cell development, but critical for activation and differentiation. This review focuses on novel STIM-dependent mechanisms for control of Ca2+ signals during T cell activation and its impact on mitochondrial function and transcriptional activation for control of T cell differentiation and function. We highlight areas that require further work including the roles of plasma membrane Ca2+ ATPase (PMCA) and partner of STIM...
Source: Trends in Biochemical Sciences - September 11, 2023 Category: Biochemistry Authors: Scott Gross Lauren Womer Dietmar J Kappes Jonathan Soboloff Source Type: research

Multifaceted control of T cell differentiation by STIM1
Trends Biochem Sci. 2023 Sep 9:S0968-0004(23)00209-8. doi: 10.1016/j.tibs.2023.08.006. Online ahead of print.ABSTRACTIn T cells, stromal interaction molecule (STIM) and Orai are dispensable for conventional T cell development, but critical for activation and differentiation. This review focuses on novel STIM-dependent mechanisms for control of Ca2+ signals during T cell activation and its impact on mitochondrial function and transcriptional activation for control of T cell differentiation and function. We highlight areas that require further work including the roles of plasma membrane Ca2+ ATPase (PMCA) and partner of STIM...
Source: Trends in Biochemical Sciences - September 11, 2023 Category: Biochemistry Authors: Scott Gross Lauren Womer Dietmar J Kappes Jonathan Soboloff Source Type: research

Transcription-coupled nucleosome assembly
Trends Biochem Sci. 2023 Aug 30:S0968-0004(23)00206-2. doi: 10.1016/j.tibs.2023.08.003. Online ahead of print.ABSTRACTEukaryotic transcription occurs on chromatin, where RNA polymerase II encounters nucleosomes during elongation. These nucleosomes must unravel for the DNA to enter the active site. However, in most transcribed genes, nucleosomes remain intact due to transcription-coupled chromatin assembly mechanisms. These mechanisms primarily involve the local reassembly of displaced nucleosomes to prevent (epi)genomic instability and the emergence of cryptic transcription. As a fail-safe mechanism, cells can assemble nuc...
Source: Trends in Biochemical Sciences - September 1, 2023 Category: Biochemistry Authors: Fran çois Robert C élia Jeronimo Source Type: research

Intrinsically disordered regions are poised to act as sensors of cellular chemistry
Trends Biochem Sci. 2023 Aug 30:S0968-0004(23)00204-9. doi: 10.1016/j.tibs.2023.08.001. Online ahead of print.ABSTRACTIntrinsically disordered proteins and protein regions (IDRs) are abundant in eukaryotic proteomes and play a wide variety of essential roles. Instead of folding into a stable structure, IDRs exist in an ensemble of interconverting conformations whose structure is biased by sequence-dependent interactions. The absence of a stable 3D structure, combined with high solvent accessibility, means that IDR conformational biases are inherently sensitive to changes in their environment. Here, we argue that IDRs are i...
Source: Trends in Biochemical Sciences - September 1, 2023 Category: Biochemistry Authors: David Moses Garrett M Ginell Alex S Holehouse Shahar Sukenik Source Type: research

Thermosensing and thermal responses in plants
Trends Biochem Sci. 2023 Aug 30:S0968-0004(23)00205-0. doi: 10.1016/j.tibs.2023.08.002. Online ahead of print.ABSTRACTThermosensors have been identified in plants in recent years. Understanding how plants sense and respond to rising temperatures is of utmost importance currently in terms of global warming and its actual and potential impact on us. This forum explores the recent understanding of plant thermosensing and thermal responses.PMID:37657995 | DOI:10.1016/j.tibs.2023.08.002 (Source: Trends in Biochemical Sciences)
Source: Trends in Biochemical Sciences - September 1, 2023 Category: Biochemistry Authors: Junwen Wu Peng Liu Yukun Liu Source Type: research

