Multifaceted control of T cell differentiation by STIM1

Trends Biochem Sci. 2023 Sep 9:S0968-0004(23)00209-8. doi: 10.1016/j.tibs.2023.08.006. Online ahead of print.ABSTRACTIn T cells, stromal interaction molecule (STIM) and Orai are dispensable for conventional T cell development, but critical for activation and differentiation. This review focuses on novel STIM-dependent mechanisms for control of Ca2+ signals during T cell activation and its impact on mitochondrial function and transcriptional activation for control of T cell differentiation and function. We highlight areas that require further work including the roles of plasma membrane Ca2+ ATPase (PMCA) and partner of STIM1 (POST) in controlling Orai function. A major knowledge gap also exists regarding the independence of T cell development from STIM and Orai, despite compelling evidence that it requires Ca2+ signals. Resolving these and other outstanding questions ensures that the field will remain active for many years to come.PMID:37696713 | DOI:10.1016/j.tibs.2023.08.006

Source: Trends in Biochemical Sciences - September 11, 2023 Category: Biochemistry Authors: Scott Gross Lauren Womer Dietmar J Kappes Jonathan Soboloff Source Type: research