Discordant skeletal muscle gene and protein responses to exercise

Trends Biochem Sci. 2023 Sep 12:S0968-0004(23)00208-6. doi: 10.1016/j.tibs.2023.08.005. Online ahead of print.ABSTRACTThe ability of skeletal muscle to adapt to repeated contractile stimuli is one of the most intriguing aspects of physiology. The molecular bases underpinning these adaptations involve increased protein activity and/or expression, mediated by an array of pre- and post-transcriptional processes, as well as translational and post-translational control. A longstanding dogma assumes a direct relationship between exercise-induced increases in mRNA levels and subsequent changes in the abundance of the proteins they encode. Drawing on the results of recent studies, we dissect and question the common assumption of a direct relationship between changes in the skeletal muscle transcriptome and proteome induced by repeated muscle contractions (e.g., exercise).PMID:37709636 | DOI:10.1016/j.tibs.2023.08.005
Source: Trends in Biochemical Sciences - Category: Biochemistry Authors: Source Type: research