Transcription-coupled nucleosome assembly
Trends Biochem Sci. 2023 Aug 30:S0968-0004(23)00206-2. doi: 10.1016/j.tibs.2023.08.003. Online ahead of print.ABSTRACTEukaryotic transcription occurs on chromatin, where RNA polymerase II encounters nucleosomes during elongation. These nucleosomes must unravel for the DNA to enter the active site. However, in most transcribed genes, nucleosomes remain intact due to transcription-coupled chromatin assembly mechanisms. These mechanisms primarily involve the local reassembly of displaced nucleosomes to prevent (epi)genomic instability and the emergence of cryptic transcription. As a fail-safe mechanism, cells can assemble nuc...
Source: Trends in Biochemical Sciences - September 1, 2023 Category: Biochemistry Authors: Fran çois Robert C élia Jeronimo Source Type: research

Intrinsically disordered regions are poised to act as sensors of cellular chemistry
Trends Biochem Sci. 2023 Aug 30:S0968-0004(23)00204-9. doi: 10.1016/j.tibs.2023.08.001. Online ahead of print.ABSTRACTIntrinsically disordered proteins and protein regions (IDRs) are abundant in eukaryotic proteomes and play a wide variety of essential roles. Instead of folding into a stable structure, IDRs exist in an ensemble of interconverting conformations whose structure is biased by sequence-dependent interactions. The absence of a stable 3D structure, combined with high solvent accessibility, means that IDR conformational biases are inherently sensitive to changes in their environment. Here, we argue that IDRs are i...
Source: Trends in Biochemical Sciences - September 1, 2023 Category: Biochemistry Authors: David Moses Garrett M Ginell Alex S Holehouse Shahar Sukenik Source Type: research

Thermosensing and thermal responses in plants
Trends Biochem Sci. 2023 Aug 30:S0968-0004(23)00205-0. doi: 10.1016/j.tibs.2023.08.002. Online ahead of print.ABSTRACTThermosensors have been identified in plants in recent years. Understanding how plants sense and respond to rising temperatures is of utmost importance currently in terms of global warming and its actual and potential impact on us. This forum explores the recent understanding of plant thermosensing and thermal responses.PMID:37657995 | DOI:10.1016/j.tibs.2023.08.002 (Source: Trends in Biochemical Sciences)
Source: Trends in Biochemical Sciences - September 1, 2023 Category: Biochemistry Authors: Junwen Wu Peng Liu Yukun Liu Source Type: research

Transcription-coupled nucleosome assembly
Trends Biochem Sci. 2023 Aug 30:S0968-0004(23)00206-2. doi: 10.1016/j.tibs.2023.08.003. Online ahead of print.ABSTRACTEukaryotic transcription occurs on chromatin, where RNA polymerase II encounters nucleosomes during elongation. These nucleosomes must unravel for the DNA to enter the active site. However, in most transcribed genes, nucleosomes remain intact due to transcription-coupled chromatin assembly mechanisms. These mechanisms primarily involve the local reassembly of displaced nucleosomes to prevent (epi)genomic instability and the emergence of cryptic transcription. As a fail-safe mechanism, cells can assemble nuc...
Source: Trends in Biochemical Sciences - September 1, 2023 Category: Biochemistry Authors: Fran çois Robert C élia Jeronimo Source Type: research

Intrinsically disordered regions are poised to act as sensors of cellular chemistry
Trends Biochem Sci. 2023 Aug 30:S0968-0004(23)00204-9. doi: 10.1016/j.tibs.2023.08.001. Online ahead of print.ABSTRACTIntrinsically disordered proteins and protein regions (IDRs) are abundant in eukaryotic proteomes and play a wide variety of essential roles. Instead of folding into a stable structure, IDRs exist in an ensemble of interconverting conformations whose structure is biased by sequence-dependent interactions. The absence of a stable 3D structure, combined with high solvent accessibility, means that IDR conformational biases are inherently sensitive to changes in their environment. Here, we argue that IDRs are i...
Source: Trends in Biochemical Sciences - September 1, 2023 Category: Biochemistry Authors: David Moses Garrett M Ginell Alex S Holehouse Shahar Sukenik Source Type: